structure and function of macromolecules how hydrocarbons and functional groups combine
DESCRIPTION
Carbohydrates (Sugars) Monosaccharides CH 2 O formula; multiple hydroxyl (-OH) groups and 1 carbonyl (C=O) group: aldehyde (aldoses) sugar ketone sugar cellular respiration; raw material for amino acids and fatty acidsTRANSCRIPT
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Structure and Function of Macromolecules
• How hydrocarbons and functional groups combine
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Polymers: Chain of repeating monomers• Most macromolecules are made from
covalent monomers• Assembling macromolecules• Condensation reaction
(dehydration reaction): One monomer provides a hydroxyl group while the other provides a hydrogen to form a water molecule
• Hydrolysis: bonds between monomers are broken by adding water (digestion)
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Carbohydrates (Sugars)Monosaccharides •CH2O formula; multiple hydroxyl (-OH) groups and 1 carbonyl (C=O) group: •aldehyde (aldoses)• sugar
•ketone • sugar • cellular respiration; • raw material for amino acids
and fatty acids
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Carbohydrates (2 monomers)
• Disaccharides • glycosidic linkage
(covalent bond) between 2 monosaccharides; • covalent bond by
dehydration reaction• Sucrose (table sugar) most
common disaccharide
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Carbohydrates (multiple monomers)• Polysaccharide• Storage: Starch (glucose
monomers ) • Plants: plastids • Animals: glycogen
• Polysaccharides Structural: • Cellulose~ most abundant organic
compound; • Chitin~ exoskeletons; cell
walls of fungi; surgical thread
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Lipids• No polymers; glycerol and fatty acid• Fats, phospholipids, steroids• Hydrophobic; H bonds in water exclude fats• Carboxyl group = fatty acid• Non-polar C-H bonds in fatty acid ‘tails’• Ester linkage: 3 fatty acids to 1 glycerol
(dehydration formation)• Triacyglycerol (triglyceride)• Saturated vs. unsaturated fats; single vs. double
bonds
Fatty acid
Triglycerol
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Phospholipids
• 2 fatty acids instead of 3 (phosphate group)• ‘Tails’ hydrophobic;
‘heads’ hydrophilic• Bilayer (double
layer); cell membranes
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Steroids• Lipids with 4 fused carbon
rings• Ex: cholesterol:
cell membranes;precursor for other steroids (sex
hormones); atherosclerosis
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Nucleic Acids
• Deoxyribonucleic acid (DNA)• Ribonucleic acid (RNA)• DNA->RNA->protein• Polymers of nucleotides
(polynucleotide): nitrogenous base, pentose sugar, phosphate group• Nitrogenous bases:
pyrimidines~cytosine, thymine, uracilpurines~adenine, guanine
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Nucleic Acids
• Pentoses:• ribose (RNA)• deoxyribose (DNA)• nucleoside (base + sugar)
• Polynucleotide:• phosphodiester • linkages (covalent);
phosphate + sugar
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Nucleic Acids
• Inheritance based on DNA replication• Double helix (Watson & Crick -
1953) • H bonds hold the base pairs together
• A =T; C =G pairing• Complementary
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Proteins• Importance: • instrumental in nearly everything organisms do; 50% dry
weight of cells; most structurally sophisticated molecules known• Monomer: amino acids (there are 20) ~carboxyl (-COOH)
group, amino group (NH2), H atom, variable group (R)….• Variable group characteristics: polar (hydrophilic), nonpolar
(hydrophobic), acid or base• Three-dimensional shape (conformation)• Polypeptides (dehydration reaction): peptide bonds~
covalent bond; carboxyl group to amino group (polar)
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Primary Structure
• Conformation: Linear structure
• Molecular Biology: each type of protein has a unique primary structure of amino acids
• Ex: lysozyme
• Amino acid substitution:hemoglobin; sickle-cell anemia
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Secondary Structure
• Conformation: coils & folds (hydrogen bonds)• Alpha Helix: coiling;
keratin• Pleated Sheet:
parallel; silk
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Tertiary Structure
• Conformation: irregular contortions from R group bonding• Hydrophobic• disulfide bridges• hydrogen bonds• ionic bonds
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Quaternary Structure
• Conformation:• 2 or more
polypeptide chains aggregated into 1 macromolecule• Collagen
(connective tissue)• hemoglobin