simulator hodgkin-huxley model - arvutiteaduse instituut · 2015. 6. 3. · -huxley simulator...
TRANSCRIPT
![Page 1: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/1.jpg)
Hodgkin-Huxley model simulator
Katrin Valdson Kristiina Pokk
Marit Asula
Tartu 2015
![Page 2: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/2.jpg)
Introduction
I� = g�(V − E� )+ g�n⁴(V − E�)+ g�ₐm³h(V − E�ₐ)
![Page 3: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/3.jpg)
Simulator
![Page 4: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/4.jpg)
Simulator
![Page 5: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/5.jpg)
Topics of the simulator exercises
Part I: Equilibrium PotentialPart II: Membrane PotentialPart III: The Action PotentialPart IV: The Fast Sodium ChannelPart V: The Delayed RectifierPart VI: Voltage-Gated Channel Parameters
![Page 6: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/6.jpg)
TTX
● neurotoxin● found in pufferfish, octupuses,
marine worms, amphibians● deadly in very small amounts● blocks Na ion channels● prevents action potential from
happening
![Page 7: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/7.jpg)
TEA
● Tetraethylammonium
● found in simple salts
● used in pharmacological research
● blocks K ion channels● prolonged action potential
![Page 8: simulator Hodgkin-Huxley model - Arvutiteaduse instituut · 2015. 6. 3. · -Huxley Simulator Cursor Zoom pan Drugs Nur_lge Stop Time (msec) print Export Merrill Voltage Clear Recall](https://reader034.vdocuments.us/reader034/viewer/2022051902/5ff15919725cfb31fd0543d8/html5/thumbnails/8.jpg)
Pronase
● group of proteolytic enzymes● extracellular fluid of a species
bacteria in soil● blocks only the Na inactivation gate● results in prolonged action potential