sleep apnea and congestive heart failure, diagnosis and ......presentation outline ♥overview of...
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Orlando, Florida – October 7-9, 2011
Sleep Apnea and Congestive Heart Failure, Diagnosis and Management
Rami Kahwash, MD
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Presentation Outline
♥ Overview of sleep disordered-breathing (SDB)♥ Pathophysiology of the cardiovascular consequences of OSA
and CSA♥ Treatment of OSA-Focus on the cardiovascular impact of
treatment♥ Treatment of CSA
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Case History
♥ 61 y/o commercial driver presents to the clinic with: ♥ Excessive daytime sleepiness♥ Snoring and pauses in breathing reported by the wife
♥ Difficult to concentrate on the job!
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Sleep History
♥ Seven and half hours of allowed sleep per night♥ Tired in the morning♥ Awakens 3-4 times at night to “use rest room”♥ Persistent loud snoring♥ Leg jerks and kicks- restless sleep
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Case History
♥ MHX:♥ Hypertension♥ Hypercholesterolemia♥ ROS:♥ 35 lbs weight gain/past two year♥ SoHx:♥ 40 Pack/year
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NEXT STEP
POLYSYMNOGHRAPHY
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EKG
Airflow
Thoracic effort
Abd. effort
SAO2
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EKG
Airflow
Thoracic effort
Abd. effort
SAO2
Obstructive Apnea: partial or complete cessation of upper airway despite continued efforts to breath
Exhale Airway obstructs Airway opens
Paradoxing
Effort gradually increases
Paradoxing Ends
Blood oxygen levels reduce to < 4% of baseline value
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AirflowAirflow
Thor. Effort
Thor. Effort
Abd. Effort
Abd. Effort
SAO2SAO2
ECGECG
Central sleep apnea: cessation of upper airway flow without respiratory effort.
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Sleep Medicine Nomenclatures
♥ Apnea: complete cessation of airflow > 10 seconds♥ Hypoapnea: decrease in airflow > 30 %, longer than 10 sec,
associated with decrease in O2 sat > 4 % or arousal♥ AHI: number of events per hour
♥ 5 -15Mild♥ 15 -30 moderate♥ >30 severe
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Prevalence of Obstructive Sleep ApneaThe Wisconsin Sleep Cohort, NEJM 1993
The Occurrence of Sleep-Disordered Breathing among random 602 Middle-Aged Adults.
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Prevalence in Middle Aged Adults
AHI = Apnea Hypopnea Index
% Men % Women
AHI ≥ 5
AHI ≥ 5 + daytime somnolence
24 9
4 2
Young; NEJM 1993
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Prevalence of OSA in StableOutpatients with Heart Failure
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Physical Examination in OSA
♥ Malampati Class (I-IV)♥ Obesity and thick neck
♥ > 17 inch males♥ > 16 inch females
♥ Craniofacial anatomy♥ Inferiorly positioned hyoid bone♥ Mandibular insufficiency ♥ Increased mid-facial height
♥ Nasal obstruction
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Mallampati Class: Independent Predictor of the Presence and Severity of OSA
Nuckton et al, Sleep 2006
Mallampati class
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SCHELLENBERG et alAJRCCM 2000
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SCHELLENBERG et al AJRCCM 2000
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Cardiovascular Consequences-Pathophysiology
Caples,et al.,Sleep,Vol. 30, No.3,2007
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OSA AND Hypertension
♥ 40% of patients with OSA have hypertension♥ 50% of patients with hypertension have OSA♥ OSA patients are more likely to be nocturnal “non-dippers”♥ Treatment of OSA reduces blood pressure
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OSA- Induced Hypertension-Animal Model
Brooks, et al. J Clin Invest 99:106, 1997
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OSA and CHF-the Sleep Heart Health
n=6,424
E Shahar, et al, AJRCCM, 2001
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SBD and Heart Failure in Clinical Practice
Congestive heart failure
Diastolic dysfunction
Systolic dysfunction
OSA
CSA
OSA
Coronary disease or hypertension
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Treatment of OSA
♥ Weight loss♥ Positive airway pressure♥ Surgery♥ Oral appliances♥ Oxygen
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Effects of CPAP
♥ Respiratory Effects:
♥ Elimination of upper airway obstruction♥ Unloading of respiratory muscles♥ Improved work of breathing♥ Improved gas exchange and elimination of desatruration
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Causative Role of Severe Untreated OSA in Cardiovascular Events
mean F/u 10 YR(Marin et al, Lancet 365:1046, 2005)
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CPAP Improves LVEF inPatients with CHF
Kaneko et al, NEJM 348:1233, 2003
CPAP group had a significant absolute increase of 8.8±1.6 percent in the left ventricular ejection fraction (P<0.001)
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CSA : Treatment
♥ Management of CHF♥ Supplemental Oxygen♥ Acetazolamide♥ Theophylline♥ Pacemaker♥ Heart Transplantation
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CANPAP
♥ 258 patients age 18-79 with heart failure, ejection fraction < 40%, and central sleep apnea despite optimal medical therapy
♥ Randomized. Mean age 63 years. Baseline ejection fraction 24.5%
No CPAP
n=130
No CPAP
n=130
Nocturnal CPAP†Titrated as tolerated to 10 cmH2O
n=128
Nocturnal CPAP†Titrated as tolerated to 10 cmH2O
n=128
Endpoints (mean follow-up 2 years):♥ Primary: Death or heart transplantation
♥ Secondary: Apnea hypopnea index, quality of life
Endpoints (mean follow-up 2 years):♥ Primary: Death or heart transplantation
♥ Secondary: Apnea hypopnea index, quality of life
† CPAP was used an average of 4 hours per day during the trial
Bradley TD et al. N Engl J Med 2005; 353:2025-2033.
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CANPAPPrimary Endpoint: Death or hospitalization
p=0.54
32 32
0
5
10
15
20
25
30
35
nocturnal CPAP no CPAP
32 32
0
5
10
15
20
25
30
35
nocturnal CPAP no CPAP
♥ Average sleep time was 304 minutes in the CPAP group and 308 minutes in the control group. Apnea hypopnea index at baseline was 40 apneas/hour
♥ There was no difference in the frequency of death or hospitalization between groups or in the cumulative number of hospitalizations (p=0.83)
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SDB and Cardiovascular Diseases-Conclusions
♥ OSA has a causative relation with hypertension♥ OSA is a independent risk factor for:
♥ Heart failure♥ CAD♥ Stroke♥ Cardiac arrhythmia
♥ OSA causes worse outcomes in stroke, CAD, and Afib. Main therapy is CPAP.
♥ CSA coexist with heart failure and aggravate its control. Main therapy is optimizing HF control
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Thank You