sickle cell anemia
DESCRIPTION
Sickle Cell Anemia. By Alex Lange & Roy Darrah. Inheritance Pattern. Parents can be carriers and show no symptoms of the disease. Sickle Cell Anemia is a autosomal reccesive pattern. Mutations. Mutations in the HBB gene causes Sickle Cell Anemia. - PowerPoint PPT PresentationTRANSCRIPT
Sickle Cell Anemia
By Alex Lange & Roy Darrah
Inheritance Pattern
• Parents can be carriers and show no symptoms of the disease.
•Sickle Cell Anemia is a autosomal reccesive pattern.
Mutations
• Mutations in the HBB gene causes Sickle Cell Anemia.
• It consists of four protein subunits, 2 alphaglobins and 2 betaglobins which form a hemoglobin (C,E,S,AS).
• Hemoglobins bind oxygen in a cell, but amino acids can switch with betaglobins making the cell nonfunctional.
Incidences• Sickle Cell Anemia is most common in people
with African, Mediterranean, and Caribbean ancestors.
• Sickle Cell Anemia is most common inherited blood disorder in the US, 70-80 thousand Americans have this disorder.
• 1 in 500 African Americans and 1 in 1000 Hispanic Americans will have this disorder.
Symptoms
• Shortness of breath• Fatigue• Delayed growth in children• Yellowing of the eyes and skin• Cells can get stuck in veins• Organ damage (lungs, kidneys, spleen,
brain)• High blood pressure
Treatments
• There is no cure to Sickle Cell Anemia except for a bone marrow transplant.
Lifetime Limitations
• People can live normal lives• Others should avoid a lot of physical activity due
to the lack of oxygen and cells• Stay away from high altitudes• Ryan Clark plays football for the Steelers and he
has Sickle Cell Anemia. Even though he struggles with extreme exercises and hypoxia from high altitudes.