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  •  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
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Page 1:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 2:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 3:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 4:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 5:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 6:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 7:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 8:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 9:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 10:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 11:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 12:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 13:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 14:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 15:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 16:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 17:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 18:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 19:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 20:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 21:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 22:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 23:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 24:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 25:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 26:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 27:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 28:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 29:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 30:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE
Page 31:  · SOC IECAS . evolocumab E o 232 632 283 OLE 234 116 624 232 OLE 440 438 212 OLE 153 434 213 -10 -20 -30 -50 -60 -70 _80 Number ofsubjects: 239 120 643 Baseline 148 420 208 OLE

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