sunday, february 19, 2012 -...

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SCIENTIFIC PROGRAM Sunday, February 19, 2012 First day of the workshop/open day at the Weizmann Institute of Science (WIS) – Rehovot 08:30 Bus departs from Tel-Aviv to the WIS campus (invited

speakers from overseas only) 09:30 Registration, exhibition and coffee 10:00 Welcome 10:05 Welcome address by: Haim Garty, Vice President of

the Weizmann Institute of Science

SESSION 1: PCD IN DEVELOPMENT & DISEASE

Chair: Adi Kimchi 10:15 STEM CELLS, APOPTOSIS AND TUMOR

SUPPRESSION Hermann Steller, HHMI/Rockefeller University, USA

10:50 MOLECULAR DISSECTION OF A PROGRAMMED

NECROSIS PATHWAY Xiaodong Wang, National Institute of Biological Sciences, China

11:25 ROLE OF AUTOPHAGY IN SUPPORTING CANCER

METABOLISM AND GROWTH Eileen White, Rutgers University, USA

12:00-13:00 Light lunch for registered participants

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Sunday, February 19, 2012

SESSION 2: MECHANISMS OF PCD

Chair: David Wallach 13:00 CUTTING BOTH WAYS: HOW CASPASES

PROMOTE AND PREVENT CELL DEATH Douglas Green, St. Jude Children's Research Hospital, USA

13:35 RELEASE OF FIND-ME SIGNALS DURING

APOPTOSIS Kodi Ravichandran, University of Virginia, USA

14:10 ARE CERTAIN BCL-2 PRO-SURVIVAL PROTEINS

ESSENTIAL FOR CANCER DEVELOPMENT OR MAINTENANCE? Jerry Adams, Walter and Eliza Hall Institute, Australia

14:45 AN UPSTREAM ROLE OF RIP1 KINASE IN

MEDIATING TNFα PRODUCTION Junying Yuan, Harvard Medical School, USA

15:20 Coffee Break 16:00 Bus departs from WIS to Ein-Gedi 18:00 Ein-Gedi: check-in

19:30 Dinner 20:30 Cocktail Reception

(“Baobab” lawn, nearby the hotel lobby)

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Monday, February 20, 2012 04:00-04:30 Coffee and Cake (Amihai Hall, adjacent to the lobby) 04:30-09:00 Masada at Sunrise (Dining room for breakfast is open until 09:45) SESSION 3: APOPTOSIS IN DEVELOPMENT I

Chairs: Kristin White & Andreas Bergmann 11:15 GENETIC ANALYSIS OF CHEMOTHERAPEUTIC

AGENT-INDUCED APOPTOSIS IN C. ELEGANS Michael Hengartner, University of Zurich, Switzerland 11:40 DEATH AND SURVIVAL IN THE C. ELEGANS

NERVOUS SYSTEM Barbara Conradt, LMU Biocenter, Germany 12:05 DROSOPHILA P53 ISOFORMS DIFFERENTIALLY

REGULATE APOPTOSIS AND COMPENSATORY PROLIFERATION

Bertrand Mollereau, Ecole Normale Supérieure of Lyon, France

12:30 THE ROLE OF APOPTOSIS/CELL COMPETITION

IN TUMOUR GROWTH IN DROSOPHILA Gines Morata, The Centro de Biología Molecular

Severo Ochoa, Spain 12:55 VASCULAR PATTERNING REGULATES

INTERDIGITAL CELL DEATH VIA A ROS-MEDIATED MECHANISM

Elazar Zelzer, Weizmann Institute of Science, Israel 13:20-14:30 Lunch

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Monday, February 20, 2012

SESSION 4: PCD SIGNALING, METABOLISM & DISEASE

Chairs: Kodi Ravichandran & Suzanne Cory 14:45 INVOLVEMENT OF P73, A P53-FAMILY MEMBER,

IN METABOLISM AND SENESCENCE Gerry Melino, University of Leicester, UK 15:10 HIPPO PATHWAY AND DNA DAMAGE RESPONSE Yosef Shaul, Weizmann Institute of Science, Israel 15:35 VDAC1-BASED PEPTIDES INTERACT WITH ANTI-

APOPTOTIC PROTEINS TO PREVENT THEIR PROTECTION AGAINST CELL DEATH

Varda Shoshan-Barmatz, Ben-Gurion University, Israel

16:00 IMMUNOGENIC CELL STRESS AND DEATH IN

ANTICANCER CHEMOTHERAPIES Guido Kroemer, Institut Gustave Roussy, France 16:25-17:00 Coffee Break

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Monday, February 20, 2012

SESSION 4 (cont’d)

Chairs: Kodi Ravichandran & Suzanne Cory 17:00 LINEAR UBIQUITIN IN CELL DEATH AND

IMMUNE SIGNALING Henning Walczak, Imperial College London, UK

17:25 CORRECTION OF AXON GUIDANCE ERRORS

RESULT IN NEURONAL CELL LOSS Oded Behar, The Hebrew University of Jerusalem,

Israel 17:50 CONTROL OF CASPASE-8 ACTIVATION BY

UBIQUITIN Avi Ashkenazi, Genentech, USA 18:15 DEATH-INDEPENDENT OUTCOMES OF FAS

RECEPTOR STIMULATION Sean Cullen, Trinity College Dublin, Ireland 18:30-19:45 Dinner 20:00-22:00 Poster session I

The “Best Poster” committee: Seamus Martin, Masayuki Miura, & Colin Duckett

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Tuesday, February 21, 2012

Session 5: The Mitochondrial Pathway

Chairs: Xiaodong Wang & Douglass Green 09:00 THE DYNAMICS OF BAX LOCALIZATION TO

MITOCHONDRIA Richard J. Youle, National Institutes of Health, USA

09:25 REGULATION OF CASPASE-DEPENDENT AND

INDEPENDENT CELL DEATH BY THE BCL-2 FAMILY Emily Cheng, Memorial Sloan-Kettering Cancer Center, USA

09:50 INTEGRATING MITOCHONDRIAL MORPHOLOGY

AND ULTRASTRUCTURE IN THE CONTROL OF APOPTOSIS: LESSONS FROM CELLULAR AND MOUSE MODELS Luca Scorrano, University of Geneva, Switzerland

10:15 NOVEL FUNCTIONS FOR ANCIENT BCL-2

FAMILY MEMBERS Jean-Claude Martinou, University of Geneva, Switzerland

10:40-11:10 Coffee Break

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Session 5 (cont’d)

Chairs: Xiaodong Wang & Douglass Green 11:10 INTERACTIONS WITH SUB-CELLULAR

MEMBRANES REGULATE BCL-2 FAMILY PROTEIN: PROTEIN INTERACTIONS WITH LIFE AND DEATH CONSEQUENCES David Andrews, McMaster University, Canada

11:35 REGULATION OF STRESS-INDUCED NUCLEAR

PROTEIN REDISTRIBUTION: A NOVEL FUNCTION AND ACTION OF BAX AND BAK Reuven Stein, Tel Aviv University, Israel

12:00 A NOVEL MITOCHONDRIAL PATHWAY THAT

REGULATES CELL FATE AND FUNCTION Atan Gross, Weizmann Institute of Science, Israel

12:25 DIFFERENTIAL CONTROL OF BAK TARGETING

AND BAK-MEDIATED CELL DEATH IN NORMAL LIVER AND LIVER TUMOR Gyorgy Hajnoczky, Thomas Jefferson University, USA

12:50 THE ATM-BID PATHWAY REGULATES

QUIESCENCE AND SURVIVAL OF HEMATOPOIETIC STEM CELLS Maria Maryanovich, Weizmann Institute of Science, Israel

13:05-14:30 Lunch 14:45-17:30 Ein-Gedi Springs and the Dead-Sea (departure 14:45 &

15:00) OR walking tour of the Botanical garden (14:30) 18:00-19:15 Dinner

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Session 6: Immunity, Signaling & Cell Clearance

Chairs: Eileen White & Gideon Berke 19:30 INTERACTIONS BETWEEN DYING CELLS AND

THE IMMUNE SYSTEM Seamus Martin, The Smurfit Institute, Trinity College, Ireland

19:55 MOLECULAR MECHANISMS OF PHAGOCYTIC

RECEPTOR ACTION IN APOPTOTIC CELL CLEARANCE Estee Kurant, Technion - Israel Institute of Technology, Israel

20:20 NEW LIVES GIVEN BY CELL DEATH:

MACROPHAGE DIFFERENTIATION FOLLOWING THEIR ENCOUNTER WITH APOPTOTIC LEUKOCYTES DURING THE RESOLUTION OF INFLAMMATION Amiram Ariel, University of Haifa, Israel

20:45-21:15 Coffee break 21:15 THE ‘APOPTOTIC’ CASPASES AS REGULATORS

OF INFLAMMATION: NEW LESSONS ABOUT CASPASE-8 FUNCTION David Wallach, Weizmann Institute of Science, Israel

21:40 THE E3 UBIQUITIN LIGASE SCF β-TrCP IS

ESSENTIAL FOR INTESTINAL BARRIER FUNCTION AND GUT HOMEOSTASIS

Yinon Ben-Neriah, The Hebrew University of Jerusalem, Israel

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Wednesday, February 22, 2012

Session 7: PCD & Inhibitor of Apoptosis (IAP) Proteins

Chairs: Hermann Steller & Guy Salvesen 09:00 IAP (INHIBITOR OF APOPTOSIS) PROTEINS AT

THE INTERFACE OF APOPTOSIS AND INTRACELLULAR SIGNALING Colin Duckett, University of Michigan Medical School, USA

09:25 IAP-ANTAGONIST REGULATION IN DROSOPHILA

Hyung Don Ryoo, New York University School of Medicine, USA

09:50 THE INHIBITOR OF APOPTOSIS PROTEIN LIVIN

PLAYS A DUAL ROLE IN TUMORIGENICITY AND MAY SERVE AS POTENTIAL TARGETS FOR CANCER THERAPY Dina Ben-Yehuda, The Hebrew University of Jerusalem, Israel

10:15 THE PRO-APOPTOTIC ARTS PROTEIN INITIATES

MITOCHONDRIAL APOPTOSIS UPSTREAM OF MOMP AND PROMOTES THE RELEASE OF CYTOCHROME C AND SMAC/DIABLO Sarit Larisch, University of Haifa, Israel

10:40 SEPT4/ARTS REGULATES STEM-CELL

DEPENDENT REGENERATION AND TUMOR FORMATION Yaron Fuchs, Rockefeller University, USA

10:55-11:25 Coffee break

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Session 8: Apoptosis in Development II

Chairs: Michael Hengartner & Gines Morata 11:25 PHYSIOLOGICAL FUNCTION OF CELL DEATH

DURING NEURAL DEVELOPMENT Masayuki Miura, University of Tokyo, Japan

11:50 THE NAB-BRK SIGNAL BIFURCATES AT JNK TO

INDEPENDENTLY INDUCE APOPTOSIS AND COMPENSATORY PROLIFERATION

Offer Gerlitz, The Hebrew University of Jerusalem, Israel

12:15 DISTINCT SPATIOTEMPORAL PATHWAYS

CONVERGE ON A UBIQUITIN LIGASE COMPLEX TO RESTRICT CASPASE ACTIVATION DURING SPERMATID TERMINAL DIFFERENTIATION IN DROSOPHILA Eli Arama, Weizmann Institute of Science, Israel

12:40 GENETIC CONTROL OF PROGRAMMED CELL

DEATH IN DROSOPHILA Andreas Bergmann, University of Massachusetts Medical School, USA

13:05-14:20 Lunch

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Session 9: PCD Without the Canonical Apoptotic Machinery

Chairs: Guido Kroemer & Yossi Shiloh 14:30 YEAST AS A CELL DEATH MODEL SYSTEM

IDENTIFIES NEW HUMAN DISEASE GENES J. Marie Hardwick, Johns Hopkins University, USA

14:55 “CHEMICAL ARMS RACE AT SEA”: THE ROLE

OF SPHINGOLIPIDS IN REGULATION OF PCD AND VIRAL REPLICATION CYCLES DURING HOST-VIRUS INTERACTIONS IN THE MARINE ENVIRONMENT Asaf Vardi, Weizmann Institute of Science, Israel

15:20 DEVELOPMENTAL CELL DEATH IN

DICTYOSTELIUM Pierre Golstein, Centre d’Immunologie de Marseille-Luminy, France


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Session 9 (cont’d)

Chairs: Guido Kroemer & Yossi Shiloh 16:10 TWO PROGRAMMED CELL DEATH SYSTEMS IN

ESCHERICHIA COLI: AN APOPTOTIC-LIKE DEATH IS INHIBITED BY THE MAZEF-MEDIATED DEATH PATHWAY Hanna Engelberg-Kulka, The Hebrew University of Jerusalem, Israel

16:35 DIE HARDER: FROM APOPTOSIS TO NECROSIS

IN YEAST Frank Madeo, University of Graz, Austria

17:00 PLANT BIOLOGY: IN THE WORLD FULL OF

DYING CELLS, CELL CORPSES AND ANCESTRAL CELL-DEATH REGULATORS Peter Bozhkov, Uppsala BioCentre, Sweden

17:20-18:45 Poster session II

The “Best Poster” committee: Seamus Martin, Masayuki Miura, & Colin Duckett

19:30 Gala Dinner at Metzoke Dragot

Departure from the hotel lobby

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Thursday, February 23, 2012

Session 10: Apoptosis in Development III

Chairs: Pascal Meier & Shai Shaham 09:00 STRESS, DEATH AND THE P53 REGULATORY

NETWORK John Abrams, University of Texas Southwestern Medical Center, USA

09:25 REGULATION OF NEURAL STEM CELL

APOPTOSIS IN DROSOPHILA Kristin White, MGH/Harvard Medical School, USA

09:50 CELL DEATH AND CORPSE CLEARANCE IN THE

DROSOPHILA OVARY Kim McCall, Boston University, USA

10:15 INDUCTION OF NON-CLASSICAL APOPTOSIS BY

THE ADENOVIRUS E4ORF4 PROTEIN Tamar Kleinberger, Technion - Israel Institute of Technology, Israel


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Session 11: Caspases, Apoptosis & Cellular Remodeling

Chairs: Moshe Oren & Avi Ashkenazi 11:00 CASPASES, PARACASPASES, AND THE SPACE

BETWEEN DEATH AND SURVIVAL Guy Salvesen, Sanford-Burnham Medical Research Institute, USA

11:25 REGULATION OF CASPASE ACTIVATION Pascal Meier, The Institute of Cancer Research, UK

11:50 MECHANISMS OF OF NEURONAL ELIMINATION DURING DEVELOPMENT Avraham Yaron, Weizmann Institute of Science, Israel

12:15 DSARM/SARM1 GOVERNS A NOVEL INJURY-

INDUCED AXON DEATH PATHWAY Marc Freeman, University of Massachusetts Medical School/HHMI, USA

12:40 RESISTANCE TO APOPTOSIS IS REGULATED DURING DEVELOPMENT Arash Bashirullah, University of Wisconsin-Madison, USA

12:55-14:00 Lunch

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Final session: Alternate Death Pathways

Chairs: Richard Youle & J. Marie Hardwick 14:15 SIGNALLING PATHWAYS CONTROLLING

AUTOPHAGY AND ITS CROSSTALK WITH APOPTOSIS Adi Kimchi, Weizmann Institute of Science, Israel

14:40 MEMBRANE PORE FORMATION AND PROGRAMMED NECROTIC CELL DEATH Zvi Fishelson, Tel Aviv University, Israel

15:05 A NEW C. ELEGANS CELL DEATH PROGRAM: IMPLICATIONS FOR NEURODEGENERATION AND CANCER Shai Shaham, Rockefeller University, USA

15:30 JUN PROTEINS ARE NOVEL REGULATORS OF AUTOPHAGY Eitan Shaulian, The Hebrew University of Jerusalem, Israel

15:55 AUTOPHAGY AND CELL DEATH: CONTEXT MATTERS Eric Baehrecke, University of Massachusetts Medical School, USA

16:20 THE ADAPTOR PROTEIN FADD PROTECTS EPIDERMAL KERATINOCYTES FROM NECROPTOSIS IN VIVO AND PREVENTS SKIN INFLAMMATION Marion Bonnet, University of Cologne, Germany


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Keynotes

Chair: Gerry Melino 17:00 THE DARK SIDE OF P53: MUTANT P53 AND

CANCER Moshe Oren, Weizmann Institute of Science, Israel

17:30 THE DNA DAMAGE RESPONSE: SURVIVAL OR

DEMISE? Yosef Shiloh, Tel Aviv University, Israel

18:00 Closing remarks 18:15 Departure

Overnight at the Grand Court hotel in Jerusalem (pre-reserved only)

Friday, February 24, 2012 08:00 Half-day tour of Jerusalem ( pre-registered only)

Departure from the Grand-Court hotel Please present tour ticket Tour will end at 13:00 at the Grand-Court hotel

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LLIISSTT OOFF PPOOSSTTEERRSS

PCD in Development

P-1 Mtch2 during meiosis: molecular characterization, Andres Goldman, URUGUAY

P-2 To die or not to die, FAK is the question, Juan Pablo Macagno, SCOTLAND, UK

P-3 Global regulation of programmed cell death and survival in C. elegans, Nadin Memar, GERMANY

P-4 Apoptosis, cellular tension and morphogenesis, Magali Suzanne, FRANCE

P-5 Embryonic and induced stem cells express TRAIL receptors but are resistant to TRAIL induced apoptosis , Vladimir Vinarsky, CZECH REPUBLIC

PCD Signaling and Disease

P-6 A genetic screen to identify genes mediating ER stress induced retinal degeneration in Drosophila, Pedro Domingos, PORTUGAL

P-7 Monitoring protein-protein interactions within the cell death network, Yuval Gilad, ISRAEL

P-8 Mechanisms of cell death of resting human T cells induced by curcumin or etoposide, Zbigniew Korwek, POLAND

P-9 The protein expression pattern of VDAC1 and MAVS in human cancer and their potential usage as novel tumor biomarkers, Avia Lavon and Ilan Sela, ISRAEL

P-10 Expression and functions of T-plastin in cutaneous T cell lymphoma (CTCL), Laurence Michel, FRANCE

P-11 Regulation of non-apoptotic caspase activity by crinkled, an unconventional myosin, Mariam Orme, UK

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P-12 Induction of cell death by apoptotic cells, Ainhoa Perez-Garijo, USA

P-13 The antiapoptotic protein AAC-11 as a novel exploitable therapeutic target in human malignancies , Jean-Luc Poyet, FRANCE

P-14 Anti-apoptotic machinery protects botrytis from PCD-inducing plant metabolites and is essential for disease establishment, Neta Shlezinger, ISRAEL

P-15 The involvement of brain inflammation and TNFα in neuronal cell death in neuronopathic forms of Gaucher disease, Einat Vitner, ISRAEL

The Mitochondrial Pathway

P-16 Anion-transport inhibitors prevent VDAC1 oligomerization and apoptosis, Danya Ben Hail, ISRAEL

P-17 The role of MTCH2/MIMP in skeletal muscle, Liat Buzaglo, ISRAEL

P-18 IAP antagonist induced mitochondrial dynamics regulate XIAP degradation, Anshuman Kelkar, USA

P-19 The VDAC1 degradation pathway and stress-induced VDAC1 truncation: Characterization, mechanism and effect on apoptosis, Hadas Pahima, ISRAEL

P-20 A Physiological System for Selective Mitochondrial Destruction in Drosophila, Yoav Politi, ISRAEL

P-21 Mek/Erk phosphorylate Mfn1 switching its functions in mitochondrial morphology and apoptosis, Aswin Pyakurel, SWITZERLAND

P-22 Direct and indirect roles of the mitochondria in caspase activation during Drosophila spermatogenesis, Liat Ravid, ISRAEL

P-23 The autophagy protein Atg12 associates with anti-apoptotic Bcl-2 family members to promote mitochondrial apoptosis, Assaf Rubinstein, ISRAEL

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P-24 VDAC1-based peptides: Novel pro-apoptotic agents and a potential therapeutic drug for B-cell chronic lymphocytic leukemia, Anna Shteinfer, ISRAEL

P-25 Nanowire PALM of mitochondrial dynamics in cell life and death: a preliminary account, Kathy Ushakov, SWITZERLAND

P-26 The effect of VDAC1 silencing by siRNA on cancer cell growth, Lilia Vasilkovsky, ISRAEL

P-27 MTCH2/MIMP: A novel regulator of liver apoptosis and metabolism, Yehudit Zaltsman, ISRAEL

P-28 Cell Penetrating VDAC1-Based Peptides Can Induce Cell Death in Various Human Cancer Cell lines, Alexandra Zooravlov, ISRAEL

Caspases, Apoptosis and Cellular Remodeling

P-29 TNFα mediated hepatitis is inhibited due to Ceramide Synthase 2 deficiency, Muhammad Ali, ISRAEL

P-30 A caspase and E2F-1 dependent feed forward mechanism of Noxa induction favors activation of cell death by the Bcl-2/Bcl-xL inhibitor ABT-737, Frédérique Braun, FRANCE

P-31 Caspase levels and execution efficiencies determine the apoptotic potential of the cell, Anat Florentin, ISRAEL

P-32 DOR is a novel regulator of autophagy and apoptosis, Saska Ivanova, SPAIN

P-33 A caspase cascade of axon degeneration during development, David Simon, USA

Alternate Death Pathways

P-34 Streptolysins S-mediated cell necrosis switches on quorum sensing in Streptococci, Moshe Baruch, ISRAEL

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P-35 PKD is a novel VPS34-kinase that regulates ROS-induced autophagy downstream of DAPK, Avital Eisenberg-Lerner, ISRAEL

P-36 DAP1, a novel substrate of mTOR, negatively regulates autophagy, Itay Koren, ISRAEL

P-37 Study of non-classical low level cell death induced by adenovirus E4orf4 protein in Drosophila model system, Antonina Pechkovsky, ISRAEL

P-38 Autophagy plays a role in Ca2+-dependent retinal degeneration in Drosophila, Shirley Weiss, ISRAEL

P-39 The protease HtrA2/Omi and the lysosomal pathway mediate a nonapoptotic physiological cell death program in Drosophila, Keren Yacobi-Sharon, ISRAEL

PCD in Unicellular Organisms

P-40 Sensing environmental stress conditions and regulation of cell fate via redox signaling in diatoms, Shilo Rosenwasser, ISRAEL

P-41 The “double edged sword” role of reactive oxygen species in regulating susceptibility to viral infection Emiliania huxleyi, Uri Sheyn, ISRAEL

Immunity, Signaling and Cell Clearance

P-42 Novel roles for the chemokine receptor D6 in the regulation of the resolution of inflammation, Miran Aswad, ISRAEL

P-43 Role of lipids in apoptotic cells collection by microglia in developing brain, Oksana Breus, GERMANY

P-44 Novel roles for ARTS in neutrophil apoptosis and macrophage-mediated resolution of inflammation, Naama Maimon, ISRAEL

P-45 Molecular mechanisms in regulation of SIMU expression, Yael Sellman, ISRAEL

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P-46 Differential Function of EGF-like (NIM) Repeats in Apoptotic Cell Clearance, Boris Shklyar, ISRAEL

P-47 Exploring the role of BID phosphorylation in inflammation and innate immunity, Lidiya Vorobiyov, ISRAEL

sunday, february 19, 2012 -...

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