state of the art ep lab
TRANSCRIPT
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State of the Art EP Lab: What’sGoing On in There?
Bob WestIowa Heart Hospital
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Disclosure of Relationships
Bob West, B.S., RCVT, CEPS
Participated in Bachmann Bundle pacing study.
Currently working with Voltage mapping study.
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Participated in TTOP trial ………………Ablation Frontiers
Participated in STOP AF trial …………..Arctic Front balloon CryoCath
Briefly participated in ENABLE study …………….Cardiofocus Laser balloon
Disclosure of Relationships
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History of Arrhythmia Ablation
1969: Surgical division of WPW pathways 1982: Catheter ablation using DC shock 1987: Catheter ablation using
radiofrequency energy (RF) ‐ cure of SVT 1992: Catheter RF ablation of atrial flutter 1995: Catheter RF ablation of atrial fibrillation=20 years of RF catheter ablation experience
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ABLATION sources
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RF, standard and irrigatedRadiofrequency energy---resistance heats tissue
4mm,5mm,8mm 10mm deeper and wider lesions
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Cryo, standard and balloonnitrous oxide freezes tissue
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Laser, balloonCardiofocus diode laser
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High intensity focused ultrasoundfocused ultrasound energy to selectively destroy biological tissue at depth
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Linear RFAblation Frontiers
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Minimal technology
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High resolution fluoroscopy
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EP 120 channel physiology recorder with programmable stimulator
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High resolution signals for diagnosis
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PVI goal is to electrically isolate the pulmonary veins
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Safe and reliable transeptal accessa steerable introducer gives added flexibility for achieving good lesions
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INTRA CARDIAC ECHO imaging for Ablation Pre ablation anatomic orientation
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Ablation Goals(what is all this stuff for?)
Maximize Success
Reduce Complications
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Death as a complication of catheter ablation of atrial fibrillation (AF) occurs in 1 of every 1000 patients
Thirty-one centers reported 32 deaths in 32,569 patients
tamponade (in 8 patients) stroke (5 patients) atrioesophageal fistula (5 patients) massive pneumonia (2 patients).
J Am Coll Cardiol 2009;53:1798-1803,1804-1806
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J Am Coll Cardiol 2009;53:1798-1803,1804-1806
32 deaths out of 32,569 patients
tamponade25%
stroke16%
other37%
pneumonia6%
A E fistula16%
avoidable complications
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Monitor the vital signs---old school!
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We routinely monitor femoral artery pressure throughout the PVI procedure
"It is of the utmost importance that tamponade (i.e., the most frequent cause of death in our survey) be recognized promptly, before it is too late."
Dr. Riccardo Cappato from the Policlinico San Donato, Milan, Italy
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Have the vital signs changed?Stable hemodynamics Early recognition
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Quick action and calm heads
Have equipment for tap available now
Critical to act soon!
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Can recent additions to technology improve outcomes?
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3-D MappingEnsite and Carto
Current improvement include CT or MRI fusion
Better understanding of anatomic variable
Map arrhythmia real-time and in review
Pinpoint critical path to determine ablation strategy
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Ensite with fusion on CT
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Non-contact Array maps Left atrial tachycardia from right atrium
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Carto- Merge
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Right septal Accessory Pathway Mapping
Retrograde map cryo lesions
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Remote Robotic Navigation Magnetic Robotic
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Sensei Robotic Catheter System
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Steriotaxis
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Steriotaxis Magnetic Navigation
High initial cost Closed architecture No irrigated catheters Soft catheter (light RF contact) Applications for ventricular rhythms, coronary
access and coronary sinus access.
Natale, Gallinghouse,Horton 1/5/09The Use of Remote Robotic Navigation
in Complex Arrhythmias webcast
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Hansen MedicalSensei Robot 14F introducer Only useful in atriums (primarily LA) Open architecture Complication rate similar to manual No cryo (8.5F lumen limitation)
Natale, Gallinghouse,Horton 1/5/09The Use of Remote Robotic Navigation
in Complex Arrhythmias webcast
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Current Investigations
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STOP AF trial Cryo balloon Pulmonary vein isolation
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Round balloon in an oval/egg shape hole!Some part of the ring will be missed!!
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To touch up missed area Freezor Max is used or the Balloon repositioned and repeated
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PVI goal is to electrically isolate the pulmonary veins
Pre cryo Post cryo
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EGD damage after EGD damage after PV Isolation with the CryoballoonPV Isolation with the Cryoballoon Catheter
Presented at the Heart Rhythm Society 2008 Scientific Sessions, San Francisco, CA May 14-17.
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To date no esophageal fistula has been seen in cryo procedures.
Conclusions: This case clearly demonstrates that Cryoballoon ablation can cause esophageal ulceration. Perhaps the absence of atrial-esophageal fistula formation with cryoablation may be related to the post-ablation healing process, rather than an inherent inability of cryoenergy to cause esophageal damage.
Ablation technology by definition causes cellular damage
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TTOP Linear Ablation Ablation Frontiers
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Linear lesions to the roof and Septum Ablation Frontiers
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technology to improve outcome
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Variation in anatomy
Location, size, branching and number of pulmonary veins
Size and location of atrial appendage Proximity of esophagus to PV antrum Phrenic nerve proximity to ablation site Coronary artery proximity to ablation
site
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Location, size, branching and number of pulmonary veins
PA CT of Left atrium Red LA Green distal PV’s White esophagus
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Size and location of atrial appendage
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Proximity of esophagus to PV antrum
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Pulmonary vein ostia are not round
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If you know there is a risk
Take every effort to avoid a bad outcome
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Phrenic nerve proximity to ablation site
(A)pre ablation (B)phrenic palsy (C)recovery
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Sanchez-Quintana found the anterior wall of the RSPV is <2mm from the right phrenic nerve in 32% of their autopsy series
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Coronary artery proximity to isthmus ablation site common atrial flutter 68 yo man
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Is deeper and wider better? 13 yo maleSTEMI during Posterior wall accessory pathway ablationEarly recognition of a complication is critical ……… emergent coronary stent interrupted this boys MI
Distal RCA occlusion
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Is something important near the ablation site?.......... Two reported coronary occlusions in Epstein’s WPW
Incidence of coronary artery injury immediately after catheter ablation for supraventricular tachcardias in infants and children.
Heart Rhythm, Volume 6,Issue 4, Pages 461-467
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15 year old male Epstein's anomaly with WPW pacing RV- right side posterior Accessory Pathway is common
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RCA 4mm from right atrial endocardial surface
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Cryo lesion paint to RCA posterior to Kent bundle
No acute or residual symptoms
Lower Incident of Thrombus Formation With Cryoenergy Versus Radiofrequency Catheter AblationKhairy et al. ,Circulation 2003;107
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What is the future?
built in Safety and a quick arrival at the goal Beautifully engineered
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Beautiful simplicity
"Things should be made as simple as possible, but not simpler." — Albert Einstein (1879–1955)
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addendum
Fall and winter 2009
Voltage substrate mapping
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LA voltage substrate map in NSR
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Reflexion HD™ High Density Mapping Catheter
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Criteria for definingLow voltage bridges
HVR
LVB
HVR
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Low voltage bridges occur in both atriums and their veins
LSVC LSVC
RAA
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Importance of low voltage bridges
“Ideally, a method to identify abnormal atrial substrate would offer the best chance to understand the underlying atrial disease, as well as, offer the best chance to intervene with ablation.”
Steven J. Bailin, MD Iowa Heart Center
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10 patients undergoing AF ablation
Cryo lesions
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The ability to map atrial substrate makes apparent the fundamental structures necessary to maintain and propagate AF
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In all 10 patients, AF was terminated to sinus rhythm
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The voltage gradients as well as high voltage areas were dramatically altered
Voltage pre ablation Voltage post ablation
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Only time and follow up will tell if this is a better method.