TamifluTamiflu

Original name: Original name: OseltamivirOseltamivir

OseltamivirOseltamivir

antiviral drugantiviral drugneuraminidase inhibitorneuraminidase inhibitor treatment of influenza A and B (flu)treatment of influenza A and B (flu)developed by developed by GileadGilead SciencesSciences (Donald (Donald

Rumsfeld is a major stockholder of Gilead Rumsfeld is a major stockholder of Gilead Sciences)Sciences)

marketed by marketed by Hoffman-La RocheHoffman-La Roche (Roche) (Roche) trade name trade name Tamiflu®Tamiflu®

stockholder - akcionář

Tamiflu moleculeTamiflu molecule

Pandemic Fears Pandemic Fears

fear of flu pandemia fear of flu pandemia substantial media attentionsubstantial media attentionused during the H5N1 avian influenza used during the H5N1 avian influenza

epidemic in Southeast Asia in 2005epidemic in Southeast Asia in 2005 production capacity is limited and production capacity is limited and

governments are stockpiling the drug governments are stockpiling the drug

substantial - značný

stockpiling - tvoření zásob strategického zboží

Avian influenza (bird flu)Avian influenza (bird flu)

a type of influenza virus a type of influenza virus that is hosted by birdsthat is hosted by birds

first identified in first identified in Serbia Serbia MontenegroMontenegro in the in the early 1900searly 1900s

H5N1 H5N1 have infected have infected 133 people in Asia 133 people in Asia since late 2003, killing since late 2003, killing 68.68.

The avian influenza subtypes The avian influenza subtypes

H1N1 caused H1N1 caused SpanishSpanish fluflu

H2N2 caused H2N2 caused AsianAsian FluFlu H3N2 caused H3N2 caused HongHong

Kong Kong FluFlu H5N1H5N1H7N7, H9N2, H7N2, H7N7, H9N2, H7N2,

H7N3H7N3

Side Effects of TamifluSide Effects of Tamiflu

General: Rash, swelling of face or tongue, General: Rash, swelling of face or tongue, toxic epidermal necrolysistoxic epidermal necrolysis

Digestive: Hepatitis, liver function tests Digestive: Hepatitis, liver function tests abnormalabnormal

Cardiac: ArrhythmiaCardiac: ArrhythmiaNeurologic: Seizure, confusionNeurologic: Seizure, confusionMetabolic: Aggravation of diabetes Metabolic: Aggravation of diabetes

rash – vyrážka liver – játra aggravation - zhoršení

swelling – otékání seizure - záchvat

digestive – zažívací confusion – zmatenost

Neurological effects and teen Neurological effects and teen deaths deaths

impaired consciousness impaired consciousness abnormal behavior abnormal behavior hallucinations hallucinations

17-year-old male jumped in front of a truck17-year-old male jumped in front of a truck14-year-old male died after falling nine 14-year-old male died after falling nine

stories from his condominium building stories from his condominium building impaired consciousness – narušené vědomí

stories (US) – poschodí

condominium building (US) – obytný dům s byty v osobním vlastnictví

How to make Tamiflu at homeHow to make Tamiflu at home

How to make Tamiflu at homeHow to make Tamiflu at home

Thanks for your attentionThanks for your attention

Marek NovotnýMarek Novotný

Martin ŠedinaMartin Šedina

http://en.wikipedia.org/http://en.wikipedia.org/

www.tamiflu.comwww.tamiflu.com

www.niaid.nih.gov/factsheets/fludrugs.htmwww.niaid.nih.gov/factsheets/fludrugs.htm