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TDMS No. 20305 - 01
Test Type: 18-33 DAYS
Route: INTRADUCTAL CANNULATION
Species/Strain: MICE/BALB/C
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL ADENO-ASSOCIATED VIRAL VECTOR (HEPO)
CAS Number: AAVIRVECEPO
Pathologist: LANNING, L.
D_MW_core_allgrp
Date Report Reqsted: 09/07/2005
Time Report Reqsted: 13:31:00
First Dose M/F: 02/02/04 / 02/09/04
Lab: MBA
C Number: C20305
Lock Date: 08/29/2005
Cage Range: ALL
Date Range: ALL
Reasons For Removal: 25021 TSAC 25020 NATD
Removal Date Range: ALL
Treatment Groups: Include ALL
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9
2 2 7 2 2 2 2 1 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
ISORMCONSALINE 0 1
0 0 0 0 2
0 0 0 1 4
0 0 0 1 5
0 0 0 1 6
0 0 0 1 9
0 0 0 2 0
0 0 0 2 1 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + M M + + + + + 6 .........................................................................................................................................................................................................
Gallbladder + + A + + + + I 6 .........................................................................................................................................................................................................
Intestine Large, Cecum + + A + + + + A 6 .........................................................................................................................................................................................................
Intestine Large, Colon + + A + + + + + 7 .........................................................................................................................................................................................................
Intestine Large, Rectum + + A + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + A + + + + A 6 .........................................................................................................................................................................................................
Intestine Small, Ileum + + A + + + + A 6 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + A + + + + A 6 .........................................................................................................................................................................................................
Liver + + A + + + + + 7 Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal
.........................................................................................................................................................................................................
Pancreas + + A + + + + + 7 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9
2 2 7 2 2 2 2 1 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
ISORMCONSALINE 0 1
0 0 0 0 2
0 0 0 1 4
0 0 0 1 5
0 0 0 1 6
0 0 0 1 9
0 0 0 2 0
0 0 0 2 1 * TOTALS
Stomach, Forestomach + + A + + + + + 7 .........................................................................................................................................................................................................
Stomach, Glandular + + A + + + + + 7
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................
Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 1 1 2 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................
Islets, Pancreatic + + A + + + + + 7 .........................................................................................................................................................................................................
Parathyroid Gland + M M + + M M + 4 .........................................................................................................................................................................................................
Pituitary Gland + + A + + + + + 7 .........................................................................................................................................................................................................
Thyroid Gland + + M + + + + + 7 Ectopic Thymus 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9
2 2 7 2 2 2 2 1 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
ISORMCONSALINE 0 1
GENERAL BODY SYSTEM NONE
0 0 0 0 2
0 0 0 1 4
0 0 0 1 5
0 0 0 1 6
0 0 0 1 9
0 0 0 2 0
0 0 0 2 1 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................
Penis + 1 .........................................................................................................................................................................................................
Preputial Gland + + A + + + + + 7 .........................................................................................................................................................................................................
Prostate + + + + + + + + 8 Inflammation, Focal, Chronic Active 2 1 2.0
.........................................................................................................................................................................................................
Seminal Vesicle + + A + + + + + 7 .........................................................................................................................................................................................................
Testes + + + + + + + + 8
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................
Lymph Node, Mandibular + M + + + + + + 7 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9
2 2 7 2 2 2 2 1 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
ISORMCONSALINE 0 1
0 0 0 0 2
0 0 0 1 4
0 0 0 1 5
0 0 0 1 6
0 0 0 1 9
0 0 0 2 0
0 0 0 2 1 * TOTALS
Lymph Node, Mesenteric + + A + + + + + 7 Hyperplasia, Lymphoid 2 1 2.0
.........................................................................................................................................................................................................
Spleen + + A + + + + + 7 Hematopoietic Cell Proliferation 1 1 1 1 1 1 1 7 1.0
.........................................................................................................................................................................................................
Thymus + + A + + + + + 7
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + 8
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + 8
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + A + + + + + 7
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9
2 2 7 2 2 2 2 1 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
ISORMCONSALINE 0 1
0 0 0 0 2
0 0 0 1 4
0 0 0 1 5
0 0 0 1 6
0 0 0 1 9
0 0 0 2 0
0 0 0 2 1 * TOTALS
Alveolus, Hemorrhage, Focal 1 1 1 3 1.0 .........................................................................................................................................................................................................
Nose + + A + + + + + 7 .........................................................................................................................................................................................................
Trachea M + M + + I + + 5
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + + + 8 .........................................................................................................................................................................................................
Harderian Gland + + A + + + + + 7
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + 8 .........................................................................................................................................................................................................
Urinary Bladder + + A + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
1 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
TRTRMCONSALINE 3 1
0 0 0 0 0 0 3 3 2 3 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + 3 .........................................................................................................................................................................................................
Gallbladder A + + 2 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + 3 .........................................................................................................................................................................................................
Intestine Large, Colon + + + 3 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + 3 .........................................................................................................................................................................................................
Liver + + + 3 Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal
.........................................................................................................................................................................................................
Pancreas + + + 3 .........................................................................................................................................................................................................
Salivary Glands + + + 3 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
1 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
TRTRMCONSALINE 3 1
0 0 0 0 0 0 3 3 2 3 * TOTALS
Stomach, Forestomach + + + 3 .........................................................................................................................................................................................................
Stomach, Glandular + + + 3
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + 3 .........................................................................................................................................................................................................
Heart + + + 3
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + 3 Subcapsular, Hyperplasia, Focal 1 1 1 3 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + 3 .........................................................................................................................................................................................................
Islets, Pancreatic + + + 3 .........................................................................................................................................................................................................
Parathyroid Gland + M + 2 .........................................................................................................................................................................................................
Pituitary Gland + I + 2 .........................................................................................................................................................................................................
Thyroid Gland + + + 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
1 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
TRTRMCONSALINE 3 1
GENERAL BODY SYSTEM NONE
0 0 0 0 0 0 3 3 2 3 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + 3 .........................................................................................................................................................................................................
Preputial Gland + + + 3 .........................................................................................................................................................................................................
Prostate + + + 3 .........................................................................................................................................................................................................
Seminal Vesicle + + + 3 .........................................................................................................................................................................................................
Testes + + + 3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + 3 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + 3 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + 3 .........................................................................................................................................................................................................
Spleen A + + 2 Hematopoietic Cell Proliferation 1 1 2 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
1 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
TRTRMCONSALINE 3 1
0 0 0 0 0 0 3 3 2 3 * TOTALS
.........................................................................................................................................................................................................
Thymus + + + 3
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M 0 .........................................................................................................................................................................................................
Skin + + + 3
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + 3
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + 3
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + 3 .........................................................................................................................................................................................................
Nose + + + 3 .........................................................................................................................................................................................................
Trachea + + + 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
1 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
TRTRMCONSALINE 3 1
0 0 0 0 0 0 3 3 2 3 * TOTALS
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + 3 .........................................................................................................................................................................................................
Harderian Gland + + + 3
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + 3 .........................................................................................................................................................................................................
Urinary Bladder + + + 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9
2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-7 SALINE 3 4
0 0 0 3 5
0 0 0 3 6
0 0 0 3 9
0 0 0 4 7
0 0 0 4 8
0 0 0 4 9
0 0 0 5 2
0 0 0 5 3
0 0 0 5 4 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + 10 .........................................................................................................................................................................................................
Gallbladder + + + + + + + + M + 9 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Liver + + + + + + + + + + 10 Hepatocyte, Inflammation, Focal, Chronic 1 1.0 1Active Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + 10
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9
2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-7 SALINE 3 4
0 0 0 3 5
0 0 0 3 6
0 0 0 3 9
0 0 0 4 7
0 0 0 4 8
0 0 0 4 9
0 0 0 5 2
0 0 0 5 3
0 0 0 5 4 * TOTALS
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + 10 .........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + + + + 10 .........................................................................................................................................................................................................
Heart + + + + + + + + + + 10 Epicardium, Mineralization, Focal 1 1 1 3 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 7 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + 10 .........................................................................................................................................................................................................
Parathyroid Gland M M M M + + M + + + 5 .........................................................................................................................................................................................................
Pituitary Gland + + + + + M + + + + 9 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + 10
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9
2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-7 SALINE 3 4
0 0 0 3 5
0 0 0 3 6
0 0 0 3 9
0 0 0 4 7
0 0 0 4 8
0 0 0 4 9
0 0 0 5 2
0 0 0 5 3
0 0 0 5 4 * TOTALS
Ectopic Thymus 1 1 1.0
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + 10 .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + 10 .........................................................................................................................................................................................................
Prostate + + + + + + + + + + 10 .........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + 10 .........................................................................................................................................................................................................
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + 10 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + M M M + 7 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + 10 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9
2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-7 SALINE 3 4
0 0 0 3 5
0 0 0 3 6
0 0 0 3 9
0 0 0 4 7
0 0 0 4 8
0 0 0 4 9
0 0 0 5 2
0 0 0 5 3
0 0 0 5 4 * TOTALS
Spleen + + + + + + + + + + 10 Hematopoietic Cell Proliferation 1 1 1 1 1 2 1 2 1 1 10 1.2 Congestion, Diffuse 2 1 2.0
.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + 10 .........................................................................................................................................................................................................
Skeletal Muscle + 1 Hemorrhage, Focal 3 1 3.0 Inflammation, Focal, Acute 2 1 2.0
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9
2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-7 SALINE 3 4
0 0 0 3 5
0 0 0 3 6
0 0 0 3 9
0 0 0 4 7
0 0 0 4 8
0 0 0 4 9
0 0 0 5 2
0 0 0 5 3
0 0 0 5 4 * TOTALS
Lung + + + + + + + + + + 10 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0 Alveolar Epithelium, Bronchiole, 1 2.0 2Hyperplasia, Focal
.........................................................................................................................................................................................................
Nose + + + + + + + + + + 10 .........................................................................................................................................................................................................
Trachea + + I I + + + + + + 8
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + + + + + 10 .........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + 10 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + + I + + 9
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-8 SALINE 5 6
0 0 0 5 7
0 0 0 6 8
0 0 0 6 9
0 0 0 7 0
0 0 0 7 3
0 0 0 7 4
0 0 0 7 5 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + M + 7 .........................................................................................................................................................................................................
Gallbladder A A + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + 8 .........................................................................................................................................................................................................
Liver + + + + + + + + 8 .........................................................................................................................................................................................................
Pancreas + + + + + + + + 8 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + 8 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-8 SALINE 5 6
0 0 0 5 7
0 0 0 6 8
0 0 0 6 9
0 0 0 7 0
0 0 0 7 3
0 0 0 7 4
0 0 0 7 5 * TOTALS
Stomach, Glandular + + + + + + + + 8
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................
Heart + + + + + + + + 8 Ventricle, Thrombosis, Focal 4 1 4.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + 8 .........................................................................................................................................................................................................
Parathyroid Gland M M + + M + + + 5 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + 8 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + 8
GENERAL BODY SYSTEM NONE
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-8 SALINE 5 6
0 0 0 5 7
0 0 0 6 8
0 0 0 6 9
0 0 0 7 0
0 0 0 7 3
0 0 0 7 4
0 0 0 7 5 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + 8 .........................................................................................................................................................................................................
Prostate + + + + + + + + 8 .........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + 8 .........................................................................................................................................................................................................
Testes + + + + + + + + 8
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................
Lymph Node, Mandibular M + + + + + + + 7 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + 8 .........................................................................................................................................................................................................
Spleen + + + + + + + + 8 Hematopoietic Cell Proliferation 1 1 1 1 2 1 1 1 8 1.1
.........................................................................................................................................................................................................
Thymus + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-8 SALINE 5 6
0 0 0 5 7
0 0 0 6 8
0 0 0 6 9
0 0 0 7 0
0 0 0 7 3
0 0 0 7 4
0 0 0 7 5 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + 8
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + 8
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + 8
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + + + 8 Alveolus, Hemorrhage, Focal 1 1 1 1 1 1 6 1.0 Alveolar Epithelium, Bronchiole, 1 2.0 2Hyperplasia, Focal
.........................................................................................................................................................................................................
Nose + + + + + + + + 8 .........................................................................................................................................................................................................
Trachea + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-8 SALINE 5 6
0 0 0 5 7
0 0 0 6 8
0 0 0 6 9
0 0 0 7 0
0 0 0 7 3
0 0 0 7 4
0 0 0 7 5 * TOTALS
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + + + 8 .........................................................................................................................................................................................................
Harderian Gland + + + + + + + + 8
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + 8 .........................................................................................................................................................................................................
Urinary Bladder A + + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9
9 6 2 2 4 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-9 SALINE 8 1
0 0 0 8 9
0 0 0 9 0
0 0 0 9 1
0 0 0 9 3
0 0 0 9 4
0 0 0 9 5
0 0 0 9 6 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + A + + + + + + 7 .........................................................................................................................................................................................................
Gallbladder + M + + + + + + 7 .........................................................................................................................................................................................................
Intestine Large, Cecum + A + + + + + I 6 .........................................................................................................................................................................................................
Intestine Large, Colon + A + + + + + + 7 .........................................................................................................................................................................................................
Intestine Large, Rectum + A + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Duodenum + A + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Ileum + A + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Jejunum + A + + + + + + 7 .........................................................................................................................................................................................................
Liver + A + + + + + + 7 Hepatocyte, Necrosis, Focal 1 1 1.0 Vacuolization Cytoplasmic, Focal 1 1 1.0 Centrilobular, Hepatocyte, Vacuolization 2 1.0 1 1Cytoplasmic, Focal
.........................................................................................................................................................................................................
Pancreas + A + + + + + + 7 .........................................................................................................................................................................................................
Salivary Glands + A + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9
9 6 2 2 4 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-9 SALINE 8 1
0 0 0 8 9
0 0 0 9 0
0 0 0 9 1
0 0 0 9 3
0 0 0 9 4
0 0 0 9 5
0 0 0 9 6 * TOTALS
.........................................................................................................................................................................................................
Stomach, Forestomach + A + + + + + + 7 .........................................................................................................................................................................................................
Stomach, Glandular + A + + + + + + 7
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + A + + + + + + 7 .........................................................................................................................................................................................................
Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 2 1 2.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + A + + + + + + 7 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + A + + + + + + 7 .........................................................................................................................................................................................................
Islets, Pancreatic + A + + + + + + 7 .........................................................................................................................................................................................................
Parathyroid Gland + M + M + + + + 6 .........................................................................................................................................................................................................
Pituitary Gland + I I + + + + + 6 .........................................................................................................................................................................................................
Thyroid Gland + A + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9
9 6 2 2 4 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-9 SALINE 8 1
0 0 0 8 9
0 0 0 9 0
0 0 0 9 1
0 0 0 9 3
0 0 0 9 4
0 0 0 9 5
0 0 0 9 6 * TOTALS
Ectopic Thymus 1 1 1.0
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................
Preputial Gland + A + + + + + M 6 .........................................................................................................................................................................................................
Prostate + A + + + + + + 7 .........................................................................................................................................................................................................
Seminal Vesicle + A + + + + + + 7 .........................................................................................................................................................................................................
Testes + + + + + + + + 8
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + A + + + + + + 7 .........................................................................................................................................................................................................
Lymph Node, Mandibular + A M + + + + + 6 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + A + + + + + + 7 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9
9 6 2 2 4 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-9 SALINE 8 1
0 0 0 8 9
0 0 0 9 0
0 0 0 9 1
0 0 0 9 3
0 0 0 9 4
0 0 0 9 5
0 0 0 9 6 * TOTALS
Spleen + + + + + + + + 8 Hematopoietic Cell Proliferation 1 3 1 2 2 1 2 2 8 1.8
.........................................................................................................................................................................................................
Thymus + A + + + + + + 7
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + 8
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + 8
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + A + + + + + + 7
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + A + + + + + + 7 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0
.........................................................................................................................................................................................................
Nose + A + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9
9 6 2 2 4 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 0
1-9 SALINE 8 1
0 0 0 8 9
0 0 0 9 0
0 0 0 9 1
0 0 0 9 3
0 0 0 9 4
0 0 0 9 5
0 0 0 9 6 * TOTALS
.........................................................................................................................................................................................................
Trachea + A + + + + + + 7
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + A + + + + + + 7 .........................................................................................................................................................................................................
Harderian Gland + A + + + + + + 7
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + 8 Right, Infarct, Multiple 3 1 3.0
.........................................................................................................................................................................................................
Urinary Bladder + A + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 DAY ON TEST 2
9
0 0 2
0 0 2
0 5 0
0 9 2
0 9 2
0 9 2
0 9 2
0 9 2
0 9 2
................................................................................................................................................................. 0BALB/C MICE MALE 0
ANIMAL ID 1 1-10 SALINE 0
1
0 0 1 0 3
0 0 1 0 4
0 0 1 0 7
0 0 1 1 0
0 0 1 1 1
0 0 1 1 2
0 0 1 1 5
0 0 1 1 6
0 0 1 1 7 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + 10 .........................................................................................................................................................................................................
Gallbladder + + + + + + + + + + 10 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + A + + + + + + 9 .........................................................................................................................................................................................................
Intestine Large, Colon + + + A + + + + + + 9 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + A + + + + + + 9 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + A + + + + + + 9 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + A + + + + + + 9 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + 10 .........................................................................................................................................................................................................
Liver + + + + + + + + + + 10 Hematopoietic Cell Proliferation 3 1 3.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + 10 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + 10
2Submandibular Gland, Degeneration, 1 2.0 Diffuse
Submandibular Gland, Inflammation, 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9
9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 1
1-10 SALINE 0 1
0 0 1 0 3
0 0 1 0 4
0 0 1 0 7
0 0 1 1 0
0 0 1 1 1
0 0 1 1 2
0 0 1 1 5
0 0 1 1 6
0 0 1 1 7 * TOTALS
Diffuse, Acute .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + 10 .........................................................................................................................................................................................................
Stomach, Glandular + + + A + + + + + + 9
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + + + + 10 .........................................................................................................................................................................................................
Heart + + + + + + + + + + 10 Epicardium, Mineralization, Focal 1 1 1 1 4 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + 10 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 7 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + 10 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + 10 .........................................................................................................................................................................................................
Parathyroid Gland M + M + + + + + + + 8 .........................................................................................................................................................................................................
Pituitary Gland + + + I M + I I + I 5 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9
9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 1
1-10 SALINE 0 1
0 0 1 0 3
0 0 1 0 4
0 0 1 0 7
0 0 1 1 0
0 0 1 1 1
0 0 1 1 2
0 0 1 1 5
0 0 1 1 6
0 0 1 1 7 * TOTALS
Thyroid Gland + + + + + + + + + + 10 Ectopic Thymus 1 1 2 1.0
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + I + + 9 .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + 10 .........................................................................................................................................................................................................
Prostate + + + + + + + + + + 10 .........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + 10 .........................................................................................................................................................................................................
Testes I + + + + + + + + + 9
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + 10 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + M + + M M + 7 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + A + + + + + + 9 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9
9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 1
1-10 SALINE 0 1
0 0 1 0 3
0 0 1 0 4
0 0 1 0 7
0 0 1 1 0
0 0 1 1 1
0 0 1 1 2
0 0 1 1 5
0 0 1 1 6
0 0 1 1 7 * TOTALS
Spleen + + + + + + + + + + 10 Hematopoietic Cell Proliferation 3 1 1 2 3 3 3 4 3 4 10 2.7
.........................................................................................................................................................................................................
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + + + 10 Epidermis, Dermis, Subcutaneous Tissue, 1 4.0 4Inflammation, Focal, Acute
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + 10
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + + + + + 10 Alveolus, Hemorrhage, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9
9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE MALE 0 ANIMAL ID 1
1-10 SALINE 0 1
0 0 1 0 3
0 0 1 0 4
0 0 1 0 7
0 0 1 1 0
0 0 1 1 1
0 0 1 1 2
0 0 1 1 5
0 0 1 1 6
0 0 1 1 7 * TOTALS
Nose + + + + + + + + + + 10 .........................................................................................................................................................................................................
Trachea + + + + + I + + + I 8
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + + + + + 10 .........................................................................................................................................................................................................
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + 10 .........................................................................................................................................................................................................
Urinary Bladder + + + I + + + + + + 9
*** END OF MALE DATA ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
ISORMCONSALINE 3 1
0 0 1 3 2
0 0 1 3 3
0 0 1 3 6
0 0 1 3 7
0 0 1 3 8 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + 6 .........................................................................................................................................................................................................
Gallbladder + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + 6 .........................................................................................................................................................................................................
Liver + + + + + + 6 Infiltration Cellular, Focal, Mononuclear 1 1.0 1Cell
.........................................................................................................................................................................................................
Pancreas + + + + + + 6 .........................................................................................................................................................................................................
Salivary Glands + + + + + + 6 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
ISORMCONSALINE 3 1
0 0 1 3 2
0 0 1 3 3
0 0 1 3 6
0 0 1 3 7
0 0 1 3 8 * TOTALS
Stomach, Forestomach + + + + + + 6 .........................................................................................................................................................................................................
Stomach, Glandular + + + + + + 6
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................
Heart + + + M + + 5
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + 6 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + 6 .........................................................................................................................................................................................................
Parathyroid Gland M + + + + + 5 .........................................................................................................................................................................................................
Pituitary Gland I + + + + + 5 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + 6 Ectopic Thymus 1 1 2 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
ISORMCONSALINE 3 1
GENERAL BODY SYSTEM NONE
0 0 1 3 2
0 0 1 3 3
0 0 1 3 6
0 0 1 3 7
0 0 1 3 8 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + M + M M 3 .........................................................................................................................................................................................................
Ovary + + I + + + 5 .........................................................................................................................................................................................................
Uterus + + + + + + 6 Endometrium, Hyperplasia, Diffuse, Cystic 1 1 2 1 4 1.3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + 6 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + 6 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + 6 .........................................................................................................................................................................................................
Spleen + + + + + + 6 Hematopoietic Cell Proliferation 2 1 1 1 1 2 6 1.3
.........................................................................................................................................................................................................
Thymus + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
ISORMCONSALINE 3 1
0 0 1 3 2
0 0 1 3 3
0 0 1 3 6
0 0 1 3 7
0 0 1 3 8 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + 6 .........................................................................................................................................................................................................
Skin + + + + + + 6
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + 6
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + 6
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + 6 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0
.........................................................................................................................................................................................................
Nose + + + + + + 6 .........................................................................................................................................................................................................
Trachea I + I + I I 2
SPECIAL SENSES SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
ISORMCONSALINE 3 1
0 0 1 3 2
0 0 1 3 3
0 0 1 3 6
0 0 1 3 7
0 0 1 3 8 * TOTALS
.........................................................................................................................................................................................................
Eye + + + + + + 6 .........................................................................................................................................................................................................
Harderian Gland + + + + + + 6
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + 6 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
TRTRMCONSALINE 4 8
0 0 0 0 1 1 4 5 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + 3 .........................................................................................................................................................................................................
Gallbladder + + + 3 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + 3 .........................................................................................................................................................................................................
Intestine Large, Colon + + + 3 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + 3 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + 3 .........................................................................................................................................................................................................
Liver + + + 3 .........................................................................................................................................................................................................
Pancreas + + + 3 .........................................................................................................................................................................................................
Salivary Glands + + + 3 .........................................................................................................................................................................................................
Stomach, Forestomach + + + 3 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
TRTRMCONSALINE 4 8
0 0 0 0 1 1 4 5 9 0 * TOTALS
Stomach, Glandular + + + 3
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + 3 .........................................................................................................................................................................................................
Heart + + + 3 Epicardium, Mineralization, Focal 1 1 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + 3 Subcapsular, Hyperplasia, Focal 1 1 1 3 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + 3 .........................................................................................................................................................................................................
Islets, Pancreatic + + + 3 .........................................................................................................................................................................................................
Parathyroid Gland M M + 1 .........................................................................................................................................................................................................
Pituitary Gland I + + 2 .........................................................................................................................................................................................................
Thyroid Gland + + + 3 Ectopic Thymus 1 1 2 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
TRTRMCONSALINE 4 8
GENERAL BODY SYSTEM NONE
0 0 0 0 1 1 4 5 9 0 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + M M 1 .........................................................................................................................................................................................................
Ovary + + + 3 .........................................................................................................................................................................................................
Uterus + + + 3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + 3 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + 3 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + 3 .........................................................................................................................................................................................................
Spleen + + + 3 Hematopoietic Cell Proliferation 1 2 1 3 1.3
.........................................................................................................................................................................................................
Thymus + + + 3
INTEGUMENTARY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
TRTRMCONSALINE 4 8
0 0 0 0 1 1 4 5 9 0 * TOTALS
.........................................................................................................................................................................................................
Mammary Gland + + + 3 .........................................................................................................................................................................................................
Skin + + + 3
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + 3
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + 3
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + 3 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0
.........................................................................................................................................................................................................
Nose + + + 3 .........................................................................................................................................................................................................
Trachea + + I 2
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 DAY ON TEST 9 9 9
2 2 2 .................................................................................................................................................................
BALB/C MICE FEMALE ANIMAL ID
TRTRMCONSALINE
0 0 1 4 8
.........................................................................................................................................................................................................
Harderian Gland + + + 3
0 0 0 0 1 1 4 5 9 0 * TOTALS
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + 3 .........................................................................................................................................................................................................
Urinary Bladder + + + 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-7 SALINE 5 3
0 0 1 5 7
0 0 1 6 4
0 0 1 6 5
0 0 1 6 6
0 0 1 6 9
0 0 1 7 0
0 0 1 7 1 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + 8 .........................................................................................................................................................................................................
Gallbladder + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + 8 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + 8 .........................................................................................................................................................................................................
Liver + + + + + + + + 8 Hepatocyte, Necrosis, Focal 1 1 1.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + 8 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-7 SALINE 5 3
0 0 1 5 7
0 0 1 6 4
0 0 1 6 5
0 0 1 6 6
0 0 1 6 9
0 0 1 7 0
0 0 1 7 1 * TOTALS
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + 8
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................
Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 2 1 2 1.5
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 1 8 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 4 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + 8 .........................................................................................................................................................................................................
Parathyroid Gland + M + M + + M + 5 .........................................................................................................................................................................................................
Pituitary Gland + + + + I + + + 7 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + M + 7 Ectopic Thymus 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-7 SALINE 5 3
GENERAL BODY SYSTEM NONE
0 0 1 5 7
0 0 1 6 4
0 0 1 6 5
0 0 1 6 6
0 0 1 6 9
0 0 1 7 0
0 0 1 7 1 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + + M M I + M 4 .........................................................................................................................................................................................................
Ovary + + + + + + + + 8 .........................................................................................................................................................................................................
Uterus + + + + + + + + 8 Endometrium, Hyperplasia, Diffuse, Cystic 1 2 1 3 1.3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + + + 8 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + M + 7 .........................................................................................................................................................................................................
Spleen + + + + + + + + 8 Hematopoietic Cell Proliferation 2 1 2 1 1 1 1 1 8 1.3
.........................................................................................................................................................................................................
Thymus + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 44
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-7 SALINE 5 3
0 0 1 5 7
0 0 1 6 4
0 0 1 6 5
0 0 1 6 6
0 0 1 6 9
0 0 1 7 0
0 0 1 7 1 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + 8 .........................................................................................................................................................................................................
Skin + + + + + + + + 8
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + 8
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + 8
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + + + 8 Alveolus, Hemorrhage, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
Nose + + + + + + + + 8 .........................................................................................................................................................................................................
Trachea + I + I + + + + 6
SPECIAL SENSES SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 45
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9
2 2 2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-7 SALINE 5 3
0 0 1 5 7
0 0 1 6 4
0 0 1 6 5
0 0 1 6 6
0 0 1 6 9
0 0 1 7 0
0 0 1 7 1 * TOTALS
.........................................................................................................................................................................................................
Eye + + + + + + + + 8 .........................................................................................................................................................................................................
Harderian Gland + + + + + + + + 8
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + 8 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + 8
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 46
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-8 SALINE 8 5
0 0 1 8 6
0 0 1 8 7
0 0 1 9 0
0 0 1 9 1
0 0 1 9 2 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + 6 .........................................................................................................................................................................................................
Gallbladder + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + 6 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + 6 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + 6 .........................................................................................................................................................................................................
Liver + + + + + + 6 .........................................................................................................................................................................................................
Pancreas + + + + + + 6 .........................................................................................................................................................................................................
Salivary Glands + + + + + + 6 Submandibular Gland, Infiltration Cellular, 1 1.0 1Focal, Mononuclear Cell
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 47
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-8 SALINE 8 5
0 0 1 8 6
0 0 1 8 7
0 0 1 9 0
0 0 1 9 1
0 0 1 9 2 * TOTALS
Stomach, Forestomach + + + + + + 6 .........................................................................................................................................................................................................
Stomach, Glandular + + + + + + 6
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................
Heart + + + + + + 6 Epicardium, Mineralization, Focal 1 1 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + 6 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + 6 .........................................................................................................................................................................................................
Parathyroid Gland M + + + + + 5 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + 6 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 48
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-8 SALINE 8 5
GENERAL BODY SYSTEM NONE
0 0 1 8 6
0 0 1 8 7
0 0 1 9 0
0 0 1 9 1
0 0 1 9 2 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland M + + + I + 4 .........................................................................................................................................................................................................
Ovary + + + + + I 5 .........................................................................................................................................................................................................
Uterus + + + + + + 6 Endometrium, Hyperplasia, Diffuse, Cystic 2 2 1 2 1 5 1.6
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + 6 Depletion Cellular, Diffuse 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + 6 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + 6 .........................................................................................................................................................................................................
Spleen + + + + + + 6 Hematopoietic Cell Proliferation 2 2 2 2 2 3 6 2.2
.........................................................................................................................................................................................................
Thymus + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 49
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-8 SALINE 8 5
0 0 1 8 6
0 0 1 8 7
0 0 1 9 0
0 0 1 9 1
0 0 1 9 2 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + 6 .........................................................................................................................................................................................................
Skin + + + + + + 6
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + 6
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + 6
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + 6 Alveolus, Hemorrhage, Focal 1 1 1 1 4 1.0
.........................................................................................................................................................................................................
Nose + + + + + + 6 .........................................................................................................................................................................................................
Trachea + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 50
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9
2 2 2 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 1
1-8 SALINE 8 5
0 0 1 8 6
0 0 1 8 7
0 0 1 9 0
0 0 1 9 1
0 0 1 9 2 * TOTALS
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + 6 .........................................................................................................................................................................................................
Harderian Gland + + + + + + 6
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + 6 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + 6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 51
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9
2 2 2 1 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-9 SALINE 0 6
0 0 2 0 7
0 0 2 0 8
0 0 2 0 9
0 0 2 1 1
0 0 2 1 2
0 0 2 1 3 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + 7 .........................................................................................................................................................................................................
Gallbladder + + + + I + + 6 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + 7 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + 7 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + 7 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + 7 .........................................................................................................................................................................................................
Liver + + + + + + + 7 .........................................................................................................................................................................................................
Pancreas + + + + + + + 7 .........................................................................................................................................................................................................
Salivary Glands + + + + + + + 7 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + 7 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 52
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9
2 2 2 1 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-9 SALINE 0 6
0 0 2 0 7
0 0 2 0 8
0 0 2 0 9
0 0 2 1 1
0 0 2 1 2
0 0 2 1 3 * TOTALS
Stomach, Glandular + + + + + + + 7
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + + 7 .........................................................................................................................................................................................................
Heart + + + + + + + 7 Epicardium, Mineralization, Focal 1 1 1 3 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + M + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + M + 6 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + 7 .........................................................................................................................................................................................................
Parathyroid Gland + + + M + + + 6 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + 7 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + + 7
GENERAL BODY SYSTEM NONE
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 53
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9
2 2 2 1 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-9 SALINE 0 6
0 0 2 0 7
0 0 2 0 8
0 0 2 0 9
0 0 2 1 1
0 0 2 1 2
0 0 2 1 3 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + + + + + M 6 .........................................................................................................................................................................................................
Ovary + + + + M + + 6 .........................................................................................................................................................................................................
Uterus + + + + + + + 7 Endometrium, Hyperplasia, Diffuse, Cystic 1 1 2 1 4 1.3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + 7 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + M + + 6 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + 7 .........................................................................................................................................................................................................
Spleen + + + + + + + 7 Hematopoietic Cell Proliferation 3 3 3 1 3 3 3 7 2.7
.........................................................................................................................................................................................................
Thymus + + + + + + + 7
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 54
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9
2 2 2 1 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-9 SALINE 0 6
0 0 2 0 7
0 0 2 0 8
0 0 2 0 9
0 0 2 1 1
0 0 2 1 2
0 0 2 1 3 * TOTALS
Mammary Gland + + + + + + + 7 .........................................................................................................................................................................................................
Skin + + + + + + + 7
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + 7
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + 7
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + + + 7 Alveolus, Hemorrhage, Focal 2 1 1 1 1 2 6 1.3
.........................................................................................................................................................................................................
Nose + + + + + + + 7 .........................................................................................................................................................................................................
Trachea + + I I + + I 4
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + + + + + + + 7 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 55
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9
2 2 2 1 2 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-9 SALINE 0 6
0 0 2 0 7
0 0 2 0 8
0 0 2 0 9
0 0 2 1 1
0 0 2 1 2
0 0 2 1 3 * TOTALS
Harderian Gland + + + + + + + 7
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + 7 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + + 7
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 56
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6
2 2 2 9 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-10 SALINE 2 7
0 0 2 2 8
0 0 2 2 9
0 0 2 3 2
0 0 2 3 3
0 0 2 3 4 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + A 5 .........................................................................................................................................................................................................
Gallbladder + + + A + A 4 .........................................................................................................................................................................................................
Intestine Large, Cecum + + + A + A 4 .........................................................................................................................................................................................................
Intestine Large, Colon + + + A + A 4 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + A + A 4 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + A + A 4 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + A + A 4 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + A + A 4 .........................................................................................................................................................................................................
Liver + + + + + A 5 Cyst, Focal 3 1 3.0
.........................................................................................................................................................................................................
Pancreas + + + A + A 4 .........................................................................................................................................................................................................
Salivary Glands + + + A + A 4 .........................................................................................................................................................................................................
Stomach, Forestomach + + + A + A 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 57
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6
2 2 2 9 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-10 SALINE 2 7
0 0 2 2 8
0 0 2 2 9
0 0 2 3 2
0 0 2 3 3
0 0 2 3 4 * TOTALS
.........................................................................................................................................................................................................
Stomach, Glandular + + + A + A 4
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................
Heart + + + + + + 6
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + A 5 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 5 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + A 5 .........................................................................................................................................................................................................
Islets, Pancreatic + + + A + A 4 .........................................................................................................................................................................................................
Parathyroid Gland + + + A + A 4 Angiectasis 1 1 1.0
.........................................................................................................................................................................................................
Pituitary Gland I + + + + M 4 .........................................................................................................................................................................................................
Thyroid Gland + + + A + A 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 58
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6
2 2 2 9 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-10 SALINE 2 7
GENERAL BODY SYSTEM NONE
0 0 2 2 8
0 0 2 2 9
0 0 2 3 2
0 0 2 3 3
0 0 2 3 4 * TOTALS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + + + + A 5 .........................................................................................................................................................................................................
Ovary + + + + + A 5 .........................................................................................................................................................................................................
Uterus + + + A + A 4 Endometrium, Hyperplasia, Diffuse, Cystic 2 1 2.0
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + A 5 .........................................................................................................................................................................................................
Lymph Node, Mandibular + + + A + A 4 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + A + A 4 .........................................................................................................................................................................................................
Spleen + + + + + + 6 Hematopoietic Cell Proliferation 3 1 3 3 4 3 6 2.8
.........................................................................................................................................................................................................
Thymus + + + A + M 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 59
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6
2 2 2 9 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-10 SALINE 2 7
0 0 2 2 8
0 0 2 2 9
0 0 2 3 2
0 0 2 3 3
0 0 2 3 4 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + A + A 4 .........................................................................................................................................................................................................
Skin + + + + + A 5
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + 6
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + A + + 5
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Lung + + + + + A 5 Alveolus, Hemorrhage, Focal 1 1 2 3 1.3
.........................................................................................................................................................................................................
Nose + + + + + A 5 .........................................................................................................................................................................................................
Trachea + I + A + A 3
SPECIAL SENSES SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 60
TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005
Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00
Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04
Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA
0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6
2 2 2 9 2 2 .................................................................................................................................................................
0BALB/C MICE FEMALE 0 ANIMAL ID 2
1-10 SALINE 2 7
0 0 2 2 8
0 0 2 2 9
0 0 2 3 2
0 0 2 3 3
0 0 2 3 4 * TOTALS
.........................................................................................................................................................................................................
Eye + + + A + A 4 .........................................................................................................................................................................................................
Harderian Gland + + + A + A 4
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + A + A 4 Renal Tubule, Bilateral, Dilatation 2 1 2.0
.........................................................................................................................................................................................................
Urinary Bladder + + + A + A 4
*** END OF REPORT ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 61