Slimbuster L 3R

Cellulite Formation

How It Works

Active ingredient for the treatment of cellulite and localized fat. Concentrated extract of unsaponifiables materials and polyunsaturated fatty acids of the green coffee oil and esterified phytosterols of Brassica campestris.

The process of cellulite formation is characterized by irregular fat buildup in the subcutaneous and connective tissues.

• Slimbuster L 3R regulates the lipolysis/lipogenesis through direct lipolysis activation and indirect lipogenesis reduction due to the increase of leptin peptide• Slimbuster L 3R increases the TGF-beta production, which is responsible for the downregulation of adipocyte differentiation

• Slimbuster L 3R stimulates the collagen and elastin production in the extracellular matrix

1- Reduces the cellulite and localized fat

2- Enhances the skin firmness and elasticity

1 Larger and more numerous adipocytes 2 Stretched collagen fibers3 Impaired circulation (veins and lymphatic vessels) 4 Skin roughness

Skin without cellulite Skin with cellulite

1

2

3

4

Dermis

Epidermis

SubcutaneousTissue

Efficacy

Human adipocytes

1. Direct lipolysis induction

3. Enhancement of skin firmness and elasticity 2. Lipolysis/lipogenesis regulation

In Vitro

NEFA – Non-esterified fatty acids / IBMX – 3-Isobutyl-1-methylxanthine

EGF – Epidermal Growth Factor.

Human adipocytes after 48 hours of incubation Human fibroblasts after 48 hours of incubation

Note*Control – non-treated cells

Free fatty acids quantificationincubation time

Slimbuster L 3R (2,5%)IBMX (5mM)Control*

2h 8h 24h

NEF

A (m

Eq/L

)

0,05 0,024

0,1450,155 0,152

0,029

0,177

0,249

0,158

0,056

0

0,1

0,150,2

0,25

0,3

ECM stimulation (Extracellular Matrix)

Slimbuster L 3R (2,5%)EGF (5ug/ml)Control*

Leptin increase

pg/m

L

706050

403050100 Control* Slimbuster L 3R

16,32

ElastinCollagen

µg/m

L

157140

74

180

140

100

160

120

806040200

61

101115

3X62,55

18 women with 23-38 years old with moderate cellulite

Twice a day for 60 dayswithout massage

Slimbuster L 3R 3%

Average anthropometric measurements of the volunteers after 30 (D30) and 60 days (D60) of treatment with Slimbuster L 3R compared to the initial time (D1).

1. Clinical evaluation of body measurements

2. Measurement reduction

In Vivo

Thighs (upper)

Thighs (lower)

Legs (lower)

Legs (upper)

Thighs (median)

Hip

D30-DI D60-DI

4mm

1mm

7mm5mm

8mm

3mm

9mm

3mm

11mm7mm

14mm

5mm

Benefits• Activates the lipolysis • Reduces the lipogenesis• Treats the cellulite and localized fat• Improves the smoothing appearance of the skin

INCICoffea arabica (Coffee) Seed Oil and Brassica campestris (Rapessed) Sterols

Application• Cream• Lotion• Gel• Gel-cream• Serum

Concentration of Use3% (w/w)

3. Subjective evaluation

After 4 and 8 weeks, the volunteers noted significant fat and cellulite reduction after treatment with Slimbuster L 3R (3% in emulsion).

Fat reduction

Cellulite reduction

39%56%

56%72%

D30 D60

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