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TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009 Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09 Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA Species/Strain: HAMSTERS/SYRIAN Lab: BAT F1_Rev1_H1 C Number: C93027B Lock Date: 06/12/1996 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL Study Gender: Male TDMSE Version: 2.1.0

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Page 1: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

F1_Rev1_H1

C Number: C93027B

Lock Date: 06/12/1996

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Male

TDMSE Version: 2.1.0

Page 2: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + 10.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + 10.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + 10.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID0 PPM

01201

01202

01203

01204

01205

01206

01207

01208

01209

01210 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 2

Page 3: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + 10

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + 10.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + 10.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEMNONE

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID0 PPM

01201

01202

01203

01204

01205

01206

01207

01208

01209

01210 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 3

Page 4: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + 10.........................................................................................................................................................................................................

Preputial Gland M M M + M M + M M M 2.........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10.........................................................................................................................................................................................................

Testes + + + + + + + + + + 10

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + + 10.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + 10.........................................................................................................................................................................................................

Spleen + + + + + + + + + + 10.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID0 PPM

01201

01202

01203

01204

01205

01206

01207

01208

01209

01210 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 4

Page 5: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

Mammary Gland M M + M M M M M + M 2.........................................................................................................................................................................................................

Skin + + + + + + + + + + 10

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + 10

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10.........................................................................................................................................................................................................

Nose + + + + + + + + + + 10.........................................................................................................................................................................................................

Trachea + + + + + + + + + + 10

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEM

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID0 PPM

01201

01202

01203

01204

01205

01206

01207

01208

01209

01210 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 5

Page 6: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

.........................................................................................................................................................................................................Kidney + + + + + + + + + + 10

.........................................................................................................................................................................................................Urinary Bladder + + + + + + + + + + 10

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID0 PPM

01201

01202

01203

01204

01205

01206

01207

01208

01209

01210 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 6

Page 7: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver M + + + + + + + + + 9.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEMNONE

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Preputial Gland M M + M M M + M M M 2.........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10.........................................................................................................................................................................................................

Testes + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID100 PPM

01211

01212

01213

01214

01215

01216

01217

01218

01219

01220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 7

Page 8: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

HEMATOPOIETIC SYSTEMNONE

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEMNONE

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + 9

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID100 PPM

01211

01212

01213

01214

01215

01216

01217

01218

01219

01220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 8

Page 9: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID100 PPM

01211

01212

01213

01214

01215

01216

01217

01218

01219

01220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 9

Page 10: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEMNONE

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Preputial Gland M M M M + + + M M 3.........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10.........................................................................................................................................................................................................

Testes + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID1000 PPM

01221

01222

01223

01224

01225

01226

01227

01228

01229

01230 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 10

Page 11: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

HEMATOPOIETIC SYSTEMNONE

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEMNONE

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + 8

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID1000 PPM

01221

01222

01223

01224

01225

01226

01227

01228

01229

01230 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 11

Page 12: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID1000 PPM

01221

01222

01223

01224

01225

01226

01227

01228

01229

01230 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 12

Page 13: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + 1

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Preputial Gland M M M M M M M M M 0.........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID6000 PPM

01231

01232

01233

01234

01235

01236

01237

01238

01239

01240 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 13

Page 14: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

.........................................................................................................................................................................................................Testes + + + + + + + + + + 10

HEMATOPOIETIC SYSTEMNONE

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEMNONE

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID6000 PPM

01231

01232

01233

01234

01235

01236

01237

01238

01239

01240 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 14

Page 15: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

Kidney + + + + + + + + + + 10

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID6000 PPM

01231

01232

01233

01234

01235

01236

01237

01238

01239

01240 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 15

Page 16: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10.........................................................................................................................................................................................................

Pancreas + + + + + + + + + 9

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEMNONE

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + 1.........................................................................................................................................................................................................

Preputial Gland M M M M M M M M + + 2.........................................................................................................................................................................................................

Prostate + + + + + + + + + 9.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + 9

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID12,000 PPM

01241

01242

01243

01244

01245

01246

01247

01248

01249

01250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 16

Page 17: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

.........................................................................................................................................................................................................Testes + + + + + + + + + + 10

HEMATOPOIETIC SYSTEMNONE

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEMNONE

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID12,000 PPM

01241

01242

01243

01244

01245

01246

01247

01248

01249

01250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 17

Page 18: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

Kidney + + + + + + + + + + 10

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID12,000 PPM

01241

01242

01243

01244

01245

01246

01247

01248

01249

01250 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 18

Page 19: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + + + + + + + + + + 10.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + 10.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + 10.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + 10.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID24,000 PPM

01251

01252

01253

01254

01255

01256

01257

01258

01259

01260 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 19

Page 20: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

.........................................................................................................................................................................................................Stomach, Glandular + + + + + + + + + + 10

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + 10.........................................................................................................................................................................................................

Parathyroid Gland + + M + + + + + M + 8.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + M + + 9.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEMNONE

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID24,000 PPM

01251

01252

01253

01254

01255

01256

01257

01258

01259

01260 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 20

Page 21: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

GENITAL SYSTEM.........................................................................................................................................................................................................

Epididymis + + + + + + + + + + 10.........................................................................................................................................................................................................

Preputial Gland + M M M + + + M M M 4.........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10.........................................................................................................................................................................................................

Testes + + + + + + + + + + 10

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + + 10.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + 10.........................................................................................................................................................................................................

Spleen + + + + + + + + + + 10.........................................................................................................................................................................................................

Thymus + + + + + + + + M + 9

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID24,000 PPM

01251

01252

01253

01254

01255

01256

01257

01258

01259

01260 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 21

Page 22: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

Mammary Gland M M + M M M M M M M 1.........................................................................................................................................................................................................

Skin + + + + + + + + + + 10

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone + + + + + + + + + + 10

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10.........................................................................................................................................................................................................

Nose + + + + + + + + + + 10.........................................................................................................................................................................................................

Trachea + + + + + + + + + + 10

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Harderian Gland + 1

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID24,000 PPM

01251

01252

01253

01254

01255

01256

01257

01258

01259

01260 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 22

Page 23: TDMS No. Route: DOSED FEED CAS Number: First Dose … file7 0 1 2 0 8 0 1 2 0 9 0 1 2 1 0 * TOTALS * .. Total animals with tissue examined microscopically; Total animals with tumor

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + 10.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + 10

SYSTEMIC LESIONS.........................................................................................................................................................................................................

Multiple Organ + + + + + + + + + + 10

*** END OF MALE DATA ***

*** END OF REPORT ***

TDMS No. 93027 - 27 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2009

Test Type: 90-DAY Peroxisome project (Gemfibrozil) Time Report Requested: 13:52:09

Route: DOSED FEED CAS Number: 25812-30-0 First Dose M/F: 10/21/94 / NA

Species/Strain: HAMSTERS/SYRIAN Lab: BAT

DAY ON TEST0092

0092

0092

0092

0092

0092

0092

0092

0092

0092

.................................................................................................................................................................

SYRIAN GOLDEN HAMSTERSMALE

ANIMAL ID24,000 PPM

01251

01252

01253

01254

01255

01256

01257

01258

01259

01260 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationx .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 23


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