target agent: vx
DESCRIPTION
O. CH. CH. CH. CH. CH. CH. CH. CH. CH. CH. CH. CH. CH. O. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. 3. P. N. S. CH. 3. H. C. 3. CH. 3. VX. O. H. C. H. C. H. C. H. C. 3. 3. 3. 3. O. P. F. sarin. CO. Et. 2. NO. 2. CO. Et. 2. parathion. - PowerPoint PPT PresentationTRANSCRIPT
H3C O
O
NCH3
CH3
CH3
acetylcholine
Target agent: VX
S
POO
O
NO2
parathion
S
POS
O
CO2Et
CO2Et
malathion
VX
O
PH3C SO
N
CH3
CH3
CH3
CH3
O
PH3CFO
sarin
CH3
CH3
O
PH3CCN
N
tabun
CH3
CH3
O
PH3CF
O
somanCH3
CH3
CH3
CH3
Other chemical agents:
Pesticides:
H3C O
O
NCH3
CH3
CH3
acetylcholine
Target agent: VX
VX
O
PH3C SO
N
CH3
CH3
CH3
CH3
Acetylcholinesterase
S
POO
O
NO2
parathion
S
POS
O
CO2Et
CO2Et
malathion
O
PH3CFO
sarin
CH3
CH3
O
PH3CCN
N
tabun
CH3
CH3
O
PH3CF
O
somanCH3
CH3
CH3
CH3
Other chemical agents:
Pesticides:
Organophosphorus Compounds
Peptides that recognize VX
NH2-Ser-GG-Arg-GG-His-GG-His-PheNH2-Arg-GG-Ser-GG-His-GG-Ser-PheNH2-Trp-GG-His-GG-His-GG-Trp-PheNH2-Arg-GG-Tyr-GG-Arg-GG-Ser-PheNH2-Tyr-GG-Trp-GG-Tyr-GG-Trp-PheNH2-His-GG-His-GG-His-GG-Arg-Phe
HO
O
N
NH
NH2
HO
O
NH2
OH HO
O
NH2
NH
NH
NH2 HO
O
NH2 OH
HO
O
NH
NH2
HisSer Arg Tyr Trp
Dr. Cyndi Wells, Dr. Ben Warner, Los Alamos Natl. Lab.
Selectivity and Recognition: Peptide/metal receptors
S
PHO OHOH
O
PH3C OHOH
O
PHO OHOH
phosphates from soil methylphosphonic acidfrom nerve agents
thiophosphatesfrom pesticides
differentiate by peptide differentiate by metal
Peptide: hydrophobic/hydrophilic, shape, sizeMetal: functional group discrimination
O
PH3C S
O
N
O
PH3CHS
HON
OHOH
H2O +++
VXmethylphosphonic
acidmercaptoamine ethanol
Degradation Products: