semiconductor solutions for the healthcare challenge...1994 2000 2010 2025 in 2025 7.3% of the...

Semiconductor Solutions for the Healthcare Challenge

Werner Neumann

electronica Medical Forum

November 11, 2008

Sept 2008 p.2Werner Neumann

STMicroelectronics Solutions for Healthcare November 2008 - p.2

Healthcare – A Challenge

Source: IDF Diabetes Atlas 2006, Wikipedia, Spectaris 2008

• Health cost in Germany 2006: 148B€

• Potential to save 2.7B€ with modern medical electronics

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1994 2000 2010 2025

In 2025 7.3% of the worlds population might suffer from diabetes

Aging pyramid for Germany, Forecast for 2050

Diabetes Impaired Million people ww



STMicroelectronics’ 3 Pillars in Healthcare

Mass Market ApplicationApproach

• Products ready now

• Development Tools

• Short Time-To-Market

Healthcare Key CTM

Partnership

Develop new dedicated

products and technologies

Government programs,Consortia,Universities

Technology,Investment into

the future



ST Healthcare Solutions

Hearing Aid, Assembly Tech.

Patient Health Records

Tele-monitoring,Home Health

Imaging

Home HealthImplantsDisposable Healthcare

MolecularDiagnostic

Driving ApplicationsEmerging Applications



ST Healthcare Solutions

Molecular Diagnostic

MolecularDiagnostic

• Medical Diagnostics – Point of Care

• Environmental Control – Air/Water

• Agro-Industrial Control – Genetically Modified Objects



ST In-Check™ Platform



ST Platform Approach To Biotech Market

Expert biologists

Big Central Lab

Automation

Hospital LabIntegration

Quantification

Miniaturization - Automation - Reliability

User friendly

Low cost

Fast

Portable



In-Check™ Platform: Main Elements

Biochip Core

Reader

Software platform

Thermal Control System

Pathogen A

Pathogen B

Pathogen C

Marker A

Marker B

Biological Content From ST partners



Core Silicon Chip

Ta/Au electrodes

Thermal Sensors - Al/Si/Cu

Fluidic Inlets - Glass

Buried Channels

Surface Channels - Dry resist

Microarray Detection Area



Concept & Application

Analysis Time: 1- 2 hours

In-Check is designed as an open platform for fast and highly automated DNA analysis.

Example Screenshot



Insulin Nanopump™ in MEMS Technology

Disposable

Healthcare

Inlet valve

Pumping chamber

Outlet valveDetector

• Small, Precise, Safe



European Imaging Project: Megaframe

• Array of diodes in Geiger mode

• One million frames per second imaging

• Count of single photons with a timing resolution of 100ps.

• A new enabler for non-invasivediagnostics with big potential:

– Optical Coherence Tomography (OCT)

– Fluorescence Lifetime Analysis (FLIM)

– Blood glucose metering

– SpO2 Blood oxygen saturation level

– http://www.megaframe.eu

OCT skin analysis video



Technologies for Implantable Devices

1200V dice

3-D MEMS dice

IGBT

MEMS

HCMOS9 LP/ULL

Low Power CMOSUltra Low Leakage

0.13um CMOS

Selected Technologies

HVG8

High Voltage Gate

0.18um CMOS

High Voltage Switch

ECG Unit(ADC)

HV H-Bridge

HV Control

Switching

High Voltage

Capacitor

Capacitor ChargerControl

CircuitMemory Techno.

Power Management

Communication

MEMS Acce-

lerometer

IPAD Device Integration / Hybrids

Implants



Solutions For Each Function

PortableHealthcare

• Glucose Meter

• Insulin Pump

• Blood Pressure

• Thermometer

• Fertility Tester

• Sensors

– MEMS accelerometer

– MEMS microphone

– MEMS technology enables implantable sensors

• Analysis

– Low Power Micro / DSP Functionality

– EEPROM Memory

– ADC, Analog Std. product and ASIC

– Power Management

– RF-ASIC/ZigBee/NFC

• Drug Delivery

– Insulin Nanopump

– MCU / Dual Core ASIC



STM32 Low Power MCU

• ST provides software routines for faster Time-to-market:

• VDE Certified Firmware for STM32 Family according IEC60335 Type B, similar to SIL-2.

• 3DES/AES Encryption Libraries



Motor Control Solutions

• Respirator

• Wheelchair

• Hospital Drug Delivery

• 8-bit: ST7FMC, 32-bit: STM32Power Electronics

• BLDC, 3ph-Induction, PMSM Motors

• Vector / Field Oriented Control

– FIR and IIR filters, PID controller

– Motor control dedicated PWM peripheral

– Dual 12-bit ADC converter, 1 MS/s with synchronization capabilities

– All libraries available now

• Examples:

– Ultra silent drive

– Voice encoding / decoding for commands

– Fast Fourier Transformation



STM32-EVALBoard, Small Packages

• Starter Kits from ST, IAR, Keil, Hitex

• Demos for USB, CAN, SD Card etc…available from www.st.com/mcu

• Hotline support

• Ultra small packages available



EEPROM

• Any Communication interface in any Density:– I2C from 1 Kb to 1 Mb

– SPI from 1 Kb to 1 Mb

– Microwire from 1 Kb to 16 Kb

• On top of standard packages (SO8, SSOP8):– MLP 2x3 up to 128 Kb

– WLCSP for the smallest high density EEPROM in the world

• ST # 1 in EEPROM

• Special Service: custom trimming of key parameter



Tele-Monitoring: ZigBee, NFC

To continuously monitor variations in:

• Temperature

• Heart rate

• Blood oxygenation

• Respiratory rate

ZigBee SN250 module

Tele-Monitoring,Home Health



Miniaturized Packages

Stack Die Through Silicon Via

WLCSPWafer Level Chip Scale Package

Bumped die

SIP System in Package

Down to 400µm pitch

µQFN

Assembly Technology



New ST Micropower Operation Amplifier for Healthcare Analog Front Ends

• Market Leader

– Over 2 Billion units of analog mixed products shipped in 2007

– 6% Market Share WW in 2007

• New Product:

– High merit factor: 5V, 60µA/890kHz

– Low Vio: 1mV max

– Very narrow dispersion of Icc and AC parameters

– Micro Packages: SC70-5, SOT23-8, MSO8-10

• Available in Q1/2009

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Summary

• ST is taking care

– Long term research

– Strong partnerships with market leaders

– State of the art products

– Radical innovative technology

• Products are available now

• Demoboards and support hotline for fast development

On-Chip Cell Sorting

semiconductor solutions for the healthcare challenge...1994 2000 2010 2025 in 2025 7.3% of the...

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