Sepsis Prevention in ICU PatientsJESSICA WILBORN

Data Reports

750,000 cases per year Sepsis is expected to increase by 1.5% per year and there will be a significant increase among the elderly Severe sepsis is the leading cause of morbidity and mortality worldwide The annual health costs is $24 billion Sepsis patients have a 75% longer hospital stay compared to patients with other conditions Patients hospitalized for septicemia are eight times more likely to die during the hospital stay Research indicates 36% improved odds of inpatient survival rate among Emergency Departments

that see higher numbers of sepsis patients (depends on hospital location and teaching status)

http://www.cdc.gov/sepsis/datareports/index.html

Sepsis

A life threatening condition where the body attacks its own tissues and organs in response to infection

Severe sepsis is progression to cellular dysfunction, organ damage, hypoperfusion,

Sepsis (infection + 2+ SIRS criteria)

Severe sepsis (infection +SIRS criteria +organ dysfunction)

Sepsis can occur in any setting and with any patient

Systemic Inflammatory Response Syndrome (SIRS)

SIRS typically precedes sepsis

Characterized as:

Temperature >38 or <36

Heart rate more than 90bpm

Respiratory rate greater than 20 breaths/min

WBC count greater than 12,000 cell/mm3 or greater than 10% immature bands

Hyperglycemia

Altered mental status

Signs & Symptoms of Sepsis

Fever

Chills

Tachycardia

Tachypnea

Abnormal lab values

Low blood pressure SBP <90mmHg

MAP < 70 mmHg

Dehydration

Altered mental status

Reduced urine output

Sepsis & the elderly

Older patients may present with atypical symptoms or may be absent

Atypical symptoms include delirium, falls, loss of appetite, weakness, malaise, and fever can be absent or subdued

Often these patients experience a delay in treatment

Poor nutrition and low immune system significantly increase the risk of sepsis

Existing comorbidities metastatic neoplasms (43%), chronic liver disease (37%), and chronic renal disease (36%) significantly increase risk of sepsis related mortality

Frequently gram negative bacilli is detected. However, gram positive bacilli becoming common due to broad spectrum antibiotic use

Higher mortality among the elderly (40-50%) compared to individuals <65

Factors to predict prognosis in critically ill patients

Pre-infectious status

Gender

Age

Nosocomial events

Comorbidities

Severity of Illness

Vulnerable Populations

Young children

Older people

Long-term invasive devices

Immunocompromised

Nurse role in prevention

According to the Nursing Times, “Nurses have a important role in detecting patients with a deteriorating condition and initiating life-saving treatments” (McClelland, H.,and Moxon, A., 2014, p.17)

Recognize the symptoms and risk factors for sepsis pertaining to the patient

Referral to physician and interdisciplinary team

Initiate Surviving Sepsis Campaign Care Bundle

Within 3 hours: measure lactate, obtain blood cultures, administer broad spectrum antibiotics, administer 30 ml/kg crystalloid for hypotension or lactate ≥ 4mmol/L

Within 6 hours: apply vasopressors for hypotension, MAP ≥65 mmHg, CVP 8-12mmHg, ScvO2 of ≥70%, remeasure lactate levels

Prevention Methods

Identify risk factors increasing susceptibility: infections, open wounds, long term invasive devices, invasive procedures, chemotherapy and anti-cancer treatments, pneumonia, and skin or soft tissue inflammation

Screening significantly increases prevention and decreases sepsis related mortality

Inservice training-poster, pocket guide, or badge reference of sepsis protocol and incorporated in new employee orientation and recertification

Implementing infection control practices

Communication of nurse to interdisciplinary team

Routine clinical assessments-vital signs and perfusion status

SSC Bundle Care- improves delivery of adequate care across all clinical settings

ReferencesAitkin, L., Schorr, C., Kleinpell, R. Implications of the new international sepsis guidelines for nursing care. American Journal of

Critical Care. 22, 3, 212-222, May 2013. ISSN: 10623264

Destarac, A.L., Ely, W.E. (2012). Sepsis in Older Patients: An Emerging Concern in Critical Care. Advances in Sepsis, 22(1), 15-22

CDC (2014). Data Reports. Retrieved from http://www.cdc.gov/sepsis/datareports/index.html

Gaieski, D. F., Edwards, J. M., Kallan, M. J., Mikkelsen, M. E., Goyal, M., & Carr, B. G. (2014). The relationship between hospital volume and mortality in severe sepsis. American Journal of Respiratory and Critical Care Medicine, 190(6), 665-74.

Retrieved from http://search.proquest.com/docview/1563097740?accountid=14589

Gille-Johnson, P., Hansson, K. E., & Gårdlund, B. (2013). Severe sepsis and systemic inflammatory response syndrome in emergency department patients with suspected severe infection. Scandinavian Journal Of Infectious Diseases,

45(3), 186-193. doi:10.3109/00365548.2012.720025

Lopez-Bushneil, K., Demaray, W. S., & Jaco, C. (2014). Reducing Sepsis Mortality. MEDSURG Nursing, 23(1), 9-14.

McClelland, H., Moxon, A., (2014). Early identification and treatment of sepsis. Nursing Times. 110(4), 14-17

Miller,Russell R., I.,II, Dong, L., Nelson, N. C., Brown, S. M., Kuttler, K. G., Probst, D. R., . . . Clemmer, T. P. (2013). Multicenter implementation of a severe sepsis and septic shock treatment bundle. American Journal of Respiratory and Critical Care Medicine, 188(1), 77-82. Retrieved from http://search.proquest.com/docview/1439092853?accountid=14589