statin tolerability: overcoming the treatment gap · 2020. 2. 13. · statin tolerability:...
TRANSCRIPT
![Page 1: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/1.jpg)
Statin Tolerability: Overcoming the Treatment Gap
IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk
Oman February 9th 2015
Peter J. Lansberg Center for Translational Molecular Medicine
Dept. of Vascular Medicine AMC - Amsterdam Netherlands
![Page 2: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/2.jpg)
'I didn't have time to
write a short letter,
so I wrote a long one
instead’
Mark Twain
![Page 3: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/3.jpg)
History of Cholesterol Lowering
• 1900 – 1920 Eureka!
• 1920 – 1960 Nothing
• 1960 – 1970 Drama
• 1970 – 1980 Hope
• 1980 – 1990 Surprise
• 1990 – 2000 Confidence
• 2000 – 2010 Inertia – Skepticism
• 2010 – 2020 ?
![Page 4: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/4.jpg)
Scientific Data
24 Cardiovascular risk guidelines
January 31th 2015 PubMed:
Cholesterol : 232 127
Chol. Low. Tx : 92 572
Statin : 34 493
![Page 5: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/5.jpg)
Scientific Data
24 Cardiovascular risk guidelines
Publications in 2014 PubMed:
Cholesterol: 11 345 (31/day)!
Chol. Low. Tx: 4 566 (12/day)!
Statin: 2 467 (7/day)!
![Page 6: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/6.jpg)
Outline Presentation
1. Statin Safety
2. Statin Tolerability
3. Statin Adherence
![Page 7: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/7.jpg)
Adherence to Statins • 2234 NSTEMI patients discharged Ator 80 mg
• 12 month follow up • Tel. interview in months 1, 6 and 12
• 27.3% of patients stopped after 35 days (21-79) • Mild side effects 48%
• No specific reason 52%
• ↑risk for discontinuation: elderly and females
• ↓ risk for discontinuation: Diabetics and post PCI
Mortality: 203 patients (9%)
HR: 4.1 (2.1-7.9) P=0.002
Colivicchi – ESC 2008 G Ital Cardiol (Rome). 2010 May;11(5 Suppl 3):124S-127S.
![Page 8: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/8.jpg)
Are all statins the same?
![Page 9: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/9.jpg)
![Page 10: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/10.jpg)
Are all patients the same?
![Page 11: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/11.jpg)
Atherosclerosis
![Page 12: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/12.jpg)
Risk Factors
![Page 13: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/13.jpg)
Question: Are Statins Safe?
![Page 14: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/14.jpg)
Number needed to treat for 1 year to:
Cause a GI Bleed1 Cause a Fatal GI Bleed1
Aspirin
Cause Severe Myositis2 Cause Fatal Myositis2
Statins
1Derry S, Loke YK. 2000 2Thompson PD, et al. 2003
Statin Safety in Perspective
248 2066
100,000 1,000,000
![Page 15: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/15.jpg)
Fatal Rhabodmyolysis
Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med 2002; 346: 539-40
![Page 16: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/16.jpg)
73 reported cases of fatal rhabdomyolysis
484,273,000 Statin prescriptions
2014: 15 – 20 million statin users
2014 estimation: 3 deaths/year
In Summary…The Risk is Small!
Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med 2002; 346: 539-40
![Page 17: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/17.jpg)
US population: ± 300 million
Peanut allergy 1.4% of population:
4.2 million affected 150 fatalities/yr!
![Page 18: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/18.jpg)
Question: Can patients tolerate statins?
![Page 19: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/19.jpg)
Muscle Related Side Effects
![Page 20: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/20.jpg)
A systematic review of statin-induced muscle problems in clinical trials
Am Heart J 2014;168:6-15.
statin treatment: 12.7% - placebo group: 12.4% (P = .06)
![Page 21: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/21.jpg)
Musculoskeletal Adverse Events With the 80-mg Dose
Reported AE
2006 Safety Analysis PROVE IT* IDEAL* TNT*
Atv 10
(n=7258)
Atv 80
(n=4798)
Prav 40
(n=2063)
Atv 80
(n=2099)
Simva 20
(n=4449)
Atv 80
(n=4439)
Atv 10
(n=5006)
Atv 80
(n=4995)
Myalgia 2.9% 2.7% NR NR 1.1% 2.2% 4.7% 4.8%
Myopathy 0 0.02%† NR NR 0.25%† 0.14%† 0.06% 0.04%
Persistent CPK
>10 x ULN
0 0.06% NR NR NR NR 0 0
Rhabdomyolysis 0 0 0 0 0.07% 0.05% 0.06% 0.04%
NR, not reported
*Studies not included in 2006 safety meta-analysis
†Investigator-reported cases: did not meet criteria for definition of myopathy (persistent CPK elevations >10 x ULN with muscle symptoms)
Newman C et al. Am J Cardiol. 2006;97:61-67; Cannon CP et al. N Engl J Med. 2004;350:1495-1504; LaRosa JC et al. N Engl J Med. 2005;352:1425-1435; Pedersen TR et al. JAMA. 2005;294:2437-2445.
![Page 22: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/22.jpg)
Statin Associated Muscle Symptoms SAMS
MYALGIA Pain MYOPATHY Weakness MYOSITIS CK >10X ULN RHABDOMYOLYSIS CK> 40X ULN
![Page 23: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/23.jpg)
Statin Myalgia Clinical Index Score
Statin Myalgia Clinical Index Score Probable 9-11 Possible 7-8 Unlikely <7
Region
Time
De-challenge
Re-challenge
![Page 24: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/24.jpg)
STOMP Study
Criculation 2013; 127: 96 - 103
6 months 420 healthy statin naïve subjects
Atorvastatin 80 mg vs Placebo
![Page 25: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/25.jpg)
The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study
atorvastatin 80 mg VS placebo 6 MONTHS n=420 • exercise capacity No significant changes • muscle strength No significant changes • Myalgia 19 vs 10 (p=0.05) • CK ≥10 x ULN none
Myalgic subjects on atorvastatin or placebo had decreased muscle strength in 5 of 14 and 4 of 14 variables, respectively
(P=0.69).
Circulation. 2013;127:96-103
![Page 26: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/26.jpg)
The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study
Circulation. 2013;127:96-103
![Page 27: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/27.jpg)
Ann Intern Med. 2013;158:526-534.
![Page 28: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/28.jpg)
Ann Intern Med. 2013;158:526-534.
Discontinuation of Statins in Routine Care
107835
57292
18778
0%
20%
40%
60%
80%
100%
120%
0
20000
40000
60000
80000
100000
120000
patients discontinued documented events
Statin use 2000 - 2008 Brigham's And Women's hospital Boston
![Page 29: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/29.jpg)
Ann Intern Med. 2013;158:526-534.
Discontinuation of Statins in Routine Care
2721
1295 996
0%
20%
40%
60%
80%
100%
120%
0
500
1000
1500
2000
2500
3000
same statin same dosage higher dosage
Statin use 2000 - 2008 Brigham's And Women's hospital Boston
Re-challenge in 6 579 patients 93% were on statin after 12 months
![Page 30: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/30.jpg)
Lesson Learned
![Page 31: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/31.jpg)
![Page 32: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/32.jpg)
FDA Warning March 2010 + May 2011
• No Simvastatin with itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, or nefazodone.
• No simvastatin >10 mg with gemfibrozil, cyclosporine, or danazol
• No simvastatin >20 mg with amiodarone or verapamil
• No simvastatin >40 mg with diltiazem
• Patients of Chinese descent should not receive simvastatin 80 mg with cholesterol-modifying doses of niacin-containing products.
• caution when such patients are treated with simvastatin 40 mg or less in combination with cholesterol-modifying doses of niacin-containing products
![Page 33: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/33.jpg)
Risk factors for statin-associated muscle symptoms.
• Anthropometric • Concurrent conditions • Surgery • Related history • Genetics • Other risk factors
![Page 34: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/34.jpg)
Hepatic Safety of Statins
![Page 35: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/35.jpg)
United Network for Organ Sharing (UNOS) Database
• From 1990 – 2002 in the US: 51 741 liver transplants
• three cases of acute liver failure related to statins * • 2 Cerivastatin
• 1 Simvastatin
These studies were retrospective analyses, and formal causality assessment of DILI and confirmation that cases
were bona-fide cases of DILI from statins were not performed!
* Russo MW, Galanko JA, Shrestha R, et al. Liver transplantation from drug induced liver injury in the United States. Liver Transpl 2004; 10:1018– 1023.
![Page 36: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/36.jpg)
Lancet 2010; 367: 1916-1922
![Page 37: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/37.jpg)
Enzyme activity during 3-year follow-up in patients with raised liver enzymes
Athyros, V. et al., Lancet 2010;376:1916-22.
Patients on statin treatment (n=227)
Patients not statin treatment (n=210)
![Page 38: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/38.jpg)
Athyros, V. et al., Lancet 2010;376:1916-22.
Cardiovascular Events in Patients with Normal and Abnormal LFT’s
3,2% 4,6%
10%
7,6%
0
2
4
6
8
10
12
Abn LFT Norm LFT
Statin
Control
22 (10%) of 227
patients
63 (30%) of 210
patients
68% RRR
P<0.0001
23% RRR
p<0001
117 (23%) of 510
patients
90 (14%) of 653
patients
Even
t rate
/1
00
pati
en
t years
![Page 39: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/39.jpg)
NAFLD at Baseline and Follow up
36 44 27 35 27 32
Am J Gastroenterol advance online publication, 14 September 2010; doi: 10.1038/ajg.2010.299
Risk reduction of moderate to severe hepatic steatosis: 70% !
![Page 40: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/40.jpg)
Use of Atorvastatin or Pravastatin in Patients with NASH
• 5 patients with NASH 20 mg Prava for 6 months1
Normalization of liver enzymes in all patients Some improvement in hepatic inflammation and
steatosis (liver biopsies)
7 patients with NASH 20 mg Atorvastatin 21 months (± 2 months)2
Well tolerated No increase in liver enzymes Significant improvement of hepatic histology in
some patietns
1. Rallidis LS, Drakoulis CK, Parasi AS. Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study. Atherosclerosis 2004;174: 193-196.
2. Horlander JC, Kwo PY, Cummings OW. Atorvastatin for the treatment of NASH. Gastroenterology 2001;120:A544.
![Page 41: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/41.jpg)
Summary of studies using statin therapy for NAFLD
F, fibrosis; CT, computed tomography; IN, inflammation; N / A, not applicable; NAFLD, nonalcoholic fatty
liver disease; NASH, nonalcoholic steato hepatitis; RCT, randomized control trial; S, steatosis; US,
ultrasound.
Am J Gastroenterol advance online publication, 14 September 2010; doi: 10.1038/ajg.2010.299
![Page 42: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/42.jpg)
Statins and Liver Disease
Decrease the risk of developing hepato-cellular carcinoma (HCC) 1
Improve portal pressure and risk for bleeding liver cirrhosis2
Double survival in HCC patients3
Inhibit hepatitis C viral replication and improve treatment response rates4,5
1. El-Serag HB, Johnson ML, Hachem C, Morgana RO. Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes. Gastroenterology 2009; 136:1601– 1608.
2. Kawata S, Yamasaki E, Nagase T et al. Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. British Journal of Cancer (2001) 84(7), 886–891
3. Abraldes JG, Albillos A, Banares R, et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009; 136:1651–1658.
4. Harrison SA, Rossaro L, Hu K, et al. Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy. Hepatology 2010; 52:864–874.
5. Rao GA, Pandya PK. Statin therapy improves sustained virologic response among diabetic patients with chronic hepatitis C. Gastroenterology 2011; 140:144–152.
![Page 43: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/43.jpg)
Statins and Liver Safety
Journal of Clinical Lipidology (2014) 8, S47–S57
![Page 44: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/44.jpg)
Statins and Liver Safety
Journal of Clinical Lipidology (2014) 8, S47–S57
1. Comprehensive List of Causes for Elevated Liver Enzymes
2. Comprehensive approach to patients with elevated liver blood testing (transaminases ,3 times the upper limits of normal)
![Page 45: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/45.jpg)
Diabetes and Statins
![Page 46: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/46.jpg)
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
Lancet 2010; 375: 735–42
13 trials 91 140 participants DM in 4278 (2226 statins/2052 controls) 9% ↑ risk for incident diabetes (95% CI 1·02–1·17) ↑risk in older participants = baseline body-mass index and change in LDL-cholesterol
concentrations
Treatment of 255 (95% CI 150–852) patients with statins
for 4 years resulted in one extra case of diabetes.
![Page 47: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/47.jpg)
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised
statin trials
Lancet 2010; 375: 735–42
![Page 48: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/48.jpg)
Risk of New-Onset DM2 According to Number of Risk Factors at Baseline
J Am Coll Cardiol 2011;57:1535–45
1. Baseline glucose >5.6 mmol/l (100 mg/dl) 2. Fasting triglycerides >1.7 mmol/l (150 mg/dl) 3. BMI >30 kg/m2 4. History of hypertension
![Page 49: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/49.jpg)
Effect of Pre-Diabetes on Incidence of New-Onset Diabetes (TNT & IDEAL)
J Am Coll Cardiol 2011;57:1535–45
![Page 50: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/50.jpg)
Diabetes RiskAssesment Form
N.A. Sattar et al. / Atherosclerosis Supplements 15 (2014) 1e15
Circle Answers and add up the points
Age Body Mass/Waist
Diet / Exercise Anti medication
History of elevated glucose Family history
![Page 51: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/51.jpg)
Major Cardiovascular Events
Event rate was almost the same patients with new onset diabetes compared to patients without diabetes at baseline
HR: 1.02, 95% CI: 0.77 to 1.35
J Am Coll Cardiol 2011;57:1535–45
![Page 52: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/52.jpg)
Statin Induced Impairment of Glucose Metabolism
Sampson UK, Linton MF and Fazio S, Curr Opin Cardiol. 2011 ; 26(4): 342–347
Inhibition of glucose-induced calcium signaling-dependent insulin secretion
Decrease Ubiquinone and Mitochondral transport/ATP production/Reduced Insulin secretion
Inhibition of the Isoprenylation of GLUT4 transporter
Beta cell oxidation, oxidative stress and nitric oxide production
Apoptosis and beta cell destruction from LDL entry
![Page 53: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/53.jpg)
Other Drugs That Affect Glucose
Atypical antipsychotics
β-blockers
Thiazide diuretics
Protease inhibitors
Niacin
![Page 54: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/54.jpg)
Statin Effects 9:1 Benefit?
Of 255 Patients Treated +1 case of diabetes
Of 255 Patients Treated -9 cases of CAD/CVA
Lancet 2010; 375: 735–42
![Page 55: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/55.jpg)
Statin Adherence
![Page 56: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/56.jpg)
https://www.lipid.org/practicetools/tools/adherence
![Page 57: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/57.jpg)
Interventions to Improve Adherence
![Page 58: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/58.jpg)
How to make people follow our advice
![Page 59: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/59.jpg)
CHANGE Behaviour
1. Own the problem 2. Measure the problem 3. Feed back 4. Trust - Time 5. Transparency 6. Repeat
![Page 60: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/60.jpg)
NEnglJMed 372;2 (january 8, 2015)
![Page 61: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/61.jpg)
Sumary of Presentation
1. Statin Safety
2. Statin Tolerability
3. Statin Adherence
![Page 63: Statin Tolerability: Overcoming the Treatment Gap · 2020. 2. 13. · Statin Tolerability: Overcoming the Treatment Gap IAS-OSLA Course Lipid Metabolism and Cardiovascular Risk Oman](https://reader036.vdocuments.us/reader036/viewer/2022071405/60faaa4162ddb3730a1dc52c/html5/thumbnails/63.jpg)