shaw centre ottawa, ontario genomics: thepowerpromise the · 2:30 pm - 3:00 pm crop genomics doane...

Powerandpromise.cvent.com/2014

#powerofgenomics@GenomeCanada@GairdnerAwards

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the Genomics and the EnvironmentPresented by Genome Canada

and the Gairdner Foundation

Conference Program

Shaw CentreOttawa, Ontario

November 24-26, 2014

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Welcome from the Governor General of Canada ..........................4Welcome from the Prime Minister of Canada ................................5Message from the Conference Co-Chairs .......................................6

Agenda at a Glance ...........................................................................8About Genome Canada and The Gairdner Foundation ...............12Floor Plan ...........................................................................................13Day 1 – Monday, November 24 .......................................................14Day 2 – Tuesday, November 25 .......................................................18Day 3 – Wednesday, November 26 .................................................26Poster Presenters ...............................................................................30Sponsors .............................................................................................37About our Sponsors ..........................................................................40

Welcome from the Governor General of Canada Welcome from the Prime Minister of Canada Message from the Conference Co-Chairs

Agenda at a Glance About Genome Canada and The Gairdner Foundation Floor Plan Day 1 – Monday, November 24 Day 2 – Tuesday, November 25 Day 3 – Wednesday, November 26 Poster Presenters Sponsors About our Sponsors

Table of contents

Genome Canada and The Gairdner Foundation are pleased to offer conference delegates complimentary Wireless Internet access.

Step 1: search available wireless networks with your deviceStep 2: connect to FREEMAN AV WIFI networkStep 3: open your preferred web browserStep 4: select ‘Access code’ as method of paymentStep 5: enter access code: GENOME (use all caps)

Please note that the access code can only be entered into one device per delegate.

WIFI access:

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Iam pleased to send greetings to everyone gathered for Genomics: the Power and the Promise, presented by the Gairdner Foundation and Genome Canada.

Humanity is facing a great many challenges, including rapid population growth, threats to food security, a growing demand for energy, and stress on our natural resources. Innovative solutions are needed in order for us to cope. With our strength in cutting-edge sciences and technology—and, in particular, genomics—Canada is among global leaders in generating new ideas and innovative approaches to addressing such pressing issues.

This unique event, under the banner of Genomics and the Environment, showcases recent discoveries in the fi eld as well as the great minds behind them who are translating ideas into practical applications that produce social and economic benefi ts for all.

In the spirit of discovery that has inspired Canadians for nearly 150 years, I wish you an outstanding event.

David JohnstonNovember 2014

I am delighted to extend my warmest greetings to everyone attending Genomics: The Power and the

Promise – hosted by Genome Canada and the Gairdner Foundation. I welcome all the conference delegates to our beautiful Nation’s Capital.

Canada is a fi tting place to explore the theme of this conference, “Genomics and the Environment,” given our country’s expertise in genomics and the strong connec-tion that Canadians have with our natural environment. Through sustained investments by our Government, Canada has built a formidable research capacity in ge-nomics – a fi eld of largely untapped power and potential.

Canada’s natural environment – our beautiful lakes and rivers, abundant forests, and majestic mountains – is part of what defi nes us as Canadians. Through Genome Canada and the Canadian Institutes of Health Research (CIHR), our Government is seizing the opportunity to use genomics to protect and leverage our natural assets, as well as to improve health outcomes for Canadians. From the ground-breaking use of genomics in sustain-able resource extraction, to improvements in agriculture and fi sheries, to breakthroughs in disease diagnosis and

treatment, Canada recognizes that genomics is a powerful tool for innovation, environmental protection, economic growth, and social benefi t.

This conference gathers the visionaries who are leading the genomics revolution in Canada and beyond, to share the newest science in such fi elds as epigenetics, food security, and oil spill clean-up. Our Government supports the objectives of this conference and we look forward to the results of your deliberations.

Canada has a strong record of scientifi c achievement. As this event will attest, the future looks just as bright. On behalf of the Government of Canada, please accept my best wishes for a thought-provoking and productive conference.Sincerely,

The Rt. Hon. Stephen Harper, P.C, M.P.Prime Minister of Canada

November 24-26, 2014

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We are delighted to welcome you to Genomics: the Power and the Promise. This event builds

on the success of our 2012 conference by the same name and is the second time our two organizations partner to convene those who are among the world’s best and brightest in this cutting-edge fi eld of science and technology.

Since the fi rst rough draft of the human genome was mapped in 2000, researchers in Canada and the world over are beginning to understand the enormous range of complexity inherent in the interplay between genes and the environment.

From the study of epigenetics, the microbiome and the infl uence of environmental factors on human health to measuring the impact of climate change on our forests, the more we have learned about the biological blueprints of living organisms, the more we have revealed about how we affect our environment and how our environment affects us.

Research conducted at the frontier of this intersection has produced an explosion of innovation in health, environmental impact mitigation and sustainable resource extraction. Genomics has transformed disease prediction, diagnosis and treatment; has helped create more sustainable energy sources such as biofuels; has revolutionized livestock breeding and dairy production; has developed biological tools to clean up oil spills and remediate tailings ponds; and, has improved breeding and management practices to make forests and crucial crops such as wheat less susceptible to pests and climate change.

Given these remarkable advances, we felt the time was ripe to bring together the experts at the forefront of these discoveries across a wide spectrum of sectors, and provide a forum for exchange of ideas and insights. We are delighted to host such a distinguished roster of speakers, panelists,

moderators and delegates. We trust you will fi nd this conference to be rewarding, thought-provoking and truly inspiring as we explore the power and promise of genomics.

Sincerely,

Pierre Meulien, PhDPresident & CEOGenome Canada

Message from the Conference Co-ChairsCANARIE helps Canadians harness the power and the promise of genomics by advancing our knowledge and innovation infrastructure.

National Research and Education Backbone Network

Research Software

Cloud Resources for Startups

Identity and Access Management Solutions

Pierre Meulien

John H. Dirks

John H. Dirks, CM, MD, FRCP, FRSCPresident & Scientifi c DirectorThe Gairdner Foundation

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Agenda at a glance

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10:30 am - 11:00 am Genomics, animal models and emerging diseases: relevance to One Health and food security

John Harding

11:00 am - 12:00 pm Panel Discussion Moderator: Ivan Semeniuk

12:00 pm - 1:30 pm LUNCH and POSTER SESSION

SESSION 3 - ADAPTATION TO ENVIRONMENTAL FACTORS IN THE RENEWABLE NATURAL RESOURCE AND AGRICULTURAL SECTORS

1:30 pm - 2:00 pm Adaptation to environmental challenges, an Arctic perspective

Louis Fortier

Monday, November 24, 2014

11:00 am Registration Opens (Registration will remain open throughout conference)

1:00 pm - 1:30 pm Welcome and Introduction

SESSION 1 - GENOMIC MEDICINE: THE HUMAN GENOME PROJECT AND WHAT IT MEANS FOR PERSONALIZED MEDICINE AND HEALTH CARE

1:30 pm - 2:00 pm Bringing genomic medicine into focusEric Green

2:00 pm - 2:30 pm Neurogenomics Guy Rouleau

Tuesday, November 25, 2014

SESSION 2 - ENVIRONMENTAL IMPACTS ON HUMAN HEALTH

7:30 am - 8:30 am Continental Breakfast

8:30 am - 9:00 am The human microbiome: a new frontier that might just affect everything

George Weinstock

9:00 am - 9:30 am Epigenetics, epigenomics and cancer Andrew Feinberg

9:30 am - 10:00 am Epigenomics of psychiatric disease Art Petronis

10:00 am - 10:30 am HEALTH BREAK and POSTER VIEWING

2:30 pm - 3:00 pm Translating personalized genomic medicine: evidence, values and health policy

Yvonne Bombard

3:00 pm - 3:30 pm HEALTH BREAK and POSTER VIEWING

3:30 pm - 4:00 pm The opportunities and implications of personal genome sequencing

Brad Popovich Alex Dickinson

4:00 pm - 5:00 pm Panel Discussion Moderator: Catherine Zahn 5:00 pm - 6:30 pm POSTER SESSION and RECEPTION

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9:30 am - 10:00 am Microbial metagenomics of oil sands tailing ponds: small bugs, big dataJulia Foght

10:00 am - 10:30 am HEALTH BREAK and POSTER VIEWING

10:30 am - 11:00 am Microbes, metagenomics and mining: enhancing sustainabilityLesley Warren

11:00 am - 12:00 pm Panel DiscussionModerator: James Baxter

12:00 pm - 12:30 pm Perspective on the conferenceGerardo Jimenez-Sanchez

12:30 pm - 12:40 pm Closing RemarksPierre MeulienJohn Dirks

ConferenceSteering Committee

The Co-Chairs would like to thank all the members of the respective sub-committees including the Conference Secretariat, Program Committee, Poster Session Committee, and Communications & Outreach Committee. A special thanks to Helina Tadesse and Valérie Meilleur for their considerable contributions.

Co-Chairs:Pierre Meulien, Genome Canada

John Dirks, Gairdner Foundation

Members:Hélène Meilleur, Director of Events and Sponsorships, Genome Canada, and Chair of Conference Secretariat

Karl Tibelius, Vice-President, Genomics Programs, Genome Canada

Cindy Bell, Executive Vice-President, Corporate Development, Genome Canada

Andrea Matyas, Director of Communications, Genome Canada

Sommer Ellis, Director of Communications, The Gairdner Foundation

6:30 pm - 9:30 pm RECEPTION and GALA DINNER

Wednesday, November 26, 2014

SESSION 4 - GENOMIC SOLUTIONS FOR ENVIRONMENTAL AND OTHER CHALLENGES IN CANADA’S NON-RENEWABLE RESOURCE SECTORS


8:30 am - 9:00 am Where angels fear to tread: reconciling natural resource development with indigenous wisdom and ecological principlesDavid Wheeler

9:00 am - 9:30 am Harnessing metagenomics in oil-spill cleanup: lessons from the Deepwater Horizon spillTerry Hazen

Agenda at a glance

2:00 pm - 2:30 pm Planetary biodiversity - agents of change Paul Hebert

2:30 pm - 3:00 pm Crop genomics Doane Chilcoat

3:00 pm - 3:30 pm HEALTH BREAK and POSTER VIEWING

3:30 pm - 4:00 pm Some like it hot: Population variation as a tool for climate change adaptation in forestrySally Aitken

4:00 pm - 5:00 pm Panel Discussion Moderator: L. Ian MacDonald

5:00 pm - 6:30 pm POSTER SESSION and RECEPTION

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Genome Canada is a not-for-profi t organization that acts as a catalyst for developing and applying genomics and genomic-based technologies, to create economic and social benefi ts for Canadians. Genome Canada connects ideas and people across public and private sectors to fi nd new uses for genomics, invests in large-scale science and technology to fuel innovation, and translates discoveries into applications, new technologies, societal impacts and solutions across key sectors of national importance, including health, agriculture, forestry, fi sheries & aquaculture, energy, mining, and the environment.

The Gairdner Foundation was created in 1957 to recognize and reward the achievements of medical researchers whose work contributes signifi cantly to improving the quality of human life. Since the fi rst awards were made in 1959, the Gairdner Awards have become Canada’s foremost international award. They hold up the pinnacle of achievement as a mirror to Canadians, and in so doing, play a role in helping Canada achieve its goals of excellence.

Business CentreCentre d`affaires

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REGISTRATION

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SPEAKER READY/MEDIA ROOM

CONFERENCE ROOM

55 Promenade Du Colonel By Drive • Ottawa, Ontario K1N 9J2

About Genome Canada The Gairdner Foundation&

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11:00 am Registration Opens

1:00 – 1:30 pm Welcome & Introduction

Master of Ceremonies – Jay Ingram, Canadian author and broadcaster

Pierre Meulien – President and CEO, Genome Canada

John Dirks – President and Scientifi c Director, The Gairdner Foundation

SESSION 1 - GENOMIC MEDICINE: THE HUMAN GENOME PROJECT AND WHAT IT MEANS FOR PERSONALIZED MEDICINE AND HEALTH CARE

1:30 – 2:00 pm Bringing Genomic Medicine into Focus

Over the last 25 years, Guy Rouleau and his team have focused on identifying the genes causing several neurological and psychiatric diseases, including autism, amyotrophic lateral sclerosis, hereditary neuropathies, epilepsy and schizophrenia, as well as providing a better understanding of the molecular mechanisms that lead to these disease symptoms. Among Dr. Rouleau’s main achievements are his contribution to the identifi cation of over 20 disease-causing genes and his discovery of new mutational mechanisms.

2:30 – 3:00 pm Translating personalized genomic medicine: evidence, values and health policy

Yvonne Bombard Assistant ProfessorUniversity of Toronto ScientistLi Ka Shing Knowledge InstituteToronto, ON, Canada

Yvonne Bombard is an interdisciplinary genomics and health services researcher specializing in the assessment and translation of genomic

Eric Green DirectorNational Human Genome Research InstituteBethesda, MD, USA

Eric Green is the Director of the National Human Genome Research Institute (NHGRI) at the U.S. National Institutes of Health. For the past 25 years, he has been at the forefront of efforts to map, sequence, and understand the human genome, including signifi cant start-to-fi nish involvement in the Human Genome Project. He is responsible for providing overall leadership of NHGRI’s research portfolio and other initiatives.

2:00 – 2:30 pm Neurogenomics

Guy Rouleau DirectorMontreal Neurological Institute and HospitalMcGill UniversityMontreal, QC, Canada

technologies in clinical care. Her research focuses on assessing the health outcomes and ethical and policy implications of integrating personalized genomic tests and technologies into health care.

3:00 – 3:30 pm Health Break and Poster Viewing

3:30 – 4:00 pm The opportunities and implications of personal genome sequencing

Brad Popovich ProfessorChief Scientifi c Offi cerGenome British ColumbiaVancouver, BC, Canada

Brad Popovich was one of the fi rst genetic counselors to immigrate to Canada in 1978. After completing his graduate and postdoctoral training, Brad became the founding director of the San Diego Children’s Hospital DNA Diagnostic Laboratory in

Day 1 • Monday, November 24

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1989 and was responsible for the translation of several new genetic research fi ndings into clinical practice. He was also a pioneer in the forensic use of DNA while in San Diego, and his laboratory was the fi rst in the US to offer solely DNA-based paternity testing.

Alex Dickinson Senior Vice-President Strategic InitiativesIlluminaSan Diego, CA, USA

Alex Dickinson is Illumina’s senior vice president of strategic initiatives. His group’s responsibilities include nation-scale population sequencing projects and the development of software for new sequencing applications. Previously, Dr. Dickinson was CEO of Helixis, a molecular diagnostic startup he co-founded with Nobel Laureate David Baltimore. The company was acquired by Illumina in 2010.

4:00 – 5:00 pm Panel Discussion on Session 1 topic Panelists include above-noted speakers as well as David Lee and Jim Ghadbane (see bios below).

ModeratorCatherine Zahn President and CEOCentre for Addiction and Mental Health

Catherine Zahn is President and Chief Executive Offi cer of the Centre for Addiction and Mental Health, Canada’s leading mental health hospital. She is a Fellow of the Royal College of Physicians and Surgeons of Canada and a Professor at the University of Toronto’s Faculty of Medicine. Dr. Zahn is internationally recognized for her contributions to education and standards of practice in neurology. She is a champion for the integration of psychiatry and neuroscience, and for steering mental illness into the mainstream of medicine and the public spotlight.

Additional panelistDavid K. Lee Director, Offi ce of Legislative and Regulatory ModernizationHealth Canada

David K. Lee is the Director of the Offi ce of Legislative and Regulatory Modernization, Health Canada, whose mandate is to modernize the Canadian Food and Drugs Act and corresponding regulatory frameworks. The modernization of these regulatory

tools will focus on food safety frameworks and the implementation of a life-cycle approach to the regulation of health products, including pharmaceuticals, biologics, and medical devices. Mr. Lee has lectured extensively on intellectual property law and pharmaceuticals law both nationally and internationally.

Additional panelistJim Ghadbane President and CEOCANARIE

Jim Ghadbane is President and CEO of CANARIE – a vital component of Canada’s digital infrastructure supporting research, education and innovation. He is responsible for the ongoing evolution of the advanced research and education network; technology innovation and the development of research software tools, and stimulating innovation and commercialization in Canada’s ICT sector.

5:00 – 6:30 pm Poster Session and Reception

Day 1 • Monday, November 24

C O N C O R D I A . C AC E N T R E F O R A P P L I E D S Y N T H E T I C B I O LO GY

BE PART OF THE THINKING

M A K I N G M E D I C I N E F O R T H E M A S S E S

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SESSION 2 - ENVIRONMENTAL IMPACTS ON HUMAN HEALTH


8:30 – 9:00 am The human microbiome: a new frontier that might just affect everything

George Weinstock Associate Director and ProfessorMicrobial GenomicsThe Jackson Laboratory for Genomic MedicineFarmington, CT, USA

George Weinstock, a pioneer in the genomic analysis of the microbiome, joined The Jackson Laboratory in September, 2013 as professor and associate director for Microbial Genomics. As a scientist dedicated to exploring how the microbiome interacts with the host genotype to infl uence health and disease, Dr. Weinstock’s ultimate goal is to elucidate genomic mechanisms that could one day inform the development of new diagnostic

Arturas Petronis ProfessorCentre for Addiction and Mental Health (CAMH)University of TorontoToronto, ON, Canada

Arturas Petronis has been a faculty member at the Centre for Addiction and Mental Health, and University of Toronto since 1997. Currently, he is Professor and Head of the Krembil Family Epigenetics Laboratory. He is also Tapscott Chair for Schizophrenia Studies at the University of Toronto. His research is dedicated to the elucidation of the role of epigenetic factors in complex non-Mendelian diseases such as schizophrenia, diabetes, and infl ammatory bowel disease. Dr. Petronis has published over 100 papers and book chapters.

10:00 – 10:30 am Health Break and Poster Viewing

10:30 – 11:00 am Genomics, animal models and emerging diseases: relevance to “One Health” and food security

and therapeutic approaches to promote health as well as treat infectious diseases and other dire medical conditions.

9:00 – 9:30 am

Epigenetics, Epigenomics and Cancer

Andrew Feinberg DirectorCenter for EpigeneticsJohns Hopkins University School of MedicineBaltimore, MD, USA

Andrew Feinberg is Director of the Center for Epigenetics in the Institute for Basic Biomedical Sciences at Johns Hopkins. He holds an Adjunct Professorship at the Karolinska Institute in Sweden and is a Presidential Scholar at Harvard’s Dana Farber Cancer Institute.

9:30 –10:00 am Epigenomics of Psychiatric Disease

John HardingProfessorWestern College of Veterinary Medicine University of SaskatchewanSaskatoon, SK, Canada

John Harding has served the Canadian swine industry for over 25 years, both in the private sector and in academia. He is presently a Professor in Swine Production Medicine at the Western College of Veterinary Medicine, University of Saskatchewan. His research activities focus on emerging and re-emerging diseases of economic signifi cance to the Canadian swine industry, including Brachyspira colitis, Periweaning Failure-to-Thrive syndrome, reproductive PRRS and porcine circovirus.

11:00 am – 12:00 pm Panel Discussion on Session 2 topic Panelists include above-noted speakers as well as Robert Cushman and Roman Szumski (see bios below).

Day 2 • Tuesday, November 25

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ModeratorIvan Semeniuk Science ReporterThe Globe and Mail

Ivan Semeniuk reports on science and science policy for The Globe and Mail. With more than 20 years of experience in science journalism, his previous roles include: US news editor for Nature, bureau chief for New Scientist magazine and producer and columnist with Discovery Channel, Canada. He is a contributing editor to Sky News magazine and he writes and hosts the award winning astronomy television series, Cosmic Vistas.

Additional panelistRobert Cushman Senior Medical AdvisorDirector General, Biologics and Therapies DirectorateHealth Canada

Robert Cushman is the Senior Medical Advisor at Health Canada and the Director General of the Biologics and Genetic Therapies Directorate. From 2005 to 2011, he served as the inaugural CEO of the Champlain Local Health Integration Network, and prior to

SESSION 3 - ADAPTATION TO ENVIRONMENTAL FACTORS IN THE RENEWABLE NATURAL RESOURCE AND AGRICULTURAL SECTORS

1:30 – 2:00 pm Adaptation to environmental challenges, an Arctic perspective

Louis Fortier Scientifi c DirectorArcticNetProfessorLaval UniversityQuebec, QC, Canada

Louis Fortier holds the Canada Research Chair on the Response of Arctic Marine Ecosystems to Climate Change at Université Laval. A specialist of zooplankton and fi sh, he has authored and co-authored over 90 scientifi c papers on subjects varying from carbon fl uxes in the Arctic Ocean to policy in a changing Arctic. He is the Project Leader for the Canada Foundation for Innovation-funded Canadian Research Icebreaker Amundsen, and the Scientifi c Director of ArcticNet, a Canadian Network of

that as Ottawa’s Medical Offi cer of Health, where he pioneered comprehensive and controversial smoke free legislation in 2001. Dr. Cushman has worked as a primary care physician in a variety of health-care settings.

Additional panelistRoman Szumski Vice-President of Life SciencesNational Research Council Canada

Roman Szumski, a Fellow of the Royal College of Physicians and Surgeons of Canada, joined NRC in July 2005 as Vice-President of Life Sciences. He is a recognized visionary leader and an innovative manager with unique experience in building strategic public-private sector partnerships in the life sciences sector. Dr. Szumski is also the Chair of the Genomics R&D Initiative, which coordinates federal science departments and agencies in the fi eld of genomics research.

12:00 – 1:30 pm Lunch and Poster Session

Centres of Excellence that brings together specialists from 30 universities for the integrated study of the transformation of the coastal Canadian Arctic.

2:00 – 2:30 pm Planetary biodiversity – agents of change

Paul HebertDirectorBiodiversity Institute of OntarioUniversity of GuelphGuelph, ON, Canada

Paul Hebert holds a Canada Research Chair in Molecular Biodiversity at the University of Guelph where he is Director of the Biodiversity Institute of Ontario. He is a Fellow of the Royal Society of Canada and has honorary degrees from the Universities of Waterloo and Windsor. He is Scientifi c Director of the International Barcode of Life Project, the largest research program ever undertaken in biodiversity science. His 400 publications have received more than 25,000 citations.


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2:30 – 3:00 pm Crop genomics

Doane ChilcoatDirectorApplied Technology Systems (ATS)DuPont PioneerJohnston, IA, USA

Doane Chilcoat is the Director of Applied Technology Systems (ATS) at DuPont Pioneer, which includes high-throughput nucleic acid and protein analysis, genomics, protein production, antibody production, analytic chemistry, chemometrics, microscopy, plant transformation and greenhouses/controlled environments. ATS includes more than 300 researchers at 6 sites on 3 continents.

3:00 – 3:30 pm Health Break and Poster Viewing

3:30 – 4:00 pm Some like it hot: Population variation as a tool for climate change adaptation in forestry

magazine of politics and public policy. He is the author of fi ve books, including the 1984 national best-seller, Mulroney: The Making of the Prime Minister. He is also the author of the critically acclaimed From Bourassa to Bourassa: Wilderness to Restoration. He served as chief speech writer to Prime Minister Mulroney from 1985-89 and later as head of public affairs at the Canadian Embassy in Washington from 1992-94. He was Editor of Policy Options magazine from 2002-12. His political column appears on iPolitics and he is a frequent commentator on CPAC and CTV.

Additional panelistAndré Lévesque Research ScientistAgriculture & Agri-Food Canada

André Lévesque is a Research Scientist with the Biodiversity group of Agriculture & Agri-Food Canada, Central Experimental Farm, Ottawa, and is a study leader for the mycology/microbiology unit. He is adjunct professor in the Biology Department of Carleton University, Ottawa. His research is on molecular taxonomy, ecology and genomics of fungi, specializing on oomycetes and other zoosporic fungi. He published genomes for different species of the genus Pythium, generated the most comprehensive phylogenies

Sally AitkenProfessorCentre for Forest Conservation GeneticsUniversity of British ColumbiaVancouver, BC, Canada

Sally Aitken is a Professor in the Department of Forest and Conservation Sciences the University of British Columbia. Her work is focused on the capacity of tree populations to adapt to or tolerate a range of climatic conditions, and implications of climate change for forest management.

4:00 – 5:00 pm Panel Discussion on Session 3 topic Panelists include above-noted speakers as well as André Lévesque and Pierre Lapointe (see bios below).

ModeratorL. Ian MacDonald Editor & PublisherPolicy Magazine

L. Ian MacDonald is Editor and Publisher of Policy, Canada’s


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and DNA barcode databases for oomycetes, and has developed several DNA-based assays for disease management, diagnostics and molecular ecology.

Additional panelistPierre LapointePresident and CEOFP Innovations

Pierre Lapointe is President and Chief Executive Offi cer of FPInnovations since December, 2008. Under his leadership, FPInnovations has positioned itself as Canada’s Forest Sector Innovation Hub. FPInnovations’ scientifi c research has supported the Forest Industry with landmark projects, from building the world’s fi rst nanocrystalline cellulose demonstration plant (in partnership with Domtar) to creating the most comprehensive CLT (cross-laminated timber) handbook for the construction industry as well as implementing the fi rst cellulose fi laments demonstration plant in the world (in partnership with Kruger).

5:00 – 6:30 pm Poster Session and Reception

6:30 – 9:30 pm Reception and Gala DinnerMaster of Ceremonies: The Honourable Kelvin Ogilvie, Senator

Address by The Honourable Ed Holder, Minister of State (Science and Technology)

Ed Holder was fi rst elected to the House of Commons in 2008 and was re-elected in 2011. On March 19, 2014, Mr. Holder was appointed Minister of State (Science and Technology). He has been a member of several committees, including the Standing Committees on Industry, Science and Technology; International Trade; and Transport, Infrastructure and Communities. Mr. Holder is a Commander of the Order of St. John, a member of the Royal Canadian Legion and a recipient of the Queen Elizabeth II Diamond Jubilee Medal and the Governor General’s 125th Anniversary of the Confederation of Canada Medal for his service to Canada.

Keynote speech by Dr. Sharon Moalem, Award-winning physician, scientist, inventor and New York Times bestselling author

The Scientifi c Signifi cance of the Rare: Why exceptional genetic conditions matter


Sharon Moalem MD, PhD

Sharon Moalem, MD, PhD - is an award-winning physician, scientist, inventor and NYT-Bestselling author. He has been researching rare genetic disorders for the last 20 years, working to fi nd novel treatments for people with rare or orphan diseases and has been awarded 21 patents worldwide for his

inventions in the fi eld of biotechnology and human health.His scientifi c work has led to the discovery of a fi rst-in-class member

of a novel class of antibiotic compounds directed against multi-resistant or ‘superbug’ microorganisms such as Methicillin-resistant Staphylococcus aureus (MRSA). Dr. Moalem has also cofounded two biotechnology companies and has served as an associate editor for the Journal of Alzheimer’s Disease.

Dr. Moalem is also a New York Times and international bestselling author whose books have been translated into more than 35 languages. His latest book, Inheritance: How Our Genes Change Our Lives and Our Lives Change Our Genes, was selected by Amazon as a Best Book of the Year in the Category of Science for 2014.

Copies of Dr. Moalem’s books can be purchased at Amazon.ca.

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SESSION 4 - GENOMIC SOLUTIONS FOR ENVIRONMENTAL AND OTHER CHALLENGES IN CANADA’S NON-RENEWABLE RESOURCE SECTORS


8:30 – 9:00 am Where angels fear to tread: reconciling natural resource development with indigenous wisdom and ecological principles

David Wheeler President and Vice-ChancellorCape Breton UniversitySydney, NS, Canada

David Wheeler is President and Vice-Chancellor of Cape Breton University. He is an internationally experienced academic and business person with more than two decades of senior executive level involvement in change management and sustainable business practice, research and teaching. In the last fi ve years,

David has focused much of his advisory work in the fi elds of energy conservation and renewable energy policy in Canada and the UK.

9:00 –9:30 am Harnessing metagenomics in oil-spill cleanup: lessons from the Deepwater Horizon spill

Terry HazenProfessorDepartment of Civil and Environmental EngineeringDepartment of MicrobiologyDepartment of Earth and Planetary SciencesUniversity of TennesseeKnoxville, TN, USA

Terry Hazen is a fellow of the American Academy of Microbiology and the American Association for the Advancement of Science. He has authored more than 295 scientifi c publications. His area of specialty is environmental microbiology, especially as it relates to bioremediation, water quality, bioenergy and carbon cycling.

Day 3 • Wednesday, November 26

9:30 – 10:00 am Microbial metagenomics of oil sands tailing ponds: small bugs, big data

Julia Foght ProfessorDepartment of Biological SciencesUniversity of Alberta Edmonton, AB, Canada

Julia Foght is Professor of Microbiology at the University of Alberta. Her research has focused primarily on hydrocarbon biodegradation, including bioremediation of oil spills and surveys of aerobic hydrocarbon-degrading microbes in Antarctica. More recently her lab has been studying anaerobic processes in oil sands tailings ponds.

10:00 – 10:30 am Health Break and Poster Viewing

10:30 – 11:00 am Microbes, metagenomics and mining: enhancing sustainability

Lesley Warren ProfessorSchool of Geography and Earth SciencesMcMaster UniversityHamilton, ON, Canada

Lesley Warren has established a pioneering, multidisciplinary research program identifying opportunities for the mining and energy resource sectors to monitor and manage their waste more sustainably through novel identifi cation of the roles bacteria play in key water quality processes. She has been identifi ed as an NSERC visionary for the Environmental Earth Sciences community.

11:00 am – 12:00 pm Panel discussion on Session 4 topic Panelists include above-noted speakers as well as Javier Gracia-Garza and Rick Lawrence (see bios below).

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priorities; communicating the impact of NRCan’s work to partners and stakeholders; creating an environment to sustain excellence in science; advancing science-policy integration; furthering the integration and performance of the forest sector innovation system; and, supporting the delivery of key programs including invasive alien species, climate change and adaptation, and genomics.

Additional panelistRick LawrencePresidentLawrence Consulting Ltd.

Rick Lawrence is the President of Lawrence Consulting Ltd., providing consulting services to the mining industry since 1987. He is also an Adjunct Professor at the University of British Columbia, where he teaches courses in mine feasibility and precious metal ore processing. Rick has been involved in consulting, process development, research and education for nearly 40 years. Rick is a Professional Engineer in BC and a Chartered Engineer in the UK.

ModeratorJames BaxterEditor & PublisheriPolitics

Over the past 25 years, James Baxter has been an award-winning sportswriter, political journalist, bureau chief and editorial writer. A third-generation public affairs journalist, Mr. Baxter’s work covering politics, fi rst in Ottawa and then in Alberta, earned him a Nieman Fellowship at Harvard University in 2008, where his studies focused on international trade law and the future of the media industry.

Additional panelistJavier Gracia-GarzaDeputy Chief ScientistNatural Resources Canada

Javier Gracia-Garza is Deputy Chief Scientist of Natural Resources Canada (NRCan) and Director General, Science Program Branch of the Canadian Forest Service at NRCan. His responsibilities include: ensuring alignment of the CFS S&T portfolio to Government of Canada and departmental

Day 3 • Wednesday, November 26

12:00 – 12:30 pm Perspective on the conference

Gerardo Jimenez-Sanchez Program DirectorGenomics and BioeconomyHarvard School of Public HealthHarvard UniversityBoston, MA, USA

Gerardo Jimenez-Sanchez is a certifi ed pediatrician, the Program Director of Genomics and Bioeconomy at Harvard School of Public Health, and Executive President of Global Biotech Consulting Group. He served as Chairman of Biotechnology at the Organization for Economic Co-operation and Development (OECD) from 2007 to 2014, founding Director of the National Institute of Genomic Medicine in Mexico, and director of the Mexican Genomic Diversity Project. He chairs the Committee on Genomics and Bioeconomy at the Human Genome Organization, and has served as a Council Member in Biotechnology to the United Nations Secretary General.

12:30 – 12:40 pm Closing remarks

Pierre Meulien Genome Canada

John Dirks The Gairdner Foundation

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NO. PRESENTER LAST NAME

PRESENTER FIRST NAME AFFILIATION TITLE

1 Abu Laban Nidal University of Alberta

Comparative genomic studies of Desulfosporosinus: functional diversity in anaerobic hydrocarbon-impacted environments

2 Akanno Everestus University of Alberta

Identifi cation of single nucleotide polymorphism markers associated with heifer fertility and calving performance using genome-wide association in beef cattle

3 Amyotte Beatrice University of GuelphComparing apples to apples: A genome-wide association study of human sensory attributes in apple

4 Bashir Naazish University of TorontoThe 3-I framework: A framework for developing public policies around pharmacogenomics testing in Canada.



5 Braden Laura University of VictoriaTranscriptomic analysis reveals host-specifi c feeding responses of the salmon louse, Lepeophtheirus salmonis.

6 Dhaliwal Nicky (Amarpreet) University of British Columbia

Value Addition Through Genomics (VALGEN) use of scenario methods: Envisioning possible futures for Canadian agricultural biotechnology commercialization

7 El-Rass Suzan University of TorontoTransposon mediated gene trapping in zebrafi sh reveals a novel cardiovascular function for PDGFRA

8 Fanton-Aita Fiorella Université de MontréalCommercialization of Molecular Diagnostics in Canada: A Landscape Analysis and Case Study

Poster Presenters

32 33



9 Freitas Aline University of SaskatchewanCharacterization of the vaginal microbiome in pregnancy

10 Graham Carly University of Regina

Degraded DNA and next generation sequencing: low quality DNA affects double digest Restriction Associated DNA Sequencing (ddRADSeq)

11 Granados Diana Paola Université de MontréalDiscovery of minor histocompatibility antigens for leukemia immunotherapy with a novel genoproteomics approach

12 Houde Andrée-Anne Université de Sherbrooke

LRP1B and BRD2: New candidate genes in fetal metabolic programming of the newborn exposed to maternal hyperglycemia



13 Hui Tony (Zhao Kun) University of British ColumbiaA high-throughput method for whole-genome single-cell methylation sequencing

14 Lalonde Emilie University of TorontoHeterogeneity Analyses Using Genomics and the Tumour Microenvironment Predict Prostate Cancer Recurrence

15 Langlais David McGill UniversityCritical innate immune genomic responses conducted by IRF8 and IRF1

16 Long Amanda University of Alberta

A fi nancial analysis of establishing poplar plantations for carbon offsets using Alberta and British Columbia’s afforestation protocols

Poster Presenters

34 35



17 Marsh Kayla Trent UniversityInsights regarding the emergence of new wheat leaf rust virulence types through transcriptome analysis

18 Morrison Jaclyn University of British ColumbiaLimited impact of phlebotomy technique on proteomic measures

19 Müller Anita Department of Fisheries and

Oceans Canada

Characterization of the Infectious Hematopoietic Necrosis Virus (IHNV) carrier state in sockeye salmon (Oncorhynchus nerka)

20 Orata Fabini University of AlbertaComparative genomics of Vibrio metoecus with its close relative Vibrio cholerae reveal its pathogenic potential

21 Peabody Michael Simon Fraser UniversityTowards improved watershed monitoring through novel genetic tests



22 Pu Ting University of British ColumbiaDiscovery of interspecifi c rust hybrids using genotyping-by-sequencing approach

23 Sénécal Karine McGill UniversityStatement of principles on the return of research results and incidental fi ndings

24 Shay Julie Simon Fraser University

IslandViewer and IslandPlot: fl exible identifi -cation, visualization, and characterization of microbial genomic regions associated with adaptations of environmental, medical, and industrial importance

25 Singh Amrit University of British ColumbiaBlood biomarkers of the late phase asthmatic response using RNA-Seq

26 Stanley Dana University of VictoriaEarly use of GE3LS methodology enhances decision support tool development for TIA biomarker test in Emergency Departments.

Poster Presenters

36 37



27 Ugochukwu Albert University of SaskatchewanThe role of DNA barcoding technology in fi sh species authentication

28Van

WyngaardenMallory

Memorial University of Newfoundland

Genetic differentiation and population connectivity in Northwest Atlantic populations of the sea scallop, Placopecten magellanicus, using whole-genome scanning

29 Viner Coby University of TorontoTranscription factor motif discovery and prediction in an expanded epigenetic alphabet

30 Wilhelm Roland University of British ColumbiaMajor cellulolytic bacteria and fungi and their carbohydrate active enzymes in temperate California forest soils

See poster abstracts in Genome, Volume 57, No. 7. available in your conference bag.

DISCOVERERS SPONSORSHIP

PIONEERS SPONSORSHIP

Poster Presenters Sponsors

38 39

IN-KIND SUPPORTPOSTER SESSIONS SPONSORSHIP

GALA TABLES SPONSORSHIP

Sponsors

Funded by the Government of Alberta

Alberta Innovates Bio Solutions leads science and innovation to grow prosperity in Alberta’s agriculture, food and forestry sectors.

bio.albertainnovates.ca

40 41

Olympic gold medalists. Oscar winners. Satellite Designers. Concordia University has them all.

Creative. Diverse. Concordia pushes boundaries by crossing disciplines. Acclaimed fi elds include aerospace, nanotechnology, journalism, psychology, genomics, cinema, studio arts, fi nance and sustainable business.

Bold, urban energy. 46,000 students in Montreal, North America’s most exciting city. Leading research, top teaching, engaged community — transformative experiences through fl exible, friendly service.

Celebrating 40 years in 2014, Concordia defi nes the next-generation university.

The University of Ottawa is the largest bilingual (English-French) university in the world. Located at the heart of Canada’s capital, we have ready access to the great institutions of our country. Our advances in social sciences, health, science and the humanities make uOttawa a unique place to learn, grow and excel.

Today’s Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information about our operations in Canada, visit www.merck.ca.

The Children’s Hospital of Eastern Ontario (CHEO), the pediatric hospital in Canada’s capital region, helps over 500,000 kids each year in Ontario, Quebec and Nunavut. It is affi liated with the University of Ottawa and is home to globally-recognized clinicians and researchers tackling cancer with viruses, mental illness, gene discovery, obesity and much more.

About our Sponsors

42 43

About our Sponsors

CANARIE designs and delivers digital infrastructure, and drives its adoption for Canada’s research, education and innovation communities. Twelve provincial and territorial network partners, together with CANARIE, collectively form Canada’s National Research and Education Network (NREN). This powerful digital infrastructure connects Canadians to national and global data, tools, colleagues, and classrooms that fuel the engine of innovation in today’s digital economy.

One million researchers, scientists and students at nearly 2,000 Canadian institutions, including universities, colleges, research institutes, hospitals, and government laboratories have access to the CANARIE Network.

Established in 1993, CANARIE is a non-profi t corporation, with the major investment in its programs and activities provided by the Government of Canada.

Founded in 1981 in Boston, Massachusetts, Genzyme evolved from a tiny start-up to one of the world’s leading biotech companies, with nearly 10,000 employees and operations in every region of the globe. Acquired by Sanofi in 2011, Genzyme now benefi ts from the reach and resources of one of the world’s largest pharmaceutical companies, with a shared commitment to improving the lives of patients.

Genzyme has long been known for our expertise in the class of rare genetic diseases known as lysosomal storage disorders (LSDs). LSDs remain the heart of our company today, but we have also expanded our focus to other rare diseases and multiple sclerosis.

Driven by our commitment to patients, we strive to develop strong relationships with patient communities and listen to their perspectives so that we can truly understand their needs. These collaborations guide us as we continue to push the boundaries of medicine and technology to develop new and better therapies where none existed before.

The Canada Foundation for Innovation gives researchers the tools they need to think big and innovate. By investing in state-of-the-art facilities and equipment in Canada’s universities, colleges, research hospitals and non-profi t research institutions, the CFI is helping to attract and retain the world’s top talent, to train the next generation of researchers, to support private-sector innovation and to create high-quality jobs that strengthen the economy and improve the quality of life for all Canadians.

The University of Guelph is ranked as one of Canada’s top comprehensive universities because of our commitment to student learning and innovative research. We are dedicated to cultivating the essentials for our quality of life - water, food, environment, animal and human health, community, commerce, culture and learning. The University community also shares a profound sense of social responsibility, an obligation to address global issues and a concern for international development.

44 45

About our Sponsors

Illumina is a leading developer, manufacturer, and marketer of life science tools and integrated systems for large-scale analysis of genetic variation and function. These systems are enabling studies that were not even imaginable just a few years ago, and moving us closer to the realization of personalized medicine. With rapid advances in technology taking place, it is mission-critical to offer solutions that are not only innovative, but fl exible and scalable, with industry-leading support and service. We strive to meet this challenge by placing a high value on collaborative interactions, rapid delivery of solutions, and meeting the needs of our customers.

Through the Genomics Research and Development Initiative (GRDI), federal science department and agencies collaborate in the fi eld of genomics research to address biological issues that are important to Canadians, focusing on the role of federal government research. The initiative delivers concerted, high-calibre genomics research to provide economic, social and environmental benefi ts for Canadians in important areas such as health, food safety, sound management of natural resources, a sustainable and competitive agriculture sector, and environmental protection, with strong collaborations with university and private sectors.

PwC Canada helps organizations and individuals create the value they’re looking for. Our 5,800 partners and staff in offi ces across the country are committed to delivering quality in assurance, tax, consulting and deals services. PwC Canada is a member of the PwC network of fi rms with more than 195,000 people in 157 countries. Find out more by visiting us at www.pwc.com/ca.

The Peter Gilgan Centre for Research and Learning (PGCRL) is the new home for research and learning at The Hospital for Sick Children (SickKids). Located at the eastern gateway to Toronto’s Discovery district, this 750,000 square-foot facility houses 21 fl oors of leading-edge research space and high-tech, innovative learning space. More than 2,000 scientists, trainees and child health research staff work in the PGCRL, and many more members of the SickKids community use our learning concourse every day.

The state-of-the-art laboratory and learning facilities are designed to enable and enhance new collaborations across research disciplines with the end goal of fi nding new ways to improve child health. This new facility was designed to accommodate the most specialized research and learning needs. The different areas of research are refl ected in six neighbourhoods of science that are connected through staircases and large, multi-level open interactive spaces to encourage interdisciplinary engagement.

46 47

About our Sponsors

The Hospital for Sick Children (SickKids) is recognized as one of the world’s foremost paediatric health-care institutions and is Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. Founded in 1875 and affi liated with the University of Toronto, SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. Its mission is to provide the best in complex and specialized family-centred care; pioneer scientifi c and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information, please visit www.sickkids.ca.

CropLife Canada represents the Canadian manufacturers, developers and distributors of pest control products and plants with novel traits. Although many aspects of the plant science industry have evolved since the organization was fi rst established in 1952, the main purpose remains the same – to advance the collective interests of the industry in Canada.

Rx&D is the association of leading research-based pharmaceutical companies dedicated to improving the health of Canadians through the discovery and development of new medicines and vaccines. Our community represents the men and women working for more than 50 member companies which invest more than $1 billion in research and development each year to fuel Canada’s knowledge-based economy, contributing over $3 billion to the Canadian economy. Guided by our Code of Ethical Practices, our membership is committed to working in partnership with governments, private payers, healthcare professionals and stakeholders in a highly ethical manner.

Alberta Innovates Bio Solutions, is a board-governed research corporation funded by the Government of Alberta. We work with partners to identify, coordinate and fund research projects to grow prosperity in Alberta’s agriculture, food and forest sectors. We provide leadership and coordination for science and innovation in these sectors that currently contribute more than $25 billion every year into the Alberta economy. AI Bio is an integral part of the Alberta Innovates family, an alliance of organizations with a legislative mandate to further research and innovation in the province. We have strong relationships with research performers, private industry, producer organizations, funding agencies, our sister Alberta Innovates corporations, and the federal, provincial and municipal governments. We work with these partners to develop solutions to help solve industry challenges and inform government policy decisions. Visit www.bio.albertainnovates.ca.

48 49

iPolitics is independent, non-partisan and committed to providing timely, relevant, insightful content to those whose professional or personal interests require that they stay on top of political developments in Ottawa and the provinces. Working in a spirit of neutral inquiry, our daily news service will include coverage of the legislative, regulatory, political and policy developments that matter most to businesspeople, professionals, politicians, public servants, political activists and the more politically-aware. www.ipolitics.ca

Genome is one of the 16 NRC Research Press journals published by Canadian Science Publishing, which are distributed worldwide to over 175 countries. Established in 1959, this monthly journal publishes original research articles, reviews, mini-reviews, and commentaries. The areas of interest include general genetics, cytogenetics, molecular genetics, evolutionary genetics, population genetics, developmental genetics, plant genetics, microbial genetics, mammalian genetics, genomics, and other related areas. The journal Editors are Dr. G. Scoles, Dr. M. Cristescu, and Dr. A. Hilliker. Genome is proudly affi liated with the Canadian Society for Molecular Biosciences, and is proud to support Genomics: The Power & The Promise.

About our Sponsors

www.genzyme.ca

A rare commitmentTo discover and deliver transformativetherapies for patients with rare and

special unmet medical needs, providinghope where there was none before.

Join us in celebrating a century of Canadian innovation and contribution to global health care advances. Visit www.canadapharma.org/100

A history of innovation –a future of infinite possibilities

THE PETER GILGAN CENTRE FOR RESEARCH AND LEARNING

www.sickkids.ca/Research/index.html

Come make a difference with us in Toronto

IMPACT

GLOBA

L

INNOVATION

TRANSFORMATIVEDISCOVERY

COLLABORATIONVISION

50 5150

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