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JKK v7-2019
The Sodium Potassium Pump (Na+/K+ ATPase)
An Example of Active Transport using a Carrier Protein Let’s work the pump
Use the ATP models and the Sodium Potassium pump pieces. • Place the sodium potassium pump in the membrane. • Open toward the inside of the cell to start. • Have sodium model pieces inside the cell, and potassium pieces outside the cell. • Use the script:
1. Cytoplasmic sodium ions (Na+) bind because they have a high affinity (“liking for”) for the carrier protein in this form.
2. Na+ binding stimulates the hydrolysis of ATP leaving a phosphate group attached to the carrier protein.
3. Phosphorylation causes a shape change, opening the carrier to the outside. Now there is a lower Na+ (sodium ion) affinity and a high K+ (potassium ion) affinity.
4. The K+ binding causes the phosphate group to be released. 5. Phosphate release causes shape to return to original form. Now there is a low K+
affinity causing them to be released into the cytoplasm. The process begins again.