syrcle_reinen mini symposium sr animal studies 30082012
TRANSCRIPT
Systematic reviews in research using animals; a policy perspective. Henk Reinen Ingrid Hartgers
Animal tests in the Netherlands
2
0
200.000
400.000
600.000
800.000
1.000.000
1.200.000
1.400.000
1.600.000
1.800.000
1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010
Aan
tal
die
rpro
eve
n
Jaar
Bron: Zo doende (NVWA)
Overview output Three R research
vaccine quality control RIVM/NVI
Test Animal model Three R method Status
Potency testing lethal challenge humane endpoints accepted Eur.Ph./WHO/FDA (general) Potency testing lethal challenge serology accepted Eur.Ph./WHO tetanus vaccine mouse Potency testing lethal challenge serology accepted EurPh./WHO diphteria vaccine guinea-pig Potency testing lethal challenge serology international validation whole cell pertussis study Potency testing multi-dose test one dose test accepted Eur.Ph./WHO Safety diphtheria dermal study in Vero cell test accepted Ph.Eur./WHO vaccine guinea-pigs
0
10
20
30
40
50
60
70
80
90
100
1989 1991 1993 1995 1997 1999 2001 2003 2005 2007
Animal use in Bilthoven
3V-Platfom RIVM, 08-09-2011
Trend?
4
0
200.000
400.000
600.000
800.000
1.000.000
1.200.000
1.400.000
1.600.000
1.800.000
1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010
Aan
tal
die
rpro
eve
n
Jaar
Reduce Replace
Refine
€
Action Plan
Action Plan
Science Education Sharing
knowlegde
Collaboration EU, global Society
6
Pagina met twee tekstblokken
7
Directive
Protection of animals Level playing field
Project evaluation
=>
authorisation
Transparancy
Monitoring
Registrations
Publications
Action Plan
Registrations
“Stimulate”
Facilitate
Regulate
Research Funds (ZonMW
Alternatives
Initiatives
Knowledge
Networks
EU
Global
Synthesis of evidence
8
Better science with less animals
Motion; standard in medical science,
should be common practice in science
using animals
Quality of publications
ZonMW , research
Raise support; awareness;
change of culture
Develop instruments, methodology,
guidelines, education
Thank you!