supplementary table 1: main characteristics of...
TRANSCRIPT
Supplementary Table 1: Main Characteristics of Included Studies
Authors Drug(s) Drug rangeor
mean dosage (mg)
Concomitant anxiolytics
Study duration (weeks)
Time considered
in our study as endpoint
Number of
subjects (ITT)
% female
Mean Age
Comorbidities Patients having
INSOMNIA as side effect
Patients having SOMNOLENCE
as side effect
Sponsor
(Abbasi et al. 2012)(65)
Sertraline + Placebo
200 No 6 T6 20 30 34.2±6.9 No 1 - No
(Abolfazli et al. 2011)
(
66)_ENREF_2
Fluoxetine + Placebo
40 No 6 T6 22 50 33.3±6.1 No 5 - No
(Aguglia et al. 1993)(67)
Fluoxetine
Sertraline
28
72
Yes 8 T8 48
40
87.5
97.5
58.9±17.3
57.5±15.5
No 2
1
1
4
No
(Akhondzadeh et al. 2003)(68)
Fluoxetine 60 No 6 T6 24 62.5 36.2±8.1 No 4 7 No
(Akhondzadeh et al. 2009)(69)
Fluoxetine + Placebo
40 No 6 T6 20 60 34.2±4.96 No 4 - No
(Akkaya et al. 2006)(70)
Reboxetine
Venlafaxine
8
150
No 10 T10 50
43
74
81.4
40.4±10.7
42.0±11.0
No -
-
22
1
No
(Alvarez et al. 2012)(71)
Venlafaxine
Placebo
225 Yes 6 T6 113
105
54.9
65.7
45.0±10.3
42.0±10.9
No 14
5
-
-
Yes
(Amini et al. 2005)(72)
Fluoxetine
Mirtazapine
20
30
Yes 6 T6 15
16
60
68.8
37.7±11.3
35.0±10.6
No -
-
2
6
No
(Andreoli et al. 2002)(73)
Reboxetine 8-10 Yes 8 T8 126 67 40.0±.12.0 No 23 - No
Fluoxetine 20-40 127 65 40.0±.11.5 15 -
(Ansseau et al. 1994)
(
74)_ENREF_11
Paroxetine 20-30 No 6 T6 56 46.4 43.7± 11.5 No - 5 Yes
(Appelhof et al. 2004)(75)
Paroxetine + Placebo
30 Yes 8 T8 45 64 46.2±11.2 No 19 21 No
(Baldwin et al. 2008)(76)
Milnacipran 100 No 12 T12 80 80 41.8±10.0 No 10 - Yes
(Baldwin et al. 2012)(77)
Duloxetine
Placebo
60 Yes 8 T8 155
148
67.7
69.6
45.3±12.0
43.4±12.5
No 13
6
-
-
Yes
(Behnke et al. 2003)(61)
Mirtazapine
Sertraline
38.3
92.7
Yes 8 T8 176
169
55.7
61.5
42 ± 11
41 ± 12
No 9
15
35
13
Yes
(Benkert et al. 2000)(78)
Mirtazapine
Paroxetine
32.7
22.9
Yes 6 T6 135
134
63
65
47.2± 11.1
47.3± 10.3
No -
-
15
10
Yes
(Benkert et al. 2006)(79)
Venlafaxine 225 No 6 T6 115 - - No 17 - Yes
(Benkert et al. 1996)(80)
Venlafaxine 225 Yes 6 T6 85 69.4 48.9± 11.7 No 8 - No
(Berk et al. 1997)(81)
Duloxetine 20 Yes 6 T6 80 77.5 38 No 17 7 No
(Berzewski et al. 1997)(82)
Reboxetine 8-20 Yes 6 T6 130 64.6 45.4± 12.0 No 10 4 No
(Bielski et al. 2004)(83)
Escitalopram 20 Yes 8 T8 97 69.4 37.3± 12.3 No - 9 Yes
Venlafaxine 225 98 47 37.5± 11.6 - 17
(Blier et al. 2010)(84)
Fluoxetine + Placebo
20 Yes 6 T6 28 - 43.8 ± 1.8 No 3 3 Yes
(Blier et al. 2009)(85)
Mirtazapine
Paroxetine
30-45
20-30
No 6+16 T6 21
19
23.8
52.6
46 ± 9
40 ± 12
No 5
8
11
5
Yes
(Bondareff et al. 2000)(86)
Sertraline 96 ± 41 Yes 12 T12 104 60.6 67.8 ± 6.0 No 21 5 Yes
(Bose et al. 2008)(87)
Escitalopram
Placebo
14 No 12 T12 130
134
59
60
68.1± 6.7
68.5±7.1
No 10
17
-
-
Yes
(Boyer et al. 2000)(88)
Sertraline 79.17 No 8 T8 140 61.4 39.87 No 10 - No
(Boyer et al. 2008)(89)
Desvenlafaxine
Desvenlafaxine
Placebo
50
100
No 8 T8 164
158
161
70
71
68
44±14
46±13
46±12
No 13
14
7
- Yes
(Brannan et al. 2005)(90)
Duloxetine
Placebo
60 Yes 7 T7 141
141
68.1
62.4
40.8±13.5
40.3±13.5
No 15
9
-
-
Yes
(Brecht et al. 2007)(91)
Duloxetine
Placebo
60 No 8 T8 162
165
75.9
71.5
48.1
52.3
No 6
3
-
-
Yes
(Bremner et al. 1995)(92)
Mirtazapine
Placebo
22 No 6 T6 50
50
60
70
39
37
No -
-
23
11
Yes
Brown (2005)(93)
Citalopram 20-60 No 12 T12 41 80.5 40.4± 10.8 No 9 - No
Placebo 41 80.5 42.9± 10.1 13 -
(Brown et al. 1995)(94)
Sertraline 117.7±58.5 No 8 T8 112 69.6 42.3± 12.8 No 27 11 Yes
(Burke et al. 2002)(95)
Citalopram
Escitalopram
Escitalopram
Placebo
40
10
20
Yes 8 T8 125
118
123
119
62
70
68
60
40.0±11.5
40.7±12.3
39.6±12.0
40.1±10.6
No 11
10
14
3
-
-
-
-
Yes
(Byerley et al. 1988)(96)
Fluoxetine
Placebo
20-80 Yes 6 T6 32
29
75
61
38.9±10.7
37.5±9.1
No 4
2
-
-
Yes
(Calabrese et al. 2003)(97)
Citalopram 24.6 No 6 T6 55 73 43 No 2 1 Yes
(Chouinard et al. 1999)
(
98)_ENREF_104
Paroxetine
Fluoxetine
25.5
27.5
Yes 12 T12 102
101
40.6± 10.7
41.2± 10.7
No No
(Claghorn et al. 1992)(99)
Paroxetine
Placebo
30 No 6 T6 168
179
50
54
40.6
42.8
Personality disorders
25
8
34
14
Yes
(Claghorn et al. 1995)(100)
Mirtazapine
Placebo
16.5 Yes 6 T6 42
40
52.4
45
39
40
No -
-
27
2
Yes
(Claghorn et al. 1996)(101)
Fluvoxamine
Placebo
92.7 ± 46.9 No 6 T6 50
50
64
64
39.0±10.9 No 3
5
19
4
No
(Clayton et al. 2006)(102)
Bupropion
Escitalopram
300-450
10-20
Yes 8 T8 276
281
58
57
37±12
36±11
No 39
28
8
22
Yes
Placebo 273 60 36±11 21 14
(Clerc et al. 1994)(103)
Venlafaxine
Fluoxetine
200
40
No 6 T6 33
34
69.7
67.6
49.0
53.6
No 0
1
-
-
Yes
(Clerc et al. 2001)(104)
Fluvoxamine
Milnacipran
200
100
Yes 6 T6 56
57
82.1
75.4
51.2± 12.6
48.7± 15.1
No 1
0
6
1
Yes
(Cohn et al. 1985)(105)
Fluoxetine
Placebo
20-80 No 6 T6 54
58
72.2
63.6
41
44
No 11
4
20
9
No
(Cohn et al. 1992)(106)
Paroxetine
Placebo
30.9 Yes 6 T6 40
40
60
42.5
42.3
41.3
No 8
5
9
7
No
(Coleman et al. 1999)(107)
Bupropion
Sertraline
Placebo
290
106
Yes 8 T8 119
115
121
56
54
59
38.1
38.3
38.5
No 24
20
8
-
-
-
Yes
(Coleman et al. 2001)(108)
Bupropion
Fluoxetine
Placebo
319
26
No 8 T8 150
154
152
63
66
61
36.6
37.1
36.7
No 21
15
10
4
17
6
Yes
(Cooper-Kazaz et al. 2007)
(109)
Sertraline + Placebo
85.5 ± 15.7 Yes 8 T8 50 58 41.0± 55.8 No 31 34 No
(Corrigan et al. 2000)(110)
Fluoxetine
Placebo
20 No 8 T8 33
34
-
-
42
42
No 6
1
3
2
No
(Costa e Silva 1998)(111)
Fluoxetine
Venlafaxine
20-40
75-150
Yes 8 T8 185
194
77.8
80.9
39.8± 10.3
40.5± 10.7
No 15
12
3
16
No
(Cunha et al. 2007)(112)
Venlafaxine
Placebo
75 No 6 T6 14
17
85.7
64.7
77.6 ±7.3
77.6 ±5.8
Mild or moderate dementia
0
2
1
1
No
(Cunningham et al. 1994)(113)
Venlafaxine
Placebo
156-160 Yes 6 T6 72
76
-
-
40.7
40.7
No -
-
31
9
Yes
(Cunningham et al. 1997)(114)
Venlafaxine XR
Venlafaxine IR
Placebo
115-125
124-140
Yes 12 T12 97
96
100
63.0
66.6
58.6
39.7± 11.0
42.8± 11.4
39.9± 10.1
No -
-
-
20
23
9
Yes
(Currier et al. 2003)(115)
Bupropion 265± 65 No 6 T6 20 30 41.0 ±7.0 No 4 - Yes
(Currier et al. 2004)(116)
Citalopram 31.3± 11.1 No 6 T6 17 29.4 42.9± 8.4 Dysthymia 3 - Yes
(Dam et al. 1998)(117)
Fluoxetine + Placebo
20 No 6 T6 17 - - No 2 0 Yes
(Serretti et al. 2005)(23)
Fluvoxamine - Yes 6 T6 61 73.4 55.7 Personality disorders
2 - No
(De Montigny et al. 1999)
(118)
Venlafaxine 260 No 8 T8 158 72.2 42.9± 9.2 Dysthymia 74 - Yes
(Debus et al. 1988)(119)
Fluoxetine 31.4 No 6 T6 18 61.1 35.4± 8.6 No 3 7 Yes
(DeMartinis et al. 2007)(120)
Desvenlafaxine
Desvenlafaxine
Desvenlafaxine
Placebo
100
200
400
No 8 T8 118
116
116
120
65
61
54
68
40.4±12.1
40.7±12.8
39.0±12.6
40.0±12.8
No 26
21
35
10
24
25
30
10
Yes
(Demir et al. Reboxetine 8-10 No 8 T8 24 83.3 - No 7 - No
2002)(121)
(Detke et al. 2002)(122)
Duloxetine
Placebo
60 Yes 9 T9 128
139
66
71
41±13
41±15
No 21
19
13
9
Yes
(Detke et al. 2004)(123)
Duloxetine
Duloxetine
Paroxetine
Placebo
80
120
20
Yes 8 T8 95
93
86
93
73.7
75.3
67.4
74.2
43.1 ±11.1
44.7±10.7
42.0±10.6
43.7±12.2
No 5
5
3
7
2
7
5
0
Yes
(Diaz-Martinez et al. 1998)
(124)
Fluoxetine
Venlafaxine
20-40
75-150
Yes 8 T8 75
70
78.6
64.3
37
37
No 18
22
15
15
Yes
(Dierick et al. 1996)(125)
Fluoxetine
Venlafaxine
20
75-112
Yes 8 T8 161
153
65.2
65.4
43.2± 13.0
43.7± 12.5
No 13
11
-
-
Yes
(Doogan et al. 1994)(126)
Sertraline
Placebo
50 Yes 6 T6 83
90
71.1
64.4
46.0
45.4
No -
-
2
0
No
(Dubè et al. 2010)(127)
Escitalopram
Placebo
15.2 Yes 8 T8 62
138
35.5
47.1
34.3±9.7
37.5±11.0
No 2
4
15
11
Yes
(Dunbar et al. 1991)(128)
Paroxetine
Placebo
10-50 No 6 T6 240
240
46.7
44.2
40.3
40.3
No -
-
27
11
Yes
(Dunner et al. 1992)(129)
Paroxetine 23.4 Yes 6 T6 136 73 68 No No
(Dunner et al. 2005)(130)
Duloxetine
Duloxetine
30-120
30-120
No 12 T12 67
70
56.7
62.9
42.3± 13.5
42.0± 12.6
No 12
12
8
9
Yes
(Eker et al. 2005)(131)
Reboxetine
Sertraline
14.4
50
No 10 T10 20
21
75
85.7
41.3 ± 9.1
40 ± 13.7
No -
-
4
1
No
(Elliott et al. 2000)(132)
Mirtazapine 46.9 ± 9.6 No 12 T12 12 8.3 36.9 ± 8.6 Dysthymia - 2 Yes
EMA Duloxetine study 2008
Duloxetine 60-120 Yes 6 T6 514 69.6 47.6± 13.3 No 27 16 Yes
EMA Sertraline study 1994
(Protocol N. 86CE21-0247)
Sertraline
Placebo
119.8 Yes 10 T10 43
42
67.4
52.4
70.4
78.5
No 4
7
11
6
Yes
EMA Sertraline study 1994
(Protocol N. 050-104)
Sertraline
Placebo
145 Yes 8 T8 149
150
-
-
-
-
No 26
16
29
18
Yes
EMA Sertraline study 1991
(Protocol N. 86CE21-0238)
Sertraline
Sertraline
Sertraline
Sertraline
Placebo
50
100
200
400
Yes 8 T8 40
39
43
37
40
70
79.5
62.8
67.6
70
37.5
38.6
37.3
37.3
37.3
No 12
12
20
12
9
5
5
7
5
5
Yes
EMA Venlafaxine study 1990
(Protocol N. 600-A-313-US)
Venlafaxine
Venlafaxine
Venlafaxine
Placebo
22
52.4
139.5
Yes 6+52 T6 79
76
79
78
69.6
69.7
60.8
69.2
38.9
38.0
38.8
38.2
No Yes
EMA Venlafaxine study 1990
Venlafaxine
Placebo
185.1 Yes 6+52 T6 70
79
70
68.3
40
39
No 7
3
31
9
Yes
EMA Venlafaxine study 1990
(Protocol N. 600A-302-US)
Venlafaxine
Placebo
160 Yes 6+52 T6 65
75
60
66.7
42.3
41.3
No 13
6
28
11
Yes
EMA Venlafaxine study 1998
(Protocol N.. 0600A1-372
US)
Fluoxetine
Venlafaxine
Placebo
20-80
75-375
Yes 6 T6 152
155
152
65.8
63.9
59.9
38.0± 9.9
40.0± 9.5
39.0± 10.6
No 39
51
15
18
27
16
Yes
EMA Venlafaxine study 1995
(Protocol N. 0600B-367-
EU)
Venlafaxine
Venlafaxine
Paroxetine
Placebo
74.8
148.2
20
Yes 8 T8 83
78
80
82
69.8
64.1
55
68.2
44.9±12.9
44.3±10.6
48.2±12.5
44.7±11.6
No 2
3
3
2
6
7
11
2
Yes
EMA Venlafaxine study 1996
(Protocol N. 0600B-209-US)
Venlafaxine
Placebo
176.6 Yes 8 T8 91
100
63.7
59
40
42
No 33
15
26
11
Yes
(Fabre et al. 1996)(133)
Fluvoxamine
Placebo
50-117 No 6 T6 46
44
76.1
68.2
-
-
No 11
2
19
2
Yes
(Fabre et al. 1992)(134)
Paroxetine
Placebo
28.7 Yes 6 T6 38
36
55.3
63.8
35.6
35.9
No -
-
10
6
No
(Fava et al. 1998)(135)
Fluoxetine 20-80 Yes 12 T12 54 - 41.3± 12.6 No 11 - Yes
Paroxetine
Placebo
20-50 55
19
-
-
41.3± 12.6
41.3± 12.6
16
2
-
-
(Fava et al. 2001)(136)
Mirtazapine 24.3-27.5 No 8 T8 50 60 43.8± 10.0 No 3 25 Yes
(Fava et al. 2005)(137)
Fluoxetine
Placebo
20 No 12 T12 47
43
53
65
36.7 ± 9.6
37.8± 12.0
No 5
6
6
3
Yes
(Fava et al. 2006)(138)
Fluoxetine + Placebo
Fluoxetine + Eszopiclone
20-40
20-40
No 8 T8 274
269
66.4
66.9
40.4± 11.3
41.6± 10.7
No -
-
20
23
No
(Fava et al. 2011)(139)
Escitalopram +Placebo
Escitalopram + Zolpidem
10
10
Yes 8+16 T8 190
192
63.7
63.2
43.0± 11.2
42.9± 12.0
No -
-
16
17
Yes
FDA Bupropion
study
Bupropion
Bupropion
Placebo
300
400
Yes 8 T8 376
114
385
-
-
-
-
-
-
No 41
18
23
7
3
8
Yes
FDA Citalopram
study
Citalopram
Placebo
10-80 Yes 8 T8 1063
446
-
-
-
-
No 159
6
186
45
Yes
FDA Desvenlafaxine
study I (Application
number 21-992)
Desvenlafaxine
Desvenlafaxine
Desvenlafaxine
Venlafaxine
100
200
400
75-225
Yes 8 T8 118
307
317
244
-
-
-
-
-
-
-
-
No 26
55
60
29
24
49
51
34
Yes
Placebo 803 - - 80 48
FDA Desvenlafaxine
study II (Reference ID:
3270749)
Desvenlafaxine
Desvenlafaxine
Desvenlafaxine
Desvenlafaxine
Placebo
50
100
200
400
Yes 8 T8 317
424
307
317
636
-
-
-
-
-
-
-
-
-
-
No 28
51
43
47
38
13
38
37
38
25
Yes
FDA Deuloxetine
study (Application
number 21-427)
Duloxetine
Placebo
20-40 Yes 8 T8 1139
777
-
-
-
-
No 125
47
80
23
Yes
FDA Escitalopram
study I (Application
number 21-323)
Escitalopram
Placebo
10-20 Yes 8 T8 715
527
-
-
-
-
No 64
24
23
12
Yes
FDA Escitalopram study I table 2 (Application
number 21-323)
Escitalopram
Escitalopram
Placebo
10
20
Yes 8 T8 310
125
311
-
-
-
-
-
-
No 22
17
12
12
11
3
Yes
FDA Escitalopram
study II
Citalopram
Escitalopram
Escitalopram
Placebo
20
10
20
Yes 8 T8 125
124
128
127
62.4
70.6
67.2
59.0
40 ± 11.5
40.6±12.3
39.6± 12.1
40.3± 10.6
No 14
12
17
4
-
-
-
-
Yes
FDA Fluvoxamine
Fluvoxamine 20-80 Yes 8 T8 1728 - - No 276 225 Yes
study Placebo 975 - - 88 58
FDA Mirtazapine study (ID: 3210056)
Mirtazapine
Placebo
21-32 Yes 8 T8 453
361
-
-
-
-
No -
-
245
65
Yes
FDA Paroxetine
study I (Reference ID:
3231319)
Paroxetine
Placebo
20-50 Yes 8 T8 421
421
-
-
-
-
No 55
25
97
38
Yes
FDA Paroxetine
study II
Paroxetine
Paroxetine
Paroxetine
Paroxetine
Placebo
10
20
30
40
Yes 8 T8 102
104
101
102
51
-
-
-
-
-
-
-
-
-
-
No -
-
-
-
-
13
19
21
22
4
Yes
FDA Paroxetine study III
Paroxetine
Placebo
25-62.5 Yes 8 T8 212
211
63.2
63.0
40.7
39.8
No 36
19
47
17
Yes
FDA Paroxetine study IV
Paroxetine
Placebo
12.5-50 Yes 12 T12 104
109
48.1
63.3
70.4±5.9
69.4±5.4
No 10
9
22
13
Yes
FDA Sertraline study (ID: 3254400)
Sertraline
Placebo
50-200 Yes 8 T8 861
853
-
-
-
-
No 138
77
112
51
Yes
FDA Venlafaxine
study I
Venlafaxine
Placebo
75-375 Yes 8 T8 1033
609
-
-
-
-
No 186
61
238
55
Yes
FDA Venlafaxine
Venlafaxine 75-375 Yes 8 T8 357 - - No 61 31 Yes
study II Placebo 285 - - 31 23
(Feiger et al. 1996)(140)
Sertraline 148 Yes 6 T6 82 48 43.0 ± 1.1 No 19 17 Yes
(Feighner et al. 1991)(141)
Bupropion
Fluoxetine
345± 60
26± 6
No 6 T6 60
60
63.3
63.3
40.9
42.9
No 10
7
4
5
Yes
(Feighner et al. 1999)(142)
Citalopram
Citalopram
Citalopram
Citalopram
Placebo
10
20
40
60
No 6 T6 131
130
131
129
129
63
66
60
53
55
38
39
39
38
38
No 17
20
28
31
14
12
17
29
25
5
Yes
(Feighner et al. (I) 1989)(143)
Fluoxetine
Placebo
80 No 6 T6 61
59
69
79
45.0±2.0
39.7±1.9
No -
-
5
2
No
(Feighner et al. (II) 1989)(144)
Fluvoxamine
Placebo
145 No 6 T6 31
19
77
89
41
41
No 4
3
9
1
No
(Ferreri et al. 2001)(145)
Fluoxetine 20 Yes 6 T6 38 71.1 45± 12 No - 0 Yes
(Finkel et al. 1999)(146)
Sertraline 102± 44 Yes 12 T12 38 67 74 ± 4.4 No 5 - No
(Flores et al. 2004)(147)
Mirtazapine 35.1 No 8 T8 142 - 18-70 No - 18 Yes
(Forlenza et al. 2001)(148)
Sertraline 50 Yes 8 T8 27 77.8 68.8 No 16 2 Yes
(Fornaro et al. 2011)(149)
Duloxetine 60 Yes 12+12 T12 40 60 47 ± 10.7 No 29 4 No
(Fortner et al. 1999)(150)
Bupropion 222± 18 No 8 T8 18 61.1 69.9 No 2 - Yes
(Garlow et al. 2012)(151)
Sertraline + Placebo
141.6±52.2 No 12 T12 77 68 41.4 ±11.5 No 21 - No
(Gaynor et al. (I) 2011)(152)
Duloxetine
Placebo
60 Yes 8 T8 262
266
68.7
69.2
46.2±13
45.7±13
No 24
8
-
-
Yes
(Gaynor et al. (II) 2011)(153)
Duloxetine
Placebo
60 No 8 T8 261
266
70.1
66.9
45.2 ±12.5
44.2 ±12.4
No 14
7
22
9
Yes
(Geretsegger et al. 1995)(154)
Paroxetine 20-30 Yes 6 T6 44 - 71.0± 5.9 No 3 - Yes
(Golden et al. 2002)(155)
Paroxetine CR
Paroxetine IR
Placebo
48.2
38.2
Yes 12 T12 212
217
211
63.2
69.1
63.0
40.7± 10.8
39.9± 11.4
39.7± 10.8
No -
-
-
49
47
17
Yes
(Goldstein et al. 2002)(156)
Duloxetine
Fluoxetine
Placebo
40-120
20
No 8 T8 70
33
70
62.9
57.6
68.6
42.3± 10.8
39.7±10.5
41.4±13.3
No 14
3
5
13
7
7
Yes
(Goldstein et al. 2004)(157)
Duloxetine
Duloxetine
Paroxetine
Placebo
40
80
20
No 8 T8 86
91
87
89
56
62
64
64
41±10
41±12
40±13
40±11
No 15
18
7
5
15
10
7
2
Yes
GSK Bupropion
study I
Bupropion 300 Yes 8 T8 816 - - No 131 - Yes
GSK Bupropion 150-450 Yes 8 T8 801 - - No 64 16 Yes
Bupropion study II
Escitalopram
Venlafaxine
Placebo
10-20
75-150
281
385
796
-
-
-
-
-
-
22
19
32
22
15
32
GSK Paroxetine study 1993
Paroxetine 30 Yes 8 T8 172 76.7 47.8 No 23 - Yes
(Guelfi et al. 1998)(158)
Fluoxetine
Milnacipran
Milnacipran
20
100
200
Yes 12 T12 100
93
96
75
60
66
5.8± 12.8
45.6±12.4
45.2± 12.5
No 10
4
4
-
-
-
Yes
(Guelfi et al. 2001)(159)
Mirtazapine
Venlafaxine
49.5 ± 8.3
255.0±59.8
Yes 8 T8 78
79
62.8
68.4
45.9±10.4
44.5± 10.8
No -
-
6
4
Yes
(Hale et al. 2010)(160)
Agomelatine
Fluoxetine
25-50
20-40
No 8 T8 250
263
77
78.3
41.8± 11.2
42.7±11.9
No -
-
15
9
Yes
(Halikas et al. 1995)(161)
Mirtazapine
Placebo
20.1 No 6 T6 49
49
42.9
59.2
63
62
No -
-
26
11
Yes
(Hewett et al. (I) 2010)(162)
Bupropion XR
Venlafaxine XR
Placebo
180
85
No 8 T8 203
198
187
63
68
67
45.6± 11.8
44.1±11.5
44.5±10.8
No 15
13
8
3
9
9
Yes
(Hewett et al. (II) 2010)(163)
Bupropion XR
Placebo
179 No 10 T10 211
207
74
70
70.9±5.6
71.3±5.9
No 13
8
-
-
Yes
(Higuchi et al. 2011)(164)
Paroxetine CR 25-50 No 8 T8 161 53 36.4± 11.5 No - 16 Yes
Paroxetine IR
Placebo
20-40 83
172
58
55
35.5± 10.4
36.8± 10.1
-
-
7
3
(Hong et al. 2003)(165)
Fluoxetine
Mirtazapine
30.7
34.1
Yes 6 T6 66
66
63.6
62.1
47.1± 15.5
47.2± 14.7
No -
-
3
8
Yes
(Høyberg et al.
1996) (166)
Mirtazapine 37.3 Yes 6 T6 56 78.6 70.5 No - 3 Yes
(Hsu et al. 2011)(167)
Citalopram
Sertraline
22.9 ± 8.5
57.1± 17.9
Yes 6 T6 21
21
52.4
66.7
43.4± 11.4
38.0± 13.8
No 1
3
1
3
No
(Hudson et al. 2007)
(
168)_ENREF_120
Duloxetine 30-60 Yes 12+26 T12 533 71.9 43.4± 12.7 Dysthymia 56 72 Yes
(Isaac et al. 2003)(169)
Milnacipran + Placebo
100 No 6 T6 39 51.3 32.3± 10.0 No 1 - No
(Jazayeri et al. 2008)(170)
Fluoxetine + Placebo
20 No 8 T8 16 75 35.1± 9.4 Dysthymia 1 2 No
(Jefferson et al. 2006)(171)
Bupropion
Placebo
300-450 Yes 8 T8 135
139
66
69
40.0
39.8
No 10
2
-
-
Yes
(Kamijima et al. 2006)(172)
Sertraline 85.0± 24.2 No 8+16 T8 361 60.4 40.4± 10.8 No - 64 Yes
(Kanemoto et al. 2004)(173)
Milnacipran 75-150 Yes 8 T8 66 56.1 56.8± 14.1 No - 1 No
(Kang et al. 2009)(174)
Mirtazapine
Venlafaxine
27.6 ± 8.6
141.4±62.4
No 8 T8 73
53
76.7
77.4
46.5± 12.6
47.2± 12.0
No 1
0
7
3
Yes
(Kaplan et al. 2002)(175)
Venlafaxine 142 No 6 or 8 T6 or T8 69 74.0 38.6 No 6 - Yes
(Kasper et al. 2005)(176)
Escitalopram
Fluoxetine
Placebo
10
20
Yes 8 T8 170
164
180
75
77
76
75±7
75±7
75±7
No 4
3
4
4
0
1
Yes
(Kasper et al. 2012)(177)
Escitalopram
Placebo
20 No 8 T8 140
71
68.6
74.6
41.6 ±12.6
42.6 ±11.6
No 3
3
0
0
Yes
(Katona et al. 1999)(178)
Reboxetine 4-6 No 8 T8 109 77.8 73.8± 6.4 No 6 - Yes
(Katona et al. 2012)(179)
Duloxetine
Placebo
60 No 8 T8 151
145
66.2
62.1
70.9 ± 5.5
70.3 ± 4.4
No -
-
16
3
Yes
(Keegan et al. 1991)(180)
Fluoxetine 53.3± 15.3 No 6 T6 19 66.7 39.5 ±13.6 No 6 5 Yes
(Keller et al. 2007)(181)
Fluoxetine
Venlafaxine
49.8±14.9
208.0±84.0
Yes 10+26+52 T10 266
781
61
65
40.0± 11.6
39.6± 12.2
No 20
22
17
16
Yes
(Khajavi et al. 2012)(182)
Citalopram + Placebo
40 No 6 T6 20 68 36.6 ± 6.8 No - 5 No
(Khan et al. 2007)(183)
Duloxetine
Escitalopram
60
13
Yes 8 T8 133
137
63.9
59.1
43.0± 13.4
41.8± 12.7
No 20
9
8
12
Yes
(Kiev et al. 1997)(184)
Fluvoxamine
Paroxetine
102 ± 44 No 7 T7 30
30
53
53
42.7
39.9
No 9
6
12
9
Yes
(Kim et al. 2011)(185)
Mirtazapine
Paroxetine
30
20
Yes 8 T8 30
30
76.7
66.7
42.4± 9.5
43.9± 9.5
No -
-
8
3
Yes
(Klysner et al. 2002)(186)
Citalopram 10-40 Yes 8+16+48 T8 230 - - No 4 - Yes
(Kranzler et al. 2006)(187)
Sertraline
Placebo
50-200 No 10 T10 159
159
34.0
62.1
41.7± 9.4
43.5± 8.5
Alcohol dependence
22
15
-
-
Yes
(Kyle et al. 1998)(188)
Citalopram 20-40 No 8 T8 179 73.4 73 No - 14 Yes
(Lanctot et al. 2010)(189)
Citalopram 20 No 6 T6 90 40 39.9± 18.0 No - 10 No
(Lapierre et al. 1997)(190)
Fluoxetine 35 ± 8 No 6 T6 62 64.5 40.2± 10.7 No 11 10 Yes
(Learned et al. (study 1) 2012)
(191)
Venlafaxine XR
Placebo
150-225 No 10 T10 133
126
39
37
43.0± 11.2
41.9± 11.8
No 11
7
7
3
Yes
(Learned et al. (study 2) 2012)
(191)
Paroxetine
Placebo
20-30 No 10 T10 166
156
33
39
44.4± 10.9
41.8± 10.9
No 7
8
-
-
Yes
(Lee et al. 2005)(192)
Fluoxetine
Milnacipran
40
100
Yes 6 T6 31
39
74.2
69.2
51 ± 12
49 ± 15
No 2
0
-
-
Yes
(Lee et al. 2007)(193)
Duloxetine
Paroxetine
60
20
Yes 8 T8 237
239
65.5
73.8
39.0± 13.9
38.0± 15.2
No -
-
27
27
Yes
(Lemoine et al. 2007)(44)
Agomelatine
Venlafaxine
25-50
75-150
No 6 T6 166
168
75.2
67.1
40.7± 10.7
39.6± 10.3
No 1
4
7
8
Yes
(Lenox-Smith et al. 2008)
(194)
Citalopram
Venlafaxine
51
191
Yes 12 T12 205
199
64.1
69
43±11.2
42±10.8
No 15
9
-
-
No
(Lepola et al. Citalopram 28.4 Yes 8 T8 160 69.4 44±11 No 7 5 Yes
2003)(195) Escitalopram
Placebo 14.0
155
154
74.8
72.1
43±11
43±12 10
3
8
2
(Lieberman et al. 2008)(196)
Venlafaxine
Venlafaxine
Desvenlafaxine
Placebo
75-150
150-225
200-400
No 8 T8 127
117
231
245
72
70
68
65
46±12
42±12
43±12
42±12
GAD,DAP, social anxiety
disorder
-
-
-
-
12
22
31
16
Yes
(Liebowitz et al. 2007)(197)
Desvenlafaxine
Placebo
179.0-195.3 No 8 T8 121
117
56
65
41.9±12.5
39.3±12.9
No 21
13
14
7
Yes
(Liebowitz et al. 2008)(198)
Desvenlafaxine
Desvenlafaxine
Placebo
50
100
No 8 T8 151
148
152
62
53
63
43±15
43±13
42±14
No 14
15
5
-
-
-
Yes
(Lin et al. 2011)(199)
Sertraline + Placebo
50 Yes 10 T10 20 80 35.2 ±10.0 No 0 1 No
(Lineberry et al. 1990)(200)
Bupropion
Placebo
286.8 No 6 T6 110
109
-
-
41.9
40.8
No 25
8
-
-
Yes
(Lopez-Ibor et al. 2004)(201)
Milnacipran 100 Yes 6 T6 51 74.5 18-70 No 11 - Yes
(Lydiard et al. 1997)(202)
Sertraline
Placebo
138.6 No 8 T8 132
129
64.4
66.7
41.2
40.2
No 8
3
14
7
Yes
(Mao et al. 2008)(203)
Escitalopram
Fluoxetine
10
20
Yes 8 T8 118
113
47.5
61.9
37.1±14.1
40.7±13.9
No -
-
8
7
Yes
(Marchesi et al. 1998)(204)
Fluoxetine 20 Yes 10 T10 67 73.1 43.6± 11.9 No - 1 Yes
(Masco et al. 1994)(205)
Bupropion + Placebo
333 No 6 T6 58 50 46.3 No 6 2 Yes
(Mathur et al. 2002)(206)
Mirtazapine 22. 9±10.5 No 6 T6 18 - - No 1 - No
(Mathur et al. 2005)(207)
Citalopram 36.0 ± 16.7 No 6 T6 20 55 - No 0 0 No
(Mehtonen et al. 2000)(208)
Sertraline
Venlafaxine
50-100
75-150
Yes 8 T8 72
75
66.7
65.3
41.0± 10.7
44.1± 11.4
No 8
9
8
5
Yes
(Mizukami et al. 2006)(209)
Milnacipran 15-75 No 12 T12 11 81.8 75.2 ± 9.4 Alzheimer's disease
- 2 No
(Moffaert et al. 1995)(210)
Mirtazapine 24-72 Yes 6 T6 100 69 46.1 ±10.8 No - 13 Yes
(Mohamed et al. 2006)(211)
Escitalopram 16.6±4.4 Yes 12 T12 20 30 73.0±4.8 Gad - 1 Yes
(Möller et al. 1993)(212)
Paroxetine 30 Yes 6 T6 112 - - No 54 22 No
(Möller et al. 2000)(213)
Sertraline 55 Yes 6 T6 115 63.4 47.7± 13.2 No - 0 No
(Montgomery et al. 2004)
(214)
Escitalopram
Venlafaxine
12.1
95.2
Yes 8 T8 146
142
73.3
71.1
49 ±15
47±14
No 11
14
9
4
Yes
(Moore et al. 2005)(215)
Citalopram
Escitalopram
40
20
Yes 8 T8 142
138
61.9
71.7
46.2± 11.1
44.1± 10.9
No 1
2
3
0
Yes
(Munizza et al. 2006)(216)
Sertraline 50-100 Yes 6 T6 60 70 46.9± 10.6 No 3 3 Yes
(Nemeroff et al. 2007)(217)
Fluoxetine
Venlafaxine
Placebo
41±17
142±64
Yes 6 T6 104
102
102
69
65
56
37.9±11.5
40.1± 11.1
40.4± 11.7
No 15
22
14
-
-
-
Yes
(Newhouse et al. 2000)(218)
Fluoxetine
Sertraline
20-40
50-100
Yes 12 T12 118
116
51.3
63.2
67± 5.9
68± 5.3
No 17
16
-
-
Yes
(Nierenberg et al. 2007)(219)
Duloxetine
Escitalopram
Placebo
60
10
Yes 8 T8 273
274
137
63.4
67.9
63.5
41.1±11.6
43.3±13.0
42.5±12.3
No 22
21
9
16
18
5
Yes
(Nonacs et al. 2005)(220)
Bupropion 262.5 Yes 8 T8 8 100 31.5 GAD,DAP, anxiety disorder
NOS
2 - Yes
(Oliè et al. 2007)(221)
Escitalopram 12.1± 4.2 Yes 12 T12 790 70.5 44.5 ±12.5 Anxiety disorders
30 12 Yes
(Onder et al. 2003)(222)
Fluoxetine
Fluoxetine
20
40
No 12 T12 34
32
50
53.1
35.6± 7.7
34.5± 8.6
No 7
17
-
-
No
(Otsubo et al. 2005)(223)
Fluvoxamine 95.1 Yes 8 T8 36 50 45.3± 13.9 No - 12 No
(Ou et al. 2010)(224)
Citalopram
Escitalopram
27.6
13.9
No 6 T6 117
115
53.8
58.3
36.4± 12.3
36.7± 12.5
No 4
3
-
-
No
(Pae et al. 2004)(225)
Paroxetine 20-40 Yes 8 T8 52 59.6 43.0± 15.0 No 2 10 Yes
(Pae et al. 2008)(226)
Escitalopram 18.3 No 8 T8 17 70.6 43.9± 11.2 No 1 3 Yes
(Park et al. 2012)(227)
Escitalopram 9.0 ± 3.8 Yes 12 T12 79 100 49.1±7.6 No - 5 Yes
(Patris et al. 1996)(228)
Citalopram
Fluoxetine
20
20
Yes 8 T8 173
184
79.2
75.5
44
43
No 8
10
-
-
Yes
(Perahia et al. 2006)(229)
Duloxetine
Duloxetine
Paroxetine
Placebo
80
120
20
Yes 8+26 T8 93
103
97
99
66.7
74.8
71.1
65.7
46.5 ±12.7
44.0± 10.8
45.8± 10.6
44.7± 10.1
No 3
6
6
0
1
3
5
0
Yes
(Perahia et al. 2008)(230)
Duloxetine
Venlafaxine
79.4 ± 22.7
189.7±37.5
No 12 T12 330
337
69.7
153.2
44.3±12.8
41.6±12.3
No 38
39
36
32
Yes
(Perlis et al. 2003)(231)
Fluoxetine
Fluoxetine
48.9± 17.6
45.0± 13.0
Yes 12 T12 9
27
67
48
37.2±12.4
35.8±11.2
No 7
6
-
-
No
(Perry et al. 1989)(232)
Fluoxetine 20-60 No 12 T12 21 57.1 42 ± 10 No - 4 No
(Rabkin et al. 1994)(233)
Sertraline 50-200 No 24 T8 28 3.6 41.0±6.6 Dysthymia 4 - Yes
(Rapaport et al. 1996)(234)
Fluoxetine
Fluvoxamine
34.2±18.8
101.9±34.2
Yes 7 T7 47
50
66
62
38.6
40.0
Dysthymia, anxiety disorder
NOS
13
18
-
-
Yes
(Rapaport et al. 2003)(235)
Paroxetine CR
Paroxetine IR
Placebo
30.4
25.7
No 12 T12 104
106
109
48.1
56.6
63.3
70.4±5.9
70.1±6.6
69.4±5.4
No 10
15
9
-
-
-
Yes
(Rapaport et al. 2009)(236)
Paroxetine CR
Paroxetine CR
Placebo
12.5
25
Yes 10 T10 164
73
179
60
60
63
67±6.11
67±6.56
68±6.73
Anxiety disorders, disthymia
14
9
11
9
5
5
Yes
(Raskin et al. 2003)(237)
Duloxetine 80-120 Yes 52 T8 1279 72.6 44.4 ±13.2 No 318 354 Yes
(Raskin et al. 2007)(238)
Duloxetine
Placebo
60 No 8 T8 207
104
60.4
57.7
72.6±5.7
73.3±5.7
Mild dementia 8
5
11
1
Yes
(Rickels et al. 1985)(239)
Fluoxetine
Fluoxetine
20-80 q.d.
20-80 b.i.d.
No 6+48 T6 94
94
60
60
37
37
No 14
9
-
-
No
(Rickels et al. 1992)(240)
Paroxetine
Placebo
31.5 ± 1.25 Yes 6 T6 55
56
69.2
59.1
43.4
46.0
No 9
5
13
4
No
(Roose et al. 2004)(241)
Citalopram
Placebo
10-40 No 8 T8 84
90
53.6
62.2
79.8 ± 4.0
79.3 ± 4.7
No 3
5
5
4
Yes
(Rosso et al. 2012)(242)
Bupropion
Duloxetine
300
120
Yes 6 T6 21
25
71.4
64
46.6
47.6
No 1
0
-
-
No
(Rudolph et al. 1998)(243)
Venlafaxine
Venlafaxine
Venlafaxine
Placebo
75
225
375
No 6 T6 89
89
88
92
40
43
33
32
43.6
43.1
43.8
41.5
No 20
18
12
9
15
16
23
4
Yes
(Rudolph et al. 1999)(244)
Fluoxetine
Venlafaxine XR
Placebo
47
175
Yes 8 T8 103
100
98
73
69
64
40
40
40
No -
-
-
12
8
6
Yes
(Russell et al. 2001)(245)
Sertraline 141.0±59.4 No 6 T6 155 65.1 41.6± 10.6 SUD, anxiety disorders,
personality disorders
43 - Yes
(Sacchetti et al. 2002)(246)
Paroxetine 20-50 Yes 12 T12 64 64.1 48.7 No 3 3 No
(Samuelian et al. 1998)(247)
Venlafaxine 105 Yes 6 T6 52 73.1 47 ± 12 No - 3 Yes
(Schatzberg et al. 2002)(248)
Mirtazapine
Paroxetine
25.7 ± 6.7
26.5 ± 5.5
No 8+16 T8 126
120
50
53.3
71.7 ± 5.7
72.0 ± 5.1
No 15
14
39
37
Yes
(Schatzberg et al. 2006)(249)
Fluoxetine
Venlafaxine
Placebo
20-60
37.5-225
Yes 8 T8 100
104
96
56
45
46
71±5
71±5
71±5
No 11
10
4
8
13
4
Yes
(Schneider et al. 2003)(250)
Sertraline
Placebo
50-100 Yes 8 T8 371
376
54
58
70.0 ± 6.8
69.6 ± 6.5
Alcohol dependence, disthymia, GAD, PD
35
23
38
16
Yes
(Schöne et al. 1993)(251)
Fluoxetine
Paroxetine
20-60
20-40
Yes 6 T6 52
54
90.4
83.3
73.7
74.3
No 7
5
-
-
Yes
(Schweizer et al. 1994)(252)
Venlafaxine
Placebo
83-179 No 6 T6 73
78
71
67
41±13
42±12
No 15
10
19
11
Yes
(Sepanjnia et al. 2012)(253)
Citalopram + Placebo
30 Yes 6 T6 20 75 32.7±5.4 Specific phobia 4 - No
(Septien-Velez et al. 2007)
(254)
Desvenlafaxine
Desvenlafaxine
200
400
No 8 T8 123
125
45.4±11.9
43.4±10.9
No -
-
12
7
Yes
Placebo 125 46.7±12.1 - 2
(Sheehan et al. 2009)(255)
Fluoxetine
Venlafaxine
Placebo
58±13.7
235±74.8
Yes 6 T6 99
94
95
69
48
64
37.8 ±11.1
41.7±12.8
39.9±13.0
No 18
18
8
-
-
-
Yes
(Sheikh et al. 2004)(256)
Sertraline
Placebo
50-100 No 8 T8 226
232
54.4
53.8
70.1±6.7
70.0±6.6
No 23
17
23
10
Yes
(Shelton et al. 2006)(257)
Sertraline
Venlafaxine
50-100
75-225
Yes 8 T8 82
76
46.3
63.2
41.2 ±12.0
37.2±11.6
Personality disorders, other axis I but MD as
primary diagnosis
19
14
-
-
Yes
(Shrivastava et al. 1992)(258)
Paroxetine
Placebo
22.0-45.5 Yes 6 T6 40
40
27.5
35
38
34.6
No -
-
10
6
Yes
(Silverstone et al. 1999)(259)
Fluoxetine
Venlafaxine XR
Placebo
39.9
140.8
Yes 12 T12 121
128
119
59.7
63.9
57.6
43.2± 10.9
41.1± 12.0
41.6± 10.8
Anxiety disorders
30
41
12
17
17
7
Yes
(Sir et al. 2005)(260)
Sertraline
Venlafaxine XR
105.4±29.5
161.4±44.4
No 8 T8 79
84
72.2
66.7
37.3± 13.5
36.8± 12.4
No 28
23
17
22
Yes
(Smith et al. 1990)(261)
Mirtazapine
Placebo
18 No 6 T6 50
50
58
58
43
43
No -
-
32
8
No
(Smith et al. 1992)(262)
Paroxetine
Placebo
33.8 No 6 T6 39
38
38.5
47.4
44.9
44.6
No 8
2
7
3
Yes
(Soares et al. 2010)
Desvenlafaxine 177.2±40.6 No 8+26 T8 296 100 56± 6 No 39 48 Yes
(
263)_ENREF_232
Escitalopram 18.1±3.9 299 100 56± 6 33 42
(Sögaard et al. 1999)(264)
Sertraline 83.1 Yes 12 T12 99 79.8 42.1± 11.1 No 19 4 Yes
(Sonawalla et al. 1999)(265)
Fluvoxamine 143±45 No 12 T12 30 53.3 39.4 ±11.3 No 11 - Yes
(Sonawalla et al. 2002)(266)
Fluoxetine 20 No 8 T8 123 49 38.9 ±10.8 Anxiety disorders
21 - No
(Stahl et al. 2010)(267)
Agomelatine
Placebo
50 No 8 T8 167
165
63.9
64.5
43.8 ±12.0
43.0±13.1
No 11
10
30
7
Yes
(Steen et al. 1997)(268)
Milnacipran 200 No 6+20 T6 30 30 48.1 ±15.2 No 10 - No
(Steffens et al. 2001)(269)
Bupropion IR or SR
250-258 No 12 T12 15 - - No 1 - Yes
(Stewart et al. 2008)(270)
Duloxetine 74±44 No 8 T8 20 55 35 ± 12 Dysthymia. PD 3 3 Yes
(Stuppaeck et al. 1994)(271)
Paroxetine 33.3 No 6 T6 78 70.5 47.5± 11.6 No 8 3 Yes
(Taner et al. 2006)(272)
Fluoxetine
Reboxetine
20-40
8-10
No 8 T8 21
22
78.4
78.4
36.8± 11.0
36.8± 11.0
No 1
4
-
-
No
(Taragano et al. 1999)(273)
Sertraline 50-100 No 8 T8 469 73 57.4± 13.9 No 9 5 Yes
(Thase et al. 1997)(274)
Venlafaxine 75-225 Yes 8 T8 95 63.2 40±11 No 33 26 Yes
Placebo 102 59.8 42±12 15 11
(Thase et al. 1997)(275)
Fluoxetine 37.2 No 6 T6 106 72 42.9±12.1 No 22 18 Yes
(Thase et al. 2002)(276)
Citalopram 23.9 No 6 T6 61 52.5 43.0±11.9 No 1 5 No
(Thase et al. 2006)(277)
Bupropion
Venlafaxine
299.6±77.1
149.8±41.3
No 12 T12 168
174
56
64
37.1± 12.3
37.4± 11.6
No -
-
2
12
Yes
(Tollefson et al. 1994)(278)
Fluoxetine 20-40 No 8 T8 62 71 40.1± 11.7 No 19 - Yes
(Tollefson et al. 1995)(279)
Fluoxetine
Placebo
20 Yes 6 T6 335
336
53.7
55.4
67.7±5.7
67.7±5.7
No 61
42
-
-
Yes
(Torta et al. 2011)(280)
Duloxetine 83.5 Yes 12 T12 27 40.7 63.6 ±10.9 No 1 - Yes
(Tourian et al. 2009)(281)
Duloxetine
Desvenlafaxine
Desvenlafaxine
Placebo
60
50
100
No 8 T8 157
148
150
160
66
69
66
58
39±12
41±13)
39±12
39±13
No 29
16
21
5
23
9
17
4
Yes
(Tzanakaki et al. 2000)(282)
Fluoxetine
Venlafaxine
20-60
75-225
Yes 6 T6 54
55
83.3
74.5
49±10
47±11
No 1
7
-
-
Yes
(Tzeng et al. 2009)(283)
Mirtazapine 33.2 No 7 T7 58 55.2 47.7 ±16.6 SUD - 4 No
(Urbina et al. 1999)(284)
Fluoxetine 20 Yes 6 T6 20 95 34.4± 1.8 No 5 - No
(Vanderkooy et al. 2002)(285)
Bupropion 143.3±25.8 No 8 T8 15 73.3 41.1± 8.8 No 5 3 No
Sertraline
Venlafaxine
Paroxetine
105.4±217.5
81.4±58.4
18.7±6.1
37
62
55
81.1
61.3
38.2
39.5± 11.4
40.8± 11.2
38.1± 11.3
5
16
7
12
17
16
(Ventura et al. 2007)(286)
Escitalopram
Sertraline
10
113.6
Yes 8 T8 104
107
54.8
59.8
40.6± 13.7
38.1± 11.5
No 14
18
12
6
Yes
(Versiani et al. 1999)(287)
Fluoxetine 20 No 8 T8 77 - - No 3 11 No
(Versiani et al. 2000)(288)
Reboxetine
Placebo
10 Yes 6 T6 28
28
46.4
50
41.7
40.0
No 7
0
-
-
Yes
(Versiani et al. 2005)(289)
Fluoxetine
Mirtazapine
20-40
10-60
Yes 8 T8 147
145
69
74
47
43
No 13
7
14
20
Yes
(Volonteri et al. 2010)(290)
Duloxetine 74.0± 24.6 No 12 T12 45 36 59.6± 12.8 Personality disorders, SUD
4 4 No
(Volpe et al. 2008)(291)
Dluoxetine 60 Yes 8 T8 30 93.3 41 ± 8 No 9 8 Yes
(Waintraub et al. 2002)(292)
Paroxetine + Placebo
20 Yes 12 T12 139 66.7 41 No 0 2 No
(Wakeno et al. 2008)(293)
Milnacipran
Paroxetine
60.0± 16.9
27.8± 7.5
Yes 6 T6 30
27
43.3
51.9
49.3± 12.6
48.3± 15.0
No -
-
3
1
Yes
(Weihs et al. 2000)(294)
Bupropion
Paroxetine
197± 53
22 ± 7
No 6 T6 48
52
54
60
69.2
71.0
No 6
8
3
14
Yes
(Weihs et al. 2002)(295)
Bupropion 277± 30.9 Yes 8+44 T8 816 68 39.4 No 131 - Yes
(Weisler et al. Bupropion 279 No 6 T6 62 53.2 40.2 No 9 5 Yes
1994)(296)
(Wheatley et al. 1998)(297)
Fluoxetine
Mirtazapine
23.8± 3.8 Yes 6 T6 66
66
59
55
47.5 ±14.8
47.2 ±15.3
No -
-
9
12
Yes
(Wijkstra et al. 2010)(298)
Venlafaxine 372.3± 14.2 Yes 7 T7 39 43.6 49.5± 12.0 No 1 1 Yes
(Wohlreich et al. 2004)(299)
Duloxetine 80-120 Yes 52 T8 101 71.3 71.9± 5.4 No 15 22 Yes
(Wohlreich et al. 2007)(300)
Duloxetine 91.9 Yes 6+104 T6 128 61.8 42.6±13.3 No 9 6 Yes
(Wohlreich et al. 2007)(301)
Duloxetine 60 Yes 7 T7 3431 75.4 48.0 ±12.9 No 210 74 Yes
(Yargic et al. 2004)(302)
Paroxetine 27.6 ± 9.5 No 8 T8 54 81.5 35.9± 13.7 No 6 - No
(Yevtushenko et al. 2007)
(303)
Citalopram
Citalopram
Escitalopram
10
20
10
No 6 T6 106
108
108
57.5
56.5
61.1
34.8 ±0.6
35.1±0.6
35.2±0.6
No -
-
-
2
0
0
No
(Yonkers et al. 2008)(304)
Paroxetine
Placebo
21.1 ±10.7 No 8 T8 35
35
100
100
26.1 ± 6.5
25.9 ± 6.5
No -
-
5
5
Yes
(Zajecka et al. 2010)(305)
Agomelatine
Agomelatine
Placebo
25
50
No 8 T8 162
163
169
66.7
66.7
66.7
43.8± 12.2
43.8± 12.2
43.8± 12.2
No 8
9
18
9
14
10
Yes
*=Note that the table does not report the antidepressants not included in the study.
GAD= generalized anxiety disorder; PD= panic disorder; NOS=not otherwise specified, SUD=substance use disorder
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