surgical anatomy of pancretico-biliary junction and significance to
TRANSCRIPT
![Page 1: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/1.jpg)
Surgical anatomy of pancretico-biliary junction and significance to pancreatico-biliary disorders
Seminar- 3rd May 2010
Anand Bharathan
![Page 2: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/2.jpg)
Outline
Embryology of PB junction Normal anatomy of PB junction Definition of APBDJ Theories of APBDJ Classification Clinical problems Mechanisms of carcinogenesis Diagnosis Treatment Summary
![Page 3: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/3.jpg)
Embryology of PB junctionTime Event
Early 4th week
Hepatic diverticulum (HD) arises in ventral mesogastriumPrecursor of EHBR & Ventral pancreas
Late 4th week
Ventral anlage -from base of HDDorsal anlage -from dorsal mesogastrium
Early 5th week
PD & EHBR demarcateEHBR remains a solid cord of cellsProximal part of hepatic diverticulum enlarges
6th week Ventral anlage is carried away from duodenum by enlarged HDBiliary system re-canalises (proximal to distal)
7th week Duodenal rotation & fusion of ventral & dorsal anlagesBiliary re-canalisation is complete
8th week Duodenal wall thickness increasesCBD & PD enter duodenum side by side
11th week Muscles of Sphincter of Oddi- from mesenchyme around CBD
12th week MPD joins CBD, Common channel moves into duodenal muscularis propria
Modified from Matsumoto Y et al. JHBP 2002;9:45-54
![Page 4: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/4.jpg)
Normal anatomy of PB junction
notch (a); biliary sphincter (b); transampullary septum (c); pancreatic sphincter (d); membranous septum of Boyden (e); common sphincter (f); smooth muscle of duodenal wall (g).
![Page 5: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/5.jpg)
Normal anatomy of P-B junction
Junction is within duodenal wall PD & CBD may have common/separate
drainage Common drainage 70-85% Separate drainage 10-13% Pancreas divisum 2%
Blumgart LH. Surgery of liver, biliary tract & pancreas, 4th ed. Pg 26
![Page 6: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/6.jpg)
Definition of APBDJ
Junction of PD & CBD is located outside the duodenal wall radiologically
Length of common channelNormal ≤0.46 cm (Mean)PBM 1.86 cm
Funabiki T et al. Lang Arch Surg 2009;394:159-169
![Page 7: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/7.jpg)
Theories of APBDJ
No proven concept exists Failure of normal separation of PD &
CBD.
Arrest of migration of PBJ into duodenum.
Terminal bile duct joins the duct of Wirsung & bile flows to duodenum thro’ WD.
Babbitt, 1969
Wong & Lister, 1981
Matsumoto Y et al., 2001
![Page 8: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/8.jpg)
No common channel theory
Matsumoto Y et al. Gastrointes Endosc 2001;53:614-619
![Page 9: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/9.jpg)
Komi classification of APBDJ
BP type
PB type
Modified fromLevy AD et al. Curr Prob Diag radiol 2003;32:233-263
![Page 10: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/10.jpg)
Other classification of APBDJ
With biliary dilatation Without biliary dilatation
![Page 11: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/11.jpg)
Clinical problems with APBDJ
Choledochal cyst Carcinoma gallbladder Carcinoma of extrahepatic biliary
tract GB adenomyomatous polyposis Pancreatitis Cholelithiasis
![Page 12: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/12.jpg)
Incidence of APBDJ
Pts of H-B surgery(n=12399)
ERCP for biliary symptoms
ERCP- mostly asymptomatic
Incidence of PBM
3.3% 0.9-1.5% in japan8.7% in Taiwan1% in europe
0.03% (n= 27,076)
PBM in GBC 10.4%
PBM in BDC 4.4%
Funabiki T et al. Lang Arch Surg 2009;394:159-169
![Page 13: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/13.jpg)
Mechanisms of carcinogenesis in APBDJ
PLA2Deconjugated
& Secondar
y bile
acids
•Reflux of pancreatic enzymes into CBD
•Activation of enzymes, Stasis, Inflammation
Hyperplasia,
Meta/dysplasi
a
•Damage to intercellular junction & CBD wall
•Recurrent inflammation
Mutations
K-ras, bcl-2P53, p14,p16
•Dilatation of CBD
•Narrowing of distal CBD
NOT precisely known
![Page 14: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/14.jpg)
Proliferative activity in BDAgent Function/ abnormality
Ornithine decarboxylase Rate limiting enzyme in polyamine synthesis
Proliferating cell nuclear antigen
Cell kinetics marker
Ki-67 Reliable marker on cell kinetics
Mucin core protein (MUC-1) Expressed in hyperplastic/ dysplastic epithelia
Cox-2 Anti-apoptotic
VEGF Angiogenesis
8-hydroxy-2-deoxyguanosine
Oxidative DNA base modified product(suggests oxidative DNA damage)
Others TGF-α, ß-catenin, Cyclin-D1
![Page 15: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/15.jpg)
Genetic changes in oncogenesis in APBDJ
Gene Function Early/Late
Bcl-2 Apoptosis inhibitor Early
MSI Marker of genomic stability 0% hyperplasia85.7% dysplasia80% cancer
Telemorase activity Marker of genomic stability Early
m-RNA indices Cell proliferation activity Early
K-ras point mutations Cell cycle control Most evident change
P53 mutations(Deletion, point mut., LOH)
DNA repair, Apoptosis induction Early
P14 ARF Inhibitor of p53-mdm2 interaction
Early
P16 INK4a Key factor in RB pathway ?
Modified fromFunabiki T et al. Lang Arch Surg 2009;394:159-169
![Page 16: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/16.jpg)
Biliary malignancy incidence
PBM 17% Gen population 0.26-1.8%
Age 10 years younger Gall stone disease low
![Page 17: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/17.jpg)
Malignancy related to APBDJ
Funabiki T et al. Lang Arch Surg 2009;394:159-169
49.4 times the population risk
800 times the population risk
![Page 18: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/18.jpg)
Malignancy in relation to biliary dilatation
Funabiki T et al. Lang Arch Surg 2009;394:159-169
800 x population risk
![Page 19: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/19.jpg)
Pancreatitis
Recurrent acute chronic Incidence 3-31% Pathogenesis Occlusion of PD
- Protein plugs - Stones - Associated SOD
Usually mild Rx Sphincter ablation
![Page 20: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/20.jpg)
Diagnosis
Secretin-MRCP ERCP Biliary amylase levels
![Page 21: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/21.jpg)
Secretin-MRCP
Increase in volume of EHBR after secretin
Problem- Bile secretion is also increased by
secretin
![Page 22: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/22.jpg)
Bile amylase
GB bile 123.568±180.827 Bile duct bile 99.018±162.506
Kamisawa T et al. World J Gastroenterol 2008;14(43):6622-6626
![Page 23: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/23.jpg)
Treatment- with biliary dilatation
Prophylactic bile duct & GB resection
![Page 24: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/24.jpg)
Treatment-without biliary dilatation
Not established. Prophylactic cholecystectomy is advised
by many. Japanese consensus- recommends BD
resection - Bile duct cancer 4% vs 5.2% (dilated
vs. undilated)
- BDC 800 x population risk- Double/triple ca 45.6% occur in
undilated- Histologic & molecular changes –
same in all
![Page 25: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/25.jpg)
Summary
APBDJ is a congenital anomaly of unclear etiology.
Incidence is highest in Japan. Detection depends on investigative
modality used. Biliary dilatation may or may not be
present. Biliary tract cancers is the major long term
concern.
![Page 26: Surgical Anatomy of Pancretico-biliary Junction and Significance To](https://reader033.vdocuments.us/reader033/viewer/2022051312/54766b99b4af9f56588b4582/html5/thumbnails/26.jpg)
Summary
GB cancer is the most common cancer. Cancer risk is same/more in undilated
biliary system. Pancreatitis is another long term issue. Sphincter ablation is recommended in
pancreatitis. Resection of bile duct & GB is
recommended irrespective of biliary ductal dilatation.