self-assembly and engineering of biological …pcself-assembly and engineering of biological...
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2015 PhD studentships in Biochemistry/Synthetic Biology
Self-Assembly and Engineering of Biological Machines Self-assembly is a common and important phenomenon in biology, physics and chemistry. Biological organisms have evolved large self-assembling organelles (i.e. bioenergetic apparatus and compartments), which play essential roles in enhancing cellular metabolic activities. The projects will apply bioinformatics, molecular genetics, biochemistry, proteomics, synthetic biology and high-resolution Nano-Imaging techniques to investigate the molecular basis that underlies the self-assembly, dynamics and physiological regulation of metabolic organelles in bacteria. We will elucidate comprehensively how cells create these functional “factories” and how their roles are dynamically regulated within the cells in response to the changing environment. Advanced understanding will facilitate the engineering of artificial bio-machines, and provide scientific solutions to grand challenges such as global food and energy security.
The Institute of Integrative Biology at the University of Liverpool (United Kingdom) provides a unique combination of facilities and expertise for research, including the Centre for Cell Imaging, Genomic Sequencing and Proteomics, Centre for X-ray and NMR, Bioinformatics and Computational Modelling. Training in all aspects of the project will be provided with access to state-of-the-art infrastructure in the Institute and with collaborators in the UK, Europe, US nd Australia, which means that there will be good opportunity for career development.
The PhD studentships will start from October 2015 for 4 years. The University has successfully advanced Liverpool-China Scholarship Council (CSC) Award program, which is overseen by CSC and the University. Highly motivated applicants (Bachelors or Masters) with background in biochemistry or molecular biology are invited to apply. Experience in microscopy would be an advantage. To apply, please send a CV, cover letter to Dr Luning Liu ([email protected], http://pcwww.liv.ac.uk/~lnliu/). The deadline is 1st December 2014.
References: Plant Physiol 2014, 165:1618-1631; Biochim Biophys Acta 2014, 1837:1263-1270; Biochim Biophys Acta, 2014, 1837: 811-824; Trends Plant Sci. 2013,18:277-286; PNAS 2012, 109: 11431-11436; PNAS 2011, 108: 9455-9459; J. Mol. Biol. 2009, 393: 27-35; J. Biol. Chem. 2008, 283: 34946-34953.
Institute of Integrative Biology
Dr Luning Liu Email: [email protected] Web: pcwww.liv.ac.uk/~lnliu/ Institute of Integrative Biology, Crown Street, Liverpool L69 7ZB, University of Liverpool, United Kingdom