supprative lung diseases
TRANSCRIPT
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Dr Taher El NaggarProf of Pulmonary Medicine
Ain Shams University
SUPPURATIVE LUNG DISEASES
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TYPES
1. ASPIRATION PNEUMONIA 2. NECROTISING/DESTRUCTIVE
PNEUMONIA ACUTE OR CHRONIC 3. LUNG ABSCESS 4. EMPYEMA 5. BRONCHIECTASIS
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All usually associated with aspiration Polymicrobial etiology, but anaerobes often involved (60-100%) Share many common features: -
i) Predisposition: - aspiration - decreased LOC - swallowing problem - dental sepsis - anaerobic infection else where - abnormal lung clearance (for. body, tumor, COPD)
ii) Purulent+++ sputum iii) Foul odour (sputum & breath) iv) Hemoptysis v) Chronicity vi) Site (posterior segment ULs, apical & basal segments
LLs)
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Bronchiectasis The word bronchiectasis is derived from Greek
roots, bronchion meaning windpipe & ektasis a stretching out.
Bronkos + Ectasia = Bronchi + Dilatation
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Definition:Permanent dilatation of bronchi with
destruction of elastic and muscular component of their, usually due to acute or chronic infection.
(AACP evidence base clinical practice guideline 2006)
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Pathophysiology:
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PathophysiologyBronchi and bronchioles involving a vicious cycle
of transmural infection and inflammation with mediator release.
(NEJM 2002 )
2 main insults - Infectious insult - Impairment of drainage, airway obstruction,
and/or a defect in host defense.
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Pathophysiology
infectionRetained secretion and
inflammation
Airway destruction and
remodeling
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Etiology & Pathogenesis:
Measles & Pertussis Adenovirus Pneumonia Tuberculosis Atypical mycobacteria
A) Infections::
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Etiology & Pathogenesis:
α 1-Antitrypsin deficiency.Pulmonary agenesis.Sequestrated segment.Bronchomalacia..
B) Developmental defects:
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Etiology & Pathogenesis:
Cystic fibrosis. Primary ciliary dyskinesia (Immotile cilia
syndrome & Kartagener’s syndrome). Human immunodeficiency virus infection (HIV). Immunoglobulin deficiency.
C) Primary impairment of mucus clearance:
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Bronchiectasis
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Focal bronchiectasisLocal or focal obstructive process of a lobe or
segment of a lung3 types of focal airway obstruction 1) luminal blockage by a FB, broncholith or
slowly growing tumor (usually benign) 2) extrinsic narrowing : Enlarged LN
Middle lobe syndrome 3) Twisting of displacement of the airway after a
lobar recretion
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Diffuse presentationInvolving much of both lungs .
Often accompanied by other sinopulmonary disease e.g. sinusitis and asthma
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Location Focal Disease
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Morphological types of Bronchiectasis:
Cystic or Saccular
Cylindrical
Varicose
(Reid, Reid, 1950)1950)
AA
BBCC
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Cylindrical/tubular bronchiectasisUniform luminal dilatation
The wall thickening is smooth
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Cylindrical/tubular bronchiectasis
C haracterized by dilated airways alone and is s ometimes seen as a residual effect of pneumon
ia.
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Cylindrical/tubular bronchiectasis
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Varicose Bronchiectasis
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Varicose bronchiectasisVaricose:Dilated,constricted,distorte
dirregular
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Cystic/saccular bronchiectasisMost severe form of bronchiectasis
Cyst like.
Dilated, thick-walled bronchus terminates in a thick-walled cyst.
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Cystic BronchiectasisBronchogram HRCT
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Cystic/saccular bronchiectasis
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Cystic/saccular bronchiectasis
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Clinical manifestationCough (90 %)Daily sputum production (76%)Dyspnea (72%), WheezingHemoptysis (56%)Recurrent pleurisy Dry Bronchiectasis (sicca haemorrhagica )Acute exacerbationLate : hypoxemia and hypercapnia
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Clinical manifestationAbnormal lung sound on auscultation (Crackles, wheezes, rhonchi)Clubbing of finger 3-24%
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Clinical Features of Bronchiectasis
Symptomssputumchronic coughhemoptysisdyspneafeverchest pain
Signscracklesfinger
clubbingcyanosiscor pulmonale
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Chest X ray : abnormal (>90%)Non specific : focal pneumonitis, scattered irre
gular opacities, linear - or plate like atelectasis
Specific : dilated and thickened airways that - appear as ring like shadows
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Acute exacerbation of bronchectasis
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Diagnosis and investigations:For the causeHistory.Investigations.
SputumCommon organisms:H.Infleunza.S.Pneumoniae.Pseudomonas.S.Aureus.TB .
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RadiologyCXR.CT scan.
Laboratory investigationsCBC.Sweat chloride test.Spermatic count and function ,Serum Igs.In asthma: IgE, eosinophilia, +ve skin test,
aspergillus +ve precipitin test.
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Functional impairment:
1.Measurement of ventilatory capacityAirway obstruction.Lung volumes and compliance.
2.Gas exchange studies
Decreased DLCO.Bronchopulmonary shunt.Abnormal V/Q scan.
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AntibioticsIndications:1.Mucoid sputum muco-purulent sputum.2.Chronic muco-purulent or purulent sputum ↑
amount or purulence, change of color, systemic symptoms or worsening of lung functions.
Aim:1.Subjective improvement of symptoms.2.Objective improvement of PFT.
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Choice of antibiotics:
1.According to culture and sensitivity.2.According to severity.3.According to chronicity.4.According to penetration of Abs.5.Duration: intermittent or long term.
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Steps in using antibioticsStart with penicillin (amoxicillin)
If failed response try augmentin
If patient is allergic to penicillin give clarithromycin or azithromycin
Add antibiotics according to C &S
Failure of response to penicillin or those with serious condition from the start IM cefotaxime, anti-staph, or anti-pseudomonas treatment
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Postural drainageValue:1.Mucociliary clearance2.Expectoration and mobilization of secretions3.Improvement of airway obstruction4.Improvement of V/ mismatchAim:Mobilization of secretions from the lung
periphery which is affected by the disease process to the hilum towards the more central unaffected segments in which cough reflex is intact and mucociliary function is preserved aided by gravity.
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Technique:1.Determination of the affected lobe2.Position3.Before drainage:Humidification if inspired air BDDeep breathing for 10 minutesCough when it comes spontaneously4.PD techniqueForced expiration without closure of the glottisKetchup bottle techniqueChest wall percussion
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Complications1. Infective exacerbations.2. Haemoptysis.3. Core pulmonale and P++.
4. Respiratory failure.5. Brain abscess.6. Amyloidosis. 7. Aspergillosis. 8. Lung cancer.
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Lung Abscess & Necrotizing Pneumonia
Localized necrotic lesion of the lung parenchyma (≥ 2 cm) containing purulent material.
The formation of multiple small abscesses (<2 cm) is referred to as necrotizing pneumonia.
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Both lung abscess & necrotizing pneumonia are Both lung abscess & necrotizing pneumonia are manifestations of a similar pathologic process.manifestations of a similar pathologic process.
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AA
AFC
RB
EDAPM
BB
CC
Lung abscess. A, Cross-sectional view of lung abscess. AFC, Air-fluid cavity;
RB, ruptured bronchus (& drainage of the liquified contents of the cavity); EDA, early development of abscess; PM, pyogenic
membrane. Consolidation (B) & excessive bronchial secretions (C) are common secondary anatomic alterations of the lungs.
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• Posterior segment of the upper lung lobe.• Apical segment of lower lung lobe.
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Classification of Lung Abscess:
According o the duration:Acute abscesses : < 4 weeks Chronic abscesses: >4
weeks. .
According to the cause::Primary abscess: Aspiration or pneumonia in or pneumonia in
the healthy host.the healthy host.Secondary abscess:: Preexisting condition (e.g. Preexisting condition (e.g.
obstruction), spread, obstruction), spread, bronchiectasis & / or an bronchiectasis & / or an immunocompromised state. immunocompromised state.
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Investigations:I. Blood picture: PMNL >20.000/mm3
High ESR Mild normocytic normochromic anaemiaII. Microbiological studies:1. Sputum Gram stain Culture AFB2. Blood culture
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4. Specimens for anaerobic culture without oropharyngeal contamination
Transtracheal aspiration. Percutaneus needle aspiration. Protected sheathed brush.
III. Radiology:1. CXR.2. CT scan. 3. Esophagus.4. Bronchoscope.
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EmpyemaDefinition:Pus in the pleural cavity
Etiology:1.Traumatic2.Non-traumatic
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Common organisms:1.G-ve (30%).2.Staph (25%).3.Pneumococcus (15%).4.Strept. melleri.5.Anaerobes (11%).6.TB.7.Mixed.
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Clinical picture:Symptoms
General: fever, headache, malaise and loss of weight
Local: Pain, dyspnea and cough sputumSignsGeneral: weight loss, fever, clubbing, mouth
for decaying teeth and groin & lumbar region for tracking pus
Local: pleural effusion or empyema necessitans.
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ComplicationsRestrictive defectPleural calcificationsBronchopleural fistulaPleuro-cutaneous fistulaPleural thickening
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Investigations:1. Blood and biochemical exam2. CXR3. CT scan4. Sputum culture5. Blood culture6. U/S guided thoracocenthesis: Chemistry Bacteriology Cytology8. Thoracoscope
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Management(Abs + Drainage)
Antibiotics:
Non-tuberculous : : antibiotics should continue 2-3 wks after stoppage of drainage.
Tuberculous: anti-tuberculous treatment for 6-9 months according to the response.
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Choice of antibioticsAnaerobesPenicillin+metronidazole-lactam+-lactamaseExtended spectrum penicillinCarbapenamsSecond generation cephalosporins.Clindamycin
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PneumococciPenicillin(high dose) then amoxicillin If allergic: first generation cephalosporins or
macrolides
StaphFlucloxacillinAnti-staph penicillinVancomycin or Teicoplanin
Gram –ve Third generation cephalosporins + aminogycoside
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• Hereditary disorder of infants, children & young adults characterized by widespread dysfunction of the exocrine glands leading to chronic pulmonary disease, pancreatic insufficiency & abnormally high levels of electrolytes in the sweat.
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Autosomal recessive disease discovered in 1989, caused by mutation in the CFTR gene that produces the protein responsible for moving the chloride ions through the cell membranes.
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11. . Sweat chloride testt > 60 mEq: confirmative 50 – 60 mEq: highly probable < 50 mEq: normal2. Chronic pulmonary disease2. Chronic pulmonary disease (99%) (99%)3. Pancreatic insufficiency3. Pancreatic insufficiency (80-90%) (80-90%)4. 4. CXR • increased interstitial marking (98%)• cystic bronchiectasis (64%)• hyperinflation (58%)
Characteristic Features of Cystic Fibrosis
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Chronic Sinusitis Nasal Polyposis
Pancreatic Insufficiency
Adapted from Welsh and Smith. Sci Am. 1995;273:52-59.
Male InfertilityCholestasisCirrhosis
Obstructive Lung Disease
BronchiectasisChronic Infection
Bowel ObstructionMalnutrition High Cl- in Sweat
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