skov-3, 48h caov-3, 48h bg-1, 48h concentration (µm) viable cells (%) sw 43 sw iv-52s sw iii-123 sw...
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10-1 1 101 102
0
20
40
60
80
100
120 SKOV-3, 48h
10-1 1 101 102
0
20
40
60
80
100
120
140
160 CaOV-3, 48h
10-1 1 101 102
0
20
40
60
80
100
120
140 BG-1, 48h
Concentration (µM)
Concentration (µM)
Concentration (µM)
Viab
le c
ells
(%)
Viab
le c
ells
(%)
Viab
le c
ells
(%)
SW 43
SW IV-52s
SW III-123
SW 43 + SW IV-52s
○●■□
SW 43
SW IV-52s
SW III-123
SW 43 + SW IV-52s
○●■□
SW 43
SW IV-52s
SW III-123
SW 43 + SW IV-52s
○●■□
A
C
B
Figure 1
Actin
PhosphoNF-B p65
NF-B p65
SW III-123 (M) 0 1 3 10
5 min
Figure 2
CaOV-3 cellsA
Figure 3
SW 43 SW IV-52s SW III-123
Casp
ase
3 ac
tivity
(fo
ld)
- TNF Ab
+ TNF Ab
SW 43
SW 43 + TNF Ab
Viab
le c
ells
(%)
B
SW 43 (µM)
SW IV-52s
SW IV-52s + TNF Ab
Viab
le c
ells
(%)
C
SW IV-52s (µM)
SW III-123
SW III-123 + TNF Ab
Viab
le c
ells
(%)
D
SW III-123 (µM)
SW 43 SW IV-52s SW III-123
Casp
ase
3 ac
tivity
(fo
ld)
- TNF Ab+ TNF Ab
BG-1 cellsA
SW 43SW 43 + TNF Ab
Viab
le c
ells
(%)
B
SW 43 (µM)
SW IV-52s
SW IV-52s + TNF Ab
Viab
le c
ells
(%)
C
SW IV-52s (µM)
SW III-123
SW III-123 + TNF Ab
Viab
le c
ells
(%)
D
SW III-123 (µM)
Figure 4