Vaccination Vs Natural Immune System Function

FDA approved Zostavax in the spring of 2006,

the vaccine halved the risk of getting shingles. Even more impressive, it cut by two-thirds the risk of developing post herpetic neuralgia,

“Bad Science” has sold over 400,000 copies, is published in 18 countries,

exposing bad behaviour in the pharmaceutical industry will be published in 2012 by 4th Estate.

Dr Ben Goldacre

CauseShingles is caused by the varicella zoster virus, the same virus that causes chickenpox. After a person recovers from chickenpox, the virus stays in the body in a dormant (inactive) state. For reasons that are not fully known, the virus can reactivate years later, causing shingles. Herpes zoster is not caused by the same virus that causes genital herpes, a sexually transmitted disease.

“There are two ways to be fooled. One is to believe what isn't true; the other is to refuse to believe what is true.”

― Søren Kierkegaard

United States each year approximately 1,000,000 individuals develop herpes zoster

20%, or 200,000 individuals, develop postherpetic neuralgia

Less than 10 percent of people younger than 60 develop postherpetic neuralgia

after a bout of HZ, while about 40 percent of people older than 60 do

Disease incidence 20%-30% over 60yo Vaccine “works” 55% of the time 99% of shingles patients have only 1 episode

Recap:

•300,000,000 Americans•1,000,000 will get herpes zoster 1 in 300•200,000 will get post herpetic neuralgia •110,000 may be helped by the shot 0.003%•Of those 99% will have 1 occurrence •Shot is $150 - $300 per shot

But Is It

Covered By

Insurance

???

But Is It

Covered By

Insurance ???

Mechanism of activation

Unless the immune system is compromised, it suppresses reactivation of the virus and prevents herpes zoster.

Why this suppression sometimes fails is poorly understood, but herpes zoster is more likely to occur in people whose immune system is impaired due to aging, immunosuppressive therapy, psychological stress, or other factors.

Upon reactivation, the virus replicates in the nerve cells, and virions are shed from the cells and carried down the axons to the area of skin served by that ganglion. In the skin, the virus causes local inflammation and blisters. The short- and long-term pain caused by herpes zoster comes from the widespread growth of the virus in the infected nerves, which causes inflammation.

deliberately induced immunosuppression:

•body from rejecting an organ transplant• bone marrow transplant• rheumatoid arthritis• Crohn's disease• splenectomy• radiation• chemotherapy•Lupus

Non-deliberate immunosuppression:• malnutrition• aging•many types of cancer• leukemia• lymphoma• multiple myeloma• chronic infections

Cortisone

One study example

Shingles Prevention Study (SPS) in Subjects 60 Years of Age and Older (What is the Placebo Ingredients)

Efficacy of ZOSTAVAX was evaluated ZOSTAVAX (n=19,270) or placebo (n=19,276).

Subjects were followed for the development of zoster for a median of 3.1 years (range 31 days to 4.90 years).

The study excluded people who were immunocompromised or using corticosteroids on a regular basis, anyone with a previous history of HZ, and those with conditions that might interfere with study evaluations, including people with cognitive impairment, severe hearing loss, etc…

Dr. Beatrice Golomb

“there isn’t anything actually known to be physiologically inert. On top of that, there are no regulations about what goes into placebos, and what is in them is often determined by the makers of the drug being studied, who have a vested interest in the outcome. And there has been no expectation that placebos’ composition be disclosed. …”

example; type 2 diabetes drug:

placebo A (composed of Peanut oil, high in B3)

placebo B (composed of Corn Oil, low in B3).

The results :

significant improvement compared to placebo A

no improvement against placebo B.

B3 aggravated diabetes

placebo A ,making the drug appear more effective than it really is.

“What’s in Placebos: Who Knows? Analysis of Randomized, Controlled Trials”

the Annals of Internal Medicine 2008

In the ZEST study, serious adverse events occurred at a similar rate in subjects vaccinated with ZOSTAVAX (0.6%) or placebo (0.5%) from Days 1 to 42 postvaccination.

Deaths in the approved Study (What is in the Placebo???)

The incidence of death was similar in the groups receiving ZOSTAVAX or placebo during the Days 0-42 postvaccination period; •14 deaths occurred who received ZOSTAVAX•16 deaths occurred who received placebo. •most common death was cardiovascular disease (10 in the group of subjects who received ZOSTAVAX, 8 in the group of subjects who received placebo).

ZOSTAVAX is a lyophilized preparation of the Oka/Merck strain of live, attenuated varicella-zoster virus

Each 0.65-mL dose contains a minimum of 19,400 PFU (plaque-forming units) of Oka/Merck strain of VZV when reconstituted and stored at room temperature for up to 30 minutes.

Each dose contains 31.16 mg of sucrose, 15.58 mg of hydrolyzed porcine gelatin, 3.99 mg of sodium chloride, 0.62 mg of monosodium L-glutamate, 0.57 mg of sodium phosphate dibasic, 0.10 mg of potassium phosphate monobasic 0.10 mg of potassium chloride; residual components of MRC-5 cells including DNA and protein; and trace quantities of neomycin and bovine calf serum. The product contains no preservatives.

Shot ingredients and Storage StorageZOSTAVAX must be stored frozen between -58°F and +5°F (-50°C and -15°C). Use of dry ice may subject ZOSTAVAX to temperatures colder than -58°F (-50°C).Before reconstitution, ZOSTAVAX SHOULD BE STORED FROZEN at a temperature between -58°F and +5°F (-50°C and -15°C) until it is reconstituted for injection. Any freezer, including frostfree, that has a separate sealed freezer door and reliably maintains a temperature between -58°F and +5°F (-50°C and -15°C) is acceptable for storing ZOSTAVAX.

Natural Protection •“The peculiar age distribution of zoster may in part reflect the frequency with which the different age groups encounter cases of varicella and because of the ensuing boost to their antibody protection have their attacks of zoster postponed.”

•contact with children with chickenpox boosts adult cell-mediated immunity to help postpone or suppress shingles,

• adults in households with children had lower rates of shingles than households without children

• indicated that pediatricians reflected incidence rates from 1/2 to 1/8 that of the general population their age

Terada K, Hiraga Y, Kawano S, Kataoka N (1995). "Incidence of herpes zoster in pediatricians and history of reexposure to varicella-zoster virus in patients with herpes zoster". Kansenshogaku Zasshi 69 (8): 908–912.

Thomas SL, Wheeler JG, Hall AJ (2002). "Contacts with varicella or with children and protection against herpes zoster in adults: a case-control study". Lancet 360 (9334): 678–682

•A 2006 study found that fresh fruit is associated with a 300% reduced risk of developing shingles

•people who consumed less than one serving of fruit a day had a risk three times as great as those who consumed more than three servings

• For those aged 60 or more, vitamins and vegetable intake had a similar association.

Thomas SL, Wheeler JG, Hall AJ (2006). "Micronutrient intake and the risk of herpes zoster: a case-control study". Int J Epidemiol 35 (2): 307–14.

Engerix-B Vaccine Study

Adults:20 ugm = 7 months = 2,284 mIU/ml20 ugm = 13 months = 9,163 mIU/ml

Adolecents:10 ugm = 8 months = 1.989 mIU/ml20 ugm = 8 months = 7,672 mIU/ml

Infants:10 ugm = 4 months = 2,942 mIU/ml10 ugm = 7 months = 713 mIU/ml

“even though the data regarding the relation between vaccination and autoimmune disease is conflicting some autoimmune phenomena are clearly related to immunization”J.Autoimmun. 2000 feb 14(1) 1-10

molecular mimicry is an important factor in autoimmune disease

first published in 1985 and since that time substantial evidence has accumulated

causing many autoimmune diseases including: diabetes, lupus, scleroderma, rheumatoid arthritis, multiple sclerosis, chronic fatigue syndrome, autism

“even though the data regarding the relation between vaccination and autoimmune disease is conflicting some autoimmune phenomena are clearly related to immunization”

J.Autoimmun. 2000 feb 14(1) 1-10

5 year old vaccinations stopped at 3 yo speech and impulse control problems

Tetanus is a severe, often fatal disease. ….. Approximately 20 percent of reported cases end in death.Tetanus in the U.S. is primarily a disease of adults, but unvaccinated children and infants of unvaccinated mothers are also at risk for tetanus and neonatal tetanus, respectively.…. The National Health Interview Survey found that in 1995, only 36 percent of adults 65 or older had received a tetanus vaccination during the preceding 10 years.

Worldwide, tetanus in newborn infants continues to be a huge problem. Every year tetanus kills 300,000 newborns and 30,000 birth mothers who were not properly vaccinated.

Even though the number of reported cases is low, an increased number of tetanus cases in younger persons has been observed recently in the U.S. among intravenous drug users, particularly heroin users.Tetanus is infectious, but not contagious, so unlike other vaccine-preventable diseases, immunization by members of the community will not protect others from the disease. Because tetanus bacteria are widespread in the environment, tetanus can only be prevented by immunization. If vaccination against tetanus were stopped, persons of all ages in the U.S. would be susceptible to this serious disease.

History of tetanus

During the mid-1800s, there were 205 cases of tetanus per 100,000 wounds among U.S. military personnel.

By the early 1900s, this rate had declined to 16 cases per 100,000 wounds92 percent reduction

During the mid-1940s, the incidence of tetanus dropped even further to .44 cases per 100,000 wounds.

99 percent reduction

Better wound hygiene

2002 there were 25 cases of tetanus and 3 deaths reported in the U.S.

Tetanus is a serious problem in underdeveloped countries

Newborn babies born in unsanitary conditions whose umbilical cords can become infected with tetanus

1994 the Institute of Medicine concluded:“ that there is compelling scientific evidence to conclude that tetanus, DT and Td vaccines can cause Guillain-Barre syndrome including death; brachial neuritis; and death from anaphylaxis (shock).”

Because either no studies or too few scientific studies had ever been conducted to investigate tetanus, DT or Td reactions, a determination could not be made as to whether DT, Td or tetanus vaccine can cause other serious health problems which are reported following tetanus vaccination:

*residual seizure disorders*demyelinating diseases of the central nervous system *transverse myelitis*optic neuritis*acute disseminated encephalomyelitis*peripheral mononeuropathy *arthritis, and *erythema multiforme (lesions of the skin or mucous membranes).

Institute Of Med 1994

78 years with immune system problems multiple medications, low energy, poor health

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