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GDA course on NGS Data Analysis

Signal Transduction

MDA course on NGS Data AnalysisValencia, 30 Sep 2015

BIER

Signal Transduction

GDA course on NGS Data AnalysisIntroduction

Signal transduction is the transmission of molecular signals from cell's exterior to its interior.

Signals received by cells must be transmitted effectively into the cell to ensure an appropriate response.

This step is initiated by cell-surface receptors and terminated by target protein.

Signal Transduction

GDA course on NGS Data AnalysisIntroduction

https://youtu.be/llY1or7gKW0

GDA course on NGS Data AnalysisIntroduction

Signal Transduction in 3 Steps

1) Reception2) Transduction3) Response

GDA course on NGS Data AnalysisIntroduction

Reception-Transduction-ResponseSignal MoleculesPhysical signals Light, electronic, mechanic, UV, heat, volume, osmotic, etc. Chemical signals Hormones, neurotransmitters, growth factors, cytokines, odor molecules, ATP, active oxygen, drugs, toxins, etc.

Reception-Transduction-Response

GDA course on NGS Data AnalysisIntroduction

Relation between proteins:

Activation

Inhibition

An Example

GDA course on NGS Data AnalysisIntroduction

Phosphorylation

GDA course on NGS Data AnalysisIntroduction

Indirect Effect & Activation

GDA course on NGS Data AnalysisIntroduction

Dephosphorylation

GDA course on NGS Data AnalysisIntroduction

Phosphorylation

GDA course on NGS Data AnalysisIntroduction

Reception-Transduction-Response

GDA course on NGS Data AnalysisIntroduction

ACTIVATION: Activation, phosphorilation, indirect expression, dephosphorilation, glycosylation.

INHIBITION: Inhibition, ubiquitination, methylation.

Reception-Transduction-Response

GDA course on NGS Data AnalysisIntroduction

Cellular Function:

Apoptosis, Survival, Growth, Migration, Proliferation, Differentiation,

Cell Cycle, Metabolism(Catabolism and Anabolism), etc

Reception-Transduction-Response

GDA course on NGS Data AnalysisIntroduction

Cellular Functions

Apoptosis, Survival, Growth, Migration, Proliferation, Differentiation,

Cell Cycle, Metabolism(Catabolism and Anabolism), etc.

Diseases

Cancer, Diabetes, Cystic fibrosis, etc.

Apoptosis Signaling Pathway

GDA course on NGS Data AnalysisIntroduction

Subpathway with Apoptosis Function

GDA course on NGS Data AnalysisIntroduction

Signaling Pathway Databases

GDA course on NGS Data AnalysisIntroduction

KEGG

Reactome

Wikipathways

Biocarta

NCI-PID

Signalink