serum osteocalcin levels in girls with central precocious puberty

POSTER PRESENTATION Open Access Serum osteocalcin levels in girls with central precocious puberty Young Jun Rhie * , Hyo Kyoung Nam, Kee Hyoung Lee From 7th APPES Biennial Scientific Meeting Nusa Dua, Bali. 14-17 November 2012 Objectives Bone plays metabolic roles through osteocalcin(OC) when it is released into the systemic circulation in uncar- boxylated form. Identified novel metabolic roles of OC include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass and mitochon- drial proliferation and functional enhancement. The onset of puberty can be influenced metabolic factors. This study was aimed to determine serum OC levels in girls with central precocious puberty(CPP) and to investi- gate the effects of OC on the onset of puberty. Methods Serum OC levels of girls CPP (n=30) and their age- matched controls (n=30) were measured. GnRH stimulation test was performed in CPP group. Bone age was determined in all subjects. Results Serum OC levels were significantly higher in CPP group compared with control group (76.8 ± 10.5 vs. 61.6 ± 15.1ng/mL, p=0.001). Serum OC levels were correlated with peak LH levels during GnRH stimulation test (r=0.348, p=0.037), bone age (r=0.403, p=0.010) and bone age advance (r=0.323, p=0.042), but not related to age, height, weight and BMI. Conclusions Serum OC seems to be associated with the onset of puberty leaving casual relations unresolved. Published: 3 October 2013 doi:10.1186/1687-9856-2013-S1-P79 Cite this article as: Rhie et al.: Serum osteocalcin levels in girls with central precocious puberty. International Journal of Pediatric Endocrinology 2013 2013(Suppl 1):P79. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea Rhie et al. International Journal of Pediatric Endocrinology 2013, 2013(Suppl 1):P79 http://www.ijpeonline.com/content/2013/S1/P79 © 2013 Rhie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Page 1: Serum osteocalcin levels in girls with central precocious puberty

POSTER PRESENTATION Open Access

Serum osteocalcin levels in girls with centralprecocious pubertyYoung Jun Rhie*, Hyo Kyoung Nam, Kee Hyoung Lee

From 7th APPES Biennial Scientific MeetingNusa Dua, Bali. 14-17 November 2012

ObjectivesBone plays metabolic roles through osteocalcin(OC)when it is released into the systemic circulation in uncar-boxylated form. Identified novel metabolic roles of OCinclude increasing insulin secretion and sensitivity,energy expenditure, reduction of fat mass and mitochon-drial proliferation and functional enhancement. Theonset of puberty can be influenced metabolic factors.This study was aimed to determine serum OC levels ingirls with central precocious puberty(CPP) and to investi-gate the effects of OC on the onset of puberty.

MethodsSerum OC levels of girls CPP (n=30) and their age-matched controls (n=30) were measured. GnRH stimu-lation test was performed in CPP group. Bone age wasdetermined in all subjects.

ResultsSerum OC levels were significantly higher in CPP groupcompared with control group (76.8 ± 10.5 vs. 61.6 ±15.1ng/mL, p=0.001). Serum OC levels were correlatedwith peak LH levels during GnRH stimulation test(r=0.348, p=0.037), bone age (r=0.403, p=0.010) andbone age advance (r=0.323, p=0.042), but not related toage, height, weight and BMI.

ConclusionsSerum OC seems to be associated with the onset ofpuberty leaving casual relations unresolved.

Published: 3 October 2013

doi:10.1186/1687-9856-2013-S1-P79Cite this article as: Rhie et al.: Serum osteocalcin levels in girls withcentral precocious puberty. International Journal of Pediatric Endocrinology2013 2013(Suppl 1):P79.

Submit your next manuscript to BioMed Centraland take full advantage of:

• Convenient online submission

• Thorough peer review

• No space constraints or color figure charges

• Immediate publication on acceptance

• Inclusion in PubMed, CAS, Scopus and Google Scholar

• Research which is freely available for redistribution

Submit your manuscript at www.biomedcentral.com/submitDepartment of Pediatrics, Korea University College of Medicine, Seoul, South

Korea

Rhie et al. International Journal of Pediatric Endocrinology 2013, 2013(Suppl 1):P79http://www.ijpeonline.com/content/2013/S1/P79

© 2013 Rhie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.

http://creativecommons.org/licenses/by/2.0

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