session 8 renal cancer cds
TRANSCRIPT
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Therapeutic Nutrition IV: Renal Disease, Cancer, &
Cognitive Dysfunction Syndrome
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Renal Disease
Beck; 10-month old, Male, Brittany Beck; 10-month old, Male, Brittany SpanielSpaniel
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What Do The Kidneys Do?
Filtration Maintain HomeostasisRelease erythropoeitinToxin excretionRegulate Acid/Base balanceConversion of Vitamin D
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Renal DiseaseKidneys are unable to excrete
adequate urea and other toxins which accumulate as internal poisons
Kidneys are unable to perform other metabolic functions
Can be acute or chronic
Hill’s Pet Nutrition, Inc.Clinical Atlas of Anatomy
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What Can CauseWhat Can Cause Renal Failure? Renal Failure?
Acute Chronic
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1-2 yrs(2%)
2-4 yrs(4%)
4 -7 yrs(11%)
7-10 yrs(14%)
10-15 yrs(33%)
> 15 yrs(36%)
Veterinary Medical Database http://www.vmdb.org
Chronic Kidney Disease in Cats (1990-2000)
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Stages of Renal Disease
*SACN, 4th Edition, Hand, Thatcher, Remillard, Roudebush
Chronic Renal Disease is Progressive and Chronic Renal Disease is Progressive and IrreversibleIrreversible
Normal RenalFunction
Loss of Renal Reserve
Renal Insufficiency
Azotemia Uremia Death
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Renal Disease GoalsSlow the disease progression by:
Reducing workload of kidneysMaintaining hydrationReducing clinical symptoms
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Renal Disease KNF1. Water
2. Restricted protein <15% Dogs <30% Cats
3. Reduced dietary phosphorus
4. Reduced dietary sodium
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Renal Disease ProductsNF Kidney Function®
Multi-Stage Renal Feline Dry & Canned Early Stage Canine Dry Formula
Prescription Diet® k/d; Prescription Diet® u/d
Prescription Diet® g/d
Renal LP 11Renal LP 21Renal MP 14
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Cognitive Dysfunction Syndrome
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Disorientation Interaction Sleep Patterns Housesoiling
D.I.S.H.
Cognitive Dysfunction Syndrome
ANIPRYL (Pfizer Animal Health)
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What Clues Might You Have to Indicate a Dog has CDS?
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Clinical Signs Checklist
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What’s the Deal with Mitochondria?Energy production generates
free radicals as a by-product
Free radicals attack mitochondria, DNA and cellular membranes
Damaged mitochondria become less efficient and product even more free radicals
Body’s natural antioxidant defenses overwhelmed
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Cognitive Dysfunction Syndrome
High fat content is susceptible to oxidative damage
Naturally low levels of protective antioxidants
High metabolic activityMagnetic
ResonanceImages
Healthy Older Brain
Older Brain with Damage
The BrainThe Brain
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Cognitive Dysfunction Syndrome Studies
Measured problem-solving ability (cognitive function)
Study Design6 months of baseline testingSplit into equal “IQ” groups based on
preliminary tests6 month feeding period
Hill’s Pet Nutrition, Inc. - Clinical Study Supporting Canine b/d®
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A Test for the Dogs
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Cognitive Dysfunction SyndromeDoes Aging Affect Cognitive Ability?
YoungYoung OldOld
Err
ors
to C
rite
rion
Err
ors
to C
rite
rion
00
5050
100100
150150
200200
250250
UnsuccessfulUnsuccessfulAgersAgers
Successful Successful AgersAgers
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How CDS is DiagnosedLarge/Giant Breed Dogs ≥ 5 yearsOther Breeds ≥ 7
One or more signs of DISH• Disorientation• Interaction Changes• Sleep/Activity Changes• Housetraining Forgotten
Rule Out Other Disease Conditions
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Cognitive Dysfunction Products
Prescription Diet® b/d
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Cancer
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What Might Some Characteristics of A Pet Food For a Cancer Patient Be?
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Cancer DefinitionsNeoplasia –
new and abnormal growth; any benign or malignant tumor
Cancer cachexia – severe malnutrition and body wasting that occurs in patients with cancer
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Cancer in Dogs and Cats
Metabolic changes result in accelerated starvation (cancer cachexia)
Side effects of chemotherapy and radiation therapy may deplete nutritional stores
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Nutritional ChangesAltered Carbohydrate Metabolism
Tumors preferentially use glucose for energy
Elevated insulin and lactate levels
Altered Protein MetabolismTumor competes for amino acids and
energy
Altered Fat MetabolismDog uses fat for energy
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Cancer - Goals
Increase remission Increase survival time Improve quality of life
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Cancer KNF
High levels of fat and protein for energy Low level of carbohydrates Therapeutic levels arginine Provide n-3 fatty acids
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Cancer/Neoplasia Products
Prescription Diet® n/d
Prescription Diet® a/d
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Next Week:
COMMON TOXICITIES