Setting the Stage – PAH Therapy Trials

Current PAH Pharmacotherapies

History of LHF Therapy

Disease Modification in LHF

HFrEF Lessons Learned – Moving Forward in PAH

RV Structure and Function in PH – The Downward Spiral

Growth and Immune Response Dysregulation in PAH

RV Function in PAH

Lessons From HFpEFRV-PA and RV-LV Interactions

Right Heart and Survival in PAH – REVEAL Registry Data

RV-PA and RV-LV Interactions

Evolution of End Point-Driven Trials in PAH

Current and Future Challenges in End Point Design

Right Heart vs Left Heart Therapies

Designing PAH Trials – The Next Steps

Combination Therapy in PAH

Combination Therapy in PAH (cont)

Conclusion

Abbreviations

Abbreviations (cont)

References

References (cont)

References (cont)

References (cont)