shunt infection. introduction ventricular catheter placement one of the most common neurosurgical...
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SHUNT INFECTION
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Introduction
Ventricular catheter placement one of the most common neurosurgical procedures
One of the most common complications associated is infection
Infection: positive CSF culture/ or from shunt hardware
More common in pediatric population
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CRITERIA –Brown and Durand et al.,
Positive CSF/ shunt tip culture in patient with clinical presentation of ABM/ shunt malfunction
At least 1 parameter of CSF inflammation
TLC->0.25x10^9 with leucocytosis
CSF lactate conc. >0.35mmol/l CSF glucose/serum glucose
<0.4 CSF glucose value <2.5mmol
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Implications
High mortality/ morbidity Extended hospital stay Loss or delay of educational/
developmental milestones Reduced health related quality of life
style Large cost
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Infection Rate
Varied rate at different centers Walter et al., 18%/ patient: 20 year
study 5% / surgical procedure Ammirati et al., 22%/ patient and
6%/ procedure Borgberj et al., 7.4% ISPN multi centric study: 6.5%
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Time to Infection
92% of infections occurred within 3 months -Casey and colleagues
This finding generally confirmed by most
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Risk factors
Age: <6 months-19% versus 7% in older population –Casey and colleagues
Time period Educational level/ surgical skill of
surgeons Length and time of surgery Use of antibiotic before and after
surgery Method for placement of distal
catheter
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Type of shunt Reason for shunt Shunt revision Concurrent infection Presence of spinal dysraphism- Daniel M
Scuba etal.,
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Route of infection
Blood stream Shunt tubing Contamination with epidermal
commensals during surgery
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Pathogenesis
Risk factors Neutrophil and monocyte adhere
poorly to shunt system Weak phagocytosis Shunt surface irregularities harbor
organism Inoculums size/ virulence of
organism/ host defense
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Organisms
Early/ late Staphylococcus epidermidis:
coagulase negative Staphylococcus aureus Escherichia coli
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Proteus mirabilis Klebsiella pneumonia Propionibacterium Fungal
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Presentation
Variable and age dependant Headache Lethargy Nausea/ vomiting Irritability Apnea
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Bradycardia Fever Gait disturbances Seizures Visual disturbances Gaze palsy
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Papilloedema Abdominal pain Erythema/ edema along shunt tube Fluid collection and pseudo cyst Features of shunt nephritis Sub acute bacterial endocarditis
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Evaluation and Diagnosis
Detailed history Physical examination Routine blood tests: Hb/ TLC/ DLC/
urine analysis/ blood cultures X-Ray USG CT scan: ventriculitis/ malfunction Shunt tap with CSF analysis and
culture
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Treatment
Surgical removal of the infected shunt
Antibiotic usage: empirical/ culture based
Re-insertion: 10- 14 days later with at least 48 hours
Shunt exteriorization Repeated lumbar drainage
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Shunt replacement: new/ contra lateral site
Procedures for pseudo-cyst/ abscess Antibiotics alone: less effective Brian T et
al.,
Role of intrathecal/ ventricular antibiotics Brian et al.,
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Prevention
Sterile surgical technique Perioperative antibiotic use Role of first dose antibiotic Post operative antibiotic coverage Use of shunt tubing with polymeric
silicon
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Impregnation of antibiotic Use of one piece system colak, albright etal.,
Hypothermia during surgery –gerszten pc
etal., Annual or biannual screening
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Pharmacology of IVT drugs
Prevent seeding of CSF by bacteria Staph species most common Drugs don’t cross BBB IVT provides higher CSF conc. of
drugs Thus better surgical prophylaxis Current concept: antibiotic must be
there when bacteria arrive
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Surgical technique- Do’s
First case in morning Minimal staff Send scrubbing technician out kestle et
al.,
Double gloving kulkarni, noel etal.,
Antibiotic prophylaxis chokesey etal., Pouring of bactericidal substance
doubly Skin draping
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Opening of shunt just before
insertion Change gloves while shunt handling Minimal manipulation with connector Shunt patency checked with
antibiotic saline Usage of AIS Single piece shunt
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Surgical technique- Dont’s
Cut/ slit/ make holes in lower shunt end
Tunnel superficially Handle skin Stitch infection as shunt infection H2 blockers Perform in presence of foci of
infection
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Thank you