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Setting new standards The easiest way to order: www.karger.com/prnes Contemporary Management of Intracranial Gliomas Editors: Chernov, M.F.; Muragaki, Y. (Tokyo); Kesari, S. (La Jolla, Calif.); McCutcheon, I.E. (Houston, Tex.) approx. 300 p. Special pre-publication price: CHF 116.00 / EUR 108.00 / USD 136.00 (hard cover) Prices subject to change, VAT not included EUR price for eurozone countries, USD price for USA and Latin America only ISBN 978–3–318–05622–8 (hard cover) to be published 4th quarter 2015 Progress in Neurological Surgery, Vol. 30 Series Editor: Lunsford, L.D. (Pittsburgh, Pa.) ISSN 0079–6492 / e-ISSN 1662–3924 Listed in MEDLINE/PubMed Contents General Aspects • Epidemiology of Intracranial Gliomas: Ostrom, Q.T; Gittleman, H.; Stetson, L.; Virk, S.; Barnholtz-Sloan, J.S. • Pathology and Genetics of Gliomas: Komori, T. • Neuroimaging of Intracranial Gliomas: Ono, Y.; Chernov, M.; Muragaki, Y.; Maruyama, T.; Abe, K.; Okada, Y. • Prognostic and Predictive Factors in Patients with Intracranial Gliomas: Chernov, M. Surgical Management • Advanced Intraoperative Technologies for Surgery of Intracranial Gliomas: Iseki, H.; Muragaki, Y.; Masamune K.; Yoshimitsu, K.; Konishi, Y.; Okamoto J. • Virtual Reality Surgical Simulation: Implications for Resection of Intracranial Gliomas: Dackson, A.; Hong, M.; Clarke, D.B. • General Surgical Principles and Rationale for Aggressive Resection of Intracranial Gliomas: Muragaki, Y.; Maruyama, T.; Nitta, M.; Saito, T.; Tamura, M.; Chernov, M. • Neurophysiological Monitoring and Awake Craniotomy for Resection of Intracranial Gliomas: Saito, T.; Tamura, M.; Maruyama, T. • Surgical Management of Gliomas in Eloquent Cortex: Ferguson, S.D.; McCutcheon, I.E. • Surgery of Insular Gliomas: Duffau, H. • Surgery of Critically-located Intracranial Gliomas: Hori, T. • Surgery of Intracranial Gliomas in Children: Balogun, J.A.; Rutka, J.T. • Surgical Management of Recurrent Intracranial Gliomas: Ferguson, S.D.; Momin, E.N.; Weinberg, J.S. • Role of Biopsies in the Management of Intracranial Gliomas: Patel, K.S.; Carter, B.S.; Chen, C.C. Contemporary Management of Intracranial Gliomas Irradiation • Fractionated Radiotherapy of Intracranial Gliomas: Ghia, A. • Adjuvant Radiosurgery in the Multimodality Management of Residual or Recurrent Glioblastoma Multiforme: Niranjan, A.; Monaco, E.A. III; Kano, H.; Flickinger, J.C.; Lunsford, L.D. • Radiosurgery for Low-Grade Intracranial Gliomas: Ganz, J.C. • Boron Neutron Capture Therapy for Malignant Gliomas: Miyatake, S.-I.; Kawabata, S.; Hiramatsu, R.; Kuroiwa, T.; Suzuki, M.; Ono, K. • Proton and Carbon Ion Therapy of Intracranial Gliomas: Combs, S. • Irradiation of Intracranial Gliomas in Children: Kortmann, R.-D.; Seidel, C.; Muller, K.; Hirsch, F.-W. • Brachytherapy of Intracranial Gliomas: Nachbichler, S.B.; Kreth, F.-W. • Role of Radiosensitizers in Radiation Treatment of Gliomas: Cohen, R.J.; Mehta, M.P. Chemotherapy • Chemotherapy for High-grade Gliomas in Adults: Puduvalli, V.K.; Hoang, N. • Chemotherapy for Oligodendrogliomas and Oligoastrocytomas: Drappatz, J.; Lieberman, F. • Chemotherapy for Diffuse Astrocytomas in Adults: Narita, Y. • Chemotherapy for Gliomas in Children: Terashima, K. • Perspectives of Personalized Chemotherapy for Gliomas based on Molecular Tumor Profiling: Soffietti, R.; Franchino, F.; Magistrello, M.; Pellerino, A.; Ruda, R. • Augmentation of Efficacy of Systemic Chemotherapy for Intracranial Gliomas: Chernov, M. • Anti-Angiogenic Therapy for Gliomas: Jo, J.; Wen, P.Y. • Novel and Prospective Molecular Targets for Therapy of Intracranial Gliomas: Butowski, N. • Search for More Effective Chemotherapeutic Regimens for Gliomas: Challenges and Hopes: Hu, J.; Kesari, S. Immunotherapy and Gene Therapy • Cytokine Therapy for Gliomas: Iwami, K.; Natsume, A.; Wakabayashi, T. • Cell-based Immunotherapy of Gliomas: Everson, R.G.; Antonios, J.P.; Liau, L.M. • Vaccine Therapy for High-grade Gliomas: Ishikawa, E.; Muragaki, Y., Yamamoto, T.; Ohno, T.; Matsumura, A. • Gene Therapy and Virotherapy for Gliomas: Kim, J.W.; Chang, A.L.; Kane, J.R.; Young, J.S.; Qiao, J.; Lesniak, M.S. • Stem Cell Therapy of Gliomas: Parker Kerrigan, B.C.; Hossain, A.; Yamashita, S.; Lang, F.F. Other Management Options and Techniques • Photodynamic Therapy for Intracranial Malignant Gliomas: Kaneko, S.; Fujimoto, S.; Yamaguchi, H.; Yamauchi, T.; Yoshimoto, T.; Tokuda, K. • Laser-induced Interstitial Thermotherapy (LITT ) of Gliomas: Karampelas, I.; Sloan, A.E. • Stereotactic Cryodestruction for Gliomas: Martynov, B.V.; Kholyavin, A.I.; Nizkovolos, V.B.; Parfenov, V.E.; Trufanov, G.E.; Svistov, D.V. • High-Intensity Focused Ultrasound Ablation Therapy of Gliomas: Alkins, R.D.; Mainprize, T.G. • Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality: Wong, E.T.; Lok, E.; Swanson, K.D. • Convection-Enhanced Delivery for Management of Malignant Gliomas: Prabhu, S.S. • Targeted Local Therapy for the Management of Intracranial High-Grade Gliomas: Paldor, I.; Chaichana, K.L.; Brem, H.; Tyler, B.M. • Microvesicles as a Platform for Glioma Therapeutic Development: Santiago-Dieppa, D.R.; Gonda, D.D.; Cheung, V.J.; Steinberg, J.A.; Carter, B.S.; Chen, C.C. • Perspectives of Nanotechnology in the Management of Gliomas: Yoon, J.W.; Jiang, W.; Rutka, J.T.; Huang, Y.; Kim, B.Y.S. Neurorehabilitation and Supportive Care • Physical and Psychological Rehabilitation of Patients with Intracranial Gliomas: Andrejeva, J.; Volkova, O. • Role of Advanced Palliative and Supportive Care in Patients with Gliomas: Pace, A.; Villani, V. Appendix • Current Evidence-based Algorithms for Management of Intracranial Gliomas Fields of Interest: Neurosurgery; Oncology; Chemotherapy, Radiology, Immunology, Genetics Editors Mikhail F. Chernov Yoshihiro Muragaki Santosh Kesari Ian E. McCutcheon Progress in Neurological Surgery Editor: L.D. Lunsford Vol. 30 Contemporary Management of Intracranial Gliomas Editors Mikhail F. Chernov Yoshihiro Muragaki Santosh Kesari Ian E. McCutcheon Coming out soon!

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Setting new standards

The easiest way to order : w w w.karger.com/prnes

Contemporary Management of Intracranial GliomasEditors: Chernov, M.F.; Muragaki, Y. (Tokyo); Kesari, S. (La Jolla, Calif.); McCutcheon, I.E. (Houston, Tex.)approx. 300 p.Special pre-publication price: CHF 116.00 / EUR 108.00 / USD 136.00 (hard cover)Prices subject to change, VAT not includedEUR price for eurozone countries, USD price for USA andLatin America onlyISBN 978–3–318–05622–8 (hard cover)to be published 4th quarter 2015

Progress in Neurological Surgery, Vol. 30Series Editor: Lunsford, L.D. (Pittsburgh, Pa.)ISSN 0079–6492 / e-ISSN 1662–3924Listed in MEDLINE/PubMed

ContentsGeneral Aspects• Epidemiology of Intracranial Gliomas: Ostrom, Q.T;

Gittleman, H.; Stetson, L.; Virk, S.; Barnholtz-Sloan, J.S.• Pathology and Genetics of Gliomas: Komori, T.• Neuroimaging of Intracranial Gliomas: Ono, Y.;

Chernov, M.; Muragaki, Y.; Maruyama, T.; Abe, K.; Okada, Y.• Prognostic and Predictive Factors in Patients with

Intracranial Gliomas: Chernov, M.

Surgical Management• Advanced Intraoperative Technologies for Surgery of

Intracranial Gliomas: Iseki, H.; Muragaki, Y.; Masamune K.; Yoshimitsu, K.; Konishi, Y.; Okamoto J.

• Virtual Reality Surgical Simulation: Implications for Resection of Intracranial Gliomas: Dackson, A.; Hong, M.; Clarke, D.B.

• General Surgical Principles and Rationale for Aggressive Resection of Intracranial Gliomas: Muragaki, Y.; Maruyama, T.; Nitta, M.; Saito, T.; Tamura, M.; Chernov, M.

• Neurophysiological Monitoring and Awake Craniotomy for Resection of Intracranial Gliomas: Saito, T.; Tamura, M.; Maruyama, T.

• Surgical Management of Gliomas in Eloquent Cortex: Ferguson, S.D.; McCutcheon, I.E.

• Surgery of Insular Gliomas: Duffau, H.• Surgery of Critically-located Intracranial Gliomas: Hori, T.• Surgery of Intracranial Gliomas in Children:

Balogun, J.A.; Rutka, J.T.• Surgical Management of Recurrent Intracranial

Gliomas: Ferguson, S.D.; Momin, E.N.; Weinberg, J.S.• Role of Biopsies in the Management of Intracranial

Gliomas: Patel, K.S.; Carter, B.S.; Chen, C.C.

Contemporary Management of Intracranial Gliomas

Irradiation• Fractionated Radiotherapy of Intracranial Gliomas:

Ghia, A.• Adjuvant Radiosurgery in the Multimodality

Management of Residual or Recurrent Glioblastoma Multiforme: Niranjan, A.; Monaco, E.A. III; Kano, H.; Flickinger, J.C.; Lunsford, L.D.

• Radiosurgery for Low-Grade Intracranial Gliomas: Ganz, J.C.

• Boron Neutron Capture Therapy for Malignant Gliomas: Miyatake, S.-I.; Kawabata, S.; Hiramatsu, R.; Kuroiwa, T.; Suzuki, M.; Ono, K.

• Proton and Carbon Ion Therapy of Intracranial Gliomas: Combs, S.

• Irradiation of Intracranial Gliomas in Children: Kortmann, R.-D.; Seidel, C.; Muller, K.; Hirsch, F.-W.

• Brachytherapy of Intracranial Gliomas: Nachbichler, S.B.; Kreth, F.-W.

• Role of Radiosensitizers in Radiation Treatment of Gliomas: Cohen, R.J.; Mehta, M.P.

Chemotherapy• Chemotherapy for High-grade Gliomas in Adults:

Puduvalli, V.K.; Hoang, N.• Chemotherapy for Oligodendrogliomas and

Oligoastrocytomas: Drappatz, J.; Lieberman, F.• Chemotherapy for Diffuse Astrocytomas in Adults:

Narita, Y.• Chemotherapy for Gliomas in Children: Terashima, K.• Perspectives of Personalized Chemotherapy for

Gliomas based on Molecular Tumor Profiling: Soffietti, R.; Franchino, F.; Magistrello, M.; Pellerino, A.; Ruda, R.

• Augmentation of Efficacy of Systemic Chemotherapy for Intracranial Gliomas: Chernov, M.

• Anti-Angiogenic Therapy for Gliomas: Jo, J.; Wen, P.Y.• Novel and Prospective Molecular Targets for Therapy

of Intracranial Gliomas: Butowski, N.• Search for More Effective Chemotherapeutic

Regimens for Gliomas: Challenges and Hopes: Hu, J.; Kesari, S.

Immunotherapy and Gene Therapy• Cytokine Therapy for Gliomas: Iwami, K.; Natsume, A.;

Wakabayashi, T.• Cell-based Immunotherapy of Gliomas: Everson, R.G.;

Antonios, J.P.; Liau, L.M.

• Vaccine Therapy for High-grade Gliomas: Ishikawa, E.; Muragaki, Y., Yamamoto, T.; Ohno, T.; Matsumura, A.

• Gene Therapy and Virotherapy for Gliomas: Kim, J.W.; Chang, A.L.; Kane, J.R.; Young, J.S.; Qiao, J.; Lesniak, M.S.

• Stem Cell Therapy of Gliomas: Parker Kerrigan, B.C.; Hossain, A.; Yamashita, S.; Lang, F.F.

Other Management Options and Techniques• Photodynamic Therapy for Intracranial Malignant

Gliomas: Kaneko, S.; Fujimoto, S.; Yamaguchi, H.; Yamauchi, T.; Yoshimoto, T.; Tokuda, K.

• Laser-induced Interstitial Thermotherapy (LITT) of Gliomas: Karampelas, I.; Sloan, A.E.

• Stereotactic Cryodestruction for Gliomas: Martynov, B.V.; Kholyavin, A.I.; Nizkovolos, V.B.; Parfenov, V.E.; Trufanov, G.E.; Svistov, D.V.

• High-Intensity Focused Ultrasound Ablation Therapy of Gliomas: Alkins, R.D.; Mainprize, T.G.

• Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality: Wong, E.T.; Lok, E.; Swanson, K.D.

• Convection-Enhanced Delivery for Management of Malignant Gliomas: Prabhu, S.S.

• Targeted Local Therapy for the Management of Intracranial High-Grade Gliomas: Paldor, I.; Chaichana, K.L.; Brem, H.; Tyler, B.M.

• Microvesicles as a Platform for Glioma Therapeutic Development: Santiago-Dieppa, D.R.; Gonda, D.D.; Cheung, V.J.; Steinberg, J.A.; Carter, B.S.; Chen, C.C.

• Perspectives of Nanotechnology in the Management of Gliomas: Yoon, J.W.; Jiang, W.; Rutka, J.T.; Huang, Y.; Kim, B.Y.S.

Neurorehabilitation and Supportive Care• Physical and Psychological Rehabilitation of Patients

with Intracranial Gliomas: Andrejeva, J.; Volkova, O.• Role of Advanced Palliative and Supportive Care in

Patients with Gliomas: Pace, A.; Villani, V.

Appendix• Current Evidence-based Algorithms for

Management of Intracranial Gliomas

Fields of Interest: Neurosurgery; Oncology; Chemotherapy, Radiology, Immunology, Genetics

EditorsMikhail F. Chernov Yoshihiro Muragaki Santosh Kesari Ian E. McCutcheon

Progress in Neurological Surgery

Editor: L.D. Lunsford

Vol. 30

Contemporary Management of Intracranial Gliomas Editors

Mikhail F. Chernov Yoshihiro MuragakiSantosh Kesari Ian E. McCutcheon

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Of related interest

Current and Future Management of Brain MetastasisProgress in Neurological Surgery, Vol. 25 Editors: Kim, D.G. (Seoul); Lunsford, L.D. (Pittsburgh, Pa.) XII + 314 p., 78 fig., 5 in color, 27 tab., hard cover, 2012ISBN 978-3-8055-9617-6

www.karger.com/prnes

Using and Understanding Medical Statistics5th, revised and extended edition Authors: Matthews, D.E. (Waterloo, Ont.); Farewell, V.T. (Cambridge) XX + 338 p., 48 fig., 103 tab., hard cover + online supplement material, 2015ISBN 978-3-318-05458-3

www.karger.com/Medical_Statistics

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Progress in Neurological Surgery

Editor: L.D. Lunsford

Vol. 25

Current and Future Management of Brain MetastasisEditors

D.G. KimL.D. Lunsford

D.E. Matthews . V.T. Farewell

Using and Understanding Medical Statistics5th, revised and extended edition

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Pr(Y=1|X=x) =exp(a + bx)

1 + exp(a + bx)

T =(O1 − E1)

2

E1

+(O2 − E2)

2

E2

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