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TRANSCRIPT
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STD Update
Ina Park, MD, MS University of California San Francisco- California Prevention Training Center and California Dept of Public Health
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Epi of Bacterial STDs Screening Chlamydia, proctitis Gonorrhea, antibiotic
resistance Syphilis, ocular syphilis PrEP and STIs
ROADMAP
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CHLAMYDIA — RATES OF REPORTED CASES BY SEX, UNITED STATES, 1994–2014
N O T E : A s o f J a n u a r y 2 0 0 0 , a l l 5 0 s t a t e s a n d t h e D i s t r i c t o f C o l u m b i a h a v e r e g u l a t i o n s t h a t r e q u i r e t h e r e p o r t i n g o f c h l a m y d i a c a s e s .
2014-Fig 1. SR, Pg 8
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GONORRHEA — RATES OF REPORTED CASES BY SEX, UNITED STATES, 1994–
2014
2014-Fig 13. SR, Pg 19
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PRIMARY AND SECONDARY SYPHILIS — REPORTED CASES BY SEX AND SEXUAL
BEHAVIOR, 27 AREAS*, 2007–2014
* 2 7 s t a t e s r e p o r t e d s e x o f p a r t n e r d a t a f o r 7 0 % o f r e p o r t e d c a s e s o f p r i m a r y a n d s e c o n d a r y s y p h i l i s f o r e a c h y e a r d u r i n g 2 0 0 7 – 2 0 1 4 . † M S M = m e n w h o h a v e s e x w i t h m e n ; M S W = m e n w h o h a v e s e x w i t h w o m e n o n l y .
2014-Fig 32. SR, Pg 33
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SYPHILIS RATES AMONG MSM: A TIMELINE
Peterman, 2015, Expert Rev Anti Infect Ther
Syphilis rates among MSM will soon be similar to those in the early 1980s
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0
10
20
30
40
50
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Perc
ent o
f Cas
es
Year
MSM WITH EARLY SYPHILIS* AND VENUES WHERE THEY MEET SEX PARTNERS
CALIFORNIA, 2005–2014
Internet
Bathhouses/ Sex Clubs
Bars/Clubs
Rev. 7/2015 * Includes primary, secondary, and early latent syphilis. California Dept of Public Health
Chew Ng, 2013 AJPH
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Location-based Select practice, HIV status, sexual role Rapid / local communication Enormous reach (Grindr-196 countries,10 million downloads)
ANONYMOUS SEX? THERE’S AN APP FOR THAT
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Sexually Active adolescents & adults <25 years old Routine chlamydia and gonorrhea screening* Others STDs and HIV based on risk
Women 25 years of age and older STD/HIV testing based on risk
HIV-positive women CT/GC (vaginal, cervical, or urine) CT/GC (rectal, if exposed) GC (pharyngeal, if exposed) Syphilis serology Trichomoniasis Hepatitis BSAg, Hepatitis C (first visit)
STD SCREENING FOR WOMEN
CDC 2015 STD Tx Guidelines, HIVMA/IDSA 2013 Primary Care Guidelines, USPSTF
Annually
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HIV Syphilis Urethral GC and CT Rectal GC and CT (if RAI) Pharyngeal GC (if oral sex)
HSV-2 serology (consider) Hepatitis B (HBsAg, freq not specified)
* At least annually, more frequent (3-6 months) if at high risk (multiple/anonymous partners, drug use, high risk partners)
CDC 2015 STD Treatment Guidelines
*
Anal Cancer in HIV+ MSM: Data insufficient to recommend routine screening, some centers perform anal Pap and HRA
• Hepatitis C (HIV+MSM, at least annually)
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N=4217 interviews and chart reviews from Medical Monitoring Project, nationally representative sample of adults in HIV care
SUBOPTIMAL STD SCREENING AMONG MSM IN HIV CARE
Flagg EW, 2015, STD
0
10
20
30
40
50
60
Syphilis Chlamydia Gonorrhea
% of sexually active HIV+ MSM screened for STIs, N=1411
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N=21994 MSM in the STD Surveillance Network (SSUN)
% SCREENED BY ANATOMIC SITE AMONG MSM IN STD CLINICS
0
10
20
30
40
50
60
70
80
90
GC CT
UrogenitalPharyngealRectal
Patton et al CID 2014
8% Urogenital CT+ 3% Pharyngeal CT+ 14% Rectal CT+
11% Urogenital GC+ 8% Pharyngeal GC+ 10% Rectal GC+
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AMONG MSM, WHAT PERCENT OF GC OR CT INFECTIONS ARE MISSED IF ONLY URINE IS
SCREENED
1. 10-20% 2. 21-50% 3. 51-70% 4. > 70%
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HIGH PROPORTION OF EXTRAGENITAL CT/GC ASSOCIATED WITH NEGATIVE URINE TEST, STD SURVEILLANCE NETWORK (N=21994)
Patton et al CID 2014
Between 70-90% of infections would be missed by only screening with urine
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Highly acceptable, similar performance compared to clinician-collected specimens Self-collection can be performed at
laboratory along with blood draw/urine collection or in the exam room before/after the provider visit May save patient an office visit May save the provider time
SELF-COLLECTED RECTAL/PHARYNGEAL STI TESTING
Van der helm, 2009, STD; Sexton, 2013 J Fam Pract; Dodge, 2012 Sex Health Freeman 2011, STD; Alexander 2008, STI; Moncada 2009, STD
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CHLAMYDIA & GONORRHEA
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CHLAMYDIA TREATMENT ADOLESCENTS AND ADULTS
Recommended regimens (non-pregnant): Azithromycin 1 g orally in a single dose Doxycycline 100 mg orally twice daily for 7 days
Recommended regimens (pregnant*): Azithromycin 1 g orally in a single dose Amoxicillin 500 mg po TID x 7 days
* Test of cure at 3-4 weeks only in pregnancy
CDC 2015 STD Treatment Guidelines www.cdc.gov/std/treatment
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CHLAMYDIA TREATMENT CHANGES FOR 2015
New Alternative Regimen (non-pregnant): Doxycycline (delayed release) 200 mg QD x 7 d Equally efficacious to doxycycline BID, ↓ GI side effects More $$$
Moved to Alternative Regimen (pregnant*): Amoxicillin 500 mg po TID x 7 days - CT persistence documented in vitro after treatment prompted removal from recommended to alternate
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PROCTITIS
No major changes Presumptive treatment of LGV for MSM with
proctitis and rectal CT is recommended: If the patient is HIV-infected OR Bloody discharge, perianal ulcers or mucosal
ulcers are present
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GONORRHEA
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GONORRHEA DUAL THERAPY UNCOMPLICATED GENITAL, RECTAL,
OR PHARYNGEAL INFECTIONS
Ceftriaxone 250 mg IM in a single dose
Azithromycin 1 g orally
(preferred) or
Doxycycline 100 mg BID x 7 days
CDC 2015 STD Treatment Guidelines www.cdc.gov/std/treatment
PLUS*
• Regardless of CT test result
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ALTERNATIVE CEPHALOSPORINS: Cefixime 400 mg orally once
PLUS Azithromycin 1 g (preferred) or doxycycline 100
mg BID x 7 days, regardless of CT
IN CASE OF SEVERE ALLERGY: Azithromycin 2 g orally once
(Caution: GI intolerance, emerging resistance)
Gonorrhea Treatment Alternatives Anogenital Infections
Gentamicin 240 mg IM + azithromycin 2 g PO OR Gemifloxacin 320 mg orally + azithromycin 2 g PO
Doxy removed as co-treatment (unless azithro allergy)
CDC 2015 STD Treatment Guidelines www.cdc.gov/std/treatment
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NIH-sponsored non-comparative randomized trial in adults with urethral or cervical gonorrhea
1. gentamicin 240 mg IM + azithromycin 2 g PO, or 2. gemifloxacin 320 mg PO + azithromycin 2 g PO
Per-protocol efficacy: gentamicin + azithromycin = 100% (202/202) gemifloxacin + azithromycin = 99.5% (198/199)
ALTERNATIVE UROGENITAL GC REGIMENS: AVOID MONOTHERAPY
Kirkcaldy, CID 2014;59:1083-91.
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ANY DOWNSIDE TO THE ALTERNATIVE REGIMENS?
Gentamicin Regimen
Gemifloxacin Regimen
Route IM or IV Oral Nausea 27% 37% Vomiting (<1 hour)
3% 7%
Availability OK FDA reported shortage in May
2015 Volume Need 6 cc
(40mg/cc)
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WHO NEEDS A TEST OF CURE FOR GC?
Patients with pharyngeal GC treated with an alternative regimen Obtain test of cure 14 days after treatment, using
either culture or NAAT
Cases of suspected treatment failure (culture and simultaneous NAAT) Consider if using non-recommended or
monotherapy
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ANTIBIOTIC-RESISTANT GONORRHEA
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B o l a n e t a l . N e w E n g l a n d J o u r n a l o f M e d i c i n e 2 0 1 2 .
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PERCENTAGE OF NEI SSERIA GONORRHOEAE ISOLATES WITH REDUCED
CEFIX IME SUSCEPTIB IL IT Y†
GONOCOCCAL ISOLATE SURVEILLANCE PROJECT (G ISP) , 2006–2015*
0
0.5
1
1.5
2
2006 2007/ 2008††
2009 2010 2011 2012 2013 2014 2015*
†Minimum inhibitory concentration (MICs) ≥0.25 µg/ml *2015 data are preliminary as of March 7, 2016 †† Cefixime susceptibility not tested in 2007 and 2008
Percentage
Dual therapy for GC Increased Ceftriaxone to 250 mg from 125 mg
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% OF URETHRAL ISOLATES WITH ELEVATED CEFTRIAXONE MINIMUM INHIBITORY CONCENTRATIONS (MICS) (≥0.125 ΜG/ML) GONOCOCCAL ISOLATE SURVEILLANCE PROJECT
2007–2014
*MSM=men who have sex with men; MSW=men who have sex with women only.
2013-Fig Z. SR. Pg. 75.
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Oral cephalosporin treatment failures reported worldwide Japan, Hong Kong, England, Austria,
Norway, France, South Africa, and Canada
Ceftriaxone treatment failures in pharyngeal gonorrhea and a few isolates with high-level ceftriaxone resistance reported
CEPHALOSPORIN TREATMENT FAILURES
The New Yorker 2012
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AZITHROMYCIN TREATMENT FAILURE IN CALIFORNIA
Gose et al. STD 2015;42:279-80.
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SUSPECTED GC TREATMENT FAILURE
• If GC culture not available, call your local health department
TEST WITH CULTURE AND NAAT:
•Gemifloxacin 320 mg + AZ 2g OR Gentamicin 240 mg IM + AZ 2g • If reinfection suspected, repeat treatment with CTX 250 + AZ 1g
REPEAT TREATMENT:
•To your local health department within 24 hours
REPORT:
•Treat all partners in last 60 days with same regimen
TEST AND TREAT PARTNERS:
•TOC 7-14 days with culture (preferred) and NAAT
TEST OF CURE (TOC):
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Partner treatment and Repeat Screening
PREVENTING CT/GC REINFECTION
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Clinical evaluation first-line option Concurrent patient-partner therapy can be
effective for for those with one primary partner Offer expedited partner treatment (EPT) CT/GC if
partner cannot be promptly treated Use of prepackaged medication is recommended Dual therapy (cefixime 400 mg + azithromycin 1 g) is crucial
if EPT is used for GC CDC recommends EPT for heterosexuals, CA guidelines do
not discriminate based on gender of sex partners
PARTNER MANAGEMENT: TAKE HOME POINTS
CDC 2015 STD Treatment Guidelines: www.cdc.gov/std/treatment CA EPT Guidelines: www.cdph.ca.gov/pubsforms/Guidelines/Documents/CA-STD-PDPT-Guidelines.pdf
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Legal Status of Expedited Partner Therapy, 6/2015
www.cdc.gov/ept
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TESTING AFTER AN STD INFECTION
Women who test positive for CT/GC, or trichomonas should be rescreened three months following treatment.
Men who test positive for chlamydia or gonorrhea
should be rescreened at three months after adequate therapy.
All patients with a bacterial STDs or trichomonas
should be tested for other STDs including CT/GC, syphilis, and HIV
CDC 2015 STD Treatment Guidelines www.cdc.gov/std/treatment
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Primary, Secondary & Early Latent: Benzathine penicillin G 2.4 million units IM in a
single dose Late Latent and Unknown Duration: Benzathine Penicillin G 7.2 million units total, given
as 3 doses of 2.4 million units each at 1 week intervals
Neurosyphilis: Aqueous Crystalline Penicillin G 18-24 million units
IV daily administered as 3-4 million IV q 4 hr for 10 -14 d
SYPHILIS TREATMENT: NO CHANGE
In pregnancy, benzathine penicillin is the only recommended therapy. No alternatives
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•Clinical experience suggests 10-14 days ok for non-
pregnant adults • <9 days is best based on limited pharmacologic data
• In pregnancy, must adhere to strict 7 days between
doses •40% of pregnant women are below treponemicidal
levels after 9 days •If a dose is missed, the entire series must be
restarted
WHAT IS THE MAXIMUM TIME ALLOWED BETWEEN PENICILLIN DOSES?
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NEUROSYPHILIS AND OCULAR SYPHILIS
Photo Courtesy: Dr. Kees Rietmeijer, STD Control , Denver PHD
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NEUROSYPHILIS: CAN OCCUR AT ANY STAGE OF SYPHILIS
• All patients with syphilis should be evaluated for neurologic symptoms and signs
• CSF examination is recommended for: • Neurologic or ophthalmic symptoms/signs
• Auditory disease, cranial nerve dysfunction, meningitis, stroke, altered mental status, loss of vibration sense, iritis, uveitis
• Evidence of tertiary disease • aortitis, gumma
• Serologic treatment failure
CDC 2015 STD Treatment Guidelines
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OCULAR SYPHILIS CLUSTER
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OCULAR SYPHILIS
Several cases of ocular syphilis were reported in multiple cities in California and in Seattle, WA Several cases resulted in permanent decline in visual acuity, including
blindness
CLINICAL ADVISORY
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CERTAIN T. PALLIDUM STRAINS ARE ASSOCIATED WITH NEUROSYPHILIS
Evaluated in ongoing study of neurosyphilis in Seattle 50% (n=22) of patients with strain type 14d/f had
neurosyphilis, compared to 23% (n=9) of patients with other strain types had
neurosyphilis
Rabbit studies Animals infected with 14a/a strain and 14d/f strain had greatest degree of neuroinvasion
Marra et al. JID 2010 Tantalo et al. JID 2005
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OCULAR SYPHILIS IN 2014-2015: SELECT CLINICAL CHARACTERISTICS
Cases both HIV+ and HIV- men and women Clinical presentation of cases has included:
• Red eye • Eye pain • Vision loss, flashing lights, blurry vision • Headache in addition to eye symptoms
• Ophthalmologic exam findings: (Can involve almost any eye structure) • Uveitis (commonly posterior uveitis & panuveitis) • Optic neuritis • Retinal detachment
Photo Courtesy: Dr. Kees Rietmeijer, STD Control , Denver PHD
MMWR October 16, 2015 / 64(40);1150-1
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NEW BUGS: MAN WITH A “DRIP”
A 23 yo male presents for evaluation of a urethral discharge without dysuria
He has been seen in clinic 15 times between 5/22/12 and 9/2/14 Sometimes visible discharge, sometimes not On 9 occasions a urethral Gram stain performed 5 times <5PMN/hpf 4 times >5PMN/hpf
GC documented 5/23/13, otherwise, tested for GC and CT at each of the 15 visits and always negative
Most recently treated with 1gm Azithromycin orally once; partner received treatment; GC and CT neg
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TODAY HE PRESENTS WITH THICK, WHITE DISCHARGE…NOW WHAT?
Source: Diepgen TL, Yihune G et al. Dermatology Online Atlas
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WHAT IS YOUR NEXT STEP?
1) Give up 2) Give him longer course of
azithromycin 3) Get a urine culture 4) Try a different antibiotic 5) Get a consult from ID 6) More than 1 of the above
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NEW STI ON THE BLOCK MYCOPLASMA GENITALIUM
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Young adults 18-24 yrs1,2
M. genitalium MORE COMMON THAN YOU THINK
1 Miller 2004; 2 Manhart 2007
1.0%
3.8%
0.6%
2.1%
Pre
vale
nce
MG CT GC TV
STD Clinic/ED Attendees3-9
13.4% 12.1%
15.2%
7.0%
22.4% 19.2% 19.2%
Seattle NewOrleans
Cincinnati Baltimore Durham
Men Women
3Totten 2001; 4Mena 2002; 5Manhart 2003; 6Huppert 2008; 7-
8Gaydos 2009a & 2009b; 9Mobley 2012 L. Manhart, with permission
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M. GENITALIUM & REPRODUCTIVE TRACT DISEASE
Definitely associated with NGU in men
Study of association with: Cervicitis PID Infertility Preterm delivery
Increased odds of adverse outcomes= ~2.0 fold higher for all conditions Statistically significant for all but infertility
Lis et al., 2015 Clin Infect Dis
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DETECTING MG INFECTIONS?
No FDA-approved diagnostic test
Nucleic Acid Amplification Test (Hologic GenProbe) Curently research use only FDA approval being sought
Commercial Laboratories (in house PCR tests) Limited test-performance information
L. Manhart, with permission
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MG CURE RATES WITH DOXYCYCLINE AND
AZITHROMYCIN
Randomized Trials
Doxycycline (100mg bid x 7d) vs. Azithromycin (1g)
45% 31% 30%
87%
67%
40%
Mena 2009 Schwebke 2011 Manhart 2013
Doxycycline
Azithromycin
Mic
robi
olog
ic C
ure
L. Manhart, with permission
CONCLUSION: AZM (1g) is superior to DOX (100mg bid x 7d). However, efficacy of AZM is not consistently high and may be declining
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Highly effective for treatment failures o 100% cure rates in most cases
Public health 340b pricing available
o Usual price for 7 day course ~ $100+
o Negotiated price to $1.21/pill
Caveat: Moxifloxacin treatment failures emerging (Japan, Seattle, Australia)
Moxifloxacin 400mg po x 7-14d
MG Treatment
L. Manhart, with permission
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If azithromycin NOT given for 1st episode: Azithromycin 1 g orally in a single dose
PLUS Metronidazole 2 g orally in a single dose OR Tinidazole 2 g orally in a single dose
If azithromycin given for 1st episode: Moxifloxacin 400 mg orally qd x 7d
PLUS Metronidazole 2 g orally in a single dose OR Tinidazole 2 g orally in a single dose (if having sex with
females)
PERSISTENT NGU TREATMENT
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EPILOGUE
Patient takes moxifloxacin 400 mg po x 7 days. Symptoms finally resolve. Take home point: Think about M. genitalium in cases of
cervicitis and urethritis treatment failure.
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BACKGROUND: STDs PREDICT FUTURE HIV RISK
1 in 15 MSM were diagnosed with HIV within 1 year.*
1 in 53 MSM were diagnosed with HIV within 1 year.*
Rectal GC or CT
1 in 18 MSM were diagnosed with HIV within 1 year.**
Primary or Secondary Syphilis
No rectal STD or syphilis infection
*STD Clinic Patients, New York City. Pathela, CID 2013:57; **Matched STD/HIV Surveillance Data, New York City. Pathela, CID 2015:61
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50%
33% 33% 28%
5.5% 0%
0%
10%
20%
30%
40%
50%
60%
Any STI Rectal STI Chlamydia Gonorrhea Syphilis HIV
STI Incidence After 12 Months of PrEP Use
HIV PrEP and STIs Kaiser Permanente San Francisco
Volk et al. CID 2015; Slide courtesy J. Volk
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HIV incidence = 0.43 cases / 100 py (95% CI 0.05-1.54) STI incidence (90 cases/100 py) high but stable over time (P> 0.1) 50.9% of participants had at least one STI during follow-up >75% of GC and >85% of CT infections were asymptomatic
0
5
10
15
20
25
30
Screening 12 24 36 48
% P
ositi
ve
Visit Week
GC, CT or Syphilis
Rectal GC or CT
Pharyngeal GC orCTUrethral GC or CT
HIV PrEP and STIs-Part II PrEP Demo Project (NIAID), n=557
Liu 2016, JAMA Int Med
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% infections for which treatment would have been delayed with q6 month, as opposed to q3 month screening
HIV PrEP and STIs-Part III: Optimal Screening Frequency (n=445)
Cohen # 870 CROI 2016
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Pilot RCT of N=30 HIV+ MSM with h/o repeat syphilis Doxycycline 100 mg po daily vs placebo + $50-100 per visit for testing STD-free Outcomes: contracting GC/CT, syphilis, or composite
outcome (any GC/CT/syphilis)
76.7% retention through 48 weeks Less infections seen for syphilis (2 vs 7 infections),
GC/CT (4 vs 8 infections), NS Composite outcome, doxy superior to placebo, OR
0.27 (0.9-0.83), p=0.02
STI PrEP?
Bolan, 2015 STD
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LET’S PUT IT IN THE WATER
doxy PreP
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Bacterial STIs are all increasing, especially among MSM Serosorting/seroadaptive strategies PrEP Efficient online access to sex
Syphilis and extragenital GC/CT are key as rectal GC/CT infections and syphilis predict future HIV acquisition.
Self-collected GC/CT testing may help overcome provider barriers, is acceptable to MSM and performs well
Ask about ocular/visual symptoms in patients with syphilis
TAKE HOME POINTS
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SF Dept of Public Health Stephanie Cohen California Dept of Public Health Jessica Frasure Julie Stoltey
ACKNOWLEDGMENTS