statins and polyketides

out of 5

Upload: jeffrey-millinger

Post on 08-Jan-2016

1 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

DESCRIPTION

Functional frameworks of important drugs in the cholesterol synthesis pathway

TRANSCRIPT

Statins: Cholesterol-Lowering DrugsHMG-CoA Reductase Inhibitors

Lipitor (Atorvastatin)marketed by Pfizer

Crestor (Rosuvastatin)marketed by Astra Zeneca

Compactin (Mevastatin)Lovastatin (Mevacor)[Isolated from the fungus [Isolated from the fungusPenicillium citrinium]Aspergillus terreus]

Zocor (Simvastatin)MK-733marketed by Merck

Polyketide Natural ProductsRapamycinFK 506 AzithromycinErythromycin

TetracyclineEpothilones

Taxol (Paclitaxel)Discodermolide

AmphotericinRadicicol

Oligomycin

Polyketide Biosynthesis

Pharmacological Effects of Statins

Functional Gene-Guided Discovery of Type II Polyketides ...€¦ · Functional Gene-Guided Discovery of Type II Polyketides from Culturable Actinomycetes Associated with Soft Coral

GBIHC180MR Statins Market to 2018 sample - … Market to 2018 - Executive Summary Statins Market to 2018 - Executive Summary Statins (HMG-CoA reductase inhibitors), the first line

Statins Have a Dose-Dependent Effect on Amputation and Survival …hemodinamiahpc.com.ar/download_carrera/artinteres/Statins Have a … · 10.1161/CIRCULATIONAHA.117.032361 6 The

Supplementary Material Associations between statins and

Production of Polyketides by Saccharomyces cerevisiae THESIS with front page.pdf · Since many useful polyketides either originate from sources that are difficult or even impossible

Statins and New-Onset Diabetes Mellitus and Diabetic Complications

Pleiotropic Eff of Statins

Engineered polyketides: Synergy between protein and host ... · Polyketides encompass one of the largest classes of chemically diverse natural products. With thousands of known polyketides,

The wonderful world of polyketides

Statins and Myoglobin

A cyclopeptide and three oligomycin-class polyketides produced … · 2020-05-25 · 1100 A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete

Statins Talk 2009

Utilization of statins and LDL-cholesterol target

Statins for Primary Prevention

Biosynthesis of Fatty Acids & Polyketides

Statins and Congenital Malformations

226 statins are overrated

1. Introduction to Natural Products Chemistry · RA Macahig FM Dayrit . 5. Polyketides (Dayrit) 2 ... Polyketides (Dayrit) 4 • The polyketides have great diversity of structures

The Relationship between ACE Inhibitors, Statins and Pneumonia

Kinetic Statins Copia

Association between statins and clinical outcomes … between statins and clinical outcomes among men ... (RP) are the key ... control) studies examining

Cholesterol and Statins · Cholesterol and Statins Author: Center for Drug Evaluation and Research Subject: Cholesterol and Statins Keywords: statins; cholesterol; infographic; reduce;

Statins and Heart Failure

The Current Status of Statins in Stroke Prevention - …medcraveonline.com/JNSK/JNSK-01-00014.pdf · The Current Status of Statins in Stroke Prevention ... benefits of statins in

Polyketides, Toxins and Pigments in Penicillium marneffei€¦ · Polyketides are synthesized via a complex enzymatic system consisting of various kinds of polyketide synthases (PKSs)

5. Polyketides RA Macahig FM Dayrit. 5. Polyketides (Dayrit)2 Polyketides rank among the largest group of secondary metabolites in terms of diversity

Sampling Terrestrial Environments for Bacterial Polyketides€¦ · Abstract: Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly

Formicamycins, antibacterial polyketides produced by

WHEN AND HOW TO PRESCRIBE STATINS

Statins and the autonomic nervous system

Biotechnology of polyketides: New breath of life for the ... · Biotechnology of polyketides: New breath of life for the novel antibiotic genetic pathways discovery through metagenomics

Statins Reduce CD40

Fatty Acids and Polyketides Paper

polyketides and terpenes › Chem564pdfs › polyketides and terpenes.pdf · polyketides and terpenes.ppt Author: Thomas Minehan Created Date: 8/24/2017 10:12:34 PM