Skin Pigmentation

Melanin in the Melanocyte Cells Eumelanin Black/Brown Pigment Pheomelanin Red/Yellow Pigment

Response to UV Radiation Pigmented Cells

Resistant to Damage by SunProtected From Melanin Antioxidants

Unpigmented Cells Sensitive to Sunlight Damage Protected by Glutathione/Selenomethionine Antioxidants

DEPIGMENTATION Properties of Glutathione/Selenium

• Protect Skin from UV Radiation which generate free radicals that cause skin damage and hyperpigmentation

• GSH redirects synthesis to the light (Pheomelanin) instead of the dark (Eumelanin)

• Inhibits enzyme tyrosinase that synthesizes dark melanins

• Skin Cell’s become more resistant to UV exposure (Brigarti, 2003)

(Burke, 1997)

Skin Brightening

Thione Complex™ lozenges with:

Glutathione & Selenomethionine

Plus Antioxidant Vitamins C & E

And the Glutathione Depigmenting Enzymes

A complement to the Skin Brightening Products

Free Radical Scavenging Functions to Reduce UV Radiation to the Skin

Works From Within To The Skin®

Melasma Blotchy Hyper-pigmentation of Face Associated with Pregnancy Topical Therapy

Hydroquinone, Retinoic Acid Thione Complex™

Oral Therapy with Glutathione/Selenium Reduces UV Radiation Impact on Affected Skin Induces Glutathione Enzymes Promotes Synthesis of Clear Melanin Inhibits Tyrosinase Enzyme that Makes Dark Melanin

The Aging Skin

Chrono-aging Sagging Skin

Photo-aging Wrinkles and Pigmented Lesions

Ultraviolet Radiation Acute: Sunburn Chronic: Oxidative Damage

Pre-malignant Lesions(Keratosis, Moles)

MalignancySquamous/Basal CellsMalignant Melanoma

Influence of Glutathione Levels in Melanin Synthesis

Pathways to Melanin Synthesis

High GSH Low GSH

↓ Eumelanin Eumelanin

(Dark Pigment) (Dark Pigment)

Conclusion:

High GSH levels influence pathway toward the production of greater amounts of clear pigment (Pheomelanin) in skin cells