sjogren’s syndrome and hyper lipoprotienemia(a) -a detrimental association sjogren’s syndrome...
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Sjogren’s Syndrome and Hyper Lipoprotienemia(a) - A Detrimental Association
- Dr. Uday Shanker Sagaram
Director, Maruthi Rheumatology Research Centre, Hyderabad, India
What is Lp(a)
• Lipoproteins are the spherical particles composed of Proteins (Apolipoproteins),
Phospholipids, Triglycerides and Cholesterol
• They are manufactured in the liver and are associated with LDL fraction of lipid profile, which
is highly risky and detrimental
• They penetrate and are strongly retained to the arterial wall
• They possess pro-inflammatory activity
• Lp(a) is a strong risk factor for CVD. The lack of clinical trial data has resulted in Lp(a) being
largely ignored by clinical guidelines
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
What is Sjogren’s Syndrome?“Chronic auto-immune disorder where, WBC attack salivary and lacrimal glands”
Causes
• Hereditary
• Viral/ bacterial infections
Diagnosis
• Xero stomia
• Kerato conjunctivis sicca
• Submandibular gland enlargement
• Hoarseness of voice
• Dysphagia, etc.
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
Tests
• Anti SSA and Anti SSB
• Ophthalmologist tests - Rose Bengal test and Schirmer test
• Immunological test
Complication(s)
• 44% times more risk of having Non-Hodgkins Lymphoma
• Pregnant women deliver Neonatal Lupus child with heart block
• Hepatitis
• Bronchitis
• Dyspareunia
• Corneal ulcer
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
What is Sjogren’s Syndrome? … contd…
• In some of the Inflammatory Arthritis patients, we noticed persistently (3-6 months)
elevated Lipid Profile in their routine blood examinations
• Research and discussion with other physicians lead to the identification of Lp(a) as the
root cause
• We then discovered associated increase in Lp(a) levels and also noticed associated
drowsiness and cardiac pain
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
When and Why did I start checking for Lp(a)
• This association is detrimental, as it produces coronary premature Atherosclerosis and
also Cerebral Vascular Stroke
• Since Sjogren’s syndrome alone generally has a long life span, only its association with
Lp(a) can reduce it
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
Why this association is to be given importance?
Effects
• Coronary Artery Calcification - In diabetic and rheumatoid arthiritis patients
• Dyslipedemia with low cholesterol level, low HDL level and high triglyserides
• Associated hypo-thyroidism
• Irritable Bowel Disorder (IBD)
• Mixed Connective Tissue Disorders (MCTD)
• Scleroderma
• Psoriatic Arthritis
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
• Treatment of Sjogren’s Syndrome (hydroxyl chloroquine and deflaza cort) combined
treatment of Lp(a) (1gm Niacin, 1000mg Omega Fatty-acids and aspirin)
• Correction of hypothyroidism, any associated diabetes and Nephropathy
• Treatment of associated dyslipidemia
• Vitamin C administration
• Bovine collustrum
Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
Treatment for Lp(a)
?Sjogren’s Syndrome and Hyper lipoproteinemia(a) - Detrimental Association
About the Presenter
• Dr. S. Uday ShankerDirector of Maruthi Rheumatology Research Center, Secunderabad, India.• Recent Awards
• Life Time Achievement Award in Medicine with Gold Medal• Bharatiya Chikitsak Award• Hind Ratan International Award and more
• Published several papers in Cardiology and Rheumatology.• Contact Information
• Email: [email protected]• Cell: +1(850) 559-2929 (USA)• Cell: +(91) 9000245586 (India)