supplementary table 1. bacterial proteins present in fecal ...q8a287...

Fecal filtrate transfer (FFT): Supplementary Tables – 1 –

Supplementary Table 1. Bacterial Proteins Present in Fecal Filtrates for Patients 4 and 5

Accession no. Description Coverage Unique

Peptides Total

Peptides

Peptide spectrum matches

MW [kDa]

P68688 Glutaredoxin-1 OS=Escherichia coli (strain K12) GN=grxA PE=1 SV=1 - [GLRX1_ECOLI]

37,65 3 3 7 9,7

P0CN75 Glyceraldehyde-3-phosphate dehydrogenase OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) GN=GPD PE=3 SV=1 - [G3P_CRYNB]

6,78 1 2 5 36,3

P0C0G7 Glyceraldehyde-3-phosphate dehydrogenase OS=Streptococcus pyogenes serotype M1 GN=gap PE=3 SV=2 - [G3P_STRP1]

6,85 1 2 3 35,9

Q5L7N5 Phosphoenolpyruvate carboxykinase [ATP] OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=pckA PE=3 SV=1 - [PCKA_BACFN]

37,38 5 19 77 59,0

C4Z0Q6 Phosphoenolpyruvate carboxykinase [ATP] OS=Eubacterium eligens (strain ATCC 27750 / VPI C15-48) GN=pckA PE=3 SV=1 - [PCKA_EUBE2]

27,53 4 12 46 59,0

C4ZBL1 Phosphoenolpyruvate carboxykinase [ATP] OS=Eubacterium rectale (strain ATCC 33656 / VPI 0990) GN=pckA PE=3 SV=1 - [PCKA_EUBR3]

28,28 2 12 35 59,0

A6LFQ4 Phosphoenolpyruvate carboxykinase [ATP] OS=Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) GN=pckA PE=3 SV=1 - [PCKA_PARD8]

48,60 9 22 73 58,9

B2RHV8 Phosphoenolpyruvate carboxykinase [ATP] OS=Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) GN=pckA PE=3 SV=1 - [PCKA_PORG3]

22,06 2 11 44 59,4

P0AA29 Thioredoxin-1 OS=Salmonella typhi GN=trxA PE=3 SV=2 - [THIO_SALTI] 47,71 4 4 26 11,8

A6KXL2 Triosephosphate isomerase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=tpiA PE=3 SV=1 - [TPIS_BACV8]

68,13 8 10 40 26,9

Q8A9J2 Uronate isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=uxaC PE=3 SV=2 - [UXAC_BACTN]

18,38 2 7 21 54,3

NOTE. Only proteins present in the fecal filtrate for patient 4 and in both duplicates of the fecal filtrate for patient 5 are shown.


Supplementary Table 2. All Proteins Detected in the Fecal Filtrate for Patient 4

Accession no. Description %

Coverage Unique

Peptides Total

Peptides


MW [kDa]

P61604 10 kDa heat shock protein, mitochondrial OS=Homo sapiens GN=HSPE1 PE=1 SV=2 - [CH10_HUMAN]

38,24 4 4 9 10,9

P31946 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 - [1433B_HUMAN]

18,70 1 5 16 28,1

P62258 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 - [1433E_HUMAN]

25,49 4 6 17 29,2

Q04917 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 - [1433F_HUMAN]

17,48 1 5 17 28,2

P61981 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 - [1433G_HUMAN]

23,48 2 6 18 28,3

P31947 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 - [1433S_HUMAN]

48,79 7 12 38 27,8

P27348 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 - [1433T_HUMAN]

24,49 2 6 18 27,7

P63104 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 - [1433Z_HUMAN]

24,49 2 6 19 27,7

Q8A287 2,3-bisphosphoglycerate-independent phosphoglycerate mutase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=gpmI PE=3 SV=1 - [GPMI_BACTN]

4,96 2 3 4 55,6

A6L050 2,3-bisphosphoglycerate-independent phosphoglycerate mutase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=gpmI PE=3 SV=1 - [GPMI_BACV8]

14,29 6 7 14 55,8

P62277 40S ribosomal protein S13 OS=Homo sapiens GN=RPS13 PE=1 SV=2 - [RS13_HUMAN]

11,26 2 2 5 17,2


17,22 3 3 7 16,3

P62244 40S ribosomal protein S15a OS=Homo sapiens GN=RPS15A PE=1 SV=2 - [RS15A_HUMAN]

12,31 2 2 3 14,8


11,64 2 2 2 16,4


24,34 4 4 12 17,7


12,63 4 4 8 31,3



Coverage Unique

Peptides Total

Peptides


MW [kDa]


25,21 3 3 5 13,4


22,89 2 2 3 9,1


15,20 2 2 9 13,7


19,13 2 2 2 13,0


28,40 7 7 18 26,7


13,64 4 4 4 29,9

P62701 40S ribosomal protein S4, X isoform OS=Homo sapiens GN=RPS4X PE=1 SV=2 - [RS4X_HUMAN]

20,91 7 7 12 29,6


20,10 4 4 6 22,9


8,03 2 2 4 28,7


14,95 3 3 6 22,1


7,69 2 2 2 24,2


22,68 6 6 10 22,6

P08865 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 - [RSSA_HUMAN]

27,12 5 5 12 32,8

Q5LH68 4-O-beta-D-mannosyl-D-glucose phosphorylase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=BF0772 PE=1 SV=1 - [MGP_BACFN]

7,18 2 2 2 43,9

P49189 4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens GN=ALDH9A1 PE=1 SV=3 - [AL9A1_HUMAN]

3,64 2 2 2 53,8

P10809 60 kDa heat shock protein, mitochondrial OS=Homo sapiens GN=HSPD1 PE=1 SV=2 - [CH60_HUMAN]

8,03 5 5 9 61,0

P27635 60S ribosomal protein L10 OS=Homo sapiens GN=RPL10 PE=1 SV=4 - [RL10_HUMAN]

9,35 2 2 2 24,6


15,15 2 2 5 17,8



Coverage Unique

Peptides Total

Peptides


MW [kDa]


9,95 2 2 2 24,2


10,70 2 2 4 23,4


18,14 4 4 10 24,1


14,13 2 2 3 21,4

Q07020 60S ribosomal protein L18 OS=Homo sapiens GN=RPL18 PE=1 SV=2 - [RL18_HUMAN]

12,77 2 2 3 21,6

Q02543 60S ribosomal protein L18a OS=Homo sapiens GN=RPL18A PE=1 SV=2 - [RL18A_HUMAN]

11,36 2 2 4 20,7


10,83 2 2 3 17,8


15,86 3 3 5 17,2


8,93 4 4 7 46,1


17,39 2 2 2 12,8


12,82 2 2 3 13,3

P83881 60S ribosomal protein L36a OS=Homo sapiens GN=RPL36A PE=1 SV=2 - [RL36A_HUMAN]

17,92 2 2 3 12,4


5,15 2 2 3 47,7


8,75 2 2 3 34,3


14,24 4 4 7 32,7


8,87 2 2 4 29,2


10,51 2 2 8 28,0

P11021 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 - [GRP78_HUMAN]

21,25 9 10 19 72,3

A6KXS0 Acetate kinase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / 4,52 2 2 3 42,8



Coverage Unique

Peptides Total

Peptides


MW [kDa]

NCTC 11154) GN=ackA PE=3 SV=1 - [ACKA_BACV8]

Q92484 Acid sphingomyelinase-like phosphodiesterase 3a OS=Homo sapiens GN=SMPDL3A PE=1 SV=2 - [ASM3A_HUMAN]

10,60 4 4 8 51,2

Q92485 Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens GN=SMPDL3B PE=2 SV=2 - [ASM3B_HUMAN]

16,26 5 5 13 50,8

Q99798 Aconitate hydratase, mitochondrial OS=Homo sapiens GN=ACO2 PE=1 SV=2 - [ACON_HUMAN]

3,59 2 2 2 85,4

P60709 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 - [ACTB_HUMAN]

43,47 10 18 95 41,7

Q6P587 Acylpyruvase FAHD1, mitochondrial OS=Homo sapiens GN=FAHD1 PE=1 SV=2 - [FAHD1_HUMAN]

13,39 2 2 8 24,8

P00813 Adenosine deaminase OS=Homo sapiens GN=ADA PE=1 SV=3 - [ADA_HUMAN]

6,61 2 2 2 40,7

P23526 Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4 - [SAHH_HUMAN]

10,19 4 4 6 47,7

A6L1X1 Adenylosuccinate synthetase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=purA PE=3 SV=1 - [PURA_BACV8]

10,17 4 4 5 46,8

P05141 ADP/ATP translocase 2 OS=Homo sapiens GN=SLC25A5 PE=1 SV=7 - [ADT2_HUMAN]

13,42 1 4 10 32,8


13,42 1 4 9 32,8

P05091 Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH2 PE=1 SV=2 - [ALDH2_HUMAN]

5,22 2 2 2 56,3

P02763 Alpha-1-acid glycoprotein 1 OS=Homo sapiens GN=ORM1 PE=1 SV=1 - [A1AG1_HUMAN]

19,40 4 4 13 23,5

P01011 Alpha-1-antichymotrypsin OS=Homo sapiens GN=SERPINA3 PE=1 SV=2 - [AACT_HUMAN]

31,44 14 14 51 47,6

P01009 Alpha-1-antitrypsin OS=Homo sapiens GN=SERPINA1 PE=1 SV=3 - [A1AT_HUMAN]

53,83 31 31 219 46,7

P01023 Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=3 - [A2MG_HUMAN]

2,10 3 3 3 163,2

P04745 Alpha-amylase 1 OS=Homo sapiens GN=AMY1A PE=1 SV=2 - [AMY1_HUMAN]

60,47 2 23 118 57,7

P19961 Alpha-amylase 2B OS=Homo sapiens GN=AMY2B PE=1 SV=1 - [AMY2B_HUMAN]

61,06 2 24 116 57,7

P02511 Alpha-crystallin B chain OS=Homo sapiens GN=CRYAB PE=1 SV=2 - [CRYAB_HUMAN]

22,29 4 4 9 20,1



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P06733 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 - [ENOA_HUMAN] 14,98 5 5 9 47,1

A6L4U5 Altronate oxidoreductase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=uxaB PE=3 SV=1 - [UXAB_BACV8]

5,64 2 2 3 53,9

Q03154 Aminoacylase-1 OS=Homo sapiens GN=ACY1 PE=1 SV=1 - [ACY1_HUMAN]

12,99 4 4 9 45,9

P15144 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 - [AMPN_HUMAN]

38,57 38 38 151 109,5

P12821 Angiotensin-converting enzyme OS=Homo sapiens GN=ACE PE=1 SV=1 - [ACE_HUMAN]

23,58 27 27 145 149,6

P04083 Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 - [ANXA1_HUMAN] 6,36 2 2 8 38,7


B1YMR6 ATP synthase subunit alpha OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15) GN=atpA PE=3 SV=1 - [ATPA_EXIS2]

4,98 1 2 2 54,6

P25705 ATP synthase subunit alpha, mitochondrial OS=Homo sapiens GN=ATP5A1 PE=1 SV=1 - [ATPA_HUMAN]

10,13 4 5 7 59,7

P06576 ATP synthase subunit beta, mitochondrial OS=Homo sapiens GN=ATP5B PE=1 SV=3 - [ATPB_HUMAN]

17,58 7 7 11 56,5

O00148 ATP-dependent RNA helicase DDX39A OS=Homo sapiens GN=DDX39A PE=1 SV=2 - [DX39A_HUMAN]

3,98 2 2 3 49,1

Q562R1 Beta-actin-like protein 2 OS=Homo sapiens GN=ACTBL2 PE=1 SV=2 - [ACTBL_HUMAN]

21,28 2 10 27 42,0

P07814 Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens GN=EPRS PE=1 SV=5 - [SYEP_HUMAN]

1,26 2 2 3 170,5

Q9Y6X5 Bis(5'-adenosyl)-triphosphatase ENPP4 OS=Homo sapiens GN=ENPP4 PE=1 SV=3 - [ENPP4_HUMAN]

6,62 2 3 9 51,6

Q13867 Bleomycin hydrolase OS=Homo sapiens GN=BLMH PE=1 SV=1 - [BLMH_HUMAN]

6,81 2 2 4 52,5

P12830 Cadherin-1 OS=Homo sapiens GN=CDH1 PE=1 SV=3 - [CADH1_HUMAN] 9,75 6 6 23 97,4

Q12864 Cadherin-17 OS=Homo sapiens GN=CDH17 PE=2 SV=3 - [CAD17_HUMAN] 26,32 15 15 45 92,2

Q9BYE9 Cadherin-related family member 2 OS=Homo sapiens GN=CDHR2 PE=1 SV=2 - [CDHR2_HUMAN]

14,43 15 15 51 141,5

Q9HBB8 Cadherin-related family member 5 OS=Homo sapiens GN=CDHR5 PE=1 SV=3 - [CDHR5_HUMAN]

14,08 8 8 43 88,2

A8K7I4 Calcium-activated chloride channel regulator 1 OS=Homo sapiens GN=CLCA1 PE=1 SV=3 - [CLCA1_HUMAN]

35,45 33 33 146 100,2

P15085 Carboxypeptidase A1 OS=Homo sapiens GN=CPA1 PE=1 SV=2 - 50,36 18 20 118 47,1



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[CBPA1_HUMAN]

P48052 Carboxypeptidase A2 OS=Homo sapiens GN=CPA2 PE=1 SV=3 - [CBPA2_HUMAN]

13,60 4 4 6 47,0

P15086 Carboxypeptidase B OS=Homo sapiens GN=CPB1 PE=1 SV=4 - [CBPB1_HUMAN]

59,23 22 24 251 47,3

Q8IVL8 Carboxypeptidase O OS=Homo sapiens GN=CPO PE=2 SV=1 - [CBPO_HUMAN]

16,31 4 4 7 42,5

Q9Y646 Carboxypeptidase Q OS=Homo sapiens GN=CPQ PE=1 SV=1 - [CBPQ_HUMAN]

4,03 2 2 6 51,9

P13688 Carcinoembryonic antigen-related cell adhesion molecule 1 OS=Homo sapiens GN=CEACAM1 PE=1 SV=2 - [CEAM1_HUMAN]

12,74 3 4 21 57,5


18,38 7 9 45 76,7


24,42 4 5 15 37,2


8,31 1 2 13 38,1

P48729 Casein kinase I isoform alpha OS=Homo sapiens GN=CSNK1A1 PE=1 SV=2 - [KC1A_HUMAN]

5,64 2 2 3 38,9

P49674 Casein kinase I isoform epsilon OS=Homo sapiens GN=CSNK1E PE=1 SV=1 - [KC1E_HUMAN]

18,03 7 7 12 47,3

P25774 Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 - [CATS_HUMAN] 14,50 4 4 5 37,5

A7IC65 Chaperone protein DnaK OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) GN=dnaK PE=3 SV=1 - [DNAK_XANP2]

5,23 1 3 8 67,6

Q99895 Chymotrypsin-C OS=Homo sapiens GN=CTRC PE=1 SV=2 - [CTRC_HUMAN]

66,04 17 17 104 29,5

P08217 Chymotrypsin-like elastase family member 2A OS=Homo sapiens GN=CELA2A PE=1 SV=1 - [CEL2A_HUMAN]

86,62 13 18 1107 28,9

P08218 Chymotrypsin-like elastase family member 2B OS=Homo sapiens GN=CELA2B PE=2 SV=2 - [CEL2B_HUMAN]

27,88 1 6 120 28,8


56,67 11 15 178 29,5


65,56 11 15 181 29,2

P17538 Chymotrypsinogen B OS=Homo sapiens GN=CTRB1 PE=2 SV=1 - [CTRB1_HUMAN]

29,28 4 4 6 27,9



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q00610 Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 - [CLH1_HUMAN]

2,33 4 4 7 191,5

Q9Y281 Cofilin-2 OS=Homo sapiens GN=CFL2 PE=1 SV=1 - [COF2_HUMAN] 11,45 2 2 9 18,7

Q86UP6 CUB and zona pellucida-like domain-containing protein 1 OS=Homo sapiens GN=CUZD1 PE=2 SV=1 - [CUZD1_HUMAN]

30,15 11 11 38 68,1

P06493 Cyclin-dependent kinase 1 OS=Homo sapiens GN=CDK1 PE=1 SV=3 - [CDK1_HUMAN]

7,07 2 2 3 34,1

P28838 Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 - [AMPL_HUMAN]

28,52 13 13 25 56,1

O43175 D-3-phosphoglycerate dehydrogenase OS=Homo sapiens GN=PHGDH PE=1 SV=4 - [SERA_HUMAN]

4,88 2 2 3 56,6

Q9UGM3 Deleted in malignant brain tumors 1 protein OS=Homo sapiens GN=DMBT1 PE=1 SV=2 - [DMBT1_HUMAN]

17,70 7 7 20 260,6

P24855 Deoxyribonuclease-1 OS=Homo sapiens GN=DNASE1 PE=1 SV=1 - [DNAS1_HUMAN]

32,62 6 6 19 31,4

P81605 Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 - [DCD_HUMAN] 22,73 2 2 2 11,3

Q86SJ6 Desmoglein-4 OS=Homo sapiens GN=DSG4 PE=1 SV=1 - [DSG4_HUMAN] 4,62 4 4 7 113,8

P15924 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 - [DESP_HUMAN] 16,09 42 42 85 331,6

P09622 Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens GN=DLD PE=1 SV=2 - [DLDH_HUMAN]

9,43 4 4 9 54,1

Q16555 Dihydropyrimidinase-related protein 2 OS=Homo sapiens GN=DPYSL2 PE=1 SV=1 - [DPYL2_HUMAN]

4,72 1 2 2 62,3


4,56 1 2 3 61,9

Q01459 Di-N-acetylchitobiase OS=Homo sapiens GN=CTBS PE=1 SV=1 - [DIAC_HUMAN]

15,84 5 5 6 43,7

P16444 Dipeptidase 1 OS=Homo sapiens GN=DPEP1 PE=1 SV=3 - [DPEP1_HUMAN]

31,63 8 8 19 45,6

P27487 Dipeptidyl peptidase 4 OS=Homo sapiens GN=DPP4 PE=1 SV=2 - [DPP4_HUMAN]

47,52 40 40 215 88,2

O95147 Dual specificity protein phosphatase 14 OS=Homo sapiens GN=DUSP14 PE=1 SV=1 - [DUS14_HUMAN]

44,44 6 6 14 22,2

P63167 Dynein light chain 1, cytoplasmic OS=Homo sapiens GN=DYNLL1 PE=1 SV=1 - [DYL1_HUMAN]

25,84 2 2 4 10,4

O14638 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Homo sapiens GN=ENPP3 PE=1 SV=2 - [ENPP3_HUMAN]

4,23 3 3 4 100,1



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q6UWV6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 OS=Homo sapiens GN=ENPP7 PE=1 SV=3 - [ENPP7_HUMAN]

32,31 10 11 41 51,5

P68104 Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1 - [EF1A1_HUMAN]

35,28 14 14 51 50,1

P26641 Elongation factor 1-gamma OS=Homo sapiens GN=EEF1G PE=1 SV=3 - [EF1G_HUMAN]

6,64 3 3 4 50,1

P13639 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 - [EF2_HUMAN]

19,11 12 12 21 95,3

P14625 Endoplasmin OS=Homo sapiens GN=HSP90B1 PE=1 SV=1 - [ENPL_HUMAN]

8,72 6 7 13 92,4

B6YQN5 Enolase OS=Azobacteroides pseudotrichonymphae genomovar. CFP2 GN=eno PE=3 SV=1 - [ENO_AZOPC]

5,84 1 2 2 46,5

Q89Z05 Enolase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=eno PE=3 SV=1 - [ENO_BACTN]

3,76 1 2 3 46,1

Q89KV6 Enolase OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) GN=eno PE=3 SV=1 - [ENO_BRADU]

4,68 1 2 2 45,1

C0Z6L3 Enolase OS=Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) GN=eno PE=3 SV=1 - [ENO_BREBN]

4,91 1 2 2 45,9

P98073 Enteropeptidase OS=Homo sapiens GN=TMPRSS15 PE=1 SV=3 - [ENTK_HUMAN]

32,97 22 22 99 112,9

P60842 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 - [IF4A1_HUMAN]

14,29 5 5 12 46,1

Q13347 Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens GN=EIF3I PE=1 SV=1 - [EIF3I_HUMAN]

5,54 2 2 4 36,5

Q9GZV4 Eukaryotic translation initiation factor 5A-2 OS=Homo sapiens GN=EIF5A2 PE=1 SV=3 - [IF5A2_HUMAN]

12,42 2 2 4 16,8

P15311 Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4 - [EZRI_HUMAN] 7,17 5 5 11 69,4

P02794 Ferritin heavy chain OS=Homo sapiens GN=FTH1 PE=1 SV=2 - [FRIH_HUMAN]

9,29 2 2 2 21,2

Q5D862 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 - [FILA2_HUMAN] 2,55 2 2 3 247,9

P21333 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 - [FLNA_HUMAN] 2,38 4 6 14 280,6

Q14315 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 - [FLNC_HUMAN] 7,08 14 16 40 290,8

P17931 Galectin-3 OS=Homo sapiens GN=LGALS3 PE=1 SV=5 - [LEG3_HUMAN] 16,00 3 3 8 26,1

Q08380 Galectin-3-binding protein OS=Homo sapiens GN=LGALS3BP PE=1 SV=1 - [LG3BP_HUMAN]

13,50 6 6 7 65,3

Q96QA5 Gasdermin-A OS=Homo sapiens GN=GSDMA PE=1 SV=4 - 6,97 3 3 4 49,3



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[GSDMA_HUMAN]

G8JZS4 Glucan 1,4-alpha-glucosidase SusB OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=susB PE=1 SV=1 - [SUSB_BACTN]

2,85 2 2 4 84,3

Q04609 Glutamate carboxypeptidase 2 OS=Homo sapiens GN=FOLH1 PE=1 SV=1 - [FOLH1_HUMAN]

19,60 10 10 16 84,3

P94598 Glutamate dehydrogenase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=gdhA PE=3 SV=2 - [DHE3_BACTN]

16,67 5 6 15 49,0

Q07075 Glutamyl aminopeptidase OS=Homo sapiens GN=ENPEP PE=1 SV=3 - [AMPE_HUMAN]

12,02 10 10 15 109,2


37,65 3 3 7 9,7

Q5HHP5 Glyceraldehyde-3-phosphate dehydrogenase 1 OS=Staphylococcus aureus (strain COL) GN=gapA1 PE=3 SV=1 - [G3P1_STAAC]

5,95 2 2 13 36,3

O43026 Glyceraldehyde-3-phosphate dehydrogenase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gpd3 PE=1 SV=1 - [G3P2_SCHPO]

11,94 2 3 12 35,7

Q757I2 Glyceraldehyde-3-phosphate dehydrogenase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=GPD PE=3 SV=2 - [G3P_ASHGO]

3,32 2 2 6 35,5

Q59199 Glyceraldehyde-3-phosphate dehydrogenase OS=Bacteroides fragilis (strain YCH46) GN=gap PE=3 SV=2 - [G3P_BACFR]

6,61 1 2 3 35,6

Q89AK1 Glyceraldehyde-3-phosphate dehydrogenase OS=Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) GN=gapA PE=3 SV=1 - [G3P_BUCBP]

7,51 1 2 3 36,8


6,78 1 2 5 36,3

B7LQ20 Glyceraldehyde-3-phosphate dehydrogenase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=gapA PE=3 SV=1 - [G3P_ESCF3]

9,37 1 3 4 35,5

P04406 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 - [G3P_HUMAN]

29,85 6 7 14 36,0


6,85 1 2 3 35,9

Q6FR65 GTP-binding nuclear protein GSP1/Ran OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) GN=GSP1 PE=3 SV=1 - [GSP1_CANGA]

9,81 2 2 9 24,3



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P63244 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 - [GBLP_HUMAN]

18,93 6 6 11 35,1

Q5B2V1 Heat shock 70 kDa protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=hsp70 PE=1 SV=1 - [HSP70_EMENI]

6,99 1 4 14 69,9

P11142 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 - [HSP7C_HUMAN]

28,95 6 16 46 70,9

P04792 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 - [HSPB1_HUMAN]

13,66 4 4 6 22,8

P07900 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 - [HS90A_HUMAN]

14,75 5 10 22 84,6

P08238 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 - [HS90B_HUMAN]

18,65 6 12 34 83,2

P41797 Heat shock protein SSA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SSA1 PE=1 SV=2 - [HSP71_CANAL]

11,59 1 5 19 70,3

P54652 Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 - [HSP72_HUMAN]

21,28 2 10 37 70,0

Q6MZM0 Hephaestin-like protein 1 OS=Homo sapiens GN=HEPHL1 PE=2 SV=2 - [HPHL1_HUMAN]

3,19 2 2 5 131,5

P09651 Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 PE=1 SV=5 - [ROA1_HUMAN]

15,05 5 5 7 38,7

Q14103 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens GN=HNRNPD PE=1 SV=1 - [HNRPD_HUMAN]

6,20 2 2 2 38,4

P31943 Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens GN=HNRNPH1 PE=1 SV=4 - [HNRH1_HUMAN]

13,36 4 4 8 49,2

P61978 Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens GN=HNRNPK PE=1 SV=1 - [HNRPK_HUMAN]

9,94 4 4 7 50,9

P52272 Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens GN=HNRNPM PE=1 SV=3 - [HNRPM_HUMAN]

2,33 2 2 2 77,5

O60506 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 - [HNRPQ_HUMAN]

3,21 2 2 3 69,6

P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 PE=1 SV=2 - [ROA2_HUMAN]

15,86 4 4 10 37,4

P09429 High mobility group protein B1 OS=Homo sapiens GN=HMGB1 PE=1 SV=3 - [HMGB1_HUMAN]

7,91 1 2 2 24,9


11,96 1 2 2 24,0



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P07305 Histone H1.0 OS=Homo sapiens GN=H1F0 PE=1 SV=3 - [H10_HUMAN] 9,28 2 2 2 20,9

P16403 Histone H1.2 OS=Homo sapiens GN=HIST1H1C PE=1 SV=2 - [H12_HUMAN]

17,84 7 7 26 21,4

P16401 Histone H1.5 OS=Homo sapiens GN=HIST1H1B PE=1 SV=3 - [H15_HUMAN]

12,39 4 4 14 22,6

P04908 Histone H2A type 1-B/E OS=Homo sapiens GN=HIST1H2AB PE=1 SV=2 - [H2A1B_HUMAN]

52,31 2 4 26 14,1

Q16777 Histone H2A type 2-C OS=Homo sapiens GN=HIST2H2AC PE=1 SV=4 - [H2A2C_HUMAN]

58,14 3 5 26 14,0

P06899 Histone H2B type 1-J OS=Homo sapiens GN=HIST1H2BJ PE=1 SV=3 - [H2B1J_HUMAN]

35,71 2 5 43 13,9

O60814 Histone H2B type 1-K OS=Homo sapiens GN=HIST1H2BK PE=1 SV=3 - [H2B1K_HUMAN]

35,71 2 5 58 13,9

P68431 Histone H3.1 OS=Homo sapiens GN=HIST1H3A PE=1 SV=2 - [H31_HUMAN]

43,38 4 4 22 15,4

P62805 Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 - [H4_HUMAN] 54,37 10 10 58 11,4

Q86YZ3 Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 - [HORN_HUMAN] 5,16 3 3 7 282,2

P01876 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 - [IGHA1_HUMAN]

70,25 7 19 172 37,6


64,71 5 17 161 36,5

P01857 Ig gamma-1 chain C region OS=Homo sapiens GN=IGHG1 PE=1 SV=1 - [IGHG1_HUMAN]

13,03 3 3 10 36,1


7,98 2 2 9 35,9

P01764 Ig heavy chain V-III region 23 OS=Homo sapiens GN=IGHV3-23 PE=1 SV=2 - [HV303_HUMAN]

18,80 1 2 5 12,6

P01766 Ig heavy chain V-III region BRO OS=Homo sapiens PE=1 SV=1 - [HV305_HUMAN]

25,00 2 2 11 13,2

P01781 Ig heavy chain V-III region GAL OS=Homo sapiens PE=1 SV=1 - [HV320_HUMAN]

17,24 2 2 5 12,7

P01765 Ig heavy chain V-III region TIL OS=Homo sapiens PE=1 SV=1 - [HV304_HUMAN]

26,09 1 2 11 12,3

P01834 Ig kappa chain C region OS=Homo sapiens GN=IGKC PE=1 SV=1 - [IGKC_HUMAN]

85,85 8 8 137 11,6

P01593 Ig kappa chain V-I region AG OS=Homo sapiens PE=1 SV=1 - 31,48 2 2 10 12,0



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[KV101_HUMAN]

P01598 Ig kappa chain V-I region EU OS=Homo sapiens PE=1 SV=1 - [KV106_HUMAN]

26,85 2 2 6 11,8

P06310 Ig kappa chain V-II region RPMI 6410 OS=Homo sapiens PE=4 SV=1 - [KV206_HUMAN]

15,04 1 2 4 14,7

P01617 Ig kappa chain V-II region TEW OS=Homo sapiens PE=1 SV=1 - [KV204_HUMAN]

38,94 2 3 11 12,3

P04207 Ig kappa chain V-III region CLL OS=Homo sapiens PE=4 SV=2 - [KV308_HUMAN]

19,38 2 2 2 14,3

P01623 Ig kappa chain V-III region WOL OS=Homo sapiens PE=1 SV=1 - [KV305_HUMAN]

50,46 4 4 13 11,7

P06312 Ig kappa chain V-IV region (Fragment) OS=Homo sapiens GN=IGKV4-1 PE=4 SV=1 - [KV401_HUMAN]

29,75 1 3 13 13,4

P01625 Ig kappa chain V-IV region Len OS=Homo sapiens PE=1 SV=2 - [KV402_HUMAN]

36,84 1 3 21 12,6

P80748 Ig lambda chain V-III region LOI OS=Homo sapiens PE=1 SV=1 - [LV302_HUMAN]

21,62 2 2 2 11,9

P01714 Ig lambda chain V-III region SH OS=Homo sapiens PE=1 SV=1 - [LV301_HUMAN]

34,26 3 3 4 11,4

P0CG05 Ig lambda-2 chain C regions OS=Homo sapiens GN=IGLC2 PE=1 SV=1 - [LAC2_HUMAN]

81,13 3 6 52 11,3

P01871 Ig mu chain C region OS=Homo sapiens GN=IGHM PE=1 SV=3 - [IGHM_HUMAN]

33,19 13 13 61 49,3

Q9Y6R7 IgGFc-binding protein OS=Homo sapiens GN=FCGBP PE=1 SV=3 - [FCGBP_HUMAN]

39,63 88 88 425 571,6

P01591 Immunoglobulin J chain OS=Homo sapiens GN=JCHAIN PE=1 SV=4 - [IGJ_HUMAN]

23,90 4 4 15 18,1

B9A064 Immunoglobulin lambda-like polypeptide 5 OS=Homo sapiens GN=IGLL5 PE=2 SV=2 - [IGLL5_HUMAN]

35,98 2 5 28 23,0

Q8WWA0 Intelectin-1 OS=Homo sapiens GN=ITLN1 PE=1 SV=1 - [ITLN1_HUMAN] 32,91 6 9 24 34,9

Q8WWU7 Intelectin-2 OS=Homo sapiens GN=ITLN2 PE=2 SV=1 - [ITLN2_HUMAN] 16,62 2 5 16 36,2

P09923 Intestinal-type alkaline phosphatase OS=Homo sapiens GN=ALPI PE=1 SV=2 - [PPBI_HUMAN]

57,01 24 24 264 56,8

P14923 Junction plakoglobin OS=Homo sapiens GN=JUP PE=1 SV=3 - [PLAK_HUMAN]

44,43 25 25 65 81,7

P06870 Kallikrein-1 OS=Homo sapiens GN=KLK1 PE=1 SV=2 - [KLK1_HUMAN] 21,37 4 4 16 28,9



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q15323 Keratin, type I cuticular Ha1 OS=Homo sapiens GN=KRT31 PE=1 SV=3 - [K1H1_HUMAN]

40,63 1 24 576 47,2

Q14532 Keratin, type I cuticular Ha2 OS=Homo sapiens GN=KRT32 PE=2 SV=3 - [K1H2_HUMAN]

17,86 2 8 132 50,3

O76009 Keratin, type I cuticular Ha3-I OS=Homo sapiens GN=KRT33A PE=2 SV=2 - [KT33A_HUMAN]

35,64 1 20 472 45,9

Q14525 Keratin, type I cuticular Ha3-II OS=Homo sapiens GN=KRT33B PE=1 SV=3 - [KT33B_HUMAN]

28,71 2 17 438 46,2

O76013 Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=2 SV=1 - [KRT36_HUMAN]

18,84 2 12 153 52,2

P13645 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 - [K1C10_HUMAN]

57,53 22 29 101 58,8


21,82 4 11 30 51,5


20,93 3 10 25 51,2

Q6A163 Keratin, type I cytoskeletal 39 OS=Homo sapiens GN=KRT39 PE=1 SV=2 - [K1C39_HUMAN]

6,92 3 3 5 55,6

Q6A162 Keratin, type I cytoskeletal 40 OS=Homo sapiens GN=KRT40 PE=1 SV=2 - [K1C40_HUMAN]

6,26 1 4 100 48,1

P78386 Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 - [KRT85_HUMAN]

52,86 6 44 824 55,8

O43790 Keratin, type II cuticular Hb6 OS=Homo sapiens GN=KRT86 PE=1 SV=1 - [KRT86_HUMAN]

53,70 6 40 729 53,5

P04264 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 - [K2C1_HUMAN]

60,71 33 38 167 66,0

P35908 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 - [K22E_HUMAN]

60,09 24 31 78 65,4


20,85 5 15 38 62,3

P02538 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 - [K2C6A_HUMAN]

22,34 3 14 38 60,0


12,37 2 9 37 51,4

Q86Y46 Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 - [K2C73_HUMAN]

5,37 2 3 8 58,9

O95678 Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 - 9,62 2 7 54 59,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[K2C75_HUMAN]

Q6KB66 Keratin, type II cytoskeletal 80 OS=Homo sapiens GN=KRT80 PE=1 SV=2 - [K2C80_HUMAN]

8,63 2 3 7 50,5

Q8IUC1 Keratin-associated protein 11-1 OS=Homo sapiens GN=KRTAP11-1 PE=2 SV=1 - [KR111_HUMAN]

7,36 2 2 19 17,1

P09848 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 - [LPH_HUMAN]

4,88 8 8 13 218,4

A6L2R5 L-arabinose isomerase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=araA PE=3 SV=1 - [ARAA_BACV8]

9,63 4 4 13 57,2

Q8TF66 Leucine-rich repeat-containing protein 15 OS=Homo sapiens GN=LRRC15 PE=2 SV=2 - [LRC15_HUMAN]

8,09 5 5 17 64,3

P30740 Leukocyte elastase inhibitor OS=Homo sapiens GN=SERPINB1 PE=1 SV=1 - [ILEU_HUMAN]

37,99 13 13 27 42,7

Q5LIN8 L-fucose isomerase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=fucI PE=3 SV=1 - [FUCI_BACFN]

11,19 1 5 7 65,3

A6L048 L-fucose isomerase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=fucI PE=3 SV=1 - [FUCI_BACV8]

10,83 2 6 10 65,6

P05451 Lithostathine-1-alpha OS=Homo sapiens GN=REG1A PE=1 SV=3 - [REG1A_HUMAN]

56,02 10 10 88 18,7

P00338 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 - [LDHA_HUMAN]

6,33 1 2 10 36,7

P07195 L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 - [LDHB_HUMAN]

6,29 1 2 9 36,6

Q8A1A2 L-rhamnose isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=rhaA PE=3 SV=1 - [RHAA_BACTN]

10,05 4 4 6 47,5

P11279 Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens GN=LAMP1 PE=1 SV=3 - [LAMP1_HUMAN]

4,08 2 2 4 44,9


4,88 2 2 8 44,9

P61626 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 - [LYSC_HUMAN] 22,30 3 3 4 16,5

Q64P62 Malate dehydrogenase OS=Bacteroides fragilis (strain YCH46) GN=mdh PE=3 SV=1 - [MDH_BACFR]

22,68 4 5 14 32,7

A6L903 Malate dehydrogenase OS=Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) GN=mdh PE=3 SV=1 - [MDH_PARD8]

21,09 3 4 11 32,8

P40926 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 14,20 4 4 9 35,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

SV=3 - [MDHM_HUMAN]

O43451 Maltase-glucoamylase, intestinal OS=Homo sapiens GN=MGAM PE=1 SV=5 - [MGA_HUMAN]

31,93 49 53 300 209,7

Q16819 Meprin A subunit alpha OS=Homo sapiens GN=MEP1A PE=1 SV=2 - [MEP1A_HUMAN]

16,35 9 9 26 84,4

Q16820 Meprin A subunit beta OS=Homo sapiens GN=MEP1B PE=1 SV=3 - [MEP1B_HUMAN]

12,27 7 7 10 79,5

Q02817 Mucin-2 OS=Homo sapiens GN=MUC2 PE=1 SV=2 - [MUC2_HUMAN] 4,96 24 24 101 540,0

Q6W4X9 Mucin-6 OS=Homo sapiens GN=MUC6 PE=1 SV=3 - [MUC6_HUMAN] 1,23 2 2 4 256,9

P60660 Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 - [MYL6_HUMAN]

15,89 2 2 2 16,9

P35579 Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 - [MYH9_HUMAN] 2,45 5 5 9 226,4

P20933 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens GN=AGA PE=1 SV=2 - [ASPG_HUMAN]

6,65 2 2 7 37,2

Q9UQQ1 N-acetylated-alpha-linked acidic dipeptidase-like protein OS=Homo sapiens GN=NAALADL1 PE=1 SV=2 - [NALDL_HUMAN]

27,30 15 15 33 80,5

P31026 NADP-specific glutamate dehydrogenase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) GN=gdh PE=3 SV=2 - [DHE4_CORGL]

8,05 1 4 18 49,0

P00370 NADP-specific glutamate dehydrogenase OS=Escherichia coli (strain K12) GN=gdhA PE=1 SV=1 - [DHE4_ECOLI]

13,65 1 5 13 48,6

P55990 NADP-specific glutamate dehydrogenase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=gdhA PE=3 SV=1 - [DHE4_HELPY]

4,69 2 2 4 49,3

P00369 NADP-specific glutamate dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gdh PE=1 SV=3 - [DHE4_NEUCR]

11,67 1 5 17 48,8

P15111 NADP-specific glutamate dehydrogenase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=gdhA PE=3 SV=2 - [DHE4_SALTY]

13,65 1 5 17 48,5

P94316 NAD-specific glutamate dehydrogenase OS=Bacteroides fragilis (strain YCH46) GN=gdhB PE=2 SV=2 - [DHE2_BACFR]

31,91 7 12 29 48,4

B2RKJ1 NAD-specific glutamate dehydrogenase OS=Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) GN=gdh PE=3 SV=1 - [DHE2_PORG3]

11,46 1 5 11 49,2

P08473 Neprilysin OS=Homo sapiens GN=MME PE=1 SV=2 - [NEP_HUMAN] 8,93 6 6 11 85,5

Q09666 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 - [AHNK_HUMAN]

4,01 3 3 13 628,7



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q9NR71 Neutral ceramidase OS=Homo sapiens GN=ASAH2 PE=1 SV=2 - [ASAH2_HUMAN]

6,54 4 4 5 85,5

P80188 Neutrophil gelatinase-associated lipocalin OS=Homo sapiens GN=LCN2 PE=1 SV=2 - [NGAL_HUMAN]

63,64 11 11 40 22,6

Q15274 Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens GN=QPRT PE=1 SV=3 - [NADC_HUMAN]

11,78 3 3 5 30,8

P19338 Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3 - [NUCL_HUMAN] 4,08 3 3 4 76,6

P04746 Pancreatic alpha-amylase OS=Homo sapiens GN=AMY2A PE=1 SV=2 - [AMYP_HUMAN]

67,32 4 25 139 57,7

P55259 Pancreatic secretory granule membrane major glycoprotein GP2 OS=Homo sapiens GN=GP2 PE=2 SV=3 - [GP2_HUMAN]

11,55 5 5 17 59,4

P16233 Pancreatic triacylglycerol lipase OS=Homo sapiens GN=PNLIP PE=1 SV=1 - [LIPP_HUMAN]

7,31 3 3 6 51,1

O95497 Pantetheinase OS=Homo sapiens GN=VNN1 PE=1 SV=2 - [VNN1_HUMAN] 4,68 2 2 4 57,0

Q06830 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 - [PRDX1_HUMAN]

24,12 4 5 9 22,1

P32119 Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 - [PRDX2_HUMAN]

14,65 1 2 2 21,9

P30041 Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 - [PRDX6_HUMAN]

6,70 2 2 2 25,0

A6VKV4 Phosphoenolpyruvate carboxykinase [ATP] OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) GN=pckA PE=1 SV=1 - [PCKA_ACTSZ]

11,15 2 5 12 59,1


37,38 5 19 77 59,0

Q8A414 Phosphoenolpyruvate carboxykinase [ATP] OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=pckA PE=3 SV=1 - [PCKA_BACTN]

31,78 3 13 54 59,1


27,53 4 12 46 59,0


28,28 2 12 35 59,0


48,60 9 22 73 58,9

B2RHV8 Phosphoenolpyruvate carboxykinase [ATP] OS=Porphyromonas gingivalis 22,06 2 11 44 59,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

(strain ATCC 33277 / DSM 20709 / JCM 12257) GN=pckA PE=3 SV=1 - [PCKA_PORG3]

B4F025 Phosphoenolpyruvate carboxykinase [ATP] OS=Proteus mirabilis (strain HI4320) GN=pckA PE=3 SV=1 - [PCKA_PROMH]

14,47 3 6 13 59,3

P00558 Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 - [PGK1_HUMAN]

10,07 3 3 5 44,6

P04054 Phospholipase A2 OS=Homo sapiens GN=PLA2G1B PE=1 SV=3 - [PA21B_HUMAN]

39,86 5 5 23 16,3

Q8IV08 Phospholipase D3 OS=Homo sapiens GN=PLD3 PE=1 SV=1 - [PLD3_HUMAN]

4,08 2 2 4 54,7

B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Azobacteroides pseudotrichonymphae genomovar. CFP2 GN=purC PE=3 SV=1 - [PUR7_AZOPC]

7,12 1 2 2 37,6

Q5LH03 Phosphoribosylaminoimidazole-succinocarboxamide synthase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=purC PE=3 SV=1 - [PUR7_BACFN]

8,92 1 2 2 35,5

Q5LDN9 Phosphoserine aminotransferase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=serC PE=3 SV=1 - [SERC_BACFN]

20,56 2 7 17 39,2

Q8A8L4 Phosphoserine aminotransferase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=serC PE=3 SV=1 - [SERC_BACTN]

20,85 2 7 19 39,4

Q13835 Plakophilin-1 OS=Homo sapiens GN=PKP1 PE=1 SV=2 - [PKP1_HUMAN] 8,43 6 6 11 82,8

Q9Y446 Plakophilin-3 OS=Homo sapiens GN=PKP3 PE=1 SV=1 - [PKP3_HUMAN] 7,53 6 6 10 87,0

Q15149 Plectin OS=Homo sapiens GN=PLEC PE=1 SV=3 - [PLEC_HUMAN] 0,60 3 3 3 531,5

Q15365 Poly(rC)-binding protein 1 OS=Homo sapiens GN=PCBP1 PE=1 SV=2 - [PCBP1_HUMAN]

5,62 1 2 4 37,5


6,58 1 2 3 38,6

P11940 Polyadenylate-binding protein 1 OS=Homo sapiens GN=PABPC1 PE=1 SV=2 - [PABP1_HUMAN]

13,36 7 7 11 70,6

P01833 Polymeric immunoglobulin receptor OS=Homo sapiens GN=PIGR PE=1 SV=4 - [PIGR_HUMAN]

42,28 26 26 110 83,2

P0CG48 Polyubiquitin-C OS=Homo sapiens GN=UBC PE=1 SV=3 - [UBC_HUMAN] 49,93 3 3 30 77,0

P02545 Prelamin-A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 - [LMNA_HUMAN] 15,66 10 10 27 74,1

P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens GN=DDX5 6,35 4 4 6 69,1



Coverage Unique

Peptides Total

Peptides


MW [kDa]

PE=1 SV=1 - [DDX5_HUMAN]

Q2M2H8 Probable maltase-glucoamylase 2 OS=Homo sapiens GN=MGAM2 PE=2 SV=3 - [MGAL_HUMAN]

1,87 1 4 29 277,8

Q99623 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 - [PHB2_HUMAN] 5,69 2 2 2 33,3

P30101 Protein disulfide-isomerase A3 OS=Homo sapiens GN=PDIA3 PE=1 SV=4 - [PDIA3_HUMAN]

8,51 4 4 5 56,7

P07237 Protein disulfide-isomerase OS=Homo sapiens GN=P4HB PE=1 SV=3 - [PDIA1_HUMAN]

8,46 5 5 6 57,1

P05109 Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 - [S10A8_HUMAN]

23,66 2 2 5 10,8

A6NCN2 Putative keratin-87 protein OS=Homo sapiens GN=KRT87P PE=5 SV=4 - [KR87P_HUMAN]

54,51 2 25 259 29,1

Q8IZP2 Putative protein FAM10A4 OS=Homo sapiens GN=ST13P4 PE=5 SV=1 - [ST134_HUMAN]

8,33 2 2 4 27,4

P14618 Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4 - [KPYM_HUMAN]

16,20 9 9 27 57,9

P61224 Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 - [RAP1B_HUMAN]

11,41 2 2 2 20,8

O00584 Ribonuclease T2 OS=Homo sapiens GN=RNASET2 PE=1 SV=2 - [RNT2_HUMAN]

9,77 2 2 3 29,5

Q13228 Selenium-binding protein 1 OS=Homo sapiens GN=SELENBP1 PE=1 SV=2 - [SBP1_HUMAN]

60,81 25 25 101 52,4

A6L5K3 Serine hydroxymethyltransferase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=glyA PE=3 SV=1 - [GLYA_BACV8]

7,28 1 3 9 46,8

B2RGR2 Serine hydroxymethyltransferase OS=Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) GN=glyA PE=3 SV=1 - [GLYA_PORG3]

7,75 1 3 8 46,6

P29508 Serpin B3 OS=Homo sapiens GN=SERPINB3 PE=1 SV=2 - [SPB3_HUMAN] 4,36 2 2 3 44,5



P02768 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 - [ALBU_HUMAN] 26,93 15 15 42 69,3

Q9HAT2 Sialate O-acetylesterase OS=Homo sapiens GN=SIAE PE=1 SV=1 - [SIAE_HUMAN]

11,09 5 5 8 58,3

P23246 Splicing factor, proline- and glutamine-rich OS=Homo sapiens GN=SFPQ PE=1 SV=2 - [SFPQ_HUMAN]

7,21 4 4 8 76,1

P16949 Stathmin OS=Homo sapiens GN=STMN1 PE=1 SV=3 - [STMN1_HUMAN] 12,75 2 2 3 17,3

P38646 Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 7,22 3 4 8 73,6



Coverage Unique

Peptides Total

Peptides


MW [kDa]

- [GRP75_HUMAN]

P14410 Sucrase-isomaltase, intestinal OS=Homo sapiens GN=SI PE=1 SV=6 - [SUIS_HUMAN]

17,13 25 27 54 209,3

P53638 Superoxide dismutase [Fe] OS=Bacteroides fragilis (strain YCH46) GN=sodB PE=3 SV=2 - [SODF_BACFR]

11,40 2 2 7 21,8

P17987 T-complex protein 1 subunit alpha OS=Homo sapiens GN=TCP1 PE=1 SV=1 - [TCPA_HUMAN]

4,86 3 3 3 60,3

P50991 T-complex protein 1 subunit delta OS=Homo sapiens GN=CCT4 PE=1 SV=4 - [TCPD_HUMAN]

3,34 2 2 4 57,9

P50990 T-complex protein 1 subunit theta OS=Homo sapiens GN=CCT8 PE=1 SV=4 - [TCPQ_HUMAN]

3,65 2 2 3 59,6


Q8WZ42 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 - [TITIN_HUMAN] 0,84 24 24 62 3813,7

Q01995 Transgelin OS=Homo sapiens GN=TAGLN PE=1 SV=4 - [TAGL_HUMAN] 9,45 2 2 2 22,6

P55072 Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 - [TERA_HUMAN]

3,23 3 3 3 89,3

P02766 Transthyretin OS=Homo sapiens GN=TTR PE=1 SV=1 - [TTHY_HUMAN] 69,39 9 9 27 15,9

Q5L923 Triosephosphate isomerase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=tpiA PE=3 SV=1 - [TPIS_BACFN]

33,47 2 5 25 26,6

Q8A0U2 Triosephosphate isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=tpiA PE=3 SV=1 - [TPIS_BACTN]

32,54 4 7 30 26,8


68,13 8 10 40 26,9

P60174 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=3 - [TPIS_HUMAN]

10,49 3 3 5 30,8

P67936 Tropomyosin alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 - [TPM4_HUMAN]

14,11 4 4 7 28,5

P07477 Trypsin-1 OS=Homo sapiens GN=PRSS1 PE=1 SV=1 - [TRY1_HUMAN] 28,34 4 5 14 26,5


P68363 Tubulin alpha-1B chain OS=Homo sapiens GN=TUBA1B PE=1 SV=1 - [TBA1B_HUMAN]

45,45 4 14 40 50,1

P68366 Tubulin alpha-4A chain OS=Homo sapiens GN=TUBA4A PE=1 SV=1 - [TBA4A_HUMAN]

39,06 2 12 28 49,9

P07437 Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2 - [TBB5_HUMAN]

47,75 1 15 63 49,6



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q13885 Tubulin beta-2A chain OS=Homo sapiens GN=TUBB2A PE=1 SV=1 - [TBB2A_HUMAN]

59,33 5 19 65 49,9

P68371 Tubulin beta-4B chain OS=Homo sapiens GN=TUBB4B PE=1 SV=1 - [TBB4B_HUMAN]

55,06 3 18 64 49,8

Q96DC9 Ubiquitin thioesterase OTUB2 OS=Homo sapiens GN=OTUB2 PE=1 SV=2 - [OTUB2_HUMAN]

12,39 3 3 4 27,2

P22314 Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 - [UBA1_HUMAN]

2,08 2 2 2 117,8


18,38 2 7 21 54,3

A6L4U4 Uronate isomerase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=uxaC PE=3 SV=1 - [UXAC_BACV8]

18,38 2 7 19 54,3

P08670 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 - [VIME_HUMAN] 19,31 8 11 32 53,6

P12955 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 - [PEPD_HUMAN]

15,42 6 6 11 54,5

Q8A9M2 Xylose isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=xylA PE=3 SV=1 - [XYLA_BACTN]

31,74 4 11 28 48,9

A6L792 Xylose isomerase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=xylA PE=3 SV=1 - [XYLA_BACV8]

37,21 7 14 35 49,0

P25311 Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=2 - [ZA2G_HUMAN]

47,65 11 11 25 34,2


Supplementary Table 3. All Proteins Detected in the Fecal Filtrate for Patient 5


Coverage Unique

Peptides Total

Peptides


MW [kDa]


26,47 3 3 11 10,9


26,02 2 6 10 28,1


11,76 2 3 10 29,2


16,26 2 4 10 28,2


22,67 2 5 11 28,3


19,59 2 5 14 27,7


13,88 2 3 16 27,7

A6L050 2,3-bisphosphoglycerate-independent phosphoglycerate mutase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=gpmI PE=3 SV=1 - [GPMI_BACV8]

3,97 2 2 7 55,8

Q13200 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 - [PSMD2_HUMAN]

2,97 2 2 3 100,1


13,29 2 2 9 18,4


11,26 2 2 5 17,2


17,88 4 4 14 16,3


12,31 2 2 4 14,8


32,89 6 6 18 17,7


13,10 2 2 6 16,1


10,24 3 3 10 31,3


25,21 3 3 5 13,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]


13,60 2 2 9 13,7


27,98 7 7 15 26,7


13,26 4 4 9 29,9


8,37 3 3 4 29,6

O14277 40S ribosomal protein S5-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps5 PE=3 SV=1 - [RS5A_SCHPO]

8,87 2 2 5 22,2


14,86 3 3 15 28,7


8,76 2 2 3 22,1


9,62 2 2 9 24,2


10,85 3 3 14 32,8

P49189 4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens GN=ALDH9A1 PE=1 SV=3 - [AL9A1_HUMAN]

3,64 2 2 6 53,8


9,25 6 6 17 61,0


9,00 2 2 7 24,2


11,27 3 3 10 24,1


14,13 2 2 8 21,4


18,09 3 3 12 21,6


18,75 2 2 8 14,8


13,38 2 2 4 17,8


12,41 3 3 6 17,2

P46779 60S ribosomal protein L28 OS=Homo sapiens GN=RPL28 PE=1 SV=3 - 15,33 3 3 6 15,7



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[RL28_HUMAN]


8,44 4 4 14 46,1


13,68 2 2 5 13,3


17,92 2 2 9 12,4


6,25 3 3 16 32,7


4,84 2 2 5 29,2


10,51 2 2 11 28,0


14,07 7 8 37 72,3

Q92485 Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens GN=SMPDL3B PE=2 SV=2 - [ASM3B_HUMAN]

4,84 2 2 4 50,8


3,59 2 2 4 85,4

Q9UVX4 Actin OS=Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) GN=ACT1 PE=3 SV=1 - [ACT_COPC7]

28,53 1 8 79 41,6


41,33 8 15 129 41,7

A1BEZ2 Adenosylhomocysteinase OS=Chlorobium phaeobacteroides (strain DSM 266) GN=ahcY PE=3 SV=1 - [SAHH_CHLPD]

6,37 1 4 12 52,4


5,09 1 3 9 47,7

B0UM37 Adenosylhomocysteinase OS=Methylobacterium sp. (strain 4-46) GN=ahcY PE=3 SV=1 - [SAHH_METS4]

7,69 1 4 15 51,1

A6L1X1 Adenylosuccinate synthetase OS=Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) GN=purA PE=3 SV=1 - [PURA_BACV8]

6,15 2 2 5 46,8

Q01518 Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=5 - [CAP1_HUMAN]

4,21 2 2 7 51,9


6,38 1 2 9 33,0


6,38 1 2 7 32,8



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P84085 ADP-ribosylation factor 5 OS=Homo sapiens GN=ARF5 PE=1 SV=2 - [ARF5_HUMAN]

11,67 2 2 3 20,5


11,11 3 3 6 47,6


50,00 22 22 120 46,7


3,66 5 5 12 163,2

P12814 Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 - [ACTN1_HUMAN]

2,35 2 2 5 103,0

O43707 Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 - [ACTN4_HUMAN]

2,31 2 2 4 104,8


68,10 1 32 426 57,7


72,41 3 34 433 57,7


Q03154 Aminoacylase-1 OS=Homo sapiens GN=ACY1 PE=1 SV=1 - [ACY1_HUMAN]

10,29 3 3 5 45,9


24,92 28 28 110 109,5

P12821 Angiotensin-converting enzyme OS=Homo sapiens GN=ACE PE=1 SV=1 - [ACE_HUMAN]

1,84 2 2 3 149,6



P05090 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 - [APOD_HUMAN]

15,34 2 2 3 21,3

P05089 Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 - [ARGI1_HUMAN] 7,14 3 3 5 34,7


8,14 4 4 8 59,7


9,26 4 4 18 56,5

A6ZP47 ATP-dependent RNA helicase DED1 OS=Saccharomyces cerevisiae (strain YJM789) GN=DED1 PE=3 SV=1 - [DED1_YEAS7]

3,31 2 2 4 65,5

P07814 Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens GN=EPRS PE=1 SV=5 - [SYEP_HUMAN]

1,06 2 2 2 170,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P12830 Cadherin-1 OS=Homo sapiens GN=CDH1 PE=1 SV=3 - [CADH1_HUMAN] 4,20 2 2 3 97,4


6,03 6 6 13 141,5

Q9HBB8 Cadherin-related family member 5 OS=Homo sapiens GN=CDHR5 PE=1 SV=3 - [CDHR5_HUMAN]

4,50 2 2 5 88,2


16,74 14 14 28 100,2

P27797 Calreticulin OS=Homo sapiens GN=CALR PE=1 SV=1 - [CALR_HUMAN] 5,04 2 2 4 48,1


17,18 5 6 16 47,1


51,80 17 18 64 47,3

Q9Y646 Carboxypeptidase Q OS=Homo sapiens GN=CPQ PE=1 SV=1 - [CBPQ_HUMAN]

4,03 2 2 4 51,9


9,89 3 4 10 57,5


9,40 4 5 13 76,7

P31944 Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 - [CASPE_HUMAN]

12,81 4 4 10 27,7

Q9UBR2 Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 - [CATZ_HUMAN] 7,26 2 2 5 33,8

P60953 Cell division control protein 42 homolog OS=Homo sapiens GN=CDC42 PE=1 SV=2 - [CDC42_HUMAN]

10,99 1 2 7 21,2

A7IC65 Chaperone protein DnaK OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) GN=dnaK PE=3 SV=1 - [DNAK_XANP2]

5,23 1 3 7 67,6


23,13 5 5 14 29,5


53,16 10 10 131 28,9


55,56 8 10 40 29,5


47,78 6 8 35 29,2

Q9Y281 Cofilin-2 OS=Homo sapiens GN=CFL2 PE=1 SV=1 - [COF2_HUMAN] 23,49 3 3 13 18,7

Q15517 Corneodesmosin OS=Homo sapiens GN=CDSN PE=1 SV=3 - [CDSN_HUMAN]

4,35 2 2 2 51,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q86UP6 CUB and zona pellucida-like domain-containing protein 1 OS=Homo sapiens GN=CUZD1 PE=2 SV=1 - [CUZD1_HUMAN]

10,05 3 3 4 68,1


7,07 2 2 3 34,1

P28838 Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 - [AMPL_HUMAN]

4,62 2 2 5 56,1


4,88 2 2 9 56,6


16,29 4 4 11 260,6


16,31 3 3 8 31,4


Q08554 Desmocollin-1 OS=Homo sapiens GN=DSC1 PE=1 SV=2 - [DSC1_HUMAN] 2,91 2 2 5 99,9

Q02413 Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=2 - [DSG1_HUMAN] 15,54 10 10 29 113,7



4,72 1 2 6 62,3


6,49 2 3 10 61,9


33,16 22 22 52 88,2


25,32 8 8 46 50,1


9,84 3 3 5 50,1


14,57 10 10 27 95,3

A9KRZ4 Elongation factor Tu OS=Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) GN=tuf PE=3 SV=1 - [EFTU_CLOPH]

6,30 1 2 3 43,8

A5FIJ9 Elongation factor Tu OS=Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) GN=tuf PE=3 SV=1 - [EFTU_FLAJ1]

5,82 1 2 3 43,0


8,09 7 7 19 92,4

B2RLL7 Enolase OS=Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) GN=eno PE=3 SV=1 - [ENO_PORG3]

6,59 2 2 3 45,8



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P98073 Enteropeptidase OS=Homo sapiens GN=TMPRSS15 PE=1 SV=3 - [ENTK_HUMAN]

6,08 4 4 10 112,9

P60842 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 - [IF4A1_HUMAN]

12,07 4 4 9 46,1


5,54 2 2 3 36,5

Q9Y262 Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens GN=EIF3L PE=1 SV=1 - [EIF3L_HUMAN]

3,37 2 2 7 66,7


Q96AE4 Far upstream element-binding protein 1 OS=Homo sapiens GN=FUBP1 PE=1 SV=3 - [FUBP1_HUMAN]

3,57 2 2 6 67,5

Q92945 Far upstream element-binding protein 2 OS=Homo sapiens GN=KHSRP PE=1 SV=4 - [FUBP2_HUMAN]

3,66 2 2 2 73,1

Q5D862 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 - [FILA2_HUMAN] 1,92 3 3 5 247,9



Q5L9E3 Glucose-6-phosphate isomerase OS=Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) GN=pgi PE=3 SV=1 - [G6PI_BACFN]

6,97 3 3 5 48,7

P94598 Glutamate dehydrogenase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=gdhA PE=3 SV=2 - [DHE3_BACTN]

3,60 2 2 2 49,0

Q07075 Glutamyl aminopeptidase OS=Homo sapiens GN=ENPEP PE=1 SV=3 - [AMPE_HUMAN]

5,02 4 4 4 109,2


37,65 4 4 17 9,7

P49433 Glyceraldehyde-3-phosphate dehydrogenase 1 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=gap1 PE=3 SV=1 - [G3P1_SYNY3]

9,44 2 2 4 36,1


11,94 2 3 16 35,7

O52631 Glyceraldehyde-3-phosphate dehydrogenase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) GN=gap PE=1 SV=1 - [G3P_CLOAB]

3,89 2 2 3 35,8


6,78 1 2 6 36,3



Coverage Unique

Peptides Total

Peptides


MW [kDa]


12,84 3 3 8 36,0


5,95 1 2 3 35,9


13,55 3 3 20 24,3


6,94 2 2 6 35,1

P34932 Heat shock 70 kDa protein 4 OS=Homo sapiens GN=HSPA4 PE=1 SV=4 - [HSP74_HUMAN]

2,98 2 2 2 94,3


6,99 1 5 25 69,9


27,86 9 15 86 70,9

P04792 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 - [HSPB1_HUMAN]

17,07 3 3 8 22,8


15,57 3 10 45 84,6


18,23 5 12 72 83,2


11,59 1 6 20 70,3

Q99729 Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens GN=HNRNPAB PE=1 SV=2 - [ROAA_HUMAN]

6,93 1 2 7 36,2


9,95 3 3 9 38,7


8,47 2 2 4 39,6

Q14103 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens GN=HNRNPD PE=1 SV=1 - [HNRPD_HUMAN]

6,76 1 2 7 38,4


14,25 6 6 21 50,9

P14866 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 - [HNRPL_HUMAN]

2,89 2 2 5 64,1

Q00839 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens 6,55 5 5 10 90,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

GN=HNRNPU PE=1 SV=6 - [HNRPU_HUMAN]


12,18 4 4 16 37,4


7,91 2 2 5 24,9


15,96 5 5 28 21,4


12,39 4 4 17 22,6

P0CN98 Histone H2A OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) GN=HTA1 PE=3 SV=1 - [H2A_CRYNJ]

29,01 2 2 14 13,9


23,81 4 4 47 13,9

P09988 Histone H3.1/H3.2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hht1 PE=1 SV=2 - [H31_SCHPO]

19,85 3 3 13 15,3




57,79 5 15 79 37,6


54,41 3 13 69 36,5

P01766 Ig heavy chain V-III region BRO OS=Homo sapiens PE=1 SV=1 - [HV305_HUMAN]

25,00 2 2 9 13,2


86,79 8 8 51 11,6

P01617 Ig kappa chain V-II region TEW OS=Homo sapiens PE=1 SV=1 - [KV204_HUMAN]

32,74 2 2 4 12,3


49,06 5 5 11 11,3


12,84 28 28 75 571,6


35,42 15 15 64 56,8


8,72 5 5 9 81,7




Coverage Unique

Peptides Total

Peptides


MW [kDa]


55,48 31 36 195 58,8


48,94 7 21 71 51,5


41,01 6 17 58 51,2

Q04695 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 - [K1C17_HUMAN]

19,44 2 9 32 48,1


57,30 28 28 191 62,0

P78386 Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 - [KRT85_HUMAN]

16,17 3 9 58 55,8


64,44 40 45 280 66,0

Q7Z794 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=2 SV=3 - [K2C1B_HUMAN]

15,57 5 8 28 61,9


71,99 32 41 167 65,4


33,90 13 24 82 62,3


37,77 1 22 83 60,0

P48668 Keratin, type II cytoskeletal 6C OS=Homo sapiens GN=KRT6C PE=1 SV=3 - [K2C6C_HUMAN]

38,65 1 23 84 60,0

Q7RTS7 Keratin, type II cytoskeletal 74 OS=Homo sapiens GN=KRT74 PE=1 SV=2 - [K2C74_HUMAN]

5,67 1 4 14 57,8

Q8N1N4 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=2 SV=2 - [K2C78_HUMAN]

5,38 1 3 6 56,8


4,65 1 2 7 50,5

Q5T749 Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 - [KPRP_HUMAN]

7,94 3 3 5 64,1


3,79 5 5 8 218,4

P02788 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 - [TRFL_HUMAN] 5,35 3 3 5 78,1

P20700 Lamin-B1 OS=Homo sapiens GN=LMNB1 PE=1 SV=2 - [LMNB1_HUMAN] 3,41 1 2 3 66,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

Q8AAW1 L-arabinose isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=araA PE=3 SV=1 - [ARAA_BACTN]

6,09 2 2 6 57,1

Q9BS40 Latexin OS=Homo sapiens GN=LXN PE=1 SV=2 - [LXN_HUMAN] 12,16 2 2 4 25,7

P05451 Lithostathine-1-alpha OS=Homo sapiens GN=REG1A PE=1 SV=3 - [REG1A_HUMAN]

15,66 3 3 11 18,7


6,33 1 2 17 36,7


6,29 1 2 15 36,6


4,80 2 2 3 44,9


P40926 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 - [MDHM_HUMAN]

14,20 4 4 17 35,5


16,48 24 25 80 209,7


6,30 4 4 9 84,4


7,85 4 4 11 79,5

P26038 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 - [MOES_HUMAN] 7,45 3 5 13 67,8

Q02817 Mucin-2 OS=Homo sapiens GN=MUC2 PE=1 SV=2 - [MUC2_HUMAN] 0,79 4 4 6 540,0


27,15 4 4 11 16,9

P19105 Myosin regulatory light chain 12A OS=Homo sapiens GN=MYL12A PE=1 SV=2 - [ML12A_HUMAN]

17,54 3 3 4 19,8


Q9UQQ1 N-acetylated-alpha-linked acidic dipeptidase-like protein OS=Homo sapiens GN=NAALADL1 PE=1 SV=2 - [NALDL_HUMAN]

2,57 2 2 3 80,5

P15586 N-acetylglucosamine-6-sulfatase OS=Homo sapiens GN=GNS PE=1 SV=3 - [GNS_HUMAN]

5,98 3 3 8 62,0

P31026 NADP-specific glutamate dehydrogenase OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) GN=gdh PE=3 SV=2 - [DHE4_CORGL]

6,04 3 3 10 49,0

P94316 NAD-specific glutamate dehydrogenase OS=Bacteroides fragilis (strain 5,39 1 3 8 48,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

YCH46) GN=gdhB PE=2 SV=2 - [DHE2_BACFR]

B2RKJ1 NAD-specific glutamate dehydrogenase OS=Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) GN=gdh PE=3 SV=1 - [DHE2_PORG3]

5,39 1 3 6 49,2

Q13765 Nascent polypeptide-associated complex subunit alpha OS=Homo sapiens GN=NACA PE=1 SV=1 - [NACA_HUMAN]

13,49 2 2 10 23,4

Q09666 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 - [AHNK_HUMAN]

1,83 2 2 13 628,7

P80188 Neutrophil gelatinase-associated lipocalin OS=Homo sapiens GN=LCN2 PE=1 SV=2 - [NGAL_HUMAN]

20,20 4 4 12 22,6


P06748 Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 - [NPM_HUMAN] 3,74 2 2 12 32,6

P15531 Nucleoside diphosphate kinase A OS=Homo sapiens GN=NME1 PE=1 SV=1 - [NDKA_HUMAN]

20,39 2 2 6 17,1


72,41 4 34 454 57,7


5,59 3 3 22 59,4



24,12 4 5 15 22,1


7,01 1 2 3 30,5


17,76 2 10 35 59,0

A1VZR5 Phosphoenolpyruvate carboxykinase [ATP] OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) GN=pckA PE=3 SV=1 - [PCKA_CAMJJ]

6,30 1 3 13 59,0

Q47VD0 Phosphoenolpyruvate carboxykinase [ATP] OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=pckA PE=3 SV=1 - [PCKA_COLP3]

4,85 1 3 13 59,3

C5BGS4 Phosphoenolpyruvate carboxykinase [ATP] OS=Edwardsiella ictaluri (strain 93-146) GN=pckA PE=3 SV=1 - [PCKA_EDWI9]

9,09 2 5 24 59,2


25,09 4 13 54 59,0

C4ZBL1 Phosphoenolpyruvate carboxykinase [ATP] OS=Eubacterium rectale (strain 35,58 8 17 51 59,0



Coverage Unique

Peptides Total

Peptides


MW [kDa]

ATCC 33656 / VPI 0990) GN=pckA PE=3 SV=1 - [PCKA_EUBR3]


27,10 7 16 73 58,9

Q9CKR4 Phosphoenolpyruvate carboxykinase [ATP] OS=Pasteurella multocida (strain Pm70) GN=pckA PE=3 SV=1 - [PCKA_PASMU]

11,15 2 7 18 58,8


8,97 1 6 22 59,4


4,32 2 2 2 44,6

P04054 Phospholipase A2 OS=Homo sapiens GN=PLA2G1B PE=1 SV=3 - [PA21B_HUMAN]

31,08 3 3 5 16,3



8,71 3 3 10 37,5


2,99 2 2 2 70,6


16,75 10 10 22 83,2



Q92841 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 - [DDX17_HUMAN]

4,94 1 3 10 80,2

P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens GN=DDX5 PE=1 SV=1 - [DDX5_HUMAN]

5,37 1 3 6 69,1


P12273 Prolactin-inducible protein OS=Homo sapiens GN=PIP PE=1 SV=1 - [PIP_HUMAN]

34,93 4 4 6 16,6

P12004 Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 - [PCNA_HUMAN]

12,26 3 3 4 28,8

Q9UQ80 Proliferation-associated protein 2G4 OS=Homo sapiens GN=PA2G4 PE=1 SV=3 - [PA2G4_HUMAN]

7,11 3 3 4 43,8

P25788 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 - [PSA3_HUMAN]

8,24 2 2 9 28,4

P60900 Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 17,48 4 4 9 27,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

SV=1 - [PSA6_HUMAN]


10,69 6 6 18 56,7


4,19 2 2 3 72,9


7,48 3 3 8 57,1

Q01105 Protein SET OS=Homo sapiens GN=SET PE=1 SV=3 - [SET_HUMAN] 7,93 2 2 10 33,5

Q08188 Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens GN=TGM3 PE=1 SV=4 - [TGM3_HUMAN]

5,19 2 2 3 76,6


14,51 1 2 3 29,1


8,33 2 2 7 27,4


21,66 12 12 54 57,9

P15153 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 - [RAC2_HUMAN]

10,94 1 2 7 21,4

P61224 Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 - [RAP1B_HUMAN]

11,41 2 2 3 20,8

P62070 Ras-related protein R-Ras2 OS=Homo sapiens GN=RRAS2 PE=1 SV=1 - [RRAS2_HUMAN]

11,27 2 2 2 23,4

P08134 Rho-related GTP-binding protein RhoC OS=Homo sapiens GN=RHOC PE=1 SV=1 - [RHOC_HUMAN]

9,84 2 2 3 22,0


33,47 13 13 30 52,4

P04279 Semenogelin-1 OS=Homo sapiens GN=SEMG1 PE=1 SV=2 - [SEMG1_HUMAN]

6,71 2 2 2 52,1

Q07955 Serine/arginine-rich splicing factor 1 OS=Homo sapiens GN=SRSF1 PE=1 SV=2 - [SRSF1_HUMAN]

16,53 4 4 11 27,7


5,23 2 2 5 39,6




P62316 Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens GN=SNRPD2 16,95 2 2 7 13,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]

PE=1 SV=1 - [SMD2_HUMAN]

P05023 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens GN=ATP1A1 PE=1 SV=1 - [AT1A1_HUMAN]

2,74 2 2 7 112,8

Q9UMY4 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 - [SNX12_HUMAN]

8,14 2 2 4 19,7

Q13813 Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens GN=SPTAN1 PE=1 SV=3 - [SPTN1_HUMAN]

0,85 2 2 3 284,4


4,81 3 3 6 76,1


P38646 Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 - [GRP75_HUMAN]

3,39 1 2 7 73,6


17,35 25 26 66 209,3


8,81 5 5 7 60,3


9,28 5 5 9 57,9

Q99832 T-complex protein 1 subunit eta OS=Homo sapiens GN=CCT7 PE=1 SV=2 - [TCPH_HUMAN]

6,08 3 3 6 59,3

P49368 T-complex protein 1 subunit gamma OS=Homo sapiens GN=CCT3 PE=1 SV=4 - [TCPG_HUMAN]

3,67 2 2 3 60,5


10,22 5 5 9 59,6

P40227 T-complex protein 1 subunit zeta OS=Homo sapiens GN=CCT6A PE=1 SV=3 - [TCPZ_HUMAN]

3,58 2 2 2 58,0



P37837 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 - [TALDO_HUMAN]

5,04 2 2 5 37,5

P37802 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 - [TAGL2_HUMAN]

11,06 2 2 8 22,4

P29401 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 - [TKT_HUMAN] 4,33 3 3 6 67,8



23,51 4 4 8 26,9



Coverage Unique

Peptides Total

Peptides


MW [kDa]

A4G646 Triosephosphate isomerase OS=Herminiimonas arsenicoxydans GN=tpiA PE=3 SV=1 - [TPIS_HERAR]

3,23 2 2 2 26,3


8,04 2 2 10 30,8


9,12 1 2 13 32,9


8,47 1 2 13 28,5


Q9BQE3 Tubulin alpha-1C chain OS=Homo sapiens GN=TUBA1C PE=1 SV=1 - [TBA1C_HUMAN]

7,35 3 3 21 49,9


12,39 1 5 71 49,6

Q9BVA1 Tubulin beta-2B chain OS=Homo sapiens GN=TUBB2B PE=1 SV=1 - [TBB2B_HUMAN]

9,66 1 4 54 49,9


12,36 1 5 70 49,8

P54577 Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=YARS PE=1 SV=4 - [SYYC_HUMAN]

5,30 3 3 5 59,1


3,31 3 3 9 117,8


7,48 3 3 7 54,3


P18206 Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 - [VINC_HUMAN] 5,47 6 6 13 123,7


31,54 10 10 32 34,2


Supplementary Table 4. All Proteins Detected in the Replicate of the Fecal Filtrate for Patient 5


Coverage Unique

Peptides Total

Peptides


MW [kDa]


19,61 2 2 9 10,9


19,51 2 5 11 28,1


11,76 2 3 10 29,2


16,26 2 4 10 28,2


16,60 3 5 13 28,3

P31947 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 - [1433S_HUMAN]

22,98 3 5 10 27,8


19,59 2 5 15 27,7


13,88 2 3 15 27,7

Q13200 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 - [PSMD2_HUMAN]

2,97 2 2 4 100,1

O43242 26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens GN=PSMD3 PE=1 SV=2 - [PSMD3_HUMAN]

3,37 2 2 3 60,9


13,29 3 3 9 18,4


11,26 2 2 9 17,2


17,88 4 4 14 16,3


12,31 2 2 6 14,8


32,24 5 5 17 17,7


13,10 2 2 2 16,1


6,48 2 2 6 31,3



Coverage Unique

Peptides Total

Peptides


MW [kDa]


15,13 2 2 5 13,4


19,34 4 4 16 26,7


12,88 4 4 13 29,9


6,08 2 2 4 29,6


12,75 3 3 9 22,9


14,86 3 3 16 28,7


9,62 2 2 5 24,2


10,85 3 3 19 32,8


6,63 4 4 16 61,0


7,37 2 2 3 24,8


14,55 2 2 5 17,8


9,00 2 2 5 24,2


7,84 2 2 10 24,1


18,09 3 3 11 21,6


18,75 2 2 6 14,8


15,33 3 3 5 15,7


6,70 3 3 8 46,1


13,68 2 2 3 13,3

P83881 60S ribosomal protein L36a OS=Homo sapiens GN=RPL36A PE=1 SV=2 - 17,92 2 2 8 12,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[RL36A_HUMAN]


9,38 4 4 12 32,7


8,06 3 3 3 29,2


10,51 2 2 10 28,0


16,67 8 9 29 72,3


4,74 3 3 7 85,4


49,07 17 17 143 41,7

A1BEZ2 Adenosylhomocysteinase OS=Chlorobium phaeobacteroides (strain DSM 266) GN=ahcY PE=3 SV=1 - [SAHH_CHLPD]

6,37 1 3 7 52,4


5,09 1 2 4 47,7

B0UM37 Adenosylhomocysteinase OS=Methylobacterium sp. (strain 4-46) GN=ahcY PE=3 SV=1 - [SAHH_METS4]

7,69 1 3 7 51,1


6,38 1 2 7 33,0


6,38 1 2 8 32,8

P84085 ADP-ribosylation factor 5 OS=Homo sapiens GN=ARF5 PE=1 SV=2 - [ARF5_HUMAN]

11,67 2 2 2 20,5


10,87 3 3 4 47,6


41,63 16 16 40 46,7


7,12 9 9 23 163,2

O43707 Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 - [ACTN4_HUMAN]

2,31 2 2 6 104,8


63,01 1 31 237 57,7


67,32 3 33 240 57,7



Coverage Unique

Peptides Total

Peptides


MW [kDa]



23,99 26 26 52 109,5



P05090 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 - [APOD_HUMAN]

15,34 2 2 2 21,3

P05089 Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 - [ARGI1_HUMAN] 7,14 2 2 3 34,7


8,14 4 4 7 59,7


9,26 4 4 19 56,5

O00148 ATP-dependent RNA helicase DDX39A OS=Homo sapiens GN=DDX39A PE=1 SV=2 - [DX39A_HUMAN]

3,51 2 2 3 49,1


1,76 2 2 4 141,5


3,17 3 3 4 100,2


10,98 3 4 6 47,1


33,57 10 11 16 47,3


5,70 1 2 3 57,5


3,13 1 2 3 76,7

P31944 Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 - [CASPE_HUMAN]

9,09 3 3 7 27,7

P60953 Cell division control protein 42 homolog OS=Homo sapiens GN=CDC42 PE=1 SV=2 - [CDC42_HUMAN]

10,99 1 2 5 21,2


8,21 2 2 3 29,5


53,16 10 10 54 28,9


25,56 3 5 13 29,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]


14,07 1 3 10 29,2

P23528 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 - [COF1_HUMAN] 11,45 2 2 13 18,5

P01024 Complement C3 OS=Homo sapiens GN=C3 PE=1 SV=2 - [CO3_HUMAN] 5,95 7 7 12 187,0


7,07 2 2 6 34,1

Q14204 Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens GN=DYNC1H1 PE=1 SV=5 - [DYHC1_HUMAN]

0,41 2 2 3 532,1


6,94 3 3 10 56,6


10,69 2 2 6 260,6


16,31 3 3 5 31,4




Q02413 Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=2 - [DSG1_HUMAN] 16,59 11 11 22 113,7



4,72 1 2 7 62,3


6,49 2 3 13 61,9


21,93 16 16 27 88,2


21,21 6 6 45 50,1


4,58 2 2 3 50,1


12,24 9 9 27 95,3


9,59 9 9 21 92,4

Q31G68 Enolase OS=Thiomicrospira crunogena (strain XCL-2) GN=eno PE=3 SV=1 - [ENO_THICR]

3,29 1 2 7 45,8

P60842 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 - 10,59 3 3 10 46,1



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[IF4A1_HUMAN]


5,54 2 2 7 36,5


Q96AE4 Far upstream element-binding protein 1 OS=Homo sapiens GN=FUBP1 PE=1 SV=3 - [FUBP1_HUMAN]

3,57 2 2 5 67,5

P02679 Fibrinogen gamma chain OS=Homo sapiens GN=FGG PE=1 SV=3 - [FIBG_HUMAN]

3,97 2 2 3 51,5

P02751 Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=4 - [FINC_HUMAN] 0,75 2 2 3 262,5




37,65 4 4 10 9,7


7,46 1 2 9 35,7


6,78 1 2 3 36,3


17,91 4 4 8 36,0


6,85 1 2 2 35,9


9,81 2 2 17 24,3


4,10 2 2 9 35,1

P00738 Haptoglobin OS=Homo sapiens GN=HP PE=1 SV=1 - [HPT_HUMAN] 22,41 7 7 10 45,2


6,99 1 4 20 69,9


29,72 10 15 83 70,9

Q92598 Heat shock protein 105 kDa OS=Homo sapiens GN=HSPH1 PE=1 SV=1 - [HS105_HUMAN]

2,10 2 2 2 96,8

P04792 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 - 25,85 4 4 10 22,8



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[HSPB1_HUMAN]


15,44 4 10 37 84,6


17,40 5 11 60 83,2


11,59 1 5 16 70,3


12,10 3 3 11 38,7


8,47 2 2 4 39,6


14,25 6 6 21 50,9

P14866 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 - [HNRPL_HUMAN]

2,89 2 2 8 64,1

Q00839 Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens GN=HNRNPU PE=1 SV=6 - [HNRPU_HUMAN]

5,33 4 4 9 90,5


12,18 3 3 14 37,4


7,91 1 2 10 24,9


10,53 1 2 7 24,0


15,49 4 4 27 21,4


12,39 4 4 19 22,6

P0C0S5 Histone H2A.Z OS=Homo sapiens GN=H2AFZ PE=1 SV=2 - [H2AZ_HUMAN] 14,84 2 2 17 13,5


23,81 4 4 47 13,9

A5DWE2 Histone H3.1/H3.2 OS=Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) GN=HHT1 PE=3 SV=1 - [H31_LODEL]

13,24 2 2 12 15,3



P01876 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 - 36,26 3 9 32 37,6



Coverage Unique

Peptides Total

Peptides


MW [kDa]

[IGHA1_HUMAN]


31,47 1 7 23 36,5


29,70 5 6 19 36,1


24,85 3 6 13 35,9


18,04 1 4 11 41,3


80,19 6 6 24 11,6


49,06 5 5 11 11,3


3,81 7 7 10 571,6

Q14974 Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 - [IMB1_HUMAN]

2,63 2 2 3 97,1


34,66 14 14 28 56,8


11,81 7 7 13 81,7


O76013 Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=2 SV=1 - [KRT36_HUMAN]

3,85 1 2 3 52,2


51,88 30 34 136 58,8


52,33 8 23 63 51,5


55,18 13 25 72 51,2

Q04695 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 - [K1C17_HUMAN]

32,41 6 13 26 48,1


56,50 29 29 140 62,0

O43790 Keratin, type II cuticular Hb6 OS=Homo sapiens GN=KRT86 PE=1 SV=1 - [KRT86_HUMAN]

19,96 2 11 32 53,5



Coverage Unique

Peptides Total

Peptides


MW [kDa]


64,60 41 47 209 66,0

Q7Z794 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=2 SV=3 - [K2C1B_HUMAN]

12,46 4 7 21 61,9


69,33 29 41 134 65,4

Q01546 Keratin, type II cytoskeletal 2 oral OS=Homo sapiens GN=KRT76 PE=1 SV=2 - [K22O_HUMAN]

13,79 1 12 34 65,8


33,22 15 27 82 62,3


42,02 5 26 83 60,0

P04259 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 - [K2C6B_HUMAN]

38,65 3 25 86 60,0

Q7RTS7 Keratin, type II cytoskeletal 74 OS=Homo sapiens GN=KRT74 PE=1 SV=2 - [K2C74_HUMAN]

5,67 1 4 14 57,8

Q8N1N4 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=2 SV=2 - [K2C78_HUMAN]

11,15 3 6 13 56,8


9,29 3 4 6 50,5

Q8IUC1 Keratin-associated protein 11-1 OS=Homo sapiens GN=KRTAP11-1 PE=2 SV=1 - [KR111_HUMAN]

7,36 2 2 8 17,1

Q5T749 Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 - [KPRP_HUMAN]

9,50 4 4 6 64,1


1,30 2 2 3 218,4

P02788 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 - [TRFL_HUMAN] 20,14 10 10 14 78,1

P20700 Lamin-B1 OS=Homo sapiens GN=LMNB1 PE=1 SV=2 - [LMNB1_HUMAN] 5,29 2 3 4 66,4

Q8AAW1 L-arabinose isomerase OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) GN=araA PE=3 SV=1 - [ARAA_BACTN]

6,09 2 2 3 57,1


9,34 2 3 21 36,7


6,29 1 2 19 36,6




Coverage Unique

Peptides Total

Peptides


MW [kDa]

P40925 Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 - [MDHC_HUMAN]

7,49 2 2 3 36,4

P40926 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 - [MDHM_HUMAN]

14,20 4 4 16 35,5


9,37 15 15 30 209,7


4,42 3 3 6 84,4


6,56 3 3 3 79,5

P26038 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 - [MOES_HUMAN] 6,24 2 4 14 67,8


27,15 4 4 12 16,9

P19105 Myosin regulatory light chain 12A OS=Homo sapiens GN=MYL12A PE=1 SV=2 - [ML12A_HUMAN]

11,11 2 2 5 19,8


P15586 N-acetylglucosamine-6-sulfatase OS=Homo sapiens GN=GNS PE=1 SV=3 - [GNS_HUMAN]

3,80 2 2 3 62,0

P15111 NADP-specific glutamate dehydrogenase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=gdhA PE=3 SV=2 - [DHE4_SALTY]

4,47 2 2 4 48,5

Q13765 Nascent polypeptide-associated complex subunit alpha OS=Homo sapiens GN=NACA PE=1 SV=1 - [NACA_HUMAN]

13,49 2 2 7 23,4


P06748 Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 - [NPM_HUMAN] 3,74 2 2 10 32,6

P15531 Nucleoside diphosphate kinase A OS=Homo sapiens GN=NME1 PE=1 SV=1 - [NDKA_HUMAN]

20,39 2 2 6 17,1


69,08 4 34 252 57,7


5,59 3 3 11 59,4



29,15 6 6 17 22,1


16,07 1 7 15 59,0



Coverage Unique

Peptides Total

Peptides


MW [kDa]

C5BGS4 Phosphoenolpyruvate carboxykinase [ATP] OS=Edwardsiella ictaluri (strain 93-146) GN=pckA PE=3 SV=1 - [PCKA_EDWI9]

9,09 2 5 14 59,2


26,03 4 12 28 59,0


33,90 6 13 22 59,0


22,80 4 11 35 58,9


12,34 4 8 17 59,4


6,00 2 2 2 44,6



8,71 2 3 12 37,5


6,03 1 2 7 38,6


4,56 3 3 3 70,6


6,15 3 3 6 83,2



Q92841 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 - [DDX17_HUMAN]

4,66 1 3 6 80,2

P17844 Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens GN=DDX5 PE=1 SV=1 - [DDX5_HUMAN]

4,56 1 3 6 69,1

P35232 Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1 - [PHB_HUMAN] 7,35 2 2 4 29,8


P12004 Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 - [PCNA_HUMAN]

17,24 4 4 7 28,8

Q9UQ80 Proliferation-associated protein 2G4 OS=Homo sapiens GN=PA2G4 PE=1 SV=3 - [PA2G4_HUMAN]

5,08 2 2 2 43,8

P25788 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 8,24 2 2 11 28,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

SV=2 - [PSA3_HUMAN]


9,54 2 2 7 26,4


21,95 5 5 11 27,4

P28072 Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 - [PSB6_HUMAN]

8,79 2 2 3 25,3


10,69 6 6 15 56,7


4,34 2 2 3 72,9


7,48 3 3 6 57,1


21,78 2 2 5 11,5


23,66 2 2 5 10,8

Q01105 Protein SET OS=Homo sapiens GN=SET PE=1 SV=3 - [SET_HUMAN] 7,93 2 2 8 33,5

Q08188 Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens GN=TGM3 PE=1 SV=4 - [TGM3_HUMAN]

8,95 4 4 7 76,6


11,37 1 2 2 29,1


8,33 2 2 7 27,4


18,64 10 10 57 57,9

P15153 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 - [RAC2_HUMAN]

15,10 2 3 6 21,4

P62491 Ras-related protein Rab-11A OS=Homo sapiens GN=RAB11A PE=1 SV=3 - [RB11A_HUMAN]

8,80 2 2 4 24,4

P08134 Rho-related GTP-binding protein RhoC OS=Homo sapiens GN=RHOC PE=1 SV=1 - [RHOC_HUMAN]

9,84 2 2 6 22,0


12,29 4 4 6 52,4


16,53 4 4 9 27,7



Coverage Unique

Peptides Total

Peptides


MW [kDa]


11,31 2 2 9 25,5


5,23 2 2 6 39,6





P05023 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens GN=ATP1A1 PE=1 SV=1 - [AT1A1_HUMAN]

3,62 3 3 9 112,8


4,81 3 3 8 76,1


P38646 Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 - [GRP75_HUMAN]

7,22 4 4 13 73,6


11,66 17 17 28 209,3

Q6UWP8 Suprabasin OS=Homo sapiens GN=SBSN PE=1 SV=2 - [SBSN_HUMAN] 9,15 2 2 2 60,5

Q9Y490 Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 - [TLN1_HUMAN] 1,46 3 3 3 269,6


5,22 3 3 3 60,3


4,82 3 3 7 57,9

Q99832 T-complex protein 1 subunit eta OS=Homo sapiens GN=CCT7 PE=1 SV=2 - [TCPH_HUMAN]

4,42 2 2 3 59,3

P49368 T-complex protein 1 subunit gamma OS=Homo sapiens GN=CCT3 PE=1 SV=4 - [TCPG_HUMAN]

3,49 2 2 3 60,5


5,84 3 3 3 59,6



P37837 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 - [TALDO_HUMAN]

5,04 2 2 3 37,5

P37802 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 - [TAGL2_HUMAN]

11,06 2 2 7 22,4



Coverage Unique

Peptides Total

Peptides


MW [kDa]

P29401 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 - [TKT_HUMAN] 2,89 2 2 5 67,8



13,55 2 2 2 26,9


22,03 5 5 13 30,8


14,04 1 3 10 32,9


16,94 2 4 12 28,5


Q9BQE3 Tubulin alpha-1C chain OS=Homo sapiens GN=TUBA1C PE=1 SV=1 - [TBA1C_HUMAN]

11,80 4 4 19 49,9


18,24 1 7 78 49,6


21,57 2 8 76 49,8

P54577 Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=YARS PE=1 SV=4 - [SYYC_HUMAN]

7,39 4 4 6 59,1


4,35 4 4 8 117,8


4,70 2 2 2 54,3


P18206 Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 - [VINC_HUMAN] 5,03 5 5 10 123,7


31,21 8 8 12 34,2

supplementary table 1. bacterial proteins present in fecal ...q8a287...

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