1. SILKPEEL SCIENCE e med, Inc. Confidential. For Internal Use Only

2. Table of Contents

Executive Summary

Overview of the SilkPeel Device

Overview ofSilkPeel Topical Solutions

A Quick and Easy Clinical Procedure

Benefit to the Clinical Practice

Comparison to Other Clinical Procedures

Confidential. For Internal Use Only 3. Executive Summary

SilkPeel, is a breakthrough system that combines precision non-invasive dermabrasion with Dermalinfusion to improve and revitalize the skin.The SilkPeel device provides a multi-functional alternative to conventional microdermabrasion that provides faster visible improvements to skin that will improve patient retention and help build our physicians practices.SilkPeel procedures are highly customizable to address various aesthetic conditions and can be safely and synergistically combined with other dermatologicprocedures.

Confidential. For Internal Use Only 4. Overview of silkpeel device

SilkPeel Science

Confidential. For Internal Use Only 5. What is the SilkPeel?

SilkPeel, is a breakthrough system that combines precision non-invasivedermabrasionwithDermalinfusionto improve and revitalize the skin.

Confidential. For Internal Use Only 6. What is Dermabrasion? Confidential. For Internal Use Only Stratum corneum Stratum lucidum Stratum granulosum Stratum spinosum Stratum basale The SilkPeel diamond-head probe removes the top-most portion of the epidermis called the stratum corneum. This isdermabrasion .Epidermis 7. Benefits of Dermabrasion

Normalization of the stratum corneum 1

Thickening of the epidermis and dermis 1

New deposition of collagen and elastic fibers 1

References :

1-Freedman, B. M., Rueda-Pedraza, E. and Waddell, S. P. The epidermal and dermal changes associated withmicrodermabrasion. Dermatol Surg 2001;27:1031-3; discussion 1033-4.

Confidential. For Internal Use Only 8. What is Dermalinfusion? Confidential. For Internal Use Only Stratum corneum Stratum lucidum Stratum granulosum Stratum spinosum Stratum basale SilkPeel Solutions are simultaneously infused into the viable epidermis. This isdermalinfusion .Epidermis 9. Why combine dermabrasion with dermalinfusion

Intact Skin

Confidential. For Internal Use Only Abraded Skin Stratum corneum Stratum lucidum Stratum spinosum Stratum basale Stratum granulosum Most topicals never penetrate past the stratum corneum Removing the stratum corneum allows penetration of topicals into the viable epidermis 10. SilkPeel Versus Traditional Microdermabrasion Confidential. For Internal Use Only Category SilkPeel Microdermabrasion Abrasive Source Diamond Head Wand Aluminum Oxide Crystals Dermalinfusion Delivered under pneumatic pressure - Tailored Treatments Exfoliation + Dermalinfusion of solutions specific for: -Dry Skin -Hyperpigmentation -Photoaging -Acne Exfoliation used for all indications Validated Cleaning / Disinfecting Method Yes No 11. OVERVIEW OF Silkpeel Topical solutions

SilkPeel Science

Confidential. For Internal Use Only 12. Conditions Addressed by SilkPeel Solutions Confidential. For Internal Use Only Condition SilkPeel Solution Dry Skin (Xerosis) Hydrating Serum Hyperpigmentation Brightening Serum Photoaging Vitamin C Serum Acne Clarifying Serum 13. Target Skin Layers for SilkPeel Solutions Confidential. For Internal Use Only Moisturizing (Epidermis) Clarifying (Hair follicle) Brightening (Melanocytes) Vitamin C (Epidermis / Dermis) 14.

Epidermis- The epidermis is the outermost layer of the skin that acts as the body's major barrier against the external environment. Dry skin occurs if the epidermis becomes dehydrated. This is also the major site of free-radical damage caused by chronic exposure to sunlight.

Dermis- The dermis is a layer of skin between the epidermis and subcutaneous tissues composed of collagen, elastic fibers and extrafibrillar matrix.Production of collagen slows as the skin ages which contributes to the formation of wrinkles.

Hair Follicle The part of the skin that grows hair. This is the primary site of acne development.

Melanocyte Melanin producing cells located in the bottom most layer (stratum basale) of the epidermis. Melanocytes can overproduce melanin thus causing hyperpigmentation in skin.

Review of Skin Anatomy Confidential. For Internal Use Only 15. Dry Skin (Xerosis)

Symptoms include a feeling of skin tightness, especially after showering, bathing or swimming, skin that appears shrunken or dehydrated, skin that feels and looks rough rather than smooth, itching (pruritus) that sometimes may be intense, slight to severe flaking, scaling or peeling, fine lines or cracks, redness and deep fissures that may bleed in severe cases

Causesinclude weather, heating, air conditioning, hot baths/showers, harsh soaps/detergents, sun exposure, psoriasis or thyroid disorders.

Source : Mayo Foundation for Medical Education and Research (MayoClinic.com)

Confidential. For Internal Use Only 16. Images of Dry Skin Confidential. For Internal Use Only Source : Procter & Gamble 17. SilkPeel Dermalinfusion Hydrating Formula: Key Ingredients for improvement of dry skin Confidential. For Internal Use Only INCI Function Glycerin A naturally-derived humectant which helps retain moisture. Sodium Hyaluronate A naturally-derived mucopolysaccharide that is a component of the Natural Moisturizing Factor (NMF), the water-soluble compounds responsible for the wettability, water-holding and absorbing powers of the skin.Provides exceptional moisturization, lubricity, luxurious slip and a remarkable afterfeel to the skin. Aloe Barbadensis Leaf Extract An extract from the leaves of Aloe barbadensis Miller. It provides remarkable conditioning and moisturizing properties to help calm and refresh skin. Allantoin An active skin protectant used for its healing, softening, and moisturizing properties. 18. Hyperpigmentation

Focal Hyperpigmentationis most often postinflammatory in nature, occurring after injury (eg, cuts and burns) or other causes of inflammation (eg, acne, lupus).

Melasmaconsists of dark brown, sharply marginated, roughly symmetric patches of hyperpigmentation on the face. It occurs primarily in pregnant women and in women taking oral contraceptives.

Lentigines(singular: lentigo) are flat, tan to brown oval spots. They are commonly due to chronic sun exposure (solar lentigines; sometimes called liver spots).

Source : The Merck Manual (www.merck.com)

Confidential. For Internal Use Only 19. Images of Hyperpigmentation Confidential. For Internal Use Only Courtesy of Reliant Technologies Source : www.clinic-skin.com 20. Silkpeel Dermalinfusion Brightening Formula: Key Ingredients for the improvement of hyperpigmentation Confidential. For Internal Use Only INCI Function Glycolic Acid Normalizes hyperkeratinization (exfoliates over-thickened skin) and increases viable epidermal thickness and dermal glycosaminoglycans content Morus Alba Bark Extract An extract of the root of the mulberry which contains skin lightening properties Kojic Acid Effective for inhibiting melanin productionArbutin An effective skin whitening by inhibition of melanin synthesis. 21. Photoaging

Among other things, chronic exposure to sunlight triggers the overproduction of reactive oxygen species (free radicals) that cause cellular damage which is partially responsible for overall photoaging of skin.

Vitamin C (L-ascorbic acid) is the main water-soluble nonenzymatic antioxidant in the human body.Vit C interacts with a wide variety of free radicals intracellularly (inside skin cells) and forms a front-line extracellular (outside of skin cells) defense against free radicals in plasma.

Source : Colven, R. M. and Pinnell, S. R. Topical vitamin C in aging. Clin Dermatol 1996;14:227-34.

Confidential. For Internal Use Only 22. Images of Photoaged Skin Confidential. For Internal Use Only Source : www.about.com Source : www.no2tanning.info 23. Vitamin C Serum: Key Ingredients for the improvement of photoagingConfidential. For Internal Use Only Topical application of an antioxidant serum, post-treatment, enhances the effect of microdermabrasion 1 . Reference : 1-Freedman, B. M. Topical antioxidant application enhances the effects of facial microdermabrasion. J DermatologTreat 2008:1-6. INCI Function Sodium Ascorbyl Phosphate Sodium ascorbyl phosphate is a stable derivative of L-ascorbic acid (vitamin C). It has been demonstrated that addition of sodium ascorbyl phosphate synergistically improves sunscreen photoprotection against UV-induced oxygen species . Additional benefits of sodium ascorbyl phosphate include anti-acne utility, stimulation of collagen synthesis and improvement in the appearance of hyperpigmentation.Tocopheryl Acetate Vitamin E is the major naturally occurring lipid-soluble antioxidant protecting skin from the adverse effects of oxidative stress including photoaging (sun damage).Vitis Vinifera (Grape) Seed Extract Contains proanthocyanidins, which are very potent antioxidants, helpful for diminishing the suns damaging effects and lessening free-radical damage. 24. Acne

Acne vulgaris(acne) is the formation of comedones, papules, pustules, nodules, and/or cysts mainly on facial skin. Acne occurs when pilosebaceous units (hair follicles and their accompanying sebaceous gland) become obstructed with plugs of sebum and desquamated keratinocytes, then colonized and sometimes infected with the normal skin anaerobePropionibacterium acnes . Manifestations differ depending on whether P. acnes stimulates inflammation in the follicle; thus acne can be noninflammatory or inflammatory.

Source : The Merck Manual (www.merck.com)

Confidential. For Internal Use Only 25. Image of Acne Confidential. For Internal Use Only Source : www.dermatology.svhm.org.au 26. Clarifying Serum: Key Ingredients for the improvement of acne Confidential. For Internal Use Only INCI Function Salicylic Acid Referred to as beta hydroxy acid (BHA), it is a multifunctional ingredient that addresses many of the systemic causes of blemishes. For decades dermatologists have been prescribing salicylic acid as an exceedingly effective keratolytic (exfoliant), but it also is an anti-irritant. In concentrations of 0.5% to 2%, it can exfoliate the surface of skin, much like AHAs. In addition, BHA has the ability to penetrate into the pore (AHAs do not), and thus can exfoliate inside the pore as well as on the surface of the skin, which makes it effective for reducing blemishes, including blackheads and whiteheads. 27. Clinical Efficacy Confidential. For Internal Use Only 28. Comedone Extraction Serum: New serum to be used for removal of comedones (black heads)

A comedone extraction serum is currently being developed for the removal of black heads.

Comedone extraction is achieved with the SilkPeel by combining a high vacuum setting with minimal abrasion and simultaneous dermalinfusion of the soon to be launched Comedone Extraction Serum.

Confidential. For Internal Use Only 29. A quick and easy clinical procedure

SilkPeel Science

Confidential. For Internal Use Only 30. Lunch-Time Rejuvenation

A typical SilkPeel treatment will last about 20 minutes.

No downtime for the patient

Patient may feel a mild exfoliation and tightening that leaves the skin feeling healthy and smooth.

Skin may have a warm, pinkish glow that will usually fade in about 30 minutes, leaving skin looking healthy and renewed.

Confidential. For Internal Use Only 31. SilkPeel Procedure

Summary of SilkPeel protocol

Confidential. For Internal Use Only 32. Benefit to the clinical practice

SilkPeel Science

Confidential. For Internal Use Only 33. Excellent Patient Satisfaction Confidential. For Internal Use Only No downtime or ugly phase Skin resurfacing w/ dermalinfusion yields faster results Improves patient retention Noninvasive Procedure Faster visible improvement in skin Enhanced patient satisfaction 34. Simple and Safe Clinical Procedure

SilkPeel procedure can be performed by a fully trained physician or aesthetician.

The risks of traditional microdermabrasion are eliminated by the SilkPeel's crystal-free technology and patients experience little to no discomfort.

Confidential. For Internal Use Only 35. Improve Outcome of Existing Procedures

SilkPeel enhances the outcome of the followingtreatments:

• Laser Resurfacing

• Chemical Peels

• Intense Pulsed Light Therapy

• LED Light Therapy

• BOTOX

• Topical Anti-Aging Regimens

Confidential. For Internal Use Only 36. Adds Value to the Physicians Practice Confidential. For Internal Use Only 37. SilkPeel FAQs

QUESTION : What is the benefit of dermalinfusion? Why not just apply a serum to the skin after traditional microdermabrasion?

ANSWER : Dermalinfusion delivers topical solutions more efficiently than topical application due to the use of pneumatic pressure which helps drive SilkPeel serums deeper into the skin.

QUESTION : Does the vacuum inhibit the SIlkPeel from effectively infusing serums?

ANSWER : No. The vacuum merely suctions excess solution on either side of the diamond head that is not absorbed into the skin.

Confidential. For Internal Use Only 38. SilkPeel FAQs

QUESTION : How can SilkPeel improve the outcome of IPL treatments?

ANSWER : When used as a pretreatment, SIlkPeel improves the penetration of light into the skin.

QUESTION : How can SilkPeel improve the outcome of Fraxel procedures?

ANSWER : The SilkPeel can be used to remove plaques and hydrate skin 2 weeks post-Fraxel treatment in order to promote enhanced repair and rejuventation of skin.

Confidential. For Internal Use Only 39. SilkPeel FAQs

QUESTION : How do you clean and disinfect the SilkPeel?

ANSWER : Unlike traditional microdermabrasion devices, the SilkPeel is the only dermalinfusion/microdermabrasion system with a validated cleaning and disinfecting method.

QUESTION : Why doesnt e med offer oxygen infusion with the SilkPeel?

ANSWER : One of the central causes of photodamage is oxidation caused by oxygen free radicals. Free radicals are generated from oxygen when skin is moderately exposed to sunlight.

Confidential. For Internal Use Only 40. SilkPeel FAQs

QUESTION : Why does the Vitamin C Dermalinfusion Serum use a vitamin C derivative rather than vitamin C?

ANSWER : The vitamin C derivative (sodium ascorbyl phosphate) is considerably more stable than vitamin C (L-ascorbic acid) in aqueous formulas. Besides being a good antioxidant, this derivative also improves acne and hyperpigmentation

QUESTION : Why do the SilkPeel serums use parabens? Arent parabens bad for you?

ANSWER : Parabens remain the most effective antimicrobial preservatives for aqueous formulations. Both U.S. (FDA & American Council on Science and Health) and European Health agencies (via European Cosmetic Directive) consider parabens safe for human use.

Confidential. For Internal Use Only