2007

AlkaloidsU 0600 Synthesis and Inhibition of Cancer Cell Proliferation of (1,3')-Bis-tetrahydro-

isoquinolines and Piperazine Systems. — Potentially reactive bistetrahydroisoquin-olines and piperazine pentacyclic systems are prepared with respect to DNA alkylation and formation of covalent adducts. The most active compounds such as (IX) and (XII) show antiproliferative activity against a variety of cancer cell lines in the micromolar range. — (AUBRY, S.; PELLET-ROSTAING, S.; FOURNIER DIT CHABERT, J.; DUCKI, S.; LEMAIRE*, M.; Bioorg. Med. Chem. Lett. 17 (2007) 9, 2598-2602; Lab. Catal. Synth. Org., Inst. Chim. Biochim. Mol. Supramol., Univ. Claude Bernard Lyon, F-69622 Villeurbanne, Fr.; Eng.) — H. Hoennerscheid

36- 188