November 15–18, 2019

Westin Copley Place BOSTON, MA

Tissue Specific Immunity: Translating our Discoveries

52nd ANNUAL MEETING OF THE SOCIETY FOR LEUKOCYTE BIOLOGY

ORGANIZERSCherié Butts, Biogen and

Silvia Uriarte, University of Louisville

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The Society for Leukocyte Biology is pleased to announce their 52nd annual meeting. The event is set to be held in Boston, Massachusetts from November 15–18, 2019. The theme of this meeting is, “Tissue-Specific Immunity: Translating our Discoveries,” integrating scientific interests of a wide scientific audience with special emphasis on how experimental data applies to human conditions. We anticipate that the upcoming meeting will stimulate exciting interactions among the participants and provide a unique experience for researchers and clinicians from academia, government and industry.

FOR ADDITIONAL INFORMATION:SOCIETY FOR LEUKOCYTE BIOLOGYPhone: 301-634-7814Fax: 301-634-7455Email: meetings@leukocytebiology.orgWeb Address: www.leukocytebiology.org

MEETING LOCATION:Ideally located in Boston, MA, USA, in the center of the city, the 2019 venue is convenient for attendees. With the attached Copley Place mall and the Boston Public Library right across the street, attendees will be able to enjoy all Boston has to offer. Conveniently located just 3.7 miles from Boston Logan Airport and on the subway line, we are excited to meet at the Westin in the Back Bay in Boston. For local touring ideas, contact the hotel’s Concierge desk or refer to the Boston tourism website.

ACCOMMODATIONS:Accommodations for the 2019 meeting will be provided by the conference hotel, The Westin Copley Place.Westin Copley Place 10 Huntington Avenue Boston, Massachusetts 02116 USA +1 617-262-9600SLB has secured a significantly reduced room rate for our guests at $249 USD per night. The deadline to book at the group rate is October 23, 2019. Book through the meeting website https://www.leukocytebiology.org/accommodations-and-travel

CHILDCARE:For attendees requiring child care, there are several options listed on the meeting website. To make arrangements, contact the listed resources or the hotel Concierge. A quiet room close to the meeting sessions will be provided for nursing mothers to have a private location for use during the daytime sessions.

SPECIAL NEEDS:SLB does not discriminate on the basis of disabilities. If you require services or auxiliary aids mentioned in the Americans with Disabilities Act in order to fully participate in this activity, please contact SLB directly at meetings@leukocytebiology.org or call 301-634-7814.

MEMBERSHIP:Membership to SLB is open to individuals in the related fields. Take advantage of the meeting registration discount and free abstract submission offered to SLB members and join today! You must be a current member at the time of registration.

ABSTRACTS AND POSTERS:All participants are highly encouraged to submit an abstract. Online abstract submissions will be accepted through July 9, 2019 with a late breaking abstract period in August 2019. You must register for the meeting prior to submitting an abstract. Abstracts submitted by July 9th will be considered for oral, poster, and poster flash talk presentations and are also eligible for award consideration. Late breaking abstracts will be considered for poster presentations only. To submit an abstract, register for the meeting online and then follow the links provided. Conference abstracts will be available to all participants as a PDF on the website and also through the meeting app. There is a $30 (regular) and $50 (late breaking) abstract fee for non-members.

AWARDS:SLB is pleased to offer a variety of award programs honoring, recognizing, and supporting investigators at various stages in their careers. Refer to https://www.leukocytebiology.org/awards to review the full list of opportunities and requirements. Apply during the abstract submission process.

• Dolph O. Adams Award• G. Jeanette Thorbecke Award• Women and Diversity Paper of the Year• Presidential Awards• Travel Awards• Early Career Faculty Travel Award• Developing Nations Travel Award• Mentoring Diversity Travel Award

DIVERSITY, INCLUSION, AND CODE OF CONDUCT:SLB is committed to providing a safe, productive and welcoming environment. All participants are expected to behave appropriately; respecting fellow attendees, presenters, sponsor representatives, volunteers, and staff. Discrimination, harassment, or bullying, in any form will not be tolerated. If you have questions about the expectations or concerns about conference behavior, please visit the full documentation of SLB Ethical Policies online (https://slb.memberclicks.net/slb-ethical-policies). Thank you for joining in these efforts to ensure a positive conference experience for everyone.

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FRIDAY, NOVEMBER 15, 2019SLB Member Organized Special Interest Group Satellite Sessions

FULL DAY SIG:

Alcohol & Tissue-Specific Immunity (AIRIG)CHAIRS: Elizabeth J. Kovacs, University of Colorado, Denver & Mashkoor A. Choudhry, Loyola University, Chicago

• Majid Afshar, MD, MS, Loyola University Chicago, Blood and Urine Biomarkers for Identifying Alcohol Misuse in Trauma Patients

• Leon G. Coleman, Jr., MD, PhD, University of North Carolina, Chapel Hill, Neuroimmune Mechanisms of Alcoholic Neurodegeneration and Negative Affect

• Rebecca McCullough, PhD, University of Colorado Denver, Targeting the Resolution of Inflammation with a Novel Cell-based Therapy in Alcoholic Liver Disease

• Vasilis Vasiliou, PhD, Yale University, Biomarkers and Novel Pathways Involved in the Development of Alcoholic Liver Disease

• H. Joe Wang, PhD, NIAAA, Funding and Training Opportunities

MORNING SIGS:

Immunomodulatory Cell DeathCHAIRS: Ben A. Croker, Boston Children’s Hospital, Kristopher Sarosiek, Harvard T.H. Chan School of Public Health

• Eric Baehrecke, Univeristy of Massachusetts Medical School, Identification of Novel Regulators of Autophagy that Promote Cell Death

• Ben A. Croker, Boston Children’s Hospital, Harvard Medical School, Effector Functions of Neutrophil Necroptosis• Andrew Oberst, University of Washington, Necroptosis Minus Cell Death Equals Antiviral Immunity in the Brain• Kristopher Sarosiek, Harvard T.H. Chan School of Public Health, Enhancing Anti-cancer Immune Responses

by Modulating Tumor Cell Death• Kate Schroder, The University of Queensland, New Insights into

Non-canonical Inflammasome Signaling and Functions in Host Defense

Progress in CRISPR-Cas Biology and Gene EditingCHAIR: Min Wu, University of North Dakota

• Zhiwei Huang, Harbin Institute of Technology, How the Unique Structures of CRISPR-Cas Facilitate the Gene Editing

• Samira Kiani, Arizona State University, How Many Applications Can the CRISPR Biotechnology Bring?• Eugene Koonin, NIH, The Expanding CRISPR Universe• Ailong Ke, Cornell, Structure and Function for CRISPR-Cas Research: The Recent Highlights• Min Wu, University of North Dakota, Can We Find or Reinvent the Best CRISPR-Cas for Gene Editing?

Resolution of InflammationCHAIRS: Charles N Serhan and Stephania Libreros, Harvard Medical School and Brigham and Women’s HospitalSponsored by Corbus Pharmaceuticals

• Charles N Serhan, Harvard Medical School and Brigham and Women’s Hospital, Novel Mediators of Inflammation Resolution and Tissue Regeneration

• Matthew Spite, Harvard Medical School and Brigham and Women’s Hospital, Lipid Mediators at the Interface of Resolution of Inflammation and Tissue Repair

• Mark Tepper, Corbus Pharmaceutics, CB1 Agonist Activates Pro-resolving Lipid Mediators in Humans• Gabrielle Fredman, Albany Medical College, Resolvin D1 Enhances Necroptotic Cell Clearance• Daniel Irimia, Harvard Medical School and Massachusetts General Hospital,

Lipid Mediators of Neutrophil Swarming

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AFTERNOON SIGS:

Immune Regulation, Autoimmunity and InfectionCHAIRS: Rachel Caspi, NIH & WanJun Chen, NIH

• Philip Murphy, NIAID, NIH, Treatment and Cure Strategies for WHIM Syndrome Immunodeficiency• Munir Akkaya, NIAID, NIH, How TLR9 Signaling Shapes the Survival, Differentiation and the

Metabolism of B Cells• Mate Tolnay, CDER, FDA, Human FCRL3 Binds Secretory IgA, an Essential Component of Mucosal

Immunity, and Restrains Regulatory T Cell Activity• Daniela Verthelyi, FDA, Modeling Neurotropic Viruses in Immunocompetent Mice: What Have We Learned So Far• Rachel Caspi, NEI, NIH, Th17 Effector Regulation in Ocular Inflammatory Disease• Billur Akkaya, NIAID, NIH, Tregs Orchestrate Antigen Specific Suppression via Stripping Cognate

Peptide-MHCII from the DC Surface• WanJun Chen, NIDCR, NIH, D-mannose Induces Regulatory T cells and Suppresses Autoimmunity

and Inflammation

Advanced Imaging Approaches to Visualize Immune Cell BehaviorCHAIRS: Margarida Barroso, Albany Medical College & Sergio Catz, The Scripps Research InstituteSponsored by the Histochemical Society

• Sergio Catz, The Scripps Research Institute, Application of Total Internal Reflection Fluorescence and Super Resolution Microscopy to the Study of Neutrophil Function

• Margarida Barroso, Albany Medical College, Fluorescence Lifetime FRET Based Approaches to Visualize Immune Cell Function

• Klaus Ley, La Jolla Institute for Immunology, Pushing the Limits of Superresolution: SuperSTORM• Mauricio Terebiznik, University of Toronto, Technical Approaches to Study Phagosome Formation and

Maturation: Use of Filamentous Particles• David Entenberg, Albert Einstein College of Medicine, Broadening the Reach of Intravital Imaging

through Surgical Engineering

Impact of Aging on Tissue Resident Immune CellsCHAIR: Rebecca Fuldner, NIA, NIH

• David Koelle, University of Washington, Skin-resident T Cell Responses to VZV Infection and Vaccination• Susan Swain, University of Massachusetts Medical School, Tissue Resident Memory Cells and Aging• Deep Dixit, Yale University, Adipose Tissue Resident Leukocytes in Aging and Inflammation• Joanne Turner, Texas Biomedical Research Institute, Exploring the Impact of Inflammaging on

Immune Function During M. tb Infection

Global Science: Focus on Advancements in Immunology ResearchCHAIR: Luis Montaner, Wistar, JLB Editor-in-Chief

• Xiaoyu Hu, Institute for Immunology, Tsinghua University, Amino Acid Metabolites Modulate Cytokine Responses and Reprogram Macrophage Polarization

• Gap Ryol Lee, Sogang University, The Role of PTEN in Th17 Cell Differentiation• Bin Li, Shanghai JiaoTong University, FOXP3+Treg Functional Stability and their Clinical Applications• Henry C Mwandumba, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, The Impact of HIV

Infection on Lung Immunity and Control of Mycobacterium Tuberculosis Infection• Clive Gray, University of Cape Town, TITLE TBA• Byoung S. Kwon, Eutilex Co., Mediates the Polarization of CD4 T cells to Th1, Th2 and Th17, and Converts

Treg to Th1 and Eradicates Solid Tumors• Motonari Kondo, Toho University School of Medicine, SATB1,

A Nuclear Protein Necessary for Establishment of Immune Tolerance

• Kensuke Miyake, The University of Tokyo, Mechanisms Controlling Innate Immune Responses to Nucleic Acids

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SATURDAY, NOVEMBER 16, 2019Poster Flash TalksSelected abstracts by early-career scientists provide short talks organized by topic.

New This Year—Elevator Pitch ContestConsider submitting a 30 second YouTube video online explaining your science. We recommend that you utilize this brief time to communicate who you are, what are the most important findings of your research and the significance. Infuse it with your personality to make it captivating for the audience. Selected trainees will participate in a 3-minute elevator pitch contest, followed by Q/A. Videos of the award winner/s will be posted on the SLB website.

New This Year—Speed Networking Career RoundtablesA roundtable format to foster discussions between scientists from academic, government, and industry and individuals seeking career advice. Pre-registration required

MTTG (Members in Transition and Training) Workshop Lunch: Building Your Profile: CVs, NIH Biosketches and LinkedInOrganized by the SLB Members in Transition and Training Group

PLENARY I: Welcome and Program OverviewTranslating Discoveries into Meaningful Therapies: Key Questions to Address and WhyCherie Butts, Biogen

Neutrophil Cytoplasts Promote TH17 Inflammation in AsthmaBruce Levy, Brigham & Women’s Hospital

A Rendezvous with MicrogliaRichard Ransohoff, Harvard Medical School and Third Rock Ventures

Neutrophils as Targets in Autoimmune Vasculitis: New ConceptsVeronique Witko-Sarsat, INSERM

Award TalksSLB Presidential Finalists (Student and Junior Faculty/Postdoc categories). SLB’s award talks Dolph Adams, G. Jeannette Thorbecke, Women and Diversity Paper of the Year, and JLB’s top cited authors

• Macrophage Sensing of Cell Death, Kenneth Rock, University of Massachusetts• Myeloid Cell-specific Deletion of Cebpb Decreases Sepsis-induced Immunosuppression in Mice,

Mohamed Elgazzar, East Tennessee State University College of Medicine

SLB LEGACY KEYNOTE LECTURETargeted Therapies that Enhance Response to Immune Checkpoint Inhibitors2019 Legacy Awardee, Ann Richmond, Vanderbilt University

Joining SLB in Boston from afar? Check out the tiered discounted registration options for our members from around the world on the society website and email jholland@leukocytebiology.org with questions.

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SUNDAY, NOVEMBER 17, 2019Women and Diversity Workshop Breakfast: Advocating For Your Goals: The Art of Saying No, So You Can Say Yes Organized by the SLB Women and Diversity Committee

PLENARY II: Mucosal ImmunityImmunity and Inflammation at the Oral Mucosa: Mechanisms and Host-modulation ApproachesGeorge Hajishengallis, University of Pennsylvania

Neutrophilic Inflammation and Gonococcal PathogenesisAlison Criss, University of Virginia

Developing Alternative Approaches for Induction of Mucosal ImmunityProsper Boyaka, Ohio State University

CONCURRENT SESSIONS 1–2:

Changes in Tissue Immunity with AgingAdvanced Age and the Gut-Lung AxisElizabeth J. Kovacs, University of Colorado Denver

Acquired Immunity in CancerCancer and the Microbiome

Giorgio Trinchieri, NIH

PLENARY III: Autoimmune DiseaseNETs–The Second Function of ChromatinArturo Zychlinsky, Max Planck Institut

Regulation of InflammationKate Fitzgerald, University of Massachusetts

Localized Immunomodulation with a Novel Form of Fas Ligand for Tolerance Induction to Allogeneic Islet GraftsEsma Yolcu, University of Louisville

CONCURRENT SESSIONS 3–4:

Resolution of Immune ResponsesType 2 Immunity in Tissue Regeneration and FibrosisTom Wynn, Pfizer

Immunity in the LungInnate Immunity and Lung Host Defense during Pneumonia

Claire Doerschuk, University of North Carolina

Poster Session ReceptionBrowse poster presentations during an evening reception

MONDAY, NOVEMBER 18, 2019Professional Workshop Breakfast: Building the Right Team through Great LeadershipOrganized by the SLB Professional Development Committee

CONCURRENT SESSIONS 5–6:Innate Immune Response to InfectionThe Inner Life of the Neutrophil: From Vesicular Trafficking to InflammationSergio Catz, Scripps Institute

AsthmaTuning T cell Responses during Lung Inflammation

Avery August, Cornell University

CONCURRENT SESSIONS 7–8:Acquired Immune Response to InfectionDengue Virus Immunity Increases Zika Virus-induced Damage During PregnancyJean Lim, Mount Sinai

Innate Immunity in CancerAdvances on the Molecular Regulation of Gene

Expression in Human NeutrophilsMarco Cassatella, University of Verona

Poster Session LunchBrowse poster presentations during lunch

SLB Member Business Meeting and Award PresentationsLearn about SLB’s activities and status and join us in congratulating several awardees.

CLOSING PLENARYA New Chapter at the Oral Mucosa: Neutrophils Coping with the Emerging Oral PathogensSilvia Uriarte, University of Louisville

Program RetrospectiveOutlook for future implications of the research presented plus onsite poster award announcements and prize drawings.

REGISTRATION INFORMATION2019 REGISTRATION FEES:

REGISTRATION TYPE Early Bird(Until July 9th, 2019)

Regular(After July 9th, 2019)

SLB Member $585 $685

Non-Member $785 $885

SLB Student Member $375 $425

Student Non-Member $460 $510

Abstract Submission Fee (non-members) $30 $50

Special Interest Group Satellites $20

One Day Member Registration Regular/Student $300/$200

One Day Non-Member Registration Regular/Student $350/$250

REGISTRATION:Registration includes all main conference scientific sessions and workshops, one program booklet, all meals, breaks and socials indicated in the program book, and access to the event app. Registration fees exclude accommodation and other meal costs. Registration and payment may be made on the SLB meeting website at https://www.leukocytebiology.org/registration-information. Registration refunds will be provided less a 15% processing fee for refunds requested in writing prior to September 15, 2019. No refunds can be given after this date. Travel and accommodation cancellations remain the sole responsibility of the individual. All fees are listed in USD.

9560 Rockville PikeBethesda, MD 20814www.leukocytebiology.org

IMPORTANT DATES:Early March 2019: Registration, Abstract

and Award submission systems open

July 9, 2019: Early bird registration discount ends, Abstract and Award systems close

Early August 2019: All award, selected talk, poster, and poster flash talk notifications sent

August 9–19, 2019: Late Breaking abstracts (for posters only) accepted

Late August 2019: Late Breaking abstract notifications sent

October 23, 2019: Discounted hotel booking deadline

52nd Annual Meeting of The Society for Leukocyte BiologyTissue Specific Immunity: Translating our Discoveries

www.leukocytebiology.org

SPECIAL JLB MEETING ISSUE!

JLB will publish a cluster of articles related to the 2019 meeting.

Look for more detailed information on the SLB website.

First submissions due January 29, 2020 for the JLB issue to publish November 2020.