www.le.ac.uk

Why do we need an EM research into ageing network?

Simon ConroyGeriatrician & Honorary Senior Lecturer

Outline

• Why ageing research at all?

• Existing support for research & delivery

• UK Clinical Research Network

• Ageing speciality group

• Possible roles for EMRAN

Why do we need research into older people?

• To improve patient care

• To test interventions

– Valid findings

– Intervention effect & health economics

– Generalisability

• Old & frail vs. old & fit

Why do we need research into older people?

• Historically older people have been excluded from clinical trials (PREDICT study)

– Ageism – societal & clinicians/researchers

– Practical features to support participation

– Study design – excluding people who can’t give consent

Leading to treatments that are not tested in the populations for whom they are given (OR not given)

Older people & research participation

• http://www.crn.nihr.ac.uk/ageing/pcpie/

Traditional evidence base

Frailty related evidence base

Existing support - EM

• Support for portfolio development

– http://www.rds-eastmidlands.nihr.ac.uk/

• Funding for portfolio development

– http://www.clahrc-em.nihr.ac.uk/clahrc-em-nihr/index.aspx

• Research delivery

– http://www.enrich.dendron.nihr.ac.uk/news-item.php?ID=141

– http://www.crn.nihr.ac.uk/ageing/

Existing support - EM

• Translating research into practice

– http://emahsn.org.uk/

• Patient & public involvement

– http://emahsn.org.uk/public-involvement/

– Local groups

UK Clinical Research Network

• Recruited over 600k study participants in 2013/14

• Infrastructure

– Set up clinical studies

– Support delivery

– Research training

– Patient & public involvement

NIHR CRN: East Midlands

• Population: 4.5 M

• Derbyshire, Lincolnshire, Nottinghamshire, Leicestershire & Rutland, Northamptonshire

• 10 NIHR hosted research networks

• 15 NHS Trusts

• 19 CCGs

• 8 universities

• Budget £23 M

UK CRN divisional structure

0 2000 4000 6000 8000 10000 12000

Ageing

Dermatology

Health services and delivery research

Musculoskeletal disorders

Oral and Dental Health

Primary Care

Public Health

Recruitment by County & Specialty in 21014-15

Derby City & County Lincolnshire

LLR Leicester City & County & Rutland Northamptonshire

Notts City & County Non-NHS - East Midlands LCRN

Ageing speciality group - remit

• Healthy ageing and frailty

• Organising and delivering interventions for health promotion

• Ageing process and early markers of ill health

• Modelling links between disease and functioning

• Education and lifelong learning

• Environmental conditions for ageing well

• Effectiveness of clinical and social care

Acronym Active Status Trust Name Local Investigator Lead Specialty

CLOTS-3

Closed - in follow-

up

Chesterfield Royal Hospital NHS Foundation

Trust Dennis, Prof M Stroke

CLOTS-3

Closed - in follow-

up

Sherwood Forest Hospitals NHS Foundation

Trust Cooke, Dr Justin Stroke

CLOTS-3

Closed - in follow-

up United Lincolnshire Hospitals NHS Trust

Leach, Dr Simon; Mangion, Dr

David Stroke

PD REHAB

Closed - in follow-

up University Hospitals of Leicester NHS Trust

Dementias and

neurodegeneration

Survey of Older Adults' views on Advance Care Planning in UK &

Japan

Closed - in follow-

up University Hospitals of Leicester NHS Trust Musa, Irfan Primary Care

Survey of Older Adults' views on Advance Care Planning in UK &

Japan

Closed - in follow-

up Formerly Nottingham City PCT Musa, Dr Irfana Primary Care

Survey of Older Adults' views on Advance Care Planning in UK &

Japan

Closed - in follow-

up Formerly Nottinghamshire County Teaching PCT Musa, Dr Irfana Primary Care

Hypertension in Dementia - Feasibility Study In Set-Up Nottingham University Hospitals NHS Trust Van Der Wardt, Dr Veronika Primary Care

The FINOF Study Open Nottingham University Hospitals NHS Trust Sahota, Prof Opinder Musculoskeletal disorders

IVANOF1 Study Open Nottingham University Hospitals NHS Trust Moppett, Dr Iain K Injuries and emergencies

The effect (s) of routine administration of Fluoxetine in patients

with a recent stroke - FOCUS Open United Lincolnshire Hospitals NHS Trust

Mangion, Dr David; Leach, Dr

Simon Stroke

PRoBaND: Parkinson's Repository of Biosamples and Network

Datasets Open University Hospitals of Leicester NHS Trust Critchley, Peter

Dementias and

neurodegeneration

PRoBaND: Parkinson's Repository of Biosamples and Network

Datasets Open Derby Hospitals NHS Foundation Trust Bajaj, Dr Nin

Dementias and

neurodegeneration

PRoBaND: Parkinson's Repository of Biosamples and Network

Datasets Open United Lincolnshire Hospitals NHS Trust Sharma, Prof Jagdish

Dementias and

neurodegeneration

Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open Formerly Lincolnshire Teaching PCT

Siriwardena, Prof Aloysius

Niroshan Respiratory disorders

Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS Lincolnshire East CCG

Siriwardena, Prof Aloysius

Niroshan Respiratory disorders

Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS Lincolnshire West CCG

Siriwardena, Prof Aloysius

Niroshan Respiratory disorders

Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS South Lincolnshire CCG

Siriwardena, Prof Aloysius

Niroshan Respiratory disorders

Increasing physical activity in older adults Open Lincolnshire Partnership NHS Foundation Trust Collins, Dr Iheanyichukwu Esiwe Primary Care

Hypertension in Dementia - Feasibility Study Open Leicester City PCT Primary Care

Hypertension in Dementia - Feasibility Study Open Formerly Derby City PCT Van Der Wardt, Dr Veronika Primary Care

Hypertension in Dementia - Feasibility Study Open Formerly Derbyshire County PCT Van Der Wardt, Dr Veronika Primary Care

Hypertension in Dementia - Feasibility Study Open Formerly Lincolnshire Teaching PCT Van Der Wardt, Dr Veronika Primary Care

Hypertension in Dementia - Feasibility Study Open Formerly Nottinghamshire County Teaching PCT Van Der Wardt, Dr V Primary Care

Hypertension in Dementia - Feasibility Study Open NHS Mansfield and Ashfield CCG Van Der Wardt, Dr V Primary Care

Hypertension in Dementia - Feasibility Study Open NHS Nottingham City CCG Van Der Wardt, Dr V Primary Care

OPTIMAL: Better health for care homes Open NHS Nottingham City CCG Pitchford, Russell

Dementias and

neurodegeneration

OPTIMAL: Better health for care homes Open Nottinghamshire Healthcare NHS Trust Pithford, Richard

Dementias and

neurodegeneration

Psychobehavioural Factors Associated with Optimal Vaccine

Possible roles for EMRAN

• Navigation & translation

• Connection & coordination

• Peer-support

• ‘Memory’

Summary

• ‘We’ve never had it so good’

• Opportunities

• Mechanisms

• Collaboration key