surgical management of bronchogenic carcinoma
TRANSCRIPT
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Surgical management of carcinoma bronchus
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Preoperative procedures for lung cancer
Comp history & physical exam Lung function tests –spirometry Radiograph of chest & suspicious bony
lesions Blood coagulation tests like BT/CT/PT CT scan of thorax, abdomen & brain Bronchoscopy Surgical evaluation of mediastinum at
mediastinoscopy or at thoracotomy PET-Positron emission tomography
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Preoperative assessment of risky patients
Chronic bronchitis Excessive obesity Barrel shaped chest Bronchospasm
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Criteria for surgical treatment
Fit patient No evidence of spread of tumour
outside the chest No clinical or investigatory evidence of
inoperability Tumour graded up to T2,N1,M0 are
indicated for surgical resection
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Preparation of the patient
Reduction of bronchial infection Reduction of bronchospasm Deep breathing exercise instructed by
physiotherapist Arrangement 3-4pints of compatible
blood transfusion Consent-which also includes the
consent for death on table
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Criteria for nonresectibility
Tumour inability to separate from aorta/sup vena cava
Inability to separate from lower end of trachea
Spread of tumour along the pulm vein to left atrium
Spread along the pulmonary artery Involvement of the oesophagial mucosa Contalateral/supraclavicular node
involvement Malignant pleural/pericardial effusion Phrenic nerve,recurrent laryngeal nerve
involvement
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Approach for lung cancer surgery
Thoracotomy thoracoscopy
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thoracotomyA thoractomy is performed
to diagnose lung cancer, remove lung cancer, and for other benign conditions. It is mainly performed in early stage non-small cell lung cancer patients.
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A double lumen endotracheal tube is used to ventilate one lung keeping the other collapsed to facilitate surgery
Patient is turned on unaffected side in lateral position keeping upper arm supported in 90”flexion & lower limb flexed at hip & knee
Posterolateral incision is taken for best exposure allowing hilium to be approached both in front & behind
Rib spreader is inserted following the approximation of subcutaneous tissues & muscles
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The anesthetist is now able to deflate the affected lung for better view of intrathoracic structures
Finally the appropriate surgical method for resection of tumour is performed
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Surgeries 1. Pneumonectomy2. Lobectomy3. Wedge resection 4. Segmental
resection5. Sleeve lobectomy
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Surgical treatment according to different stages
Surgical resection Surgical resection
with complete mediastinal lymph node dissection
En block resection of tumour with involved chest wall
Sleeve resection or pneumonectomy
Stage IA,IB,IIA,IIB & some IIIA
Stage IIIA• Tumours with chest
wall invasionT3• Sup sulcus tumours• Proximal airway
involvt
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• Stage IIIA,IIIB,N2• Stage IIIB + carinal
invasion T4 Without N2 involt
Rt & chemotherapy Pneumonectomy
with tracheal sleeve resection with direct reanastomosis of contralat mainstem bronchus
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LobectomySurgical removal of a
lobe of a lungIndication1. Peripheral growth
but confined to one lobe
2. Patient unfit for pneumonectomy for elderly age& impaired lung function
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Following dissection of fissures & hilar structures in thoracotomy the branches of pulmonary artery & vein is isolated & ligated
The bronchus is later sewn or stapled After the completion of operation the
remaining lung is reinflated
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Wedge resectionit is the surgical removal
of a small portion of the lung along with healthy tissue that surrounds the lung.
It is carried out by thoracoscopy or VATS
The newer methods are excision of portion of lobes using stapling devices,cautery or laser ablation
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Sleeve lobectomySurgical removal of a
lobe along with some part of the involved bronchus
Indication-a tumor arising at the origin of a lobar bronchus precluding simple lobectomy, but not infiltrating as far as to require pneumonectomy.
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It is a most valuable procedure in cases wherein the growth involves a part of bronchus
Here a sleeve of the main bronchus is removed with the lobe & the two ends of the main bronchus are re-anastomosed
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SegmentectomyIt is the surgical removal of
one or more bronchopulmonary segments of an individual lobe through ligation & division of bronchopulmonary structures
Indication-localized peripheral tumour in an elderly patient with poor respiratory function
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When a segment is to be resected the appropriate segmental artery & bronchus are divided at the hilium & clamp is then placed at the distal end of bronchus
The remaining lung is inflated by increasing endotracheal pressure
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PneumonectomyIt is the surgical removal
of the whole lung Indication1. Tumours involving
many lobes but confined to the lung
2. Centrally tumours involving the main bronchus or those that straddle the fissures
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Standard pneumonectomy Extended radical pneumonectomyHere the pulmonary artery is first
dissected , divide & sutured followed by superior or inferior pulmonary vein
Finally the main bronchus is divided keeping in mind no blind stump remains to prevent bronchoplueral fistula.
Mortality rate is 5-10%
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VATS-video assisted thoracoscopic surgery
A type of minimally invasive surgery
it is used to detect stage, and/or remove lung cancer.
3 1/4-1/2” incisions are made between ribs &3 ports are inserted to hold instruments.
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VATS here a camera is
attached to the thoracoscope with the image displayed on television screen
pneumonectomy , lobectomy & empyema drainage are possible
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Advantages of thoracoscopy over thoracotomy
Mean blood loss is less No intraoperative death cases or any
major complications Shorter hospitalization Lesser post operative pain Lesser postoperative complication Less impairment of pulmonary
functions Better quality of life
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Postoperative care
PrincipleAfter lobectomy/ segmental resection• Early expansion of remainder of lung• Prevent trachobronchial infection• Efficient physiotherapy • Fluid overload to be avoided• Mobilization in 2-3days• Breathing exercise
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Post operative measures Expectoration-actively encouraged Analgesics-to relieve pain & increase
expectoration Postural draining Antibiotic cover Ambulation Chest tube management
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Pain management
4 strategies1. Patient controlled analgesia with I V
bolus opiates2. Paravertebral,extraplueral catheter
delivered3. Oral analgesic& paracetamol4. Avoid rib fracture & entrapment of
intercostal nerves to prevent chronic unavoidable pain
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Chest tube Drain Large calibre 24-28F
Intercostal drains inserted by making exit site thr 7th-8th intercostal space
Apical drain & Basal drain The intercostal tubes are
connected to underwater seal
The tube is clamped & released every hourly for 1min & draining is noted
Tube is removed after 24hrs
Suction should never be performed
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Complications of surgeryEarly Sputum retention Atrial fibrillation Bronchospasm Surgical
emphysema Hemorrhage Persistent air leak
Late Empyema Bronchoplueral
fistula
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Bronchoplueral fistula Serious complication Following
pneumonectomy the space left behind is initially filled with air which gradually gets filled with tissue fluid
Dehiscence of bronchial stump leads to fistula formation & the fluid is expectorated in large quantities
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• In order to avoid bronchoplueral fistula the bronchus is divided close to the trachea or adjacent lobar bronchus
• The bronchial stump is usual stapled after pneumonectomy
• Postoperatively the patient is nursed sitting up turned to affected side to prevent infected fluid entering remaining lung & use of chest drain
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Mortality according to cell types
Carcinoma 5-Years survival ratesSquamous cell carcinoma
35-50%
Adenocarcinoma 25-45%
Adenosquamous carcinoma
20-35%
Undifferentiated carcinoma
15-25%
Small cell carcinoma 0-5%
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MortalityStage
Stage I
Stage II
Stage IIIa
Stage IIIb,IV
Treatment
Surgery followed by chemotherapy
Surgery followed by chemotherapy & radiation
Surgery followed by radiotherapy with/without chemotherapy before or after surgery
Surgery for lung tumour & brain tumour
5-year survival rates
60 to 70%
40 to 50%
15 to 30%
10 to 15%
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SHUKRIYA