Solutions for CRRT Comparisons March 2009

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NxStage prepackaged fluids for acute renal care

NxStage provides a full range of easy-to-use, convenient and economical sterile dialysate fluids that

simplify the delivery of intensive care dialysis. NxStage PureFlow™ prepackaged solutions offer

significant advantages:

They are available with bicarbonate or lactate buffers, giving you treatment options.

NxStage PureFlow Solutions ensure fluid quality, with potential clinical benefits. They meet

or exceed AAMI, USP, and European Pharmacopoeia standards. Products are terminally sterilized

and pyrogen-free (< 0.25 EU/mL).

They eliminate the need to install large, complex water purification systems.

They allow for simple dosing and usage, reducing workload on busy ICU staff.

• Convenient 5-liter bags minimize interventions.

Your choice of solution buffer:

Bicarbonate—The body’s natural buffer; may be suitable for patients

with lactic acidosis and/or liver failure. The two-compartment bag with

unique peel-seam interface simplifies preparation and mixing.

Lactate—Simplest, most economical solution; no mixing required.

Effectiveness for most patients is well-supported in clinical literature.

NxStage PureFlow Solutions for use in acute hemodialysis with the

NxStage System One include:

Lactate Buffer Bicarbonate BufferConstituent(mEq/L)

RFP-204 RFP-205 RFP-207 RFP-400 RFP-401 RFP-402 RFP-453 RFP-454

Lactate 40 35 45 0 0 0 0 0

Bicarbonate 0 0 0 35 35 35 25 25

Potassium 1 3 1 2 4 0 2 4

Sodium 140 140 140 140 140 140 130 130

Calcium 3 3 3 3 3 3 0 0

Magnesium 1 1 1 1 1 1 1.5 1.5

Chloride 105 112 100 111 113 109 108.5 110.5

Glucose(mg/dL)

100 100 100 100 100 100 100 100

NxStage PureFlow Solutions are indicated for use with renal replacement systems that utilize sterile

premixed dialysate. They are not indicated for direct infusion.

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FLEXIBLE • SAFE • PROTOCOL NEUTRAL

Normocarb HF is a pharmaceutical-grade,clinically-tested, FDA approved, protocol-neutral

hemofiltration solution for CRRT.

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NORMOCARB HF™ Formulation

NORMOCARB HF™ is a clear, sterile, nonpyrogenic, electrolyte concentrate used in Continuous Renal

Replacement Therapy (CRRT) as a replacement solution in hemofiltration or hemodiafiltration.

Composition

Undiluted NORMOCARB HF™ 25 contains 90.73 g/L sodium chloride (NaCl), 2.06 g/L magnesium

chloride hexahydrate (MgCl2•6H2O) and 28.35 g/L sodium bicarbonate (NaHCO3) in water for injection.

Undiluted NORMOCARB HF™ 35 contains 82.84 g/L sodium chloride (NaCl), 2.06 g/L magnesium

chloride hexahydrate (MgCl2•6H2O) and 39.70 g/L sodium bicarbonate (NaHCO3) in water for injection.

Diluted NORMOCARB HF™ 25 or NORMOCARB HF™ 35 solutions when prepared as directed, contain

the following:

Quote

"Normocarb HF

from the

pharmacy

eliminates

concerns I have

about bedside

preparation and

solution

selection. In our

critical-care

environment, we

need to put

maximum focus

on patient care,

and on

eliminating

errors.

Normocarb HF

provides me with

a safe, flexible

solution that I know I can trust."

Copyright © 2007 Dialysis Solutions Inc. | All Rights Reserved

NC 25 HF NC 35 HF

mEq/L mEq/L

SODIUM (Na) 140.0 140.0

MAGNESIUM (Mg) 1.5 1.5

CHLORIDE (Cl) 116.5 106.5

BICARBONATE (HCO3) 25.0 35.0

POTASSIUM (K) 0 0

CALCIUM (Ca) 0 0

pH 8.55 +/- 0.25 8.55 +/- 0.25

PrismaSate® DialysateEasy-to-use dialysate formulas specifically designed for critical care.

PrismaSate® dialysate offers six formulas specifically designed forContinuous Renal Replacement Therapy (CRRT). These dialysateformulas save time and expense and provide unmatched prescriptionflexibility. PrismaSate features:

• Sterile, bicarbonate-based solution better controls andcorrects acidosis

• Each 5-liter, two-compartment bag contains electrolytes andbicarbonate in easy-to-mix solutions that reduce pharmancy laborand the potential for human error

• No additional syringes, lines or sterile water needed

• Enables fast and easy bedside preparation and reduced bagchanges

• Includes bar code label to verify that the right formula isbeing administered to the right patient

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PrismaSol Replacement SolutionWe've done the compounding so you don't have to.

PrismaSol replacement solutions, like PrismaSate® dialysate, is commerciallyproduced. This feature, when compared with manual compounding and othersolutions that require mixing, assists in the reduction of the complexity and the riskof error.

• Sterile bag enables fluid to remain stable for 24 hours after the protectiveover-wrap is removed and has a 12-month shelf life, ensuring cost-effectivenessand easy storage

• Pre-mixed 5-liter bag reduces bag changes and eliminates the need forcompounding

• Fast and easy bedside preparation, read-to-mix within the confines of a 2-compartment, 5-liter bag

• Provides both options of a spike port and luer lock port for connecting thereplacement fluid line

PrismaSolSterile Hemofiltration and Hemodiafiltration solution

PrismaSol solution is a clear, sterile solution free of bacterial endotoxins. This solution is used in Continuous RenalReplacement Therapies (CRRT) as a replacement solution in hemofiltration and hemodiafiltration.

It contains no bacteriostatic or antimicrobial agents.

PrismaSol is packaged in a two-compartment bag. The small compartment A contains electrolytes and the largecompartment B contains buffer. The final reconstituted solution (5000 mL) is obtained after breaking the red frangible pinbetween compartments A and B and mixing both solutions. The compositions of the solution before and after reconstitutionare described in the following tables.

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• SUPPORT CENTER• PRODUCTS• PATIENT RESOURCES

PrismaSol Replacement SolutionWe've done the compounding so you don't have to.

PrismaSol replacement solutions, like PrismaSate® dialysate, is commerciallyproduced. This feature, when compared with manual compounding and othersolutions that require mixing, assists in the reduction of the complexity and the riskof error.

• Sterile bag enables fluid to remain stable for 24 hours after the protectiveover-wrap is removed and has a 12-month shelf life, ensuring cost-effectivenessand easy storage

• Pre-mixed 5-liter bag reduces bag changes and eliminates the need forcompounding

• Fast and easy bedside preparation, read-to-mix within the confines of a 2-compartment, 5-liter bag

• Provides both options of a spike port and luer lock port for connecting thereplacement fluid line

PrismaSolSterile Hemofiltration and Hemodiafiltration solution

PrismaSol solution is a clear, sterile solution free of bacterial endotoxins. This solution is used in Continuous RenalReplacement Therapies (CRRT) as a replacement solution in hemofiltration and hemodiafiltration.

It contains no bacteriostatic or antimicrobial agents.

PrismaSol is packaged in a two-compartment bag. The small compartment A contains electrolytes and the largecompartment B contains buffer. The final reconstituted solution (5000 mL) is obtained after breaking the red frangible pinbetween compartments A and B and mixing both solutions. The compositions of the solution before and after reconstitutionare described in the following tables.

Legal Notice »

© Copyright Gambro Lundia AB, 2007

• Home

• Products

• Intensive Care Products

• Solutions

• PrismaSol Replacement Solution

• SUPPORT CENTER• PRODUCTS• PATIENT RESOURCES• CAREERS • NEWS • CONTACT US

PRODUCTS

• In-Center Hemodialysis Products• Intensive Care Products

o Solutions PrismaSate® Dialysate PrismaSol Replacement Solution

o Prismaflex® Systemo Prisma® Systemo Other productso FAQ Intensive Care Productso Intensive Care Product Catalog

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Search