INSIDE:

FIGHTING CANCER WITHOUT FEARTop-notch cancer care

LOCAL METEOROLOGIST OVERCOMES CANCEREarly detection is key

ADVANCING CANCER SCIENCEPartners invest in scientific research

HOPESpring 2010

A P U B L I C A T I O N O F T H E B A R B A R A A N N K A R M A N O S C A N C E R I N S T I T U T E

Dear Friends,

I am extremely honored to serve as the president and chief executive officer of the Barbara Ann Karmanos Cancer Institute.

Since joining Karmanos Feb. 1, I have personally seen how the institution lives up to its reputation for world-class cancer care and cutting-edge scientific research. Oncologists and other medical professionals have long been aware of scientific advancements made here, such as the development of new cancer-fighting drugs that have gone on to receive FDA approval by the U.S. government. This translates into having advanced treatment options and therapies for our patients.

I came to Karmanos because I want to lead and be associated with an institution that will make a significant impact on cancer. Judging from what I’ve seen so far, I know I am in the right place.

John C. Ruckdeschel, M.D.PRESIDENT AND CHIEF EXECUTIVE OFFICERBARBARA ANN KARMANOS CANCER INSTITUTE

PRESIDENT’S LETTER

When David Lepper was diagnosed with an aggressive cancer that affects the head and neck area, he knew he wanted to be treated at the Karmanos Cancer Center. Following surgery, radiation and chemotherapy, he has been cancer-free for six years.

(Read more on pages 4–5)

ON THE COVER

Cover image by Stephen Lengnick, Plum Street Studio

Gerold Bepler, M.D., Ph.DPresident & Chief Executive Officer

...................................................SPRING 2010

VOLUME 6 | NUMBER 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

ABOUT KARmANOS

The Barbara Ann Karmanos Cancer Institute is one of only 40 National Cancer

Institute-designated comprehensive cancer centers in the United States. Federal designation

as a comprehensive cancer center is the pinnacle of translational oncology research.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

EXECUTIVE STAFF

GEROLD BEPLER, M.D., Ph.D. President and Chief Executive Officer

ANN G. SCHwARTz, PH.D., MPH Executive Vice President/Deputy Director

GEORGE YOO, M.D., FACSChief Medical Officer

GARY MORRISONChief Operating Officer

CYNTHIA K. SIKINASenior Vice President/Chief Financial Officer

NICK KARMANOS Vice President, Development

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Alan S. Schwartz, ChairRandolph J. Agley, Vice Chair

Charles E. Becker, Lead Vice ChairRichard M. Gabrys, Vice Chairw. James Prowse, Vice Chair

Jonathan S. AaronEugene Applebaum

Gerold Bepler, M.D., Ph.D. (ex officio)Paul Borman

Armando R. CavazosStephen D’Arcy (ex officio)

Debbie DingellJoseph Dresner

David w. DrewsMichael E. Duggan

Lillian ErdeljanMichael Ferrantino, Jr.

Nathan ForbesStanley FrankelMyron Frasier

Bruce A. GershensonAdnan Hammad, Ph.D.

Patricia HartmannDavid Jacob

Eleanor M. JosaitisPeter Karmanos, Jr.C. Michael KojaianEdward C. Levy, Jr.

Mary MatujaTimothy Monahan

Paul L. NineJay Noren, M.D., MPH (ex officio)

Thomas D. OgdenFred D. Olson

Valerie M. Parisi, M.D. (ex officio)Hilary Ratner, Ph.D.

Eunice RingRichard F. Roth

Gary SakwaNazli G. Sater

Marc R. SchechterNettie H. SeabrooksNedda N. ShayotaRobert A. Stone

David TrottVainutis K. Vaitkevicius, M.D.

Nancy Yaw

KARmANOS CANCER INSTITUTE BOARD OF DIRECTORS

(as of 4/15/10)

Charles E. Becker, ChairTimothy Monahan, Vice Chair

Gerold Bepler, M.D., Ph.D. (ex officio)Leslie C. Bowman

Armando R. CavazosKenneth Eisenberg

Myron FrasierThomas A. GossS. Scott Hunter

Denise Ilitch

Valerie M. Parisi, M.D. (ex officio)w. James Prowse

Anthony J. RuscianoAlan S. Schwartz (ex officio)

Nettie H. SeabrooksMaureen L. StapletonJane R. Thomas, Ph.D.

Manuel Valdivieso, M.D.Antoinette J. wozniak, M.D. (ex officio)

George Yoo, M.D. (ex officio)

KARmANOS CANCER CENTER BOARD OF DIRECTORS

2 FEATURES A NEW WAY FORWARD

new president & CEO poised to take Karmanos to next level

FIGHTING CANCER WITHOUT FEAR“The doctors at Karmanos are amazing.”

– Cancer survivor David Lepper

THE IMPORTANCE OF EARLY DETECTIONWDiV Local 4 meteorologist shares his success story

8 COMPASSIONATE CARE GETTING THE RIGHT DIAGNOSIS

identifying environmentally caused cancers

DRIVING FORCEpancreatic cancer survivor forms

Sky Foundation to further research and awareness

12 AT KARMANOSA PARTY IN PINK

Karmanos presents Komen Detroit race for the Cure®

UP CLOSEConnie Claybaker, B.A., MBA

Vice president of research Administration

WE ALL START SOMEWHEREMedical staff talks about first jobs

ADVANCING CANCER SCIENCEThe partners – a dedicated group of volunteers raising funds

20 AROUND TOWN

21 KROGER’S ACTS OF KINDNESSA tremendous force in the fight against cancer

CONTENTS06

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2 | HOPE

On Feb. 1, the Karmanos Cancer Institute entered a new era as it introduced Gerold Bepler, M.D., Ph.D., as its new president and chief executive officer. Dr. Bepler is a noted thoracic oncologist who was previously director of the Comprehensive Lung Cancer Center at the Moffitt Cancer Center in Tampa, Fla.

Dr. Bepler spoke with HOPE about his vision for Karmanos and the future of cancer care. He also offered a glimpse of his personal life and how he entered medicine.

Q: What attracted you to the position? Why did you want to lead Karmanos?

A: My goal has always been to lead an institution that is solely focused on cancer care. But I didn’t want it to be just anywhere – I wanted to go to a place that can make a significant impact on cancer. Karmanos is one of those places. It offers solid clinical care, it has all the elements to discover new cancer therapies and it has the tools to translate those therapies directly to patient care.

Q: What are your top priorities as the new President and CEO?

A: First, to develop the next gen-eration of cancer treatments. Second, given the uniqueness of our patient demographics, reduce cancer disparities. Third, facilitate access to top of the line cancer care, for example, by bringing the latest advances in cancer care closer to home for suburban patients at our treatment center in Farmington Hills, the Karmanos-Crittenton Cancer Center in Rochester Hills, and the Huron Valley-Sinai Hospital Charach Cancer Treatment Center in Commerce. Construction begins

soon for another cancer center in Monroe. we want to leverage these outreach initiatives to bring the next gen-eration of cancer care to patients across the region.

Q: Can you describe your current research efforts?

A: I’m focused on discovering and validating molecules useful for therapeutic decision making in patients, which is often called personalized medicine. An increasing amount of information is available about the molecular profile of tumors and we have better tools to analyze those tumors. Together, these components will ultimately lead to better up-front selection of cancer treatments for each patient; i.e., to avoid potential toxicity from less effective treatment and to achieve maximum effect of available therapies.

Q: How will Karmanos elevate its care to the next level?

A: we’ll place a priority on building team science – bringing scientists with different areas of expertise together for group research projects. This follows the

same concept as our multidisci-plinary team approach to cancer treatment, only from a research perspective. we will apply for team science grants, such as the National Cancer Institute-sponsored SPORE (Specialized Program of Research Excellence) grants, which are intended to support a strong collaboration between scientists and clinicians. These collaborations will foster research that can be translated into improved cancer diagnosis and treatment.

Q: In your view, what separates Karmanos from other hospitals in our area that also provide cancer treatment?

HOPE | FEATURE

FORWARD

GEROLD BEPLER, m.D., Ph.D.

Title: President and Chief Executive Officer

Age: 53

Birthplace: Giessen, Germany

Education: M.D., Ph.D., Philipps University School of

Medicine and Dentistry, Marburg, Germany. Postdoctoral fellowships completed at the

National Cancer Institute, Philipps University and the Duke University Medical Center.

Current residence: Bloomfield Township

Family: Wife, Tracey; children Tristan, 18,

Breiton, 12, Isabelle, 9, and Christian, 6.

Hobbies: Family activities, do-it-yourself home

repairs and projects.

Favorite composers and musicians: Beethoven, J.S. Bach, Schubert, the Red Hot

Chili Peppers, Queen, Phil Collins, Sting, and Sarah Brightman.

New President and CEO is Poised to Take Karmanos to the Next Level

A New Way

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A: Karmanos is one of only 40 National Cancer Institute-designated comprehensive cancer centers in the United States. As part of this, we offer a Phase I Clinical Trials Program [which tests newly developed cancer-fighting drugs]. Dr. Patricia LoRusso, who leads the program, has helped build it into one of the best Phase I programs in the world. Karmanos patients have access to new medications that are not available at community hospitals. we can match patients to a particular clinical trial, which is part of our personalized medicine model.

Q: What inspired you to become a doctor?

A: when I was growing up, I wanted to be a musician, not a physician. I played the piano and wound up studying at the music conservatory in Frankfurt. But I soon realized I’d never reach the level of the other students around me. I had always liked mathematics, biology and physics, so I gravitated toward medicine. One of my idols was Albert Schweitzer, a musician and theologian who became a physician (http://www.albertschweitzer.info).

Q: Why did you choose to enter oncology?

A: Oncology was intellectually stimulating. There wasn’t as much known about cancer at the time. I thought it

was an incredible challenge. Combining molecular biology with basic science and patient care is fascinating.

Q: Why did you decide to practice medicine in the United States instead of your native country?

A: The opportunities are much greater in the U.S. than in Germany. There are many top-notch universities and research facilities here. And the U.S. has always been at the forefront of cancer research.

Q: Has anyone in your family been touched by cancer?

A: Yes. My grandfather died of leukemia, and my father has leukemia. He’s doing well, and I continue to provide long-distance care to him.

Q: What message do you want to relay to Karmanos patients and their families?

A: There is hope. Newly-diagnosed patients have many different treatment options today – there are new ways to approach the disease through surgery and radiological intervention, and there are new cancer-fighting drugs. we’re making new discoveries every day, which will one day lead to the end of this disease.

GEROLD BEPLER, m.D., Ph.D

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4 | HOPE

KARmANOS PhySICIANS hELP PATIENT FACE ThE DISEASE WITh CONFIDENCE

Fighting Cancer without Fear

“People shouldn’t be afraid of cancer, because in many cases it can be successfully treated. There are great therapies available for cancer patients today. And the doctors at Karmanos are amazing.

— DAVID LEPPER

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At first, David Lepper thought the small bump just below his right ear was nothing to worry about.

“My doctor noted it during my annual physical,” says Lepper, 57, a fundraising consultant from Trenton. “It was a small, hard bump about the size of a pea. My doctor thought it was best to have a biopsy performed, and I’m sure glad I did.”

In July 2003, Lepper’s radiologist performed a biopsy and diagnosed him with parotid mucoepidermoid carcinoma, an aggressive cancer that affects the head and neck area. After receiving the diagnosis, Lepper knew exactly where he wanted to go for treatment.

“I referred myself to the Karmanos Cancer Center because I had previously worked in its Development Depart-ment,” he says. “I knew a lot about the high level of care Karmanos physicians provide. I felt very comfortable going there, knowing that I’d receive top-notch care.”

Lepper says he was especially impressed by Karmanos’ multidisciplinary team approach to patient care. Specialists from each diagnostic, treatment and supportive care discipline comprise 13 multidisciplinary teams (MDTs) to ensure that patients are properly diagnosed and receive the very best treatment. This approach is part of what makes Karmanos one of 40 National Cancer Institute-designated comprehensive cancer centers in the United States. Lepper and his wife met with representatives from Karmanos’ Head & Neck Oncology Multidisciplinary Team.

“I really appreciated the fact that Karmanos brought the team together to discuss my case,” Lepper says. “They helped me feel confident in my decision to undergo surgery.”

In August 2003, John Jacobs, M.D., professor of otolaryn-gology at Karmanos and wayne State University School of Medicine, performed a complicated five-hour procedure to remove the tumor from Lepper’s parotid gland. Doing so required great precision because of the gland’s proximity to the facial nerve.

“It’s a tricky procedure,” Dr. Jacobs says. “Typically, you create a flap of skin and elevate it off the patient’s face, then find the facial nerve. Only then do you remove the tumor.

Damage to the facial nerve can cause your mouth to droop or prevent you from closing an eye – it would appear as if you’d had a stroke. with the improvements made in chemotherapy and radiation therapy, we’ve been able to perform more conservative surgeries. In David’s case, we removed the tumor while preserving nerve function.”

Lepper’s tumor was larger than it appeared on the surface – about 1-1/2 centimeters, or the size of a cherry.

“This type of cancer is not very common,” Dr. Jacobs says. “There are roughly 40,000 new head and neck cancers diagnosed in the U.S. each year, and mucoepidermoid is just a small fraction of that number. Still, it’s regarded as a high-grade lesion. If unchecked, the tumor can continue to grow, paralyzing the face and possibly spreading to the lungs and brain. That’s why it’s critical to get an early diagnosis. with few exceptions, if the cancer is caught early enough, we have the tools to help.”

After surgery, Lepper received six months of aggressive chemotherapy and radiation therapy to destroy any remnant of the cancer. Since he worked for the wayne State University School of Medicine at the time, Lepper usually walked to his radiation appointments. Finally, in June 2004, doctors told Lepper he was cancer-free.

“I felt so great at that moment,” Lepper says. “I continue going to Karmanos for my regular checkups, and there’s been no sign of cancer for six years. I have some minor numbness in my ear, but otherwise, I feel wonderful.”

Lepper says battling cancer taught him the importance of setting fear aside and maintaining a positive attitude.

“I’ve always been a pretty positive person, and I had great confidence in the physicians at Karmanos,” he says. “People shouldn’t be afraid of cancer, because in many cases it can be successfully treated. There are great therapies available for cancer patients today. And the doctors at Karmanos are amazing. They’re hard-working people who really care about their patients.”

To learn more about cancer screening and diagnosis or to make an appointment, call 1-800-KARMANOS.

without Fear

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6 | HOPE

Twenty-one years ago, Paul Gross thought he’d be the least likely person to contract cancer.

“I worked out regularly and had a low-fat, high-fiber diet,” says Gross, meteorologist and executive producer of weather on wDIV-TV in Detroit. “I was just 27 at the time. So when I learned I had cancer, it was surprising. I went through a roller coaster of emotions.”

Gross’ urologist diagnosed him with an aggressive form of testicular cancer. And as with many cases of the disease, Gross felt no pain.

“I noticed that my left testicle was getting larger and my jeans were getting tighter in that area,” Gross says. “I didn’t even know you could get cancer there, but I knew it was important to have it checked out.”

Gross’ academic training helped him take a scientific approach to tackling his disease. He has a Bachelor of Science degree from the University of Michigan’s Department of Atmospheric, Oceanic and Space Science.

“I learned that my type of cancer cell was very responsive to the chemotherapy that was available,” he says. “I just dove into treatment and focused on solving the problem.”

In February 1989, Gross underwent surgery, and then four rounds of aggressive chemotherapy to destroy a secondary tumor located in the lymph nodes behind his left kidney. He was treated at a Detroit hospital affiliated with the Michigan Cancer Foundation, now known as the Karmanos Cancer Center.

“The chemo worked very well,” Gross says. “within two days of treatment, I could literally feel the tumor shrinking. I continued with regular checkups every six months. Finally, 11 years after the initial diagnosis, my oncologist looked over my blood work and discharged me. I was always confident that I’d beat the disease. Being discharged brought a sense of finality and created a kind of exclamation point. I could move forward with my life.”

DANGEROUS, BUT CURABLE

Compared with other cancers, testicular cancer is rare. But it is still the most common form of solid tumor cancer in American males between the ages of 15 and 34, says Ulka Vaishampayan, M.D., team leader of Karmanos’ Genitourinary Oncology Multidisciplinary Team and associate professor of internal medicine at the wayne State University School of Medicine.

“Very few patients present with testicular pain – just swelling in that area,” Dr. Vaishampayan says. “Because this type of cancer is so aggressive, it’s very important to have any testicular mass checked right away. The mass can become much larger within a month or two.”

Dr. Vaishampayan adds that testicular cancer is among the more treatable forms of cancer even in the advanced stages, but the cure rate is much better when the cancer is caught early.

“This type of tumor is very sensitive to chemotherapy and radiation therapy,” she says. “The chances of being cured drop when the disease is detected at an advanced stage. But on average, about 75 percent of patients can be completely cured. It’s essential that patients see a urologist with an expertise in oncology and seek treatment at a place that offers a multidisciplinary approach to patient care.”

A common misconception about testicular cancer is that a man cannot lead a normal life after treatment, Dr. Vaishampayan says.

“There is a chance that a man cannot have children follow-ing chemotherapy, but this is not common,” she says. “This is one cancer that is a prime example of research making a huge difference in people’s lives and these young men, if treated correctly, have a very high possibility of leading normal, productive lives. One example is the case of [cyclist] Lance Armstrong. He maintained his athletic capacity after treat-ment for testicular cancer. Men like him who are willing to speak about this disease are a source of inspiration for others.”

WDIV LocaL 4 MeteoroLogIst shares hIs story about battLIng testIcuLar cancer

Early DetectionThe ImporTance of

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hAVING AN OPEN DISCUSSION

Since beating testicular cancer, Gross, like Armstrong, has supported efforts to raise awareness about the disease. In June, Gross will be the emcee of Karmanos’ sixth-annual Survivor-ship Celebration, which honors cancer survivors and gives them the chance to rejoice in having beaten the disease.

“I’m honored to be the emcee of the event,” he says. “No one is happy that they had cancer, but I’ve found something positive to take away from the experience. If I can help inspire one person to get through their own struggle with cancer by telling my story, then I’ve done my job.”

Gross also says there’s no need for men to feel ashamed about testicular cancer or avoid the subject.

“Our society has no problem talking about breast cancer, so why should we be squeamish about discussing testicular cancer?” Gross asks. “The fact is, it’s the most common cancer to hit men in the prime of their lives. But it’s also curable when caught early enough. My message is the importance of early detection – be aware of your body and don’t be afraid to go to the doctor. If you need treatment, effective therapies exist.”

For more information about testicular self exams or to make an appointment, visit www.karmanos.org or call 1-800-KARMANOS.

KARmANOS TO hONOR CANCER SURVIVORS

As any cancer survivor will tell you, beating the disease requires great inner strength and a positive outlook. To honor survivors and their families for their amazing resiliency and fortitude, Karmanos is holding its sixth annual Survivorship Celebration on June 17 from 5:30-8 p.m. at the Silver Garden Conference Center in Southfield. WDIV Local 4’s Paul Gross will emcee the event.

“There are always months designated toward raising awareness of particular cancers, but those are national in scope and more medically focused,” says Kelly Brittain, director of Patient Community Education and Support Services at Karmanos. “The Survivorship Celebration is an uplifting occasion that allows Karmanos cancer survivors and their supporters to enjoy their triumph over the disease.” During the event, Karmanos will present the Patricia Milner Sachs Heart of a Survivor Award to a survivor who shows great compassion, commitment, spirit and courage in helping others fight cancer. The award is named after a Karmanos employee who lost her 11-year battle with melanoma in June 2006.

The Survivorship Celebration is free and tickets are not required. For more information about the event, call 1-800-KARMANOS or visit Karmanos.org.

PAUL GROSS

COmPASSIONATE CARE

8 | HOPE

Karmanos Raises Awareness of Environmentally Caused Cancers

Sometimes asking the right questions makes all the difference.That’s what Barb Van Haren of west Bloomfield discovered after spending years going from doctor to doctor trying to determine the cause of a persistent cough. Frustrated by her unresolved illness, Van Haren visited Michael Harbut, M.D., MPH, FCCP, co-director of Karmanos’ National Center for Vermiculite and Asbestos-Related Cancers, and professor of internal medicine at wayne State University School of Medicine. As an expert in the diagnosis and treatment of environmentally caused cancers, Dr. Harbut asked Van Haren questions related to possible exposure to toxins.

As it turned out, Van Haren had Stage I lung cancer, possibly caused by exposure to asbestos as a child. Through a mixture of clinical experience and knowledge of environ-mental agents, Karmanos physicians caught Van Haren’s cancer early enough to save her life. She underwent surgery to remove a nodule in her right lung in May 2007. Today she is cancer-free.

“Dr. Harbut is my guardian angel,” says Van Haren, 61. “Not many doctors have the knowledge of environmentally caused cancer. Several doctors I visited told me my illness was all in my head. But Dr. Harbut really listened to me. He was very detailed and thorough in compiling my medical history. If he wasn’t as persistent about my case, had he not asked me the right questions, I’d have lung cancer today.”

ENVIRONmENTAL FACTORS

when Van Haren first saw Dr. Harbut about her cough in early 2007, he performed tests that revealed chronic allergy and inflammation issues. He placed her on antibiotics, but also ordered a CT scan because of what he learned about her history.

“I lived in a basement apartment in Chicago until I turned six,” Van Haren says. “we had to walk through the furnace room to get to our apartment, so there’s a chance that I was exposed to asbestos. I never smoked, but my mother was a chain smoker, so I was exposed to second-hand smoke through age 18.”

An initial CT scan showed a nodule on Van Haren’s right lung and doctors placed her on more antibiotics. when a subsequent CT scan showed the nodule had grown, Karmanos’ Thoracic Oncology Multidisciplinary Team reviewed her case and recommended surgery. After a biopsy showed that the nodule was cancer, Karmanos surgeons removed the lower lobe in her right lung.

“Technically, I’ve been cancer-free since that surgery,” Van Haren says. “Because it was caught so early, I didn’t have to do chemo or radiation therapy. I was overwhelmed with joy when I learned the cancer was gone.”

RAISING ThE STANDARD OF CARE

“Mrs. Van Haren’s case is a great example of the inter-section of various disciplines that should be part of 21st century health care,” Dr. Harbut says. “we not only applied basic clinical science, but also epidemiology, enhanced radiographic techniques and tenacity. we didn’t dismiss her case – instead we kept looking to find the cause of her symptoms. Her remote exposure to asbestos and CT scans raised the likelihood of her having cancer. And as the biopsy showed, it was.”

To help more physicians learn how to identify cancers caused by environmental exposures in their earliest stages or before they begin, in January Dr. Harbut created and launched Karmanos’ Environmental Cancer Initiative, in partnership with Blue Cross Blue Shield of Michigan and the U.S. Centers for Disease Control’s Agency for Toxic Substances and Disease Registry.

According to Dr. Harbut, asbestos and cigarette exposures individually confer a five- to 10-fold increased risk of lung cancer, but exposure to both increases that number to a 54- to 90-fold increased risk.

“Michigan has a higher rate of lung cancer than other states, and recent data suggests that more than 30 percent of lung cancers are caused by environmental agents after controlling for smoking,” Dr. Harbut says.

GETTING ThERight Diagnosis

“The three major environ-mental agents that contribute to this are asbestos in products like insulation, arsenic in drinking water and radon gas that can seep through basement walls. we want to elevate the standard of care pertaining to the diagnosis and treatment of patients with exposure to these toxins.”

The Environmental Cancer Initiative consists of four, hour-long online courses that give physicians the diagnostic tools to iden-tify patients at risk before symptoms become appar-ent. There is no charge to enroll and Blue Cross compensates physicians for their time with an incentive payment upon completion of the course. The program is the first of its kind in the country.

“Environmental cancers can be very aggressive,” Dr. Harbut says. “That’s why early detection is imperative. Patients should not dismiss unexplained symptoms that may be associated with certain environmental cancer-causing agents. when in doubt, check it out.”

Van Haren concurs with Dr. Harbut’s advice.

“Don’t ignore symptoms like a persistent cough – get it diagnosed early,” she says. “I’m very fortunate to be in the care of Karmanos doctors,” she says. “Not only are they among the best in the country, they take the time to listen to me and provide top-notch care.”

For more information on the Environmental Cancer Initiative, visit www.karmanos.org and click on the “Education” tab.

COmPASSIONATE CARE

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BARB VAN hAREN

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COmPASSIONATE CARE

CANCER SURVIVOR SUPPORTS RESEARCH

FOR EARLy PANCREATIC CANCER TEST

According to the National Cancer Institute, more than 42,000 people will be diagnosed with pancreatic cancer this year and more than 35,000 patients will die from the disease. Pancreatic cancer and its mortality rates have changed little in the past three decades – the five-year survival rate is just five percent.

This cancer is particularly deadly because its symptoms are initially subtle and often attributed to other ailments. Because the pancreas is located in the center of the abdomen deep inside the body, it’s often difficult to identify the disease at an early stage. In many cases, by the time the disease is correctly diagnosed, the cancer has spread to the patient’s lymph nodes, liver or lungs, significantly reducing the chance for a cure.

As with all cancers, getting an early diagnosis is critical. And researchers at the Karmanos Cancer Institute, the wayne State University School of Medicine and Henry Ford Health System are working together to develop a new blood test that will help detect pancreatic cancer at an early stage.

Sheila Sky Kasselman, a tenacious pancreatic cancer survivor from west Bloomfield, is a driving force behind the research. As she recovered from cancer surgery in 2008, she began raising the funds necessary to launch the project.

ShEILA SKy KASSELmAN

FORCEDriving

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COmPASSIONATE CARE

TRUE TO hER PROmISE

Kasselman had dealt with various ailments for about a year before doctors determined their true cause. Fortunately, her disease was diagnosed at Stage 1 – early enough for successful treatment.

“I had lost 12 pounds in a month, and I normally weigh about 110,” says Kasselman, 69, a retired financial planner. “Then I developed diabetes and became jaundiced. A CT scan in October 2007 revealed a tumor at the head of my pancreas.”

Kasselman underwent simultaneous chemotherapy and radiation therapy for six weeks to shrink the tumor. In January 2008, surgeons removed the tumor in a 10-hour procedure that impacted her pancreas, small intestine, bile duct and stomach.

“I was told that it was a very involved, high-risk surgery,” Kasselman says. “But I remained mentally strong. In my diary I wrote, ‘I’m not going to die. I have way too much to accomplish.’ I made a promise to myself and my family that I would do everything I could to challenge this disease.”

Kasselman has remained true to her promise. while recovering from surgery, she formed the Sky Foundation to help increase awareness of pancreatic cancer and raise funds to help researchers find better ways of diagnosing the disease. Through her Henry Ford Hospital gastro-enterologist, Ann Silverman, M.D., Kasselman learned about the research underway at Karmanos.

EARLy STAGE BIOmARKERS

Michael Tainsky, Ph.D., leader of Karmanos’ Molecular Biology and Genetics Program and professor in the Department of Pathology at the wayne State University School of Medicine, had spent seven years researching diagnostic biomarkers for ovarian cancer. Inspired by Kasselman’s enthusiasm and drive to help pancreatic cancer patients, Dr. Tainsky and his team began working with Dr. Silverman on developing an early detection blood test.

“we’re using the same approach we applied when researching ovarian cancer biomarkers,” says Research Associate Steve Dudas, Ph.D., a member of Dr. Tainsky’s research team. “we’re collecting serum samples from a number of bio-repositories and through the National Cancer Institute’s Early Detection Research Network. we basically look for profiles of cancer-associated auto-antibodies in the blood that would be indicative of a malignancy in the pancreas. Identifying these auto-antibodies as cancer biomarkers will help us develop an advanced screening blood test.”

Dr. Dudas says the Sky Foundation was instrumental in launching the project.

“we’ve worked with the foundation almost since its inception to raise the funds needed to begin the discovery phase of our research,” he says. “It takes time and money to launch a study of this magnitude. we’re optimistic that we’ll carry our work forward to the point where we can apply for additional funding from the National Institutes of Health.”

Thus far, the Sky Foundation has raised about $165,000 and continues to advance toward its initial $500,000 fundraising goal. The foundation has become a labor of love for Kasselman.

“I’m very fortunate to be one of the few people who survive the disease,” she says. The foundation is my way of giving back – we want to supply hope for patients, as well as solid scientific data. we have tremendous faith in the research team and their collaborative efforts to develop a diagnostic tool that will save lives.”

To get involved or to make a contribution, call the Sky Foundation at 248-978-9845 or the Karmanos Cancer Institute at 313-576-8119. You can also visit skyfoundationinc.org. For more information about cancer services, call 1-800-KARMANOS or visit Karmanos.org.

STEVE DUDAS, PH.D.Photo by Brad Kasselman

AT KARmANOS

12 | HOPE

Woodward Avenue in Midtown Detroit is never more beautiful than the day it’s decked out for the Susan G. Komen Detroit Race for the Cure®. About 30,000 people descend upon Comerica Park each year to increase breast cancer awareness, celebrate survivorship and raise much-needed funds to support local breast cancer education, screening programs and cancer research. This year’s race, scheduled for Saturday, May 22, will be the 19th annual event.

“The Komen Detroit Race for the Cure is a big Detroit party for the entire family,” says Maureen Keenan Meldrum, race chair and director of Breast Cancer Special Programs at the Karmanos Cancer Institute. “Our job is to keep it fresh and wonderful. we promise the same mix of traditions that people have come to love about our race, as well as some cool new surprises.”

Despite the tough economy, last year’s event raised just over $2 million. Each year, 75 percent of the proceeds remain within the local community for breast cancer

screening and treatment programs for medically underserved populations. The remaining funds support breast cancer research grants for projects across the globe, including work underway at Karmanos.

The theme of the 2010 race is “The Power of 10.” Organizers are encouraging race participants to increase their involvement with actions like asking 10 more people to make a donation or telling 10 more women about the importance of mammograms.

in PinkA PARTY

KARMANOS CANCER CENTER MAMMOGRAPHY SCREENING GUIDELINES

Last November, the United States Preventative Services Task Force issued new breast cancer screening guidelines that were met with some controversy. Karmanos Cancer Center breast cancer specialists are not adopting these new guidelines. Karmanos recommends that:

1. Beginning at age 40, women should speak to their doctors about mammography to understand the potential benefits and risks, and determine what is best for them. Though mammography is not perfect, it

remains the best tool for physicians to detect a tumor that is too small to be felt.

2. Continue with self-breast exams. Women need to be familiar with their bodies and immediately contact their physician if they detect a lump or other abnormality.

3. Discussions about the new guidelines do not apply to women who are considered to be of high risk for breast cancer. This includes, but is not limited to:

• Anyone with a strong family history of breast cancer. • Women with a history of breast cancer. • Women who detect a lump in their breast.

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in Pink May 22 Marks the 19th Annual Komen Detroit Race for the Cure®

“At first, I went to the event to support my mom. But I also found that going helps build you up – and you need a lot of support when you face cancer.

— SHERRY THROWER

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As with all cancers, early detection is the key. And one of the most valuable tools for an early breast cancer diagnosis is a mammogram.

“Early diagnosis not only results in a lower death rate, but also more treatment options,” says Sharon Helmer, M.D., clinical service chief of the Karmanos Cancer Center Imaging Department and medical director of Breast Imaging. “It opens up the possibility of conservative therapy for breast conservation. It also gives patients more treatment options in terms of chemotherapy and radiation therapy.”

Dr. Helmer emphasizes that mammograms aren’t perfect and can sometimes show a false positive or miss cancers that are present, but it’s still the best method available for detecting the disease. “It is very important for women to have annual mammograms beginning at age 40,” she says.

“Until the early 1990s, little progress had been made in decreasing breast cancer mortality,” Dr. Helmer adds. “But since the development of mammography, the breast cancer death rate has declined by 30 percent. It’s been extremely successful.”

For further information about mammography screenings, visit karmanos.org or call 1-800-KARMANOS.

“Everyone knows someone who has been touched by breast cancer,” Meldrum says. “As a breast cancer survivor myself, I know how comforting it is to become involved with the race. The biggest thing participants take away from the event is tremendous optimism from seeing so many pink shirts and happy cancer survivors.”

One of those survivors is Sherry Thrower of Detroit. Doctors diagnosed her with breast cancer in 2007 after a routine mammogram.

“My mother is a three-time cancer survivor, so I understand the importance of regular mammograms,” says Thrower, 43. “She was treated at Karmanos, so I was very comfortable seeing them for a second opinion. They concurred with the first diagnosis, and I had chemotherapy, a mastectomy and radiation therapy in 2008. Now, I’m

cancer-free. I had an awesome team of doctors and they were always positive. I’d recommend them for their expertise and attitude.”

Thrower has attended the last three Komen Detroit Race for the Cure events with her mother.

“At first, I went to the event to support my mom. But I also found that going helps build you up – and you need a lot of support when you face cancer. I heard many wonderful stories about survivorship at the race. It’s a very uplifting, positive event.”

For Early Detection,GET A MAMMOGRAM

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WhAT:

The 19th Annual Susan G. Komen Detroit Race for the Cure®

5K Run/Walk and 1-Mile Walklocally presented by the Karmanos Cancer Institute.

WhEN: Saturday, May 22, 7-11:30 a.m. Street closures will begin at 7 a.m. Opening Ceremony 8 a.m.Race and walk 9 a.m.Closing Ceremony 10:30 a.m.

WhERE: Comerica Park, Detroit.

Why: To help save lives and end breast cancer forever.

FOR mORE INFORmATION: karmanos.org/detroitraceforthecure

RACE INFO

AT KARmANOS

Throughout her career spanning 30+ years, Connie Claybaker has worn a lot of hats. From catalog distribu-tion center accountant to restaurant owner to her current role as vice president of Research Administration at the Karmanos Cancer Institute, she’s put many different skills to work. But through all her career moves, the common thread is strong leadership.

“I love developing business processes, handling complex projects and leading people,” says Claybaker, who joined Karmanos in 2003 and assumed her current position last June. “I’m a people-oriented person who thrives in environ-ments that support independent thinking and collaboration.”

Claybaker’s department helps Karmanos obtain federal, state, and corporate funding for its research activities, in-cluding clinical trials. The department manages hundreds of grant proposals and contracts at any one time and provides administrative support services for the competitive Cancer Center Support Grant. This grant is key to Karmanos’ des-ignation as a comprehensive cancer center by the National Cancer Institute. Karmanos is one of just 40 such centers in the United States.

“Of those 40 comprehensive cancer centers, only a dozen or so are stand alone, independent hospitals,” Claybaker says. “Karmanos is one of those and we only treat cancer. That’s an important distinction, because Karmanos patients know that no matter who they encounter here, that person gives their undivided attention to curing cancer. Embedded within that is my job – taking the administrative burden off our cancer researchers so they can do what they do best.”

Claybaker launched her career in the mid-1970s as a staff accountant at the J.C. Penney Distribution Center in Colum-bus, Ohio. From there, she held accounting and management positions at various companies before opening a health food restaurant, the Hip Pocket Deli, in Columbus.

“Running a restaurant was very physical work,” Claybaker says. “Things like tofu and pickles came in these enormous tubs that you had to carry. It was physically exhausting work.”

After about two years in the restaurant business, Claybaker joined Riverside Methodist Hospitals in Columbus to manage its accounts payable and payroll department. After advancing to director of Medical Staff Administra-tion, she knew that working in health care was her true calling. She moved to Michigan in 1999 and joined Karmanos after managing financial and grant activities at other health care organizations.

“when you enter health care, it becomes a passion,” Claybaker says. “I’ve never touched a patient or administered a drug, but I don’t feel as though I haven’t made a contribution. Research is much more than just a mission statement at Karmanos. Everyone here is very passionate about what they do and many people wear it on their sleeves. That’s infectious. I’m proud of this organization because it clearly gives itself to patients for unselfish reasons. It’s clear to me that our work will one day help someone’s parent or grandparent or loved one beat this disease.”

TITLE: Vice President of Research Administration

BIRTHPLACE: Coshocton, Ohio

EDUCATION: B.A., Accounting and Management (Cum Laude); MBA, Capital University, Columbus, Ohio.

HOME: West Bloomfield

HOBBIES: Golf, reading, going to the movies and playing with her dog, Buster. “I just began reading Barbara Kingsolver’s new novel, ‘The Lacuna.’ A perfect weekend for me is sleeping in, watching a movie and having dinner with friends.”[B

IO] CONNIE CLAyBAKER, B.A., mBA

Connie Claybaker (center) with staff members Valerie wade and Evano Piasentin in the Leonard N. Simons Cancer Research Library located in Karmanos’ Prentis Cancer Research Center.

Photo by Gregg W. Hettel

Up Close: CONNIE CLAyBAKER, B.A., mBA

sharon heLMer, M.D. Clinical Service Chief, Imaging Department, Medical Director of Karmanos Breast Imaging

“I got my first job at age 16 as a waitress at the Deer Run Golf Club in Horton, Michigan. Not only did I take the golfers’ orders in the clubhouse, I also prepared the food in the kitchen and then had to serve and clear the table. I could make incredible fried onion rings…a skill I often regretted. That job was my first taste of dealing with the public. I learned a lot that summer about working with people from different backgrounds and with different expectations. I’ve carried many of those lessons with me – particularly about treating everyone equally and with respect no matter how they treat you.”

ho-sheng LIn, M.D., FacsLeader, Head & Neck Oncology Multidisciplinary Team

“when I was 16, I worked as a technician in a microbiology laboratory in Ocala, Florida. This was my dream job because I got to work in a medically related field and the job sounded cooler than working in a supermarket or fast food restaurant. However, the job wasn’t very glamorous. Most of the time, I was washing test tubes and bottles filled with germs. I don’t think they had very good OSHA (Occupational Safety and Health Administration) regulations back then. However, I did learn some microbiological techniques and some cool bug names, such as ‘streptococcus.’”

LIsa Zajac, Msn, aPrn-bc, ocnInformatics Nursing Specialist

“I got my first job at the Dearborn Toys “ ” Us when I was 17. I started as a “Geoffrey’s Helper” (helping shoppers on the sales floor), but also worked as a cashier and stocking shelves. I loved helping a grandparent find a gift for their grandchild during the holiday season. I also enjoyed working until 2 a.m. straightening the shelves for the next day. One night we had to re-shelve 140 carts of merchandise that customers left in the wrong spot. This job really prepared me to be a nurse. I not only learned about providing excellent customer service, but, at times, I worked days, afternoons and midnights, just as I’ve done at Karmanos through the years.”

MIchaeL sIMon, M.D., MPhMedical Oncologist

“In the summer after my senior year of high school, I worked evenings and some weekends at a Baskin-Robbins ice cream store in the Chicago neighborhood where I grew up. During the day, I was a day camp counselor at the Henry Hart Jewish Community Center. I loved being outside and working with kindergarten-age children. we often took them to a large park on Chicago’s north side for various activities. I enjoyed the ice cream shop because friends and family came regularly for ice cream. Making the various sodas was fun – eventually I learned how to make some of the more complicated orders.”

KARMANOS MEDICAL STAFF SHARE STORIES ABOUT THEIR FIRST JOBS

WE ALL STARTSomewhere

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Photo by Gregg W

. Hettel

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Every day, Karmanos Cancer Institute scientists and clinicians break new ground in their search for better cancer detection and treatment methods. Because there’s a tremendous cost in terms of equipment and staffing, funding from sources outside Karmanos is essential for launching and maintaining these exciting research initiatives. And that’s where fundraising groups like Partners come in.

Partners is a dynamic group of volunteers, ages 25 to 50, who are dedicated to making an impact in the fight against cancer. Philanthropists Anna and Harry Korman created Partners in 1994 in honor of their late daughter, Suzanne, who died of cancer at age 36. They established a research fund with the hope of finding better treatments and earlier detection methods for cancer patients. Since the group’s formation, it has raised more than $5.6 million for Karmanos through fundraising events and individual donations.

One initiative Partners has supported with $750,000 in donations over the past five years is Karmanos’ National Oncogenomics and Molecular Imaging Center (NOMIC). Directed by Principal Investigator Stephen Ethier, Ph.D., NOMIC is engaged in developing technology that will help physicians better diagnose cancer by defining gene mutations that characterize cancers in individual patients. This research will one day allow physicians to create highly customized treatment therapies based on the specific gene mutations identified in a patient.

“we knew we’d have to make a significant investment in NOMIC in order to meet our research goals,” Dr. Ethier says. “Partners has been instrumental in helping us launch the program. Through their generous donations, we’ve been able to purchase state-of-the-art equipment and attract cutting-edge researchers. NOMIC simply wouldn’t exist without their support.”

Partners funding has also helped NOMIC secure more than $14 million in grants from the U.S. Army Medical Research and Materiel Command.

“In order to secure federal funding for research, you have to prove that your project will generate results,” Dr. Ethier says. “we don’t just spend funds from groups like Partners, we try to leverage it to obtain more funding. Having the lab up and running allowed us to obtain federal grants.

“The bottom line is, financial assistance from Partners doesn’t just support cool science – it helps us take care of patients in ways never before possible. Our goal is to make sure we’re bringing the best technology to cancer patients.”

Beyond NOMIC, according to Dr. Ethier, Partners funds have purchased vital research equipment that ensures cutting-edge research continues in the research labs, and ensures that Karmanos’ shared resource laboratories always have state-of-the-art equipment, which is essential to a strong cancer center. This ultimately benefits the nearly 6,000 new patients who come to Karmanos annually for

ADVANCINGAT KARmANOS

Partners Vigorously Supports Karmanos ResearchersCancer Science

From left: Ramsi Haddad, Ph.D., director, Laboratory of Translational Oncogenomics; Raj Atikukke, post-doctoral fellow, and Irene Broner, lab manager. Photo by Gregg W. Hettel

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PARTNERS GOLF OUTINGmonday, August 30Franklin Hills Country Club

Nearly 200 golfers participate in a competitive scramble. For their generous contributions, guests enjoy a great day of golf, food, drink and prizes.

PARTNERS NIGhTSaturday, September 11Detroit Institute of Arts

Partners Night is the group’s signature event. It includes an incredible silent auction, a raffle, fine strolling savory fare, and live entertainment and dancing.

UPCOmING PARTNERS EVENTS

treatment. As it looks to the future, Partners plans to raise funds for a laboratory to investigate lung cancer.

“I find it personally rewarding to be part of a group of young, enthusiastic people dedicated to raising money for cancer research,” says Dan Cornwell, executive co-chair of Partners and financial planning consultant. “It’s worthwhile for me to be part of this group considering cancer has impacted my family and many of my clients.

“The staff at the Karmanos Cancer Institute has always been generous with time and resources. Partners members are gratified to know that our efforts make a real difference to those on the front lines of cancer research. Supporting Karmanos scientists aligns with our group’s goal of one day bringing cancer under complete control.”

J.J. Modell, who shares the executive co-chair position with Cornwell, has been a member of the organization for about 10 years and has seen the change that comes about from the Partners’ efforts.

“During my time with the Partners organization, I have seen firsthand the wonderful and tremendous progress that has been made in the fight against cancer,” Modell said. “Partners members are pleased to know they are helping bring hope to Karmanos’ patients.”

To learn how to become a member of Partners, call (313) 576-8107 or e-mail partners@karmanos.org.

For more information on these events, contact the Partners at (313) 576-8107 or partners@karmanos.org.

Photo by Gregg W. Hettel

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AROUND townFUND-RAISING EVENTS

MAy

hORSEmEN’S PARADISE TRAIL RIDESaturday, May 159 a.m. – 2 p.m.

Belle Isle

NORTh BROThERS FORD & ThE CITy OF WESTLAND 12Th ANNUAL

5K FUN RUN/WALKSaturday, May 15

8 – 11 a.m.Bailey Recreation Center 36651 Ford Rd, Westland

ThE $500,000 ODySSEy 2-BALL PUTT ChALLENGE PRESENTED

By CARL’S GOLFLANDSaturday, May 15

10:30 a.m. – 2:30 p.m.Carl’s Golfland

1976 S. Telegraph Rd., Bloomfield Hills

2ND ANNUAL KEN WOOD mEmORIAL GOLF OUTING

Saturday, May 15Noon – 5 p.m.

Pheasant Run Golf Course1150 S. Canton Center Road, Canton

ARTUNES ON ThE mOUNTAINSaturday, May 2211 a.m. – 10 p.m.

Bald Mountain State Recreation Area 1330 East Greenshield Road, Lake Orion

JUNE

Noodles & Company Benefit NightThursday, June 3

4 – 9 p.m.Noodles & Company #8007

470 S. Main Street, Royal Oak

hANK GREENBERG mEmORIAL GOLF INVITATIONAL

Monday, June 21Oakland Hills Country Club

3951 W. Maple Road, Bloomfield Hills

2010 SOLSTICE RUNSaturday, June 267 a.m. – Noon

Downtown Northville

JULy

INTERNATIONAL DRAGON BOATS FESTIVAL

Friday, July 9 – Sunday, July 11Windsor, ON

SKIN IIISaturday, July 24

Location to be determined

ThREE ShOTS AGAINST CANCERSaturday, July 24

8 a.m. Wyandotte Shores Golf Course 3625 Biddle Avenue, Wyandotte

RyAN O’DONNELL GOLF OUTINGSaturday, July 24

Sycamore Hills Golf Club 48787 North Avenue, Macomb

TORCh LAKES CLASSICS RENDEzVOUS Saturday, July 24

Torch Lake in Bellaire

AUGUST

6Th ANNUAL TAmmy z GOLF OUTINGSaturday, August 7

Mystic Creek, One Champions Circle, Milford

PUmmILL CANCER GOLF CLASSIC Saturday, August 14

The Links at Whitmore Lake 1111 6 Mile Rd, Whitmore Lake

BAPS ChARITIES ANNUAL WALKAThONAugust 21

8 a.m. 1150 Canton Center Road South, Canton

10Th ANNUAL KENNETh J. SCOTT mEmORIAL GOLF OUTING

Sunday, August 22Fox Hills Golf & Banquet Center

8768 North Territorial Road, Plymouth

hERO FOUNDATION GOLF OUTINGSaturday, August 2811:30 a.m. – 5 p.m.

Twin Lakes Golf & Swim Club in Oakland Township 455 Twin Lakes Drive, Oakland Township

PARTNERS GOLFMonday, August 30

Franklin Hills Country Club 31675 Inkster Road, Franklin

As a community partner, the Kroger Company is a tremendous force in the fight against cancer.

Over the past four years, Kroger’s Michigan Division has made a strong commitment to supporting cancer research and patients at the Karmanos Cancer Institute and American Cancer Society. Each year, Kroger’s combined in-store promotions raise about $150,000 for Karmanos. The funds primarily support ovarian and breast cancer research.

“Kroger’s primary customers are women between the ages of 25 and 54, and cancer is one of their biggest health concerns,” says Dale Hollandsworth of Kroger Consumer Communications. “we have an obligation to support initiatives that address those concerns. we welcome the opportunity to team with a world-class organization like the Karmanos Cancer Institute to improve treatments for breast and ovarian cancer and even find a cure for these life-threatening diseases.”

In 2006, Kroger launched its Teal Ribbon campaign at its stores to support the Gail Purtan Ovarian Cancer Research Fund at Karmanos. Three years ago, Kroger began raising funds for breast cancer research through coin box donations at checkout lines, the sale of special “Recipes for Hope” cookbooks and other promotions.

“Kroger is committed to funding research to help find a cure for cancer and the Karmanos Cancer Institute and the American Cancer Society are uniquely suited to lead this effort,” says Rick Going, president of Kroger’s Michigan Division. “we’re thrilled to partner with the Karmanos Cancer Institute and the American Cancer Society and hope our donations, through the generous support from our partners, customers and associates, will have even more impact on cancer research initiatives.”

Kroger associates also showed their appreciation for Karmanos patients last August when they sent a basket of Kroger bakery cookies to the Phase I clinical trial unit. Patients in this unit are enrolled in research studies that

evaluate new cancer-fighting drugs. Kroger plans to continue providing treats for Phase I patients in the coming months.

“we are grateful for the extraordinary support of Kroger and its customers,” says Nick Karmanos, vice president of Development for Karmanos. “Kroger’s continued generosity to provide resources for cancer research and education is an exceptional example of corporate partnership and their commitment to this community.”

One in eight women will be diagnosed with breast cancer. A woman’s risk of getting ovarian cancer in her lifetime is about one in 67. Early detection is critical to saving lives and research is a vital component in finding better ways to diagnose and treat the disease.

If your organization is interested in partnering with the Karmanos Cancer Institute, call 313-576-8111.

ONGOING DONATIONS FUND CANCER RESEARCH AT KARMANOS

KROGER’S

Acts of Kindness

NONPROFIT ORGU.S. POSTAGE

PAIDDETROIT, MI

PERMIT NO. 1579Email: hope@karmanos.org

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

MARY ANN SHORT Vice President,

Marketing and Communications

LINDA H. REMINGTON EditorDirector,

Marketing and Communications

Associate Editors:

PATRICIA A. ELLISMedia Relations Manager

ELIzABETH KATzExternal Marketing and Communications Associate

CHRISTINE PARKERInternal Marketing and Communications Associate

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Photos by Stephen Lengnick, Plum Street Studio

Copyright 2010 Barbara Ann Karmanos Cancer Institute

A diagnosis of cancer makes most people think of what they can’t do. But to us, the most important part of the word canceris can. It’s confident. It inspires. And it’s driven us to become oneof the nation’s leaders in cancer treatments. If you’re fightingcancer, you need expertise. Ask your doctor for a referral or youcan call 1-800-Karmanos or visit www.karmanos.org.

Hear cancer. Think Karmanos.

Cancersmilelaughsingplayrunfightwinlive

4817 KAR ALA AD 3/29/07 1:10 PM Page 1

Karmanos.org1-800-KARMANOS

Mail Code: NCO6MC

4100 JOHN R DETROIT, MI 48201

The Karmanos-Crittenton Cancer Center recently celebrated its grand opening with a ribbon-cutting ceremony. The new 30,000-square-foot facility brings state-of-the-art cancer care to patients in Rochester Hills and the surrounding communities. Photos by David Dalton

Steve Stolaruk, who donated the land for this facility, Gerold Bepler, M.D., Ph.D., president & CEO, Karmanos Cancer Institute; and Lynn Orfgen, president & CEO, Crittenton Hospital Medical Center, cut the ribbon.

The Karmanos-Crittenton Cancer CenterGrand Opening

“Ford Corporate Flowers” by Chris McCauley - A guest admires artwork at the cancer center provided by local artists from Oakland University and Paint Creek Center for the Arts.

Interior photo of bldg: Photography by Beth Singer Photographer, Inc.