stephen holt md-toxic waistlines impair longevity

8/8/2019 Stephen Holt MD-Toxic Waistlines Impair Longevity

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TOXIC WAISTLINES IMPAIR

LONGEVITY

Stephen Holt, MD, PhD, DSc, DNM, LLD.

Distinguished Professor of Medicine

(Emeritus)

Scientific Advisor, Natural Clinician LLCContact: [email protected]


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WEIGHT CONTROL

(COMPREHENSIVE PROGRAM) Calorie Control

Energy Expenditure

Socio-behavioral Interventions

Detoxification

Sleep Restoration

Stress Management

Insulin Resistance/Syndrome X


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THE POT BELLY

The hallmark of obesity in mature subjects andwaistline expansion is common in Syndrome X.

A sign ofvisceral adiposity associated with ugly

disease companions of obesity.

Visceral fat elaborates hormones and inflammatorymessenger molecules

Visceral fat concentrates organic chemicals that can

interfere with intermediary metabolism in fat stores

e.g. organophosphates, parabens etc.The pot belly is a toxic waste dump in the body

and it is a useless acquired endocrine organ.


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DETOXIFICATION

Organochemicals appear to important

miscreants in obesity

Lessons from the 9/11 World Trade Center

collapse where rescue workers developedMetabolic Syndrome X as a result of several

factors, including toxicants.

Sta

nda

rd detoxifica

tion protocols do noteffectively eliminate organic toxins that are

stored in in visceral fat.


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DETOXIFICATION

Extensive detoxific

ation progr

ams in

volving s

auna(about 33 continuous days), vitamin supplement

regimens, exercise and lifestyle change are quite

effective (9/11 Detox Program, Manhattan).

Ancillary detoxific

ation techniques m

ayadd

valuebut are unlikely to succeed when used alone e.g.

colon cleansing, colon hydrotherapy, dietary

changes, chelation therapies etc.

There is

acle

ar evidence-b

ase to

appro

ach obesity

management from a perspective of environmental

medicine and detoxification programs are emerging

as evidence-based in weight loss protocols.


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THERMOGENESIS

Heat production by the body

Obligatory (digestion, absorption

and metabolism)

Adaptive (increase in metabolic

rate stimulated by eating)


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THERMOGENIC

NUTRACEUTICALS

Caffeine*

Green Tea Polyphenols

Coffee Bean Polyphenols

Fucoxanthin

Hydroxycitrate*

Berry Antioxidants*

Natural Amines (p-synephrine)

*PROBLEMS


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NATURAL AMINES

(PLANT ALKALOIDS) Stimulate adrenergic receptors:

alpha-1, alpha-2, Beta-1, Beta-2,

Beta-3, ephedra is non-selective Beta-3 receptor semi-selectivity

(p-synephrine)

Patented extracts ofCitrusaurantium (ADVANTRA Z)


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CITRUS AURANTIUM EXTRACTS:

ADVANTRA Z (P-SYNEPHRINE)

P-Synephrine has less propensity to

stimulate cardiovascular orCNS function

(BP, Heart Rate/Arrythmogenesis), but

may increase muscle mass (increased

muscle uptake ofamino acids).

Evidence-base for: lipolysis,

thermogenesis, ergogenesis, increased

muscle mass.


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ADVANTRA Z PATENTS U.S. 6,224,873: Regulation ofappetite, body weightand athletic function with materials derived fromcitrus varieties.

U.S. 6,316,499: Methods for increasing muscle mass

ofa human with materials derived from citrusvarieties.

U.S. 6,340,481: Regulation ofathletic function withmaterials derived from citrus varieties.

U.S. 6,340,482: Methods for inducing weight loss ina human with materials derived from Citrus varieties.


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SAFETY DATA (ADVANTRA Z)

Ephedra withdrawal 2004, New

YorkTimes Article, 2004.

Case reports, but combinations andincomplete reporting cloud the

issues (Nykamp et al, 2004)

No serious adverse event reporting

or product liability claims (>10y.)


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SAFETY DATA (ADVANTRA Z)

Haller et al, 2000, blood pressure rosepost exercise but normalized at 90 min(peak diastolic BP)

Talbott et al, 2007, Advantra Z (80mg ofp-synephrine) showed no increase in BP,resting heart rate over six weeks of

supplementa

tion. Haaz et al, 2006, generally stable heart

rate and BP in humans, animals variable.


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ADVANTRA Z EFFICACY

Gougeon et al, 2008. Advantra Z increasesmetabolic rate and enhances thermal

responses to food, notably in females.

Preuss et al, 2002. Citrus aurantium may be

the best thermogenic susbstitute for ephedra.

Metabolic rate increase with Advantra Z and

p-synephrine in several clinical observations

(Germano C. Advantra Z, KensingtonPublishers, 1998, Holt S, Peel Off the

Weight, HIOM, 2009).


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ADVANTRA Z EFFICACY

(SUMMARY)

Three studies show weight loss: Colker

et al, 1999, Jones, 2001, Germano, 1998 Four studies show enhancement of

metabolic rate: Colker et al, 1999,

Pathakand Gougeon, 1999,

Hedrei

andGougeon, 1997, Germano, 1998)


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CAUTIONS WITH AMINES

Children, Pregnancy

MAO Inhibitors/Cough ColdRemedies

Established cardiovascular or

stroke risk


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METABOLIC SYNDROME X

A key management initiative to

promote longevity. It highlights

the most significant componentsof the pathophysiology of obesity.

Clinical Metabolic Syndrome X

Nutritional Factors


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MARINE FISH OIL

EPA and DHA in at least a dosage of

600 mg and 400 mg, respectively.

Enhanced bio

availability of

active fatty

acids and improved patient compliance

by enteric coating.

Cardiovascularand anti-inflammatory

benefits with PPAR-receptoractions.

Very important in Syndrome X.


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COMBAT SLEEPLESSNESS

Sleep deprivation alters hormonal

controls ofappetite, ghrelin increase,

leptin decrease.

Restoration of sleep rhythms may cause

weight loss without other interventions.

Sleeplessness induces stress response. Insulin resistance decreased with sleep.


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CALORIE RESTRICTION

MIMETICS

CR increases average and maximum

lifespan

CRM c

an mimic the benefici

albiophysiological changes that occur

during CR

Clinical Calorie Restriction Mimetics

(cinnamon, avocado, resveratrol,

gymnema, alpha lipoic acid)


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ANTI-AGING SIGNIFICANCE

Excess bodyweight is associated with

premature morbidity and mortality.

70 million Americans h

ave Syndrome X.

Calorie restriction mimetics often

regulate blood glucose and decrease

insulin resistance.

Telomere shortening is associated with

insulin resistance and CVS disease.


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FACT

OBESE KIDS BECOME UNHAPPY,UNHEALTHY OBESE ADULTS


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CONCLUSION

Patented extracts ofCitrus aurantium(Advantra Z) are the most credibleevidence-based weight lossnutraceuticals to date.

Thermogenesis combined with lipolysis,ergogenesis and retain lean body massoccur with ADVANTRA Z.

Calorie Restriction is a cornerstone for

weight control and longevity promotion(Calorie Restriction Mimetics)

Contact: [email protected]

stephen holt md-toxic waistlines impair longevity

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