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SERIN 2013 - Programme www.eaaci-serin.org

SERIN 201321 – 23 March 2013

Leuven, Belgium

Symposium on Experimental Rhinology and Immunology of the Nose

www.eaaci-serin.org

Abstracts


Abstracts

Oral Abstracts Sessions

Thursday, 21 March 2013

09:25 – 10:05 Free paper session: Epidemiology / clinical rhinology

Local allergic rhinitis: natural history Rondon, Carmen; Campo, Paloma; Doña, Inmaculada; De La Roca, Federico; Blanca Lopez, Natalia; Blanca, MiguelCarlos Haya Hospital, Malaga, Spain; Carlos Haya Hospital, Allergy Service, Malaga, Spain; Ciudad Real General Hospital, Allergy Service, Malaga, Spain; Infanta Leonor Hospital, Allergy Service, Madrid, Spain

Symptoms chronic rhinosinusitis with and without nasal polypsDietz de Loos, Dirk; Hopkins, Claire; Fokkens, Wytske1Academic Medical Centre, Otorhinolaryngology, Amsterdam, Netherlands; Guy’s Hospital, Otorhinolaryngology, London, UK

A historical cohort study of eosinophilic infl ammation in chronic rhinosinusitis with nasal polyps in Okayama, JapanHirai, Misato; Okano, Mitsuhiro; Noyama, Yasuyuki; Haruna, Takenori; Nishizaki, KazunoriOkayama Saiseikai General Hospital, Okayama, Japan; Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head & Neck Surgery, Okayama, Japan

Quality of life and use of medication in chronic allergic and non-allergic rhinitis patientsSegboer, Christine; Holland, Carlijn; Reinartz, Suzanne; Terreehorst, Ingrid; Gevorgyan, Artur; Hellings, Peter; van Drunen, Cornelis; Fokkens, WytskeAcademic Medical Center Amsterdam, Otorhinolaryngology, Amsterdam, Netherlands; Universital Hospital Leuven, Otorhinolaryngology, Amsterdam, Belgium

12:10 – 12:30 Free paper session: Infl ammatory mechanisms

Sinunasal ultrastructure of the transplant hematopoietic stem cell and chronic grast -versus-host disease with rhinosinusitisOrtiz, Erica; Vigorito, Afonso Celso; Meirelles, Luciana R.; Sakano, Eulalia; Daniele Nicola, Ester MariaUniversity of Campinas, Sao Paulo, Brazil, Otolaryngology Head-Neck, Campinas, Brazil; University of Campinas, Sao Paulo, Brazil, Hematology, Campinas, Brazil; University of Campinas, Sao Paulo, Brazil, Patology, Campinas, Brazil; University of Campinas, Sao Paulo, Brazil, Otolaryngology Head-Neck, Campinas, Brazil; University of Campinas, Sao Paulo, BRazil, Otolaryngology Head-Neck, Campinas, Brazil

Platelet Activating Factor-induced mast cell degranulation is inhibited by rupatadine, and to a lower extent by levocetirizine and desoratadine, in a mast cell line (LAD-2)Mullol, Joaquim; Muñoz-Cano, Rosa; Torres-Atencio, I; Ainsua, E; Martin, M; Sanchez-Lopez, J; Bartra, Joan; Picado, Cesar; Valero, AntonioHosp Clinic, IDIBAPS, Barcelona, Spain

16:10 – 16:30 Free paper session: Cellular contributions to immune responses

Two year persistent treatment eff ect in reducing nasal symptoms of cat allergy ast er 4 doses of cat-pad, the fi rst in a new class of synthetic peptide immuno-regulatory epitopesHafner, Roderick; Couroux, Peter; Armstrong, Kristen; Patel, Deepen; Larche, Mark; Haumann, BrettCircassia Ltd, R&D, Oxford, UK; Cetero Research, R&D, Missisauga, Canada; Adiga, Life Sciences, Hamilton, Canada; Cetero Research, R&D, Toronto, Canada; McMaster University, Department of Medicine, Hamilton, Canada

Expression of the epithelial polymeric immunoglobulin receptor is decreased in allergic rhinitis and eosinophilic rhinosinusitisHupin, Cloé; Rombaux, Philippe; Lecocq, Marylène; Pilette, CharlesCliniques Universitaires Saint-Luc, Service d’Oto-Rhino-Laryngologie, Bruxelles, Belgium; Université Catholique de Louvain, IREC, Pole de Pneumologie, ORL & Dermatologie, Bruxelles, Belgium


Friday, 22 March 2013

09:15 – 10:00 Free paper session: Phenotypes and endotypes

Downregulation of epithelial MHC II expression in chronic rhinosinusitis with polyps Arebro, Julia; Tengroth, Lotta; Kumlien Georén, Susanna; Winqvist, Ola; Cardell, Lars-OlafKarolinska University Hospital, Division of ENT diseases, CLINTEC, Stockholm, Sweden; Karolinska University Hospital, Department of Medicine, Unit of Clinical Allergy R, Stockholm, Sweden

Matrix metalloproteinases, tissue inhibitor of metalloproteinase and transforming growth factor a1 in the remodeling of chronic rhinosinusitis in north ChinaWang, XiangDong; Wang , ChengShuo; Bo, MingYu; Wang, Hong; Li, Ying; Fan, ErZhong; Zhang, Nan; Bachert, Claus; Zhang, LuoDepartment of Otorhinolaryngology Head and Neck Surgery of Beijing Tongren Hospital, Beijing Institut, Beijing, China; Beijing Tongren Hospital, Capital Medical University, Department of Otorhinolaryngology Head and Neck Su, Beijing, China; Beijing Tongren Hospital, Capital Medical University, Department of Otorhinolaryngology, Beijing, China; Beijing Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Beijing, China; Ghent University Hospital, Department of Otorhinolaryngology, Ghent, Belgium; Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Beijing, China

Smoking and non-allergic sinonasal diseaseBacker, Vibeke; von Buchwald, Christian; Håkansson, Kåre; Thomsen, Simon Francis; Linneberg, AllanBispebjerg Hospital, Dept. of respiratory medicine L, Copenhagen, Denmark; Copenhagen University Hospital, Dept. of head and neck surgery, Copenhagen, Denmark; Copenhagen University Hospital, Copenhagen, Denmark; Glostrup Hospital, Centre for prevention and Health, Copenhagen, Denmark

The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3-year prospective observational studyVlaminck, Stephan; Vlaminck, Stephan; Vauterin, Tom; Lerut, BobAZ St-Johnn hospital, Brugge, Belgium; AZ St John hospital, ENT/Rhinology, Brugge, Belgium; AZ StJohns hospital, ENT/Rhinology, Brugge, Belgium; AZ St-Johns hospital, ENT/Rhinology, Brugge, Belgium

11:45 – 12:30 Free paper session: Clinical rhinology

Perceived stress is related to health-related quality of life in patients with chronic rhinosinuitisPangercic, Ana; Markota, Danijela; Grgec, Maja; Kosec, Andro; Tomljenovic, Dejan; Kalogjera, LivijeUniversity Clinical Hospital “Sestre Milosrdnice”, Zagreb, Croatia; Zagreb School Of Medicine, Zagreb, Croatia, Zagreb School Of Medicine, Zagreb, Croatia, University Clinical Hospital “Sestre Milosrdnice”, ENT, Zagreb, Croatia

Nasal allergen provocation test in nasal polyposis with and without allergyCalus, Lien; Devuyst, Lien; De Ruyck, Natalie; Van Zele, Thibaut; Bachert, Claus; Gevaert, PhilippeUniversity Hospital Ghent, Upper airway research laboratory, Gent, Belgium; University hospital Ghent, Upper airway research laboratory, Ghent, Belgium

Short and long-term safety of MP29-02*: a new therapy for the treatment of allergic rhinitisPrice, David; Bousquet, Jean; Hellings, Peter; Scadding, Glenis; Fokkens, Wytske; Munzel, Ullrich; Bachert, ClausUniversity of Abderdeen, Abderdeen, UK; Hopital Arnaud de Villeneuve University Hospital, Montpellier, France; University Hospitals Leuven, Dept of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium; The Royal National Throat, Nose and Ear Hospital, London, UK; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; 7Ghent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium

A new therapy (MP29-02*) eff ectively controls nasal symptoms of seasonal allergic rhinitis irrespective of severityScadding, Glenis; Price, David; Bousquet, Jean; Hellings, Peter; Fokkens, Wytske; Munzel, Ullrich; Bachert, ClausThe Royal National Throat, Nose and Ear Hospital, London, UK; University of Aberdeen, Dept of General Practice & Primary Care, Abderdeen, UK; Hopital Arnaud de Villeneue University Hospital, Montpellier, France; University Hospitals Leuven, Dept of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; Ghent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium

15:45 – 16:30 Free paper session: Neural mechanisms in upper AW disease

The role of nasal trigeminal nerves expressing trp channels in modulation of cough threshold & urge to cough – possible clinical applicationPlevkova, Jana; Biringerova, Zuzana; Gavliakova, Silvia; Hanuskova, Eva; Buday, Tomas; Brozmanova, MarianaComenius University, Jessenius Faculty of Medicine, Martin, Slovakia; Comenius University, Jessenius Faculty of Medicine, Department of Pathophysiology,


Martin, Slovakia

Subjects with local allergic rhinitis can be identifi ed by basophil activation testCampo, Paloma; Rondon, Carmen; Gomez, Enrique; Blanca-Lopez, Natalia; Torres, M Jose; Barrionuevo, Esther; Herrera, Rocio; Galindo, Luisa; Mayorga, Cristobalina; Blanca, MiguelCarlos Haya Hospital, Allergy Service, Malaga, Spain; Carlos Haya Hospital, Allergy Research Laboratory, Malaga, Spain; Infanta Leonor Hospital, Allergy Service, Madrid, Spain

Chemoattractant levels in nasal secretions as indicators of clinical severity in chronic polypous rhinosinusitisPeric, Aleksandar; Vojvodic, Danilo; Baletic, Nenad; Radulovic, VesnaFaculty of Medicine, Military Medical Academy, Department of Otorhinolaryngology, Belgrade, Belgrade, Serbia; Faculty of Medicine, Military Medical Academy, Department of Clinical and Experimental Immunology, Belgrade, Serbia; Municipal Institute for Lung Diseases, Department of Pneumology, Belgrade, Belgrade, Serbia

Apoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposisValera, Fabiana; Küpper, Daniel S; Malinsky, Rafael; Milanezi, Cristiane; Silva, João S; Tamashiro, Edwin; Anselmo-Lima, Wilma TSchool of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil; School of Medicine of Ribeirão Preto - University of São Paulo, ENT Division, Ribeirão Preto, Brazil; school of Medicine of Ribeirão Preto - University of São Paulo, ENT Division, Ribeirão Preto, Brazil; School of Medicine of Ribeirão Preto - University of São Paulo, Biochemistry Department, Ribeirão Preto, Brazil

Poster Abstracts Sessions

We kindly ask you to put up your poster on Thursday morning, 21 March 2013. All posters will be on the poster boards from the beginning until the end of the Symposium. Ast er the Symposium (on Saturday, 23 March 2013) please make sure to remove all poster-mounting material from the board. The organisers will remove posters not taken down on time and will not take any further responsibility for the material.

Epidemiology / clinical rhinology1Clarithromycin induced allergy in 49-year-old female patientRadovic, VesnaSTADA Hemofarm A.D., Belgrade, Serbia

2 The role of feeding during infancy on nasopharyngeal colonization with common respiratory pathogens in childrenBakhshaee, Mehdi; Jafari Ashtiani, Sara; Ghazvini, Kiarash; Khalaghi, Ali; Rajati, MohsenMashhad University of Medical Sciences, Mashhad, Iran; Azad University of Medical Sciences, Dentistary, Tehran, Iran; Mashhad University of Medical Sciences, Microbiology, Mashhad, Iran; Mashhad University of Medical Sciences, Otorhinolaryngology-Head & Neck surgery, Mashhad, Iran; Mashhad University of Medical Sciences, Otorhinolaryngology-Head & Neck Surgery, Mashhad, Iran

3 Evaluation of birch pollen sensitization profi le in allergic rhinoconjunctivitis patients from bucharest region using component-resolved diagnosisPopescu, Florin-Dan; Vieru, Mariana; Tudose, Adriana MihaelaUniversity of Medicine and Pharmacy “Carol Davila”, Department of Allergology, Bucharest, Romania

4 Epidemiology of eosinophilic otitis media with asthma and eosinophilic nasal polyposis in JapanTaniguchi, Masami; Mitsui, Chihiro; Higashi, Noritaka; Ono, Emiko; Ishii, Toyota; Fukutomi, Yuma; Akiyama, KazuoSagamihara National Hospital, Adult Allergy Department, Sagamihara, Japan; Sagamihara National Hospital, Department of Otolaryngology, Sagamihara, Japan

5 Rhinitis prevalence and incidence in a cohort of children with recurrent wheezing: from preschool age to adolescencePereira, Ana; Gaspar, Ângela; Morais-Almeida, MárioHospital CUF-Descobertas, Immunoallergy Department, Lisbon, Portugal

6 Prevalence and burden of rhinitis and rhinoconjunctivitis in 9- to 11-year-old childrenPereira, Ana; Gaspar, Ângela; Morais-Almeida, MárioHospital CUF-Descobertas, Immunoallergy Department, Lisbon, Portugal


7 The eff ect of nasal breathing on the exercise induced bronchospasm in children with allergic asthma and rhinitisTurkalj, Mirjana; Canaki, Martina; Magdic, Robert; Lipej, Marcel; Bulat, Sandra; Zivkovic, Jelena; Plavec, DavorChildren’s Hospital Srebrnjak, Zagreb, Croatia; Children’s Hospital Srebrnjak, Allergy Department, Zagreb, Croatia

8 Effi cacy of sublingual immunotherapy with grass pollen in allergic rhinitisLosappio, Laura; Frati, Franco; Dell’Albani, Ilaria; Incorvaia, Cristoforo; Pastorello, Elide AnnaNiguarda, Milano, Italy; Stallergenes, Medical and Scientifi c, Milan, Italy; Stallergenes, Medical and Scientifi c, Milano, Italy; ICP, Allergy/Pulmonary Rehabilitation, Milano, Italy; Niguarda, Allergology and Immunology, Milano, Italy

9 Allergic profi le of Congolese individuals exposed to fl our dust as compared with a non-exposed work group Nyembue Tshipukane , Dieudonné; Kembia, Eliseé; Lusamba, Léonie; Nkoy, Marie Jeanne; Kamanga, boniface; Kayembe, Jean-Marie; Vanoirbeek, Jeroen; Scheers, Hans; Buntinx, Frank; Hellings, Peter; Jorissen , MarkUniversity of Kinshasa, Otorhinolaryngology Department, Kinshasa, Belgium; Hopital sino-congolais, ENT service, Kinshasa, Congo; University of Kinshasa, Medecine Physique, Kinshasa, Congo; University of Kinshasa, Pneumologie, Kinshasa, Congo; KU leuven, Occupational, Environmental Medicine, Leuven, Belgium; KU leuven, Academic Center for General Practice, Leuven, Belgium; KU leuven, Experimental Oto-rhino-laryngology, Leuven, Belgium

10 Chronic rhinitis in glassblowersBaletic, Nenad; Peric, AleksandarMilitary Medical Academy, Belgrade, Serbia; Military Medical Academy, ENT, Belgrade, Serbia

11 Primary ciliary dyskinesia and humoral immunodefi ciency - what is the missing link?Boon, Mieke; Jorissen, Mark; De Boeck, Kris; Meyts, IsabelleUZ Gasthuisberg Leuven, Pediatric Pulmonology, Leuven, Belgium; UZ Gasthuisberg Leuven, Otorhinolaryngology, Leuven, Belgium; UZ Gasthuisberg Leuven, Pediatric Immunology, Leuven, Belgium

12 Longer treatment duration with slit leads to higher patient’s satisfaction and clinical improvement. outcomes of the samites studyMarti, Enric; Sanchez-Salguero, Carlos; Scorza, Enrique; Garcia, Mario AlbertoClinica Internacional de Medicina Avanzada (CIMA), Allergy Service, Barcelona, Spain; Hospital Virgen de las Montañas, Allergy Service, Cadiz, Spain; Stallergenes Iberica, Medical Department, Barcelona, Spain

13 Anaphylaxis by inhalation of alergenic proteins from anisakis simplexGarcia Navarro, Dalhila Janett; Montoro De Francisco, Ana; Chivato Perez, Tomas; Membrillo De Novales, Francisco Javier; Nuñez Hernandez, Maria Angeles; De Mateo Hernandez, Belen; Fernandez Lopez, Manuel; Mateos Galvan, Jose MariaHospital Central de la Defensa “Gómez Ulla”, Madrid, Spain; Hospital Central de la Defensa “Gómez Ulla’’, Allergy Department, Madrid, Spain; Hospital Central de la Defensa “Gomez Ulla”, Allergy Department, Madrid, Spain; Hospital Central de la Defensa “Gomez Ulla”., Internal Medicine Department, Madrid, Spain

ENT14 IL-5, IL-8 and tgf-beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue´s cellularity and disease relapsingAnselmo-Lima, Wilma T; Gallego, Aline J; Cavallari, Fransérgio E; Küpper, Daniel S; Milanezi, Cristiane; Silva, João S; Oliveira, Siomara Bambirra; Faria, Franscesca M; Tamashiro, Edwin; Valera, Fabiana CPSchool of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil; School of Medicine of Ribeirão Preto - University of São Paulo, ENT Division, Ribeirão Preto, Brazil; School of Medicine of Ribeirão Preto - University of São Paulo, Biochemistry Department, Ribeirão Preto, Brazil; School of Medicine of Ribeirão Preto - University of São Paulo, Pathology Department, Ribeirão Preto, Brazil

15 Allergic fungal rhinosinusitis (afrs) -- more than a fungal disease?Dutre, Tineke; Al Dousary, Surayie; Zhang, Nan; Bachert, ClausUniversity Hospital Ghent, Ghent, Belgium; Rhinology Research Chair, Medical College, King Saud University, Department of Otorhinolaryngology, Riyadh, Saudi Arabia; Upper Airway Research Laboratory, University Ghent, Department of Otorhinolaryngology, Ghent, Belgium

16 Changes in paranasal sinus mucosa due to the nasopharyngian obstructionManole, Felicia, Faculty Of Medicine Oradea, Oradea, Romania; Faculty Of Medicine Oradea, Ent, Oradea, Romania

17 The correlation between chronic sinusitis and chronic adenoiditis in childrenManole, Felicia,

Faculty Of Medicine Oradea, Oradea, Romania; Faculty Of Medicine Oradea, Ent, Oradea, Romania


18 Comparative proteomic analysis of tear fl uid versus nasal mucus in allergic rhinitis patients and healthy controlsTomazic, Peter Valentin; Birner-Grünberger, Ruth; Obrist, Britta; Wolf, Hanno; Lang-Loidolt, DorisENT-University Hospital Graz, Graz, Austria; Medical University of Graz, Institute of Pathology, Graz, Austria; Medical University of Graz, Center of Medical Research, Graz, Austria; Hospital Bruck an der Mur, Dept. of Ophthalmology, Bruck an der Mur, Austria; Medical University of Graz, ENT-University Hospital, Graz, Austria

19 Filtering eff ect of a protective pollen-grid toward airborne fungal sporesFassio, Filippo; Marvelli, Silvia; Rizzoli, Elisabetta; Marchesini, MarcoAllergy Practice, Florence, Italy; Laboratorio di Palinologia, C.A.A. Giorgio Nicoli s.r.l., Bologna, Italy; Dipartimento di Biologia ed evoluzione, Università degli Studi di Ferrara, Ferrara, Italy

20 Dry extract bno 1011 inhibits human infl uenza a replication and neuraminidase activity in oseltamivir-resistant and -sensitive viral strainsSeifert, Stephanie; Wosikowski, Katja; Haunschild, JuttaBionorica SE, Preclinical and Project Management (R&D), Neumarkt i.d.Opf., Germany

Infl ammatory mechanisms

21 Anti-infl ammatory eff ect of rebamipide on the ocular surfaceUeta, Mayumi; Sotosono, Chie; Yokoi, Norihiko; Kinoshita, ShigeruDoshisha University, Kyoto Prefectural University of Medicine, Uji, Japan; Kyoto Prefectural University of Medicine, ophthalmology, kyoto, Japan

22 Doxycycline induced erythema fi xum multilocularis in 75-year-old female patientRadovic, VesnaSTADA Hemofarm A.D., Belgrade, Serbia

23 Thymosin α1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitisDalm, Virgil; Neeleman, Rochus; de Wit, Harm; Drexhage, HemmoErasmus MC, Immunology, Rotterdam, Netherlands

24 Interleukin-33 promotes proliferation of mouse mast cells through c-kit and p38 mapk -dependent pathwaySaluja, Rohit; Eberle, Jürgen; Maurer, MarcusCharite Universitatmedizin, Department of Dermatology and Allergy, Berlin, Germany; Charite - Universitätsmedizin, Department of Dermatology and Allergy, Berlin, Germany

25 Cellular responses to staphylococcus aureus alpha-toxin are associated with clinical outcomes in chronic rhinosinusitis with nasal polypsOkano, Mitsuhiro; Haruna, Takenori; Noyama, Yasuyuki; Hirai, Misato; Nishizaki, Kazunori; Fujiwara, TazukoOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Otolaryngolody-Head & Neck Surgery, Okayama, Japan; Okayama Saiseikai General Hospital, Otolaryngolody-Head & Neck Surgery, Okayama, Japan

26 Early growth response protein 1 and dual specifi city protein phosphatase 1 are involved in down-regulation of allergic responsesGolebski, Kornel; van Egmond, Danielle; de Groot, Esther; Fokkens, Wytske; van Drunen, CornelisAcademic Medical Center, ENT, Amsterdam, Netherlands

27 Minimal persistent infl ammation in japanese cedar pollinosis and a prophylactic eff ect of intranasal corticosteroidsNoyama, Yasuyuki; Okano, Mitsuhiro; Hirai, Misato; Haruna, Takenori; Nishizaki, KazunoriOkayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama, Japan; Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Department of Otolaryngology-Head & Neck Surgery, Okayama, Japan; Okayama Saiseikai General Hospital, Department of Otolaryngology-Head & Neck Surgery, Okayama, Japan

28 The imbalance in expression of genes of innate immunity of children with adenoid hypertrophy vegetationsSvitich, Oxana; Gankovskii, Viktor; Gankovskaya, Ludmila; Rahmanova, IrinaI.Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Molecular Immunology Department, Moscow, Russia; Russian National Research Medical University named ast er N.I. Pirogov, Otolaryngology Department, Moscow, Russia; Russian National Research Medical University named ast er N.I. Pirogov, Immunology Department, Moscow, Russia; Russian National Research Medical University named ast er N.I. Pirogov, Otolaryngology Department, Moscow, Russia


29 Grass pollen nasal challenge is associated with increases in Th2 cytokines, Eotaxin, MDC and IL-6 in nasal fl uidScadding, Guy; Eifan, Aarif; Penagos, Martin; Koed, Gitte Konsgaard; Wurtzen, Peter Adler; Shamji, Mohamed; Durham, StephenImperial College, London, London, UK; Imperial College, London, Allergy and Clinical Immunology, London, UK; ALK-Abello, Vaccine Research and Discovery, Hørsholm, Denmark

30 Peripheral blood lymphocytes` functional activity in allergic rhinitisOrlova, Elena; Orlova, ElenaNational Academy of Sciences of Belarus, Minsk, Belarus; National Academy of Sciences of Belarus, National Academy of Sciences of Belarus, Minsk, Belarus

Cellular contributions to immune responses

31 The role of mast cells, interleukin-13 and transient receptor potential channels in a mouse model of chemical-induced airway hyperresponsivenessDevos, Fien; De Vooght, Vanessa; Nemery, Benoit; Hoet, Peter; Vanoirbeek, JeroenKU Leuven, Occupational, Environmental and Insurance Medicine, Leuven, Belgium

Clinical rhinology

32 Immunocap isac as an important diagnostic tool in rhino-sinusitisDr Michael, Rudenko; Dr Suranjith, Seneviratne; Dr Robert, Boyle; Dr Katya, Burova; Dr William, Egner; Ms Amina, Bhayat-Cammak; Mr Neal, BradshawLondon Allergy and Immunology Centre, Outpatient clinic, London, UK; Protein Reference Unit Sheffi eld Teaching Hospitals, Immunology, London, UK; Protein Reference Unit Sheffi eld Teaching Hospitals, Immunology, Sheffi eld, UK; Thermo Fisher Scientifi c, ImmunoDiagnostics, London, UK

33 Rupatadine oral solution improves rhino-conjunctive symptoms control in children with 6-11 years weighing ¡Ý25 kg with persistent allergic rhinitisIzquierdo, Iñaki; Potter, Paul; Maspero, Jorge; Vermeulen, Jan; BArkai, Laszlo; Nemeth, Ildiko; Baillieau, Rene; Garde, Jesus M; Giralt, Josep; Domenech, Alejandro; Nieto, AntonioUriach Pharma, Clinical Research, Palau de Plegamans, Spain; Allergy Diagnostic and Clinical Research Unit, University Cape Town, Palau de Plegamans, South Africa; Fundacion CIDEA, Allergy Department, Palau de Plegamans, Argentina; Parow Research, Allergic Dept, Palau de Plegamans, South Africa; BAZ Megyei Korhaz, Gyermekegeszsegugyl Kozpont, Miskolc, Hungary; Szent Erzsebet Korhaz, Non-profi t Kozhasznu Kst , Jaszbereny, Hungary; Centro de Alergia, Centro de Alergia, Mar de Plata, Argentina; Servicio de Alergia, Hosp G. Universitario de Elche, Elche, Spain; Pediatric Allergy and Pneumology Unit, Children’s hosp La Fe, Valencia, Spain

34 Long-term results of functional endoscopic sinus surgery in children with chronic rhinosinusitis with nasal polypsCornet, Marjolein; Georgalas, Christos; Reinartz, Susanne; Fokkens, WytskeAMC, Amsterdam, Netherlands; AMC, ENT, Amsterdam, Netherlands

35 Chronic rhinosinusitis with nasal polyps in the elderlyCornet, Marjolein; Fokkens, WytskeAMC, Amsterdam, Netherlands; AMC, Otorhinolaryngology, Amsterdam, Netherlands

36 Early interventional treatment with intranasal corticosteroids is superior to post-onset treatment in japanese cedar/cypress pollinosisHaruna, Takenori; Okano, Mitsurhiro; Higaki, Takaya; Noyama, Yasuyuki; Hirai, Misato; Nishizaki, KazunoriOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Otolaryngolody-Head & Neck Surgery, Okayama, Japan; Okayama Saiseikai General Hospital, Otolaryngolody-Head & Neck Surgery, Okayama, Japan

37Clinical signifi cance of performing a nasal challenge test in children with allergic rhinitisLukina, Olga; Ksenzova, LudmilaScienntifi c Centre of Children,s Health” under the Russian Academy of Medical Sciences, Moscow, Russia; Scientifi c Center of Children’s Health, pulmonology and allergology, Moscow, Russia

38 Pulsating Aerosols for the Rhinosinusitis Treatment -Evaluation of an innovative Method in a Multicentric SurveyMentzel, Heribert W.; Ledermueller, Rosina; Watt, KirsteenPARI GmbH, Starnberg, Germany; PARIGmbH, Medical Aff airs, Starnberg, Germany; PARI GmbH, International Marketing, Starnberg, Germany


39 A new therapy (MP29-02*) eff ectively treats patients with seasonal allergic rhinitis who suff er most from the bothersome nasal symptom of congestionBachert, Claus; Price, David; Scadding, Glenis; Fokkens, Wytske; Hellings, Peter; Munzel, Ullrich; Bousquet, JeanGhent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium; University of Aberdeen, Dept of General Practice & Primary Care, Abderdeen, UK; The Royal National Throat, Nose and Ear Hospital, London, UK; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; University Hospitals Leuven, Dept of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; Hopital Arnaud de Villeneuve University Hospital, Montpellier, France

40 Azelastine hydrochloride and budesonide (nasal sprays): eff ectiveness combination therapy monitored by acoustic rhinometry and clinical symptom score in the treatment of allergic rhinitisZanellato Fabbri, Natalia; de Lima Zollner, Ricardo; Abib Junior, EduardoUniversity of Campinas, Campinas, Brazil; University of Campinas, Department of Internal Medicine -Faculty of Medica, Campinas, Brazil

41 A new therapy (MP29-02*) provides eff ective relief from all individual nasal and ocular symptoms of seasonal allergic rhinitisHellings, Peter; Bachert, Claus; Bousquet, Jean; Scadding, Glenis; Fokkens, Wytske5; Munzel, Ullrich; Price, DavidUniversity Hospitals Leuven, Leuven, Belgium; Ghent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium; Hopital Arnaud de Villeneuve University Hospital, Montpellier, France; The Royal National Throat, Nose and Ear Hospital, London, UK; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; Univserity of Abderdeen, Dept of General Practice & Primary Care, Abderdeen, UK

42 A new effi cacy parameter (complete/near complete symptom relief) in allergic rhinitis management: results with a new therapy MP29-02*Bousquet, Jean; Scadding, Glenis; Price, David; Hellings, Peter; Hellings, Peter; Fokkens, Wytske; Munzel, Ullrich; Bachert, ClausHopital Arnaud de Villeneuve University Hospital, Montpellier, France; The Royal National Throat, Nose and Ear Hospital, London, UK; University of Abderdeen, Dept of General Practice & Primary Care, Abderdeen, UK; University Hospitals Leuven, Dept of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; Ghent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium

43 Acoustic rhinometry ast er nasal provocation test, 6 months interim analysis of alumites study, a randomized, controlled, multicentre phase iv study with house dust mites subcutaneous immunotherapySanchez, Jaime; Vidal, Carmen; Hernandez, Dolores; Valero, Antonio; Castello, Jose Vicente; Pelaez, Antonio; Garcia, Mario AlbertoHospital Clinic Universitari de Barcelona, Allergy Service, Barcelona, Spain; Complejo Hospitalario de Santiago. Hospital del Conxo, Allergy Service, Santiago de Compostela, Spain; Hospital Universitario y Politecnico La Fe, Allergy Service, Valencia, Spain; Hospital General de Castellon, Allergy Service, Castellon, Spain; Hospital Clinico Universitario de Valencia, Allergy Service, Valencia, Spain; Stallergenes Iberica, Medical Department, Barcelona, Spain

44 Long-term control in chronic rhinosinusitis ast er endoscopic sinus surgeryvan der Veen, Julie; Timmermans, Marieke; Jorissen, Mark; Hellings, PeterUniversity Hospitals Leuven, Department Otorhinolaryngology-Head & Neck Surgery, Leuven, Belgium

45 A new therapy (MP29-02*) eff ectively targets the entire seasonal allergic rhinitis symptom complexPrice, David; Bousquet, Jean; Bachert, Claus; Fokkens, Wytske; Scadding, Glenis; Munzel, Ullrich; Hellings, PeterUniversity of Aberdeen, Abderdeen, UK; Hopital Arnaud de Villeneuve University Hospital, Montpellier, France; Ghent University Hospital, Dept of Oto-rhinolaryngology, Ghent, Belgium; Academic Medical Center, Dept of Otorhinolaryngology, Amsterdam, Netherlands; The Royal National Throat, Nose and Ear Hospital, London, UK; Meda Pharma, Biostatistics & Market Access, Bad Homburg, Germany; University Hospitals Leuven, Dept of Otorhinolaryngology, Head and Neck Surgery, Leuven, Belgium

46 Observational study: evaluating symptom control in allergic rhinitis at three years ast er starting immunotherapyDroessaert, Valerie; Timmermans, Marieke; Ceuppens, Jan; Jorissen, Mark; Hellings, PeterUniversity Hospitals of Leuven, Leuven, Belgium; University Hospitals of Leuven, ENT Department, Leuven, Belgium; University Hospitals of Leuven, Allergology Department, Leuven, Belgium

The nose as key organ

47 Usefulness of examination of nasal patency by PNIF in the Polish population based on ECAP (Epidemiology of Allergic Disorders in Poland) multi-centre studyKrzych-Falta, Edyta; Lusawa, Adam; Samolinski, BoleslawDepartment of Prevention of Environmental Hazards and Allergology, Warsaw Medical University,, Warsaw, Poland; Medical University, Department of Prevention of Environmental Hazards, Warsaw, Poland; Medical Uniwersity of Warsaw, Department of Prevention of Environmental Hazards, Warsaw, Poland


48 Analysis of the PNIF measurement (Peak Nasal Inspiratory Flow) in ECAP study (The Epidemiology of Allergic Diseases in Poland)Modzelewska, Dominika; Krzych-Falta, Edyta; Lusawa, Adam; Samolinski, BoleslawDepartment of Prevention of Environmental Hazards and Allergology, Warsaw, Poland; Medical Uniwersity of Warsaw, Department of Prevention of Environmental Hazards, Warsaw, Poland

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