skin pigmentation melanin in the melanocyte cells eumelanin black/brown pigment pheomelanin...
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Skin Pigmentation
Melanin in the Melanocyte Cells Eumelanin Black/Brown Pigment Pheomelanin Red/Yellow Pigment
Response to UV Radiation Pigmented Cells
Resistant to Damage by SunProtected From Melanin Antioxidants
Unpigmented Cells Sensitive to Sunlight Damage Protected by Glutathione/Selenomethionine Antioxidants
DEPIGMENTATION Properties of Glutathione/Selenium
• Protect Skin from UV Radiation which generate free radicals that cause skin damage and hyperpigmentation
• GSH redirects synthesis to the light (Pheomelanin) instead of the dark (Eumelanin)
• Inhibits enzyme tyrosinase that synthesizes dark melanins
• Skin Cell’s become more resistant to UV exposure (Brigarti, 2003)
(Burke, 1997)
Skin Brightening
Thione Complex™ lozenges with:
Glutathione & Selenomethionine
Plus Antioxidant Vitamins C & E
And the Glutathione Depigmenting Enzymes
A complement to the Skin Brightening Products
Free Radical Scavenging Functions to Reduce UV Radiation to the Skin
Works From Within To The Skin®
Melasma Blotchy Hyper-pigmentation of Face Associated with Pregnancy Topical Therapy
Hydroquinone, Retinoic Acid Thione Complex™
Oral Therapy with Glutathione/Selenium Reduces UV Radiation Impact on Affected Skin Induces Glutathione Enzymes Promotes Synthesis of Clear Melanin Inhibits Tyrosinase Enzyme that Makes Dark Melanin
The Aging Skin
Chrono-aging Sagging Skin
Photo-aging Wrinkles and Pigmented Lesions
Ultraviolet Radiation Acute: Sunburn Chronic: Oxidative Damage
Pre-malignant Lesions(Keratosis, Moles)
MalignancySquamous/Basal CellsMalignant Melanoma
Influence of Glutathione Levels in Melanin Synthesis
Pathways to Melanin Synthesis
High GSH Low GSH
↓ Eumelanin Eumelanin
(Dark Pigment) (Dark Pigment)
Conclusion:
High GSH levels influence pathway toward the production of greater amounts of clear pigment (Pheomelanin) in skin cells