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Rare Diseases Never Seen or Diagnosed by Today’s Clinicians Non-traditional Routes of Infection Emerging Patterns of Resistance Increased Virulence Bioterrorism: Bioterrorism: Challenges of Challenges of Training Training

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Page 1: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Rare Diseases Never Seen or Diagnosed by Today’s

Clinicians Non-traditional Routes of Infection Emerging Patterns of Resistance Increased Virulence

Bioterrorism: Bioterrorism: Challenges of TrainingChallenges of Training

Page 2: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

The Biological Terrorist The Biological Terrorist SpectrumSpectrum

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Mass CasualtyMass Casualty Devices/AgentsDevices/Agents

Numbers of CasualtiesNumbers of Casualties

HoaxesHoaxes

• Classical AgentsClassical Agents• State SponsorshipState Sponsorship

• Many AgentsMany Agents• Individual/GroupIndividual/Group

Non-Mass CasualtyNon-Mass Casualty Devices/AgentsDevices/Agents

Page 3: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence
Page 4: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence
Page 5: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence
Page 6: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Screensaver Intervention:Screensaver Intervention:16.7% increase in correct responses

38.8

52.459.1

75.8

0

10

20

30

40

50

60

70

80

% C

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ct

Pre-EDPost-ED

Baseline Intervention

Page 7: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Web Site UsageWeb Site Usagewww.bioterrorism.uab.edu

Weeks 1-1922 Oct 2001-28 Feb 2002

12,180 Unique Visitors 580,300 Total Hits 70 Countries 883 CME certificates issued

Page 8: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Neisseria meningitidis Bacillus anthracis

Public Health Preparation=Bioterrorism Preparation

Naturally Occurring Bioterrorism

“ “Dual-Use”Dual-Use”

Page 9: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

First Point of Care:Emergency MedicinePrimary Care Providers:

Internal MedicinePediatricsOb/GynFamily Practice

Hospital Infection ControlInitial Diagnostics:

PathologyRadiology

Consultative Specialties:Infectious DiseasePulmonology and Critical CareDermatologyNephrologySurgical SubspecialtiesOther Medical Subspecialties

Medical SpecialtiesMedical Specialties

Page 10: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Agents of ConcernAgents of Concern

Category A:SmallpoxAnthraxPlague

TularemiaVHF’sBotox

Category B:Q fever

BrucellosisGlanders

VE, WEE and EEERicin toxin

Epsilon toxinStaph enterotoxin B

Category C:Nipah virusHantavirus

Tick-borne HF’sTick-borne Encephalitis

Yellow feverMDR TB

Page 11: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence

Link between anthrax, hijackers probed

October 9, 2001 Posted: 4:41 PM EDT (2041 GMT)

WEST PALM BEACH, Florida (CNN) -- Federal officials said Tuesday their investigation into a deadly anthrax infection in Florida included a closerlook at forensic evidence gathered in the weeks since the September 11 terrorist attacks, especially items traced to the suspected hijackers, such as luggage,documents and cars.

The bacteria is blamed for the death of photo editor at the supermarket tabloid The Sun. A mailroom employee also tested positive for exposure to anthrax, but is not exhibiting symptoms of the disease.

Elsewhere in Florida, officials Tuesday were checking reports of a "white powdery residue" in the mail of two locations in Naples, on the west coast. Reports ofpossible anthrax virus in Weston and Deerfield Beach, on the east coast, proved unfounded.

October 9, 2001, CNN

Page 12: T Rare Diseases t Never Seen or Diagnosed by Today’s Clinicians t Non-traditional Routes of Infection t Emerging Patterns of Resistance t Increased Virulence