Shakila Thangaratinam PhD, MD, MRCOG

Professor of Maternal and Perinatal Health Barts and the London School of Medicine

Barts Health NHS Trust Queen Mary University of London

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Summary of CV

Clinical portfolio

Qualifications

CCT: Obstetrics & Gynaecology MBBS, MRCOG, MD, PhD

Special interests Maternal Medicine

Research portfolio

Qualification PhD, Health Technology Assessment in Maternal and Perinatal Medicine, University of Birmingham.

Research interests Prediction and prevention of pre-eclampsia and gestational diabetes Obesity in pregnancy Evidence synthesis

Diagnostic methodology Evidence Based Medicine Publications Over 40 publications in peer-reviewed journals Grants Income of over £6 million HTA –NIHR: £250k (Obesity IPD meta analysis, 2013)

HTA-NIHR: £560k (DAPPA study, 2012) HTA-NIHR: £780k (PREP study, 2010) HTA-NIHR: £1.8m (EMPIRE trial, 2010) HTA-NIHR: £120k (Obesity in pregnancy Evidence Synthesis, 2009) HTA-NIHR: £320k (PET CT in cervical cancer Evidence Synthesis, 2009) HTA-NIHR: £229k (Sentinel nodes in vulval cancer Evidence Synthesis, 2009) EME(MRC/NIHR): £1.4m (TABLET Trial, 2010) HTA-NIHR: £940k (Pulse Ox study, 2007) European Union Leonardo da Vinci programme: €240k (eBayesMet, 2009) BWH R&D, UK; £50k (SOAP, 2010) Marie Curie (IRSES): €180 (EBM Connect, 2010) HEIF 4 Higher Education Institution Fund: £19k (kNOTE, 2009)

Peer review for grants Wellbeing of Women, CAIBER Spain, Heart Research UK, ZonMW Netherlands Peer review for journals Lancet, BMJ, JAMA, BJOG, EJOG, BMC, UOG Management & Leadership

R&D Director for Women’s Health, Barts Health NHS Trust

Joint Lead, Multidisciplinary Evidence Synthesis Hub (mEsh), QMUL

Executive Board Member: Maternal Medicine Clinical Study Group

Executive Board Member, CEL Local Clinical Research Network

National Obesity Steering Group Member: RCOG lead at Academy Of Medical Royal Colleges

Chair of the Trial Steering Committee, PREVIEW RCT

Founder, Katherine Twining Research Network

Board Member of ELLY Appeal, Barts Charity

Medical Education Portfolio

Senior Clinical Examiner for Undergraduate OSCE Educational supervisor for postgraduate trainees E-modules for college tutors and educational supervisors in West Midlands

Undergraduate lectures: Pre-eclampsia, Diabetes in pregnancy Personal mentor for Student Selected Activity (SSA) Obstetrics and Gynaecology representative at Exam Board E-modules for EBM trainers in 7 EU countries Tutor in Basic Surgical Skills course

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Development of online modules for www.aceonline.org.uk and examiner for MRCOG part 2 course (www.acecourses.co.uk)

Medical Education Research: peer-reviewed publications Post-graduate Critical Appraisal training days for trainees in all specialities Training the Teachers to teach critical appraisal (consultants from all specialties)

Personal details

Name Shakila Thangaratinam Date of Birth 24 March 1973 Marital Status/Sex Married/Female Nationality British Work Address High Pines, 71 Walsall Road, Little Aston, Sutton Coldfield, West Midlands,

B74 3BA Telephone numbers 0121 352 0517 Email a.coomarasamy@bham.ac.uk mls@smlegalservices.co.uk Medical School University of Birmingham Medical MBBS 1996 (Dr MGR Medical University, Madras, India) Postgraduate MRCOG May 2001 MRCOG 2003 Qualifications MD May 2004 PhD 2011 (University of Birmingham) MD 1999 (Dr MGR Medical University, Madras, India) CCT 2010 Professional Bodies Nov 2008 GMC Full Registration No 5207639

Medical Defence Union British Maternal and Fetal Medicine Society

Employment History Oct 2012 – to date Professor of Maternal and Perinatal Health

Barts and the London School of Medicine, Queen Mary University of London

Mar 2011 – Sep 2012

Clinical Senior Lecturer and Consultant in Obstetrics and Maternal Medicne Barts and the London School of Medicine, Queen Mary University of London

Apr 2006 – Feb 2011 Clinical Lecturer in Obstetrics and Gynaecology and Clinical Epidemiology Birmingham Women’s Hospital, University of Birmingham Sep 2005 – Mar 2006 Specialist Registrar in Obstetrics and Gynaecology University Hospital North Staffordshire, Stoke-on-Trent Sep 2004 – Aug 2005 Clinical Research Fellow in Obstetrics and Gynaecology Keele University, Keele Dec 2003 – Aug 2004 Specialist Registrar in Obstetrics and Gynaecology University Hospital North Staffordshire, Stoke-on-Trent Apr 2003 - Nov 2003 Senior SHO in Obstetrics and Gynaecology Bassetlaw District General Hospital, Worksop Apr 2002 – Mar 2003

SHO in Obstetrics and Gynaecology Derby City General Hospital, Derby

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Dec 2001 – Mar 2002

SHO in Obstetrics and Gynaecology James Paget Hospital, Great Yarmouth

Experience in India Apr 1999 – Oct 2000 Senior SHO in Obstetrics and Gynaecology Christian Fellowship Hospital, Oddanchatram, India Apr 1996 – Mar 1999 Postgraduate trainee in Obstetrics and Gynaecology (MD) (36 months) Madras Medical College, Dr MGR Medical University, Madras, India

Career summary I started my career in Obstetrics and Gynaecology as a postgraduate trainee at Madras Medical College, Dr MGR Medical University. It is one of the leading universities in India responsible for undergraduate and postgraduate training. My interest in research began during my tenure there while evaluating the diagnostic role of cardiotocograph in mothers with meconium stained liquor for my MD. I subsequently worked as a senior SHO at Christian Fellowship Hospital in Oddanchatram, India. In recognition of my work, the British Council sponsored me in 2001 to undertake further training in UK. After 2 years in the clinical arena as an SHO, in 2004, I pursued my research interests by accepting the job of Clinical Research Fellow at Keele University. I had the opportunity to undertake Health Technology Assessment projects, especially diagnostic and therapeutic systematic reviews. During this period I was involved in the development of diagnostic EBM course at Birmingham Women’s Hospital. In 2006 I joined University of Birmingham as a Clinical Lecturer in Obstetrics and Gynaecology and Clinical epidemiology with Prof Khan and registered for PhD. The job offered excellent research training in Health Technology Assessment projects involving systematic reviews, clinical trials and research methodology in addition to medical education projects. At the end of my term as Clinical Senior Lecturer, I was offered the Professorship at Queen Mary University of London (QMUL). I am currently based at the Women’s Health Research Unit at Barts and the London School of Medicine and Dentistry, QMUL. I hold an honorary appointment as Consultant in Obstetrics and Maternal Medicine at Barts Health NHS Foundation Trust. I am the R and D Director of the Women’s Health CAG (Clinical Academic Group) at Barts Health NHS Trust.

Clinical experience

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I completed my Advanced Training in Specialist Medicine (ATSM) in Maternal Medicine, Labour ward management and Medical Education and Completion of Core Training (CCT) in Obstetrics and Gynaecology in Aug 2010. My special interest is Maternal Medicine in Obstetrics. My training in maternal medicine was undertaken in the largest and busiest tertiary obstetric unit in West Midlands (Birmingham Women’s Hospital) with 9000 deliveries per year. This involves management of obstetric patients in the joint diabetic, epilepsy, endocrine, cardiac, haematology, substance misuse, mental health, HIV, renal and immunology clinics in partnership with clinicians at Queen Elizabeth Hospital. My academic work has complemented my interest in maternal medicine as evidenced by my work in pre eclampsia and epilepsy. My PhD in “Health Technology Assessments in maternal and perinatal medicine” has provided me the opportunity to evaluate the tests and treatments in this aarea. Currently I provide obsteric services in the delivery suite and run the joint obstetric diabetic clinic and the endocrinology clinics at Barts Health NHS Foundation Trust. The diabetic clinic provides services to high risk mothers who are predominantly of Asian origin. My work in this clinic is closely linked to the recently funded multinational FP7 research project (GIFTS) on nutrition and outcomes in Asian women. I spend 2-4 hours training the juniors every week, particularly in surgery, although this is not part of my formal job plan. My oncall commitment is for obstetrics (1:9). My clinical work objectives for the coming two years include further development of the quality and range of services within the obsteric unit, update the guidelines and supervise audits.

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Academic work and publications

The following figure outlines my core research themes and the relevant projects. I have a strong interest in clinical trials, diagnostic research, evidence synthesis and evidence based medicine. My research work is largely collaborative with national and international partners.

My research strength is mainly in clinical trials, evidence synthesis and EBM (Evidence Based Medicine) projects. My work in pre-eclampsia is further expanded by studying the genetic effects on the development of early onset pre-eclampsia and its complications. I was awarded a PhD by the University of Birmingham for my work on Health Technology Assessment in Maternal and Perinatal Medicine. The output from the PhD directly led to 3 successful HTA grants (PREP, EMPIRE, and Pulse Ox) and NICE recommendations for tests in pre-eclampsia. I am part of the core team at Women’s Health Research Network at Barts and the London and involved in the recruitment of researchers, development of the department and establishing links with other units in North East London through the newly founded Katherine Twining Network. Evidence Synthesis research I have established a strong portfolio of research activities in systematic review projects. I co-lead the Multidisciplinary Evidence Synthesis Hub (mEsh) of QMUL, a unit dedicated to the development and publication of systematic review projects. I am currently funded by the NIHR to undertake IPD (Individual Patient Data) Meta analysis on dietary and lifestyle interventions in pregnancy. The core methodology of my PhD was evidence synthesis, and it served the dual purpose of collating the best available evidence to inform practice and identifying the gaps for further research. It led to eight peer reviewed publications and was instrumental in securing NIHR funding of £3 million in total for three clinical trials. I built on this work to applying for NIHR Commissioned calls on relevant systematic review projects and was successful. All three projects have now been completed, and the work on obesity has been published in BMJ and widely reported by the media. Portfolio studies

I lead two multicentre NIHR clinical trials involving 50 centres in UK. I am supported by a strong research team established by me and currently responsible for setting up five portfolio studies in the CEL Comprehensive Clinical Research Network (CLRN). I was instrumental in establishing the Katherine Twining Network as a multidisciplinary collaborative Network of seven Trusts in North East London. I

Maternal and Perinatal Medicine Evidence synthesis Global Network

Pre - eclampsia Obesity Epilepsy Endocrine

• PREP HTA study* (£750k) • DAPPA HTA study (£560k) • TIPPS project (PhD) • HugeNet genetic reviews

• Obesity HTA review*(£120k) • GIFTS FP7 (£1m) • BAHAMAS project • IPD meta analysis

• EMPIRE HTA Trial* (£1.8m) • SOAP study (£50k)

• TABLET HTA Trial (£1.4m)

IPD meta analysis-Weight management in

pregnancy

•

Sentinel nodes in vulval cancer HTA review* (£229k)

• PET CT in cervical cancer HTA review* (£320k)

• eBayesMet Leonardo( € 240k) • EBM CONNECT Marie Curie ( € 180k) • kNOTE HEIF4 (£20K)

Diagnostic methodology research programme

Perinatal: Pulse Ox HTA study (£940k ) Research themes

Research projects

Main contributor to project development with >0.15fte funding *

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obtained support from the Central and East London (CEL) CLRN to allow us to effectively accrue large numbers needed into trials rapidly. The Network membership is composed of academics, R&D managers, professionals and consumers. Studies selected receive support for Trust R&D approvals; research ethics applications; service user involvement; honorary NHS contracts for researchers; project publicity; promotion of the study with the services; participant recruitment; liaising with patients; screening and assessment of patients; and dissemination of results. As Clinical Lecturer at Birmingham Women’s Hospital, I was part of the team that recruited over 9000 patients in 2008-10 and the specialty delivered comparatively the highest number of accruals. Impact of research My work has been instrumental in changing existing national and international guidelines and clinical practice. The following are some of the examples

- My systematic reviews on the role of uric acid and proteinuria in the prediction of complications in women with pre-eclampsia identified their limited role in clinical practice. The NICE ‘ Hypertensive Disorders in Pregnancy’ guideline directly referenced these papers in recommending not to test for proteinuria once established, and to avoid use of uric acid results alone in the management of women with pre-eclampsia.

- The meta analysis on the accuracy of ultrasound in diagnosing miscarriage in early pregnancy, highlighted the possibility of falsely diagnosing miscarriage with existing guidelines. The work was presented to the journalists from over 15 media, through the Science Media Centre, London. It was widely taken up by the mainstream media and I was interviewed by national media including ITN and Sky with invitations from Radio 3 and 4. The RCOG (Royal College of Obstetricians and Gynaecologists) responded by changing its guidelines in this field the following week (http://www.qmul.ac.uk/media/news/items/smd/57260.html).

- I led the NIHR HTA work evaluating the effect of dietary and lifestyle interventions in reducing or preventing obesity in pregnancy. The findings of this project, published in the BMJ were widely taken up by the mainstream media including BBC, Sky, ITN, The Times, Telegraph, Independent and Metro. The figures from the QMUL communication office estimate that the findings reached an estimated audience of 12 million readers.

Student supervision I derive immense pleasure in supporting the development of my junior researchers. I currently supervise two MD students (L Velauthar and F Fong). I am the educational supervisor for two postgraduate trainees, one of them an Academic Foundation Fellow.

Grants

I hold over £ 6 million in research grants. I was instrumental in the conception, design and development of the proposal reflected in my time more than 0.15fte in these HTA projects. Sponsor EME (NIHR/ MRC) HTA - NIHR Title Effects of weight management interventions on maternal and fetal outcomes in

pregnancy: Individual patient data (IPD) meta analysis of randomised trials and model based economic evaluation

Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (CI), Mol BW, Riley R et al Chief Investigator

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Amount awarded £250k (Period of award: 2013-2015 for 24 months) Sponsor EME (NIHR/ MRC) HTA - NIHR Title PREP study (Development and Validation of a rule for Prediction of Risk of

Complications in Early Onset Pre eclampsia) Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (20% fte), Khan KS, Deeks J J et al

Project Lead/ Co-Investigator Amount awarded £730k (Period of award: 2011-2014 for 30 months) Sponsor EME (NIHR/ MRC) HTA - NIHR Title EMPIRE trial (Antiepileptic drug management in Pregnancy: An evaluation of

effectiveness cost-effectiveness and acceptability of dose adjustment strategies) Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (15% fte), Mc Corry D, Khan KS, Deeks J J et al

Project Lead/ Co-Investigator Amount awarded £1.8m (Period of award: 2011-2015 for 42 months)

Sponsor EME (NIHR/ MRC) HTA - NIHR Title Lifestyle and dietary interventions in pregnancy to reduce excessive weight gain:

evidence synthesis Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (20% fte), Coomarasamy A, Khan KS et al

Project Lead/ Co-Investigator Amount awarded £120k (Period of award: 2010 -11)

Sponsor EME (NIHR/ MRC) HTA - NIHR Title Sentinel lymph node status in vulval cancer: Systematic quantitative review and

decision analytic modelling based economic analysis. HTA evidence synthesis Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (15% fte), Roberts T et al

Co-Investigator Amount awarded £229k (Period of award: 2010-2012 for 18 months)

Sponsor EME (NIHR/ MRC) HTA - NIHR Title Clinical effectiveness of PET-CT imaging in restaging recurrent cervical cancer:

Systematic review of evidence and economic modelling. HTA Evidence synthesis Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S (20% fte), Roberts T, Sundar SS

Co-Investigator Amount awarded £320k (Period of award: 2010- 2011 for 18 months) Sponsor EME (NIHR/ MRC) HTA - NIHR Title Pulse Ox study: Pulse oximetry as a screening test for congenital heart disease in

newborn babies Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Ewer A, Thangaratinam S, Daniels J, Deeks J, Roberts T, Pattison H, Khan KS

Co-Investigator Amount awarded £940,787 (Period of award: 2007-2011)

Sponsor EME (NIHR/ MRC) HEIF 4 Higher Education Institution Fund: Knowledge Transfer Development Fund Title Knowledge Transfer in Evidence-based Medicine: kNOTE Project

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Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S, Arvanitis T et al Chief Investigator

Amount awarded £19k (Period of award: 2009-2010) Sponsor EME (NIHR/ MRC) EME (NIHR) Title TABLET Trial (A multicentre placebo-controlled randomised trial of levothyroxine to

improve reproductive outcomes in euthyroid women with thyroid auto-antibodies) Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Coomarasamy A, Thangaratinam S, Jayne Franklyn, Mark Kilby and others

Co-Investigator Amount awarded £1.4m (Period of award: 2011 -2014) Sponsor EME (NIHR/ MRC) European Union Leonardo da Vinci programme Title eBayesMet Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Walczak J, Thangaratinam S, Khan KS, et al

Co-Investigator Amount awarded €240K (Period of award: 2009-2011)

Sponsor EME (NIHR/ MRC) Marie Curie International Research Staff Exchange Scheme (IRSES)

Title Evidence-Based Medicine COllaboratioN NEtwork for systematic reviews and guideline development researCh and disseminaTion (EBM CONNECT)

Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Thangaratinam S, Arvanitis T, Khan KS et al Co-Investigator

Amount awarded €180k (Period of award: 2010-2011)

Sponsor EME (NIHR/ MRC) NIHR HTA

Title How accurate is spot urinary protein:creatinine ratio (SPCr) and spot albumin:creatinine ratio (SACr) compared to 24-hour protein estimation to assess women with hypertensive disease in pregnancy (HDP) after 24 weeks gestation.

Applicants Arri Coomarasamy, Jayne Franklyn, Mark Kilby and others. Waugh J, Thangaratinam S, Robson S et al Co-Investigator

Amount awarded £560k (Period of award: 2012-2014)

Sponsor Title Role EME (NIHR/ MRC)

Barts Charity Effect of Mediterranean diet in preventing pre-eclampsia in women with metabolic risk factors: A randomised controlled trial. Chief Investigator

Amount awarded £498k (Period of award: 2014-2016)

Title

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I have published over 40 research articles in peer-reviewed journals. The impact of some of my work is highlighted in italics below.

1. Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK. Pulse oximetry screening for critical congenital heart defects (CCHD) in asymptomatic newborn infants: A systematic review and meta analysis involving 229,421 babies. Lancet

201.379:2459-2464

2. Thangaratinam S, Rogozinska E, Jolly K, Glinkowski S, Roseboom T, Tomlinson JW,

Kunz R, Mol BW, Coomarasamy A, Khan KS. Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ 2012; 344:e2088

IMPACT: The findings were widely taken up and published by the main stream media including The Times, The Telegraph, Independent, Daily mail, BBC, Metro (front page), Mirror and Herald

http://www.bbc.co.uk/news/health-18101423

http://www.skynews.com.au/health/article.aspx?id=752033&vId=

http://www.herald.ie/lifestyle/dieting-during-pregnancy-good-for-baby-3111026.html

http://www.mirror.co.uk/news/technology-science/science/mums-to-be-should-stick-to-healthy-diet-838211

http://www.independent.co.uk/life-style/health-and-families/health-news/now-dieting-in-pregnancy-is-good-for-you-7764002.html

Telegraph.co.uk

http://www.telegraph.co.uk/health/healthnews/9271565/Pregnant-women-should-not-eat-for-two.html

3. Thangaratinam S, Rogozinska E, Jolly K, Duda W et al. Interventions to reduce or

prevent obesity in pregnant women: a systematic review. Health Technol Assess 2012 (in press).

4. Jeve Y, Rana R, Bhide A, Thangaratinam S. Accuracy of first-trimester ultrasound in the diagnosis

of early embryonic demise: a systematic review. Ultrasound Obstet Gynecol. 2011;38:489-96. IMPACT: The findings of this paper were disseminated through a press release involving more than 15 press

associations. It was widely taken up by the mainstream media including interviews in ITN, Sky. The RCOG responded by changing its guidelines in this field the next week based on the findings. http://www.qmul.ac.uk/media/news/items/smd/57260.html

5. Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association

of thyroid antibodies with miscarriage and preterm birth: A meta-analysis. BMJ 2011; 342:2616

IMPACT: This meta-analysis resulted in a £1.4million EME (MRC/NIHR) grant to conduct a multicentre placebo-controlled randomised trial of levothyroxine in euthyroid women with thyroid antibodies awaiting conception of a pregnancy (The TABLET trial).

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6. Wilson A, Lissauer D, Thangaratinam S, Khan KS, MacArthur C, Coomarasamy A. Clinical officers versus medical doctors for Caesarean surgery in the developing world: A meta-analysis of controlled studies. BMJ 2011; 342:2600

7. Ewer AK, Middleton LJ, Furmston AT, Bhoyar A, Daniels JP, Thangaratinam S, Deeks JJ, Khan KS; PulseOx Study Group. Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet. 2011 Aug 27;378(9793):785-94.

IMPACT: The findings of this study is very likely to influence national and international health policies on screening for congenital heart disease in newborn. This paper was extensively publicised by the main-stream media.

8. Gupta P, Thangaratinam S, Shehmar M, Gee H, Karri K, Bondili A, Khan KS. An electronic raining-the-trainers programme: developing resources for training in educational supervision in obstetrics and gynaecology. The Obstetrician and Gynaecologist 2012; 14: 39-44

9. Thangaratinam S, Koopmans CK, Iyengar S, Zamora J, Ismail KMK, Mol BWJ, Khan KS for TIPPS

(Tests In Prediction of Pre-eclampsia’s Severity) review group. Accuracy of liver function tests for predicting adverse maternal and fetal outcomes in pre-eclamptic women: A systematic review. Acta Scand Obstet Gynecol 2011;90:574-85

10. Thangaratinam S, Gallos I, Ismail KMK, Khan KS for TIPPS (Tests In Prediction of Pre-eclampsia’s

Severity) review group. Accuracy of symptoms for predicting adverse maternal and fetal outcomes in pre-eclamptic women: A systematic review and meta analysis. Acta Scand Obstet Gynecol 2011;90:564-73

11. Thangaratinam S, Langenveld J, Mol BW, Khan KS. Prediction and primary prevention of pre-eclampsia. Best Pract Res Clin Obstet Gynaecol. 2011;25:419-33

12. Oude Rengerink K, Thangaratinam S, Barnfield G, Suter K, Horvath AR, Walczak J, Wełmioska A, Weinbrenner S, Meyerrose B, Arvanitis TN, Onody R, Zanrei G, Kunz R, Arditi C, Burnand B, Gee H, Khan KS, Mol BW. How can we teach EBM in clinical practice? An analysis of barriers to implementation of on-the-job EBM teaching and learning. Med Teach. 2011;33:e125-30.

13. Gallos I, Shehmar M, Thangaratinam S, Coomarasamy A, Gupta J. Oral progestogens versus

Levonorgestrel-releasing Intrauterine System for endometrial hyperplasia - A Systematic Review and Meta-analysis. Am J Obstet Gynecol. 2010;203:547.e1-10

14. Walczak J, Kaleta A, Gabry E, Kloc K, Thangaratinam S et al. How are "teaching the teachers"

courses in evidence based medicine evaluated? A systematic review. BMC Medical Education 2010; 10:64

15. Veenendaal, M. V, Thangaratinam, S, Yates, D, Painter, R. C, de Rooij, S. R, van der Post, J. A, et

al. Is the Fetal Origins Hypothesis of Diabetes Supported by Animal Research? A Systematic Review and Meta-Analysis of the Evidence. J Dev Orig Health Dis 2011; 2: S126

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16. Thangaratinam S, Coomarasamy A, O'Mahony F, Sharp S, Zamora J, Khan KS, Ismail KM. Estimation of proteinuria as a predictor of complications of pre-eclampsia: a systematic review. BMC Med 2009. 24:10

IMPACT: The NICE guideline recommendations on testing for proteinuria in pre-eclampsia was directly influenced by this paper and referenced. The findings of this paper was publicised with a press release and widely reported in online medical information sites.

17. Knox EM, Thangaratinam S, Kilby MD, Khan KS. A review of the methodological features of systematic reviews in fetal medicine. Eur J Obstet Gynecol Reprod Biol 2009. 146: 121-128

18. Thangaratinam S, Barnfield G, Weinbrenner S, Meyerrose B, Arvanitis TN, Horvath AR, Zanrei G,

Kunz R, Suter K, Walczak J, Kaleta A, Oude Rengerink K, Gee H, Mol BWJ and Khan KS. Teaching trainers to incorporate evidence-based medicine (EBM) teaching in clinical practice: the EU-EBM project. BMC Med Edu 2009. 9: 59

19. Thangaratinam S, Coomarasamy A, Sharp S, Ismail KMK, Khan KS for the TIPPS (Tests in

Prediction of Pre-eclampsia’s Severity) review group Tests for predicting complications of pre-eclampsia: A protocol for systematic reviews of the literature BMC Pregnancy Childbirth 2008. 8:38

20. Thangaratinam S, Walker P, Freeman-Wang T, Luesley D, Cruickshank M, Redman CW.

Identifying the performance criteria for appraisal of colposcopists: benchmarking Delphi. BJOG. 2007. 114: 1288-91.

21. Sheikh L, Johnston S, Thangaratinam S, Kilby MD, Khan KS. A review of the methodological

features of systematic reviews in maternal medicine. BMC Med. 2007. 24; 5:10.

22. Thangaratinam S, Ismail K, Sharp S, Coomarasamy A, O'Mahony F, Khan KS, O'Brien S; TIPPS (Tests in Prediction of Preeclampsia’s Severity) Review Group. Prioritisation of tests for the prediction of preeclampsia complications: a Delphi survey. Hypertens Pregnancy 2007. 26:131-8.

23. Thangaratinam S, Daniels J, Ewer AK, Zamora J, Khan KS.Accuracy of pulse oximetry in screening

for congenital heart disease in asymptomatic newborns: a systematic review. Arch Dis Child Fetal Neonatal Ed. 2007. 92: F176-80.

24. Krone RE, Ewer AK, Barrett TG, Moy RJ, Bakour S, Maher ER, Thangaratinam S, Cox P, Martin B,

Khan KS, Zeegers MP. The Birmingham Registry for Twin and Heritability Studies (BiRTHS).Twin Res Hum Genet. 2006. 9: 907-12.

25. Coomarasamy A, Thangaratinam S, Gee H, Khan KS.Progesterone for the prevention of preterm

birth: a critical evaluation of evidence.Eur J Obstet Gynecol Reprod Biol. 2006. 129: 111-8.

26. Hassan I, Thangaratinam S, O'Mahony F, Ismail KM.Inferior vena cava thrombosis and recurrent pancreatitis in pregnancy. J Obstet Gynaecol. 2006. 26: 372-3.

27. Thangaratinam S, Yanamandra SR, Deb S, Coomarasamy A.Specialist training in obstetrics and

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gynaecology: a survey on work-life balance and stress among trainees in UK.J Obstet Gynaecol. 2006. 26: 302-4.

28. Thangaratinam S, Ismail KM, Sharp S, Coomarasamy A, Khan KS; Tests in Prediction of Pre-

eclampsia Severity review group.Accuracy of serum uric acid in predicting complications of pre-eclampsia: a systematic review. BJOG. 2006. 113: 369-78.

29. Thangaratinam S, Ismail KMK, O’Brien S. Evidence Based Management of Premenstrual

syndrome; Eur Clinics Obstet Gynaecol. 2006. 2: 65-71

30. Thangaratinam S, O’Brien S.Antidepressants and Premenstrual syndrome. Gynaecology Forum 2006.1; 1.

31. Thangaratinam S, Chapman G. Postnatal depression. WellBeing 2005. RCOG publication,

London.

A selection of Published Abstracts

1. Tan A, Thangaratinam S, Kilby M et al. Systematic review of association between thyroid autoantibodies and adverse pregnancy outcome. BMFMS 14th Annual Conference, Newcastle 2010.

2. Thangaratinam S, Iyengar S, Coopmans C et al. Accuracy of liver function tests in predicting complications of pre eclampsia, FIGO XIX World Congress of Obstetrics and Gynaecology, Cape Town 2009.

3. Thangaratinam S, Barnfield G, Arvanitis T et al. Clinically integrated E-curriculum for Learning and Teaching EBM: The EU EBM Training the Trainers project, Oxford 2008.

4. Thangaratinam S, Redman CW. Results of BSCCP Delphi on performance criteria for appraisal of colposcopists. Annual BSCCP Conference, London, Mar 2006

5. Thangaratinam S, Ismail KMK, Coomarasamy A, O’ Mahony F, Khan KS, O’Brien S Proteinuria as a predictor of complications of pre eclampsia: A Systematic review: 6th International Scientific meeting, Cairo, Sep 2005

6. Thangaratinam S, Ismail KMK, Coomarasamy A, Khan KS. Accuracy of serum uric acid in predicting complications of pre-eclampsia: A systematic review; 6th International Scientific meeting, Cairo, Sep 2005

7. Thangaratinam S, Ismail KMK, Coomarasamy A, O’ Mahony F, Khan KS, O’Brien S. Prioritisation of Tests for the prediction of Pre-eclampsia Complications: A Delphi survey: 6th International Scientific meeting, Cairo, Sep 2005

8. Thangaratinam S, Mitchell D, Scott IV, Clow WM Treatment of Refractory Vulval Histiocytosis: A case report: British Gynaecological Society Annual Meeting in conjunction with the Dutch Gynaecologic Oncology Group, Newcastle upon Tyne, Nov 2003.

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Invited talks and oral presentations

Effect of interventions on reduction or prevention of Obesity: An IPD meta analysis. Global Obstetric Research Network (GONET), London 2012 Clinical trials in Katherine Twining Network. Queen Mary University of London, London 2012 Prediction of risks in early onset pre-eclampsia. Katherine Twining Network, London invited speaker June 2011. Pre eclampsia: How accurate are the tests in predicting complications? Obstetric Unit at St Georges NHS trust, London 2010. Accuracy of liver function tests in predicting complications of pre eclampsia, FIGO XIX World Congress of Obstetrics and Gynaecology, Cape Town 2009. EU EBM training the Trainers e-curriculum. The Birmingham Conference, West Midlands Workforce Deanery and the Centre for Research in Medical and Dental Education, Birmingham 2009. Clinically integrated E-curriculum for Learning and Teaching EBM:The EU EBM Training the Trainers project, Oxford 2009. Evidence Based Medicine: EU EBM training the Trainers e-curriculum, Quality Counts: Developing Theory and Practice in Medical Education Research, Cardiff, 2008. Results of BSCCP Delphi on performance criteria for appraisal of colposcopists. Annual BSCCP Conference, London 2006. Systematic review on the accuracy of proteinuria and uric acid in women with pre eclampsia. British Maternal Fetal Medicine Society (BMFMS) Meeting, Cardiff 2006. Tests in the prediction of complications of pre-eclampsia: Systematic review on the accuracy of proteinuria and uric acid to be presented at Blair Bell Research Society Competition meeting, RCOG, London 2005. Proteinuria as a predictor of complications of pre eclampsia: A Systematic review presented at 6th International Scientific meeting, Cairo, Egypt 2005. Role of Fish oil in pre-term labour-Critical Appraisal of a Topic meeting, University Hospital North Staffordshire, Stoke on Trent 2005. Introduction to Critical Appraisal of a Topic meeting, University Hospital North Staffordshire, Stoke on Trent 2005. Surgical management of Urodynamic Stress Incontinence-Multidisciplinary meeting at University

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Hospital North Staffordshire, Stoke on Trent 2005. Critical Appraisal of Therapy – Southern Hub regional teaching for year 1-3 registrars, Coventry 2004. Systematic review of tests that predict complications of pre-eclampsia: A protocol- For Mike Grant prize, University Hospital North Staffordshire, Stoke on Trent 2004. Antenatal and Intrapartum management of twin pregnancies audit- Interdistrict Audit meeting at Burton 2004. Regular presentation of cases for the Low Apgar Meet, 2004. Audit presentation on ‘Treatment of CIN’ –Derby City General Hospital, Derby 2003. Audit presentation on ‘Induction of Labour’-Bassetlaw District General Hospital, Worksop 2003. Audit presentation on ‘Care of women undergoing Termination of Pregnancy’-James Paget Healthcare NHS Trust, Great Yarmouth 2002. Role of vaginal misoprostol in induction of labour. At 16th Annual conference of Obstetric & Gynaecologic Society of South India, Madras 2000.

Teaching Teaching is a very important part of my work and I derive immense satisfaction from interacting with students. I have played an active role in undergraduate and postgraduate teaching as a Clinical Lecturer and now as a Senior Lecturer. Selected Undergraduate Teaching

Undergraduate lecture on “Pre-eclampsia” which fits within the ‘RED’ (Reproduction, Endocrinology and Human Development) module of the undergraduate curriculum.

Undergraduate lecture on “Diabetes in Pregnancy Incontinence, Infertility and Contraception”.

Undergraduate tutor for case-based learning.

Senior Clinical Examiner for Undergraduate OSCE examination.

‘Personal Mentor’ for students at University of Birmingham: In this role, I supported students through their time at University, offering advice and guidance on academic and personal matters.

Various small-group undergraduate teaching Postgraduate teaching I have taught senior trainees in their Masterclass in WestMidlands and conducted Symposia for junior trainees on Pre-eclampsia and Recurrent Pregnancy Loss

Medical Education Projects

- EU Evidence Based Medicine: Training the Trainers (EU EBM TTT) project

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The multinational Leonardo da Vinci European project Evidence Based Medicine: Training the Trainers across the Healthcare Sector was run by me as the project manager. The project involves collaboration with 7 EU countries (Germany, Netherlands, Switzerland, Italy, Poland, Hungary and UK) and is responsible for developing e modules. Through this project I have been involved in curriculum design and development and piloting of curriculum in 5 European countries (UK, Netherlands, Hungary, Poland, Switzerland) in addition to the development and validation of assessment tool for training the trainers in EBM.

- Training the Trainers e-curriculum: West Midlands Deanery The School of Obstetrics and Gynaecology of West Midlands Deanery has commissioned the development of Training the Trainers e modules for the regional educational supervisors. I am involved in its conception, development, packaging and dissemination of the modules.

Course Tutor

I regularly hold Critical Appraisal Workshops for junior and senior STs in the London region I was one of the core organisers and tutors in the two day national level Diagnostic Methods Workshop at the Education Resource Centre, Birmingham which was incorporated into the MSc programme in Health Technology Assessment at the University of Birmingham. I have been part of the team that has started a similar EBM workshop at University Hospital North Staffordshire and Keele University. I was involved in running the Basic Surgical Skills Course at the Birmingham Women’s Hospital for the past 3 years. I deliver lectures and demonstrate in the Third and Fourth Degree Perineal repair course at Birmingham Women’s Hospital and was part of the team involved in teaching at the Third Degree Perineal Repair Workshop at University Hospital North Staffordshire, Stoke-on-Trent. I have been involved in the development of part 1 and part 2 MRCOG online courses (www.acecourses.co.uk and www.aceonline.org.uk).

Journal Club

I established the bimonthly Critical Appraisal of Topic, CAT club, for junior and senior clinicians. It offers an interactive forum for learning and application of critical appraisal skills. I co-ordinated the running of the weekly Journal club at Birmingham Women’s Hospital. I have introduced new critical appraisal tool, the GATE (Graphic Appraisal Tool for Epidemiology) tool. The fortnightly CAT (Critical Appraisal of a Topic) meeting at University Hospital North Staffordshire was established and run by me during my tenure as Clinical Research Fellow. I also regularly teach junior and senior registrars critical appraisal of literature. The monthly ‘Low Apgar and CTG teaching’ meet run by me at the University Hospital North Staffordshire provided an opportunity for discussion and learning in a multidisciplinary setting.

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Training courses & Conferences Fair selection course for interviewers, Queen Mary University of London, London Aug 2011

Perinatal 2011, Harrogate

Clinical Research Methodology conference, Bristol, 2011

Consultant Induction Course, Barts and the London NHS Trust, London June 2011

Safeguarding Children, Barts and the London NHS Trust, London June 2011

Integrated Research Application System (IRAS) workshop, The Joint Research and Development Office, Queen Mary University of London, London Aug 2010

GCP (Good Clinical Practice in Clinical Trials) Certificate, May 2010

Advanced Labour Ward Practice, Royal College of Obstetricians and Gynaecologists, London Nov 2009

Quality Counts: Developing Theory and Practice in Medical Education Research, Cardiff, Nov 2008

UK Conference on Evidence Based Health Care, Oxford Dec 2008

Medical Complications in Pregnancy, Royal College of General Practitioners, London Nov 2008

Basic Ultrasound in Obstetrics (Practical), Birmingham Women’s Hospital, Sep 2007

Basic Ultrasound in Obstetrics and Gynaecology (Theory), RCOG, London, Jan 2006

Management of Obstetric Emergencies and Trauma (MOET), Stone, Jun 2004

Third degree perineal trauma repair course, University Hospital North Staffordshire, Mar 2004

Evidence Based Medicine Workshop, Education Resource Centre, Birmingham, May 2004

Evidence Based Medicine: Tutors course, Education Resource Centre, Birmingham, Sep 2004

Basic Laparoscopic skills workshop, MAST centre, Birmingham Women’s Hospital, Birmingham, Nov 2003

Basic life support Training course, Bassetlaw District General Hospital, Feb 2003

Advanced Life Support in Obstetrics (ALSO), Manchester, May 2002

West Midlands O&G Specialist registrar protected teaching, Gynaecologic Oncology, Shrewsbury, Feb 2004

How to get your paper accepted for publication, North Trent Deanery, Sheffield, May 2003

Modern management of Labour, RCOG, Nov 2002

16th Annual conference of Obstetric & Gynaecologic Society of South India, Madras 2000

Annual conference of Federation of Obstetricians and Gynaecologists of South India, Madras India, Feb 1999

Management and Leadership

My work as senior academic is multidisciplinary by nature and requires good interpersonal and leadership skills. As a clinical academic with over 7 years’ experience, I have taken a keen interest in research management, governance and training. I have appointed several research posts across both the Trust and University. I have substantial experience of chairing meetings effectively: I have been the lead for EU multinational projects and have chaired Trials Steering Committees and Trial Management Groups. Through experience of managing large trials and HTA projects, and contribution to independent supervision of large national multi-centre trials, I have acquired and developed research organisational and leadership qualities. My research leadership role is further demonstrated by

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membership of Executive Committee of the British Maternal Fetal Medicine Society (2011 onwards), RCOG member on the National Obesity Steering Group of the Academy of Medical Royal Colleges (2012 onwards), Katherine Twining Network (2010 onwards) and the Reproductive Health and Childbirth speciality group of the Birmingham and Black Country Comprehensive Local Research Network (2008-2011). As part of the core team at Women’s Health Research Network, I am actively involved in the recruitment of researchers, development of the department and establishing links with other units in North East London through the newly founded Katherine Twining Network. I co-ordinate and supervise a team that has 2 trial co-ordinators, 10 research nurses and midwives, a data assistant and an administrator. I work closely with the 50 principal investigators involved in the portfolio studies and manage the budget of research projects of around £3 million. I am adept in team working for provision of patient care within the NHS environment and research projects within the academic milieu. My 360 degree assessments carried out as part of my appraisals show that I have universally received high scores for the question on team working.

Personal qualities and aspirations

I am a passionate optimist who strongly believes that with motivation, will power and hard work most challenges can be overcome. I have a ‘can do’ attitude to life. I have always endeavoured to give the very best at all times in my professional and personal life.

My exposure to healthcare in rural India and my training in UK has enabled me to appreciate the stark contrasts in healthcare systems. I am a Board member of ELLY Appeal (East London International Women’s Health) of Barts Charity, an appeal dedicated to bring relevant ideas, clinical evidence, resources, projects and training to improve global health, with the aim of reducing maternal death and disability in the developing world.

I am motivated and enthusiastic in my work and thrive in an intellectually simulating workplace. I relax after a hectic day at work by indulging in pencil sketching and listening to music. I am skilled in ‘Rangoli’, an indigenous decoration art on the floor. I hold a red belt in Zenshin Karate.