seer cancer statistics review 1975-2015...seer 13 delay-adjusted incidence b, 1992-2015 all races...

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ancer Statistics Review

1975-2015N

ational Cancer Institute

Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute. (https://surveillance.cancer.gov/joinpoint/).The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

a Trends are from the SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).b Trends are from the SEER 13 areas (SEER 9 Areas, Los Angeles, San Jose-Monterey, Rural Georgia, and the Alaska Native Registry).c Trends are from US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.d The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpoint.e API - Asian/Pacific Islander, AI/AN - American Indian/Alaska Native, NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska

Natives. Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registry.The Hispanic and Non-Hispanic mortality trends exclude deaths from New Hampshire and Oklahoma.

g Data for American Indian/Alaska Native are based on the CHSDA(Contract Health Service Delivery Area) counties.* The APC/AAPC is significantly different from zero (p

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Reference: Cancer Incidence Rates Adjusted for Reporting Delay.Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review.

a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval.

All Races, Females White Females Black Females All

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Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review.a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).- Statistic not shown. Rate based on less than 16 cases for the time interval.


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Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Review.a US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.

Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).- Statistic not shown. Rate based on less than 16 cases for the time interval.


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a SEER 18 areas. Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130),unless noted.

b US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130), unless noted.

c Rates are per 100,000 and are age-adjusted to the world (WHO 2000-2025) standard million.- Statistic not shown. Rate based on less than 16 cases for the time interval.

SEER Incidencea U.S. Mortalityb All Races White Black All Races White BlackFemales Females Females Females Females Females

Age-Adjusted Rates, 2011-2015Age at Diagnosis/Death:

All ages 7.4 7.4 8.4 2.3 2.2 3.7Under 65 7.0 7.2 7.1 1.8 1.7 2.565 and over 10.4 9.2 17.5 5.7 5.0 11.7

All ages (WHO world std)c 6.4 6.5 7.1 1.9 1.8 2.9

Age-Specific Rates, 2011-2015Age at Diagnosis/Death:

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1975-2015N


a Based on End Results data from a series of hospital registries and one population-based registry.b SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta).

Based on follow-up of patients into 2015. Expected survival rates are derived from the U.S. Annual Life Tables.c SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey,

Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey andGeorgia excluding ATL/RG). Expected survival rates are derived from life tables by socio-economic status, geography and racedeveloped by the SEER program.Based on follow-up of patients into 2015.

d Period survival provides a 2014 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts. It is computed here using three year calendar blocks (2010-2012: 0-1 year survival),(2009-2011: 1-2 year survival), (2008-2010: 2-3 year survival), (2007-2009: 3-4 year survival), (2006-2008: 4-5 years survival).

e Stage at diagnosis is classified using SEER Summary Stage 2000. Stage distribution percentages may not sum to 100 due to rounding.f The difference between 1975-1977 and 2008-2014 is statistically significant (p

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a Based on the SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).Expected survival rates are derived from the U.S. Annual Life Tables.

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Survival Time

1-year 86.6 87.2 87.1 87.7 89.2 89.0 89.4 88.1 89.6 88.4 85.8 88.0 86.6 86.4 87.3 86.3 88.3 87.3 88.8 87.7 85.0 87.1 86.6 87.12-year 77.8 77.2 77.9 79.5 82.2 81.8 80.1 81.3 82.9 81.1 79.2 79.6 79.1 77.3 77.4 78.6 78.7 79.4 79.8 79.8 76.2 78.0 79.73-year 73.2 72.7 73.1 75.2 78.8 77.8 75.8 76.7 78.4 76.5 75.5 74.9 75.8 73.3 72.4 75.7 74.7 75.7 74.2 73.5 72.3 73.74-year 70.3 69.6 70.4 72.2 76.0 74.6 73.3 74.0 76.2 74.3 72.5 72.5 72.4 69.9 70.0 73.6 72.9 72.6 71.1 70.9 69.55-year 68.3 67.6 68.6 70.4 74.9 73.5 71.8 72.5 74.5 72.2 70.5 69.8 70.3 67.5 68.2 71.9 71.1 69.8 68.4 69.16-year 67.1 65.7 67.3 69.0 73.7 72.7 70.1 70.9 73.4 71.1 69.3 68.9 68.7 66.0 67.4 70.0 70.2 67.3 67.37-year 66.0 64.1 66.1 68.1 72.5 71.6 69.6 69.7 73.0 70.3 68.0 68.0 67.3 65.3 67.0 68.9 69.2 66.28-year 65.0 62.8 65.0 67.2 71.8 70.6 69.2 69.4 72.6 70.0 67.5 67.6 66.0 63.6 65.9 68.4 67.99-year 64.3 62.2 64.3 66.2 70.8 69.1 67.7 68.8 72.2 68.9 67.0 67.2 65.6 62.7 65.2 67.610-year 63.1 61.5 63.7 65.6 70.0 68.6 67.0 67.8 70.9 68.3 66.8 66.5 65.2 61.8 64.511-year 62.4 60.8 63.1 64.9 69.7 68.0 66.1 67.1 69.4 67.9 66.0 66.0 64.3 61.212-year 61.7 60.0 62.3 64.3 68.6 66.8 65.9 66.1 68.7 66.8 65.0 65.3 64.013-year 61.1 59.5 61.6 63.8 67.1 66.2 65.6 64.8 67.7 65.9 64.0 65.014-year 60.5 58.7 61.0 63.2 66.6 65.5 65.3 64.6 67.0 65.5 63.615-year 59.8 57.9 60.4 62.6 66.3 64.8 64.9 64.2 66.8 64.816-year 59.3 57.2 59.7 62.0 65.5 64.4 63.2 64.0 66.517-year 58.6 56.2 58.9 61.6 64.7 63.4 62.4 63.618-year 58.1 55.4 58.7 60.7 64.2 62.6 62.319-year 57.3 54.9 58.2 60.2 63.7 61.820-year 56.6 54.2 57.2 59.9 63.3

Table 5.9Cancer of the Cervix Uteri (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races, Females

Year of Diagnosis

https://seer.cancer.gov/expsurvival/

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Devcan 6.7.6, April 2018, National Cancer Institute (https://surveillance.cancer.gov/devcan/).Source: Incidence data are from the SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta,

San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey,and Georgia excluding ATL/RG). Mortality data are from the NCHS public use data file for the total US.

a Underlying incidence and mortality data for American Indian/Alaska Native are based on the CHSDA(Contract Health Service Delivery Area)counties.

b Hispanic is not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives.Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry.

- Statistic could not be calculated.A percent of 0.00 represents a value that is below 0.005.

Risk of Being Risk of Being

Race/ Current Diagnosed with Cancer Risk of Dying Race/ Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 0.00 0.00 0.03 0.62 0.22 Asian/ 0 0.00 0.00 0.02 0.61 0.24

10 0.00 0.03 0.14 0.62 0.23 Pacific 10 0.00 0.02 0.08 0.62 0.24

20 0.03 0.14 0.28 0.62 0.23 Islander 20 0.02 0.08 0.18 0.62 0.24

30 0.11 0.24 0.36 0.59 0.22 30 0.06 0.16 0.28 0.60 0.24

40 0.14 0.25 0.35 0.49 0.21 40 0.10 0.22 0.33 0.54 0.23

50 0.12 0.22 0.30 0.36 0.18 50 0.12 0.23 0.33 0.45 0.21

60 0.11 0.19 0.24 0.25 0.14 60 0.11 0.22 0.30 0.34 0.18

70 0.09 0.15 - 0.16 0.10 70 0.11 0.20 - 0.24 0.14

80 0.07 - - 0.08 0.06 80 0.10 - - 0.14 0.10

White 0 0.00 0.00 0.04 0.60 0.21 American 0 0.00 0.00 0.02 0.75 0.22

10 0.00 0.04 0.15 0.61 0.21 Indian/ 10 0.00 0.02 0.14 0.76 0.22

20 0.03 0.15 0.29 0.61 0.21 Alaska 20 0.02 0.14 0.31 0.76 0.22

30 0.12 0.26 0.37 0.58 0.21 Nativea 30 0.12 0.29 0.42 0.74 0.22

40 0.14 0.26 0.35 0.47 0.19 40 0.18 0.31 0.39 0.64 0.20

50 0.12 0.21 0.28 0.33 0.16 50 0.14 0.22 0.31 0.48 0.16

60 0.10 0.18 0.21 0.22 0.12 60 0.09 0.18 0.31 0.36 0.13

70 0.08 0.13 - 0.14 0.09 70 0.11 0.25 - 0.30 0.09

80 0.06 - - 0.07 0.05 80 0.18 - - 0.25 0.06

Black 0 0.00 0.00 0.03 0.71 0.36 Hispanicb 0 0.00 0.00 0.03 0.81 0.30

10 0.00 0.03 0.13 0.73 0.36 10 0.00 0.03 0.14 0.82 0.30

20 0.03 0.13 0.26 0.73 0.36 20 0.03 0.14 0.29 0.82 0.30

30 0.10 0.23 0.36 0.70 0.36 30 0.11 0.26 0.40 0.79 0.30

40 0.13 0.27 0.40 0.61 0.34 40 0.15 0.29 0.44 0.69 0.28

50 0.14 0.27 0.39 0.50 0.31 50 0.14 0.29 0.42 0.54 0.25

60 0.14 0.27 0.36 0.38 0.26 60 0.16 0.29 0.39 0.41 0.21

70 0.15 0.25 - 0.28 0.20 70 0.14 0.25 - 0.27 0.16

80 0.13 - - 0.17 0.13 80 0.13 - - 0.16 0.12

Table 5.10

Cancer of the Cervix Uteri (Invasive)

Risk of Being Diagnosed With Cancer in 10, 20 and 30 Years,

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age, and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females, 2013-2015 By Race/Ethnicity

https://surveillance.cancer.gov/devcan/

SEER Cancer Statistics Review 1975-2015 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval. The AAPCs are calculated bythe Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute.

- Statistic not shown. Rate based on less than 16 cases for the time interval.Trend based on less than 10 cases for at least one year within the time interval.

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

b The SEER 9 areas are San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle,Utah, and Atlanta.The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey, Los Angeles, the AlaskaNative Registry, and Rural Georgia.The SEER 18 areas comprise the SEER 13 areas plus California excluding SF/SJM/LA, Kentucky,Louisiana, New Jersey, and Georgia excluding ATL/RG.

c The 2006-2015 AAPC estimates are based on a Joinpoint analysis with up to 4 Joinpoints overdiagnosis years 1992-2015.

d The 2006-2015 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2015.

e Hispanic and Non-Hispanic are not mutually exclusive from whites, blacks, Asian/PacificIslanders, and American Indians/Alaska Natives. Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry. The 2006-2015 Hispanic andNon-Hispanic mortality trends exclude deaths from New Hampshire and Oklahoma.

f Incidence data for American Indian/Alaska Native are based on the CHSDA(Contract Health ServiceDelivery Area) counties.

g US Mortality Files, National Center for Health Statistics, CDC.h The 2006-2015 mortality AAPCs are based on a Joinpoint analysis using years of death 1992-2015.* The APC is significantly different from zero (p

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a Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah and Atlanta.

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey, Los Angeles, the Alaska Native Registry and Rural Georgia.The SEER 18 areas comprise the SEER 13 areas plus California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey andGeorgia excluding ATL/RG.

- Statistic not shown. Rate based on less than 16 cases for the time interval.

All Races Whites Blacks All Ages Ages

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a US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

b The SEER 9 areas are San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah and Atlanta.The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey, Los Angeles, the Alaska Native Registry and Rural Georgia.The SEER 18 areas comprise the SEER 13 areas plus California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey andGeorgia excluding ATL/RG.

- Statistic not shown. Rate based on less than 16 cases for the time interval.

All Races Whites Blacks All Ages Ages


a US Mortality Files, National Center for Health Statistics, Centers for Disease Control andPrevention. Rates are per 100,000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130).

b Difference between state rate and total U.S. rate is statistically significant (p

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a US 2015 cancer prevalence counts are based on 2015 cancer prevalence proportions from the SEER registries and 1/1/2015US population estimates based on the average of 2014 and 2015 population estimates from the US Bureau of the Census.Prevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 40/23 years.

b c d Statistics based on (b) SEER 9 Areas (c) SEER 13 Areas excluding the Alaska Native Registry(d) NHIA for Hispanic for SEER 13 Areas excluding the Alaska Native Registry.

e Maximum limited-duration prevalence: 40 years for 1975-2015 SEER 9 data; 23 years for 1992-2015 SEER 13 data(excluding the Alaska Navtive Registry) used to calculate prevalence for Hispanics and Asian Pacific Islanders.

f Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groups.g h i (g) Cases diagnosed more than 40 years ago were estimated using the completeness index method (Capocaccia et. al. 1997,

Merrill et. al. 2000). (h) Complete prevalence is obtained by summing 0 to =40. (i) Age-specific completeness indexwas approximated using empirical data from historical Connecticut tumor registry.

- Statistic not shown. Statistic based on fewer than 5 cases estimated alive in SEER for the time interval.+ Not available.

Years Since Diagnosis 0 to

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Source: SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey,Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey andGeorgia excluding ATL/RG).Percents may not sum to 100 due to rounding.

a Excludes Kaposi Sarcoma, mesothelioma, lymphomas, leukemias, myelomas, lymphoreticular, and immunoproliferative diseases.b Estimates for American Indian/Alaska Native are based on the CHSDA(Contract Health Service Delivery Area) counties.c Hispanic is not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives.

Underlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry.d Epidermoid carcinoma includes squamous, basal, and transitional cell carcinomas.e Adenocarcinoma includes histologies 8140-8147,8160-8162,8180-8221,8250-8507,8514,8520-8551,8560,8570-8574,8576,8940-8941.f Other adenocarcinomas include histologies 8141-8147,8160-8162,8180-8221,8250-8507,8514,8520-8551,8571-8574,8576,8940-8941.g Other specific carcinomas include histologies 8012-8015,8030-8046,8150-8155,8170-8175,8230-8249,8508,8510-8513,8561-8562,

8575,8580-8671.h Sarcoma includes histologies 8680-8713,8800-8921,9040-9044,9120-9136,9150-9252,9370-9373,9540-9582.- Statistic not shown due to fewer than 16 cases during the time period.

Asian/Pacific American Indian/All Races White Black Islander Alaska Nativeb Hispanicc

Histologya Count Percent Count Percent Count Percent Count Percent Count Percent Count Percent

Carcinoma 16,209 97.9% 12,057 98.1% 2,214 96.7% 1,555 98.6% 134 97.8% 3,579 98.0%Epidermoid carcinomad 10,744 64.9% 7,762 63.1% 1,691 73.9% 1,021 64.7% 96 70.1% 2,434 66.6%(8050-8131)Squamous cell carcinoma 7,581 45.8% 5,447 44.3% 1,222 53.4% 719 45.6% 79 57.7% 1,632 44.7%(8070)

Squamous cell, 1,110 6.7% 780 6.3% 207 9.0% 99 6.3% - - 269 7.4%keratinizing (8071)

Squamous cell, 1,434 8.7% 1,083 8.8% 175 7.6% 147 9.3% - - 389 10.7%non-keratinizing (8072)

Squamous cell, 346 2.1% 261 2.1% 40 1.7% 27 1.7% - - 76 2.1%Microinvasive (8076)

Other (8050-8069, 273 1.6% 191 1.6% 47 2.1% 29 1.8% - - 68 1.9%8073-8075,8077-8131)

Adenocarcinomae 4,748 28.7% 3,784 30.8% 407 17.8% 460 29.2% 34 24.8% 1,003 27.5%Adenocarcinoma, NOS (8140) 2,461 14.9% 1,964 16.0% 212 9.3% 231 14.6% - - 528 14.5%Adenosquamous (8560,8570) 542 3.3% 401 3.3% 62 2.7% 72 4.6% - - 140 3.8%Other adenocarcinomasf 1,745 10.5% 1,419 11.5% 133 5.8% 157 10.0% - - 335 9.2%

Other specific carcinomasg 302 1.8% 212 1.7% 49 2.1% 36 2.3% - - 55 1.5%Unspecified, Carcinoma, NOS 415 2.5% 299 2.4% 67 2.9% 38 2.4% - - 87 2.4%(8010-8011,8020-8022)

Sarcomah 64 0.4% 42 0.3% 17 0.7% - - - - - -

Other specific types 172 1.0% 112 0.9% 35 1.5% 17 1.1% - - 29 0.8%(8720-8790,8930-8936,8950-9030,9060-9110,9260-9365,9380-9539)

Unspecified (8000-8005) 115 0.7% 83 0.7% 23 1.0% - - - - 29 0.8%

Total 16,560 100.0% 12,294 100.0% 2,289 100.0% 1,577 100.0% 137 100.0% 3,652 100.0%

Table 5.16

Cancer of the Cervix Uteri (Invasive)

Percent Distribution and Counts by Histology among Histologically Confirmed Cases, 2011-2015Females by Race

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20150

5

10

15

20

25

30

35

1975 1985 1995 2005 2015

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence, SEER Delay Adjusted Incidence and US Death RatesCancer of the Cervix Uteri, by Race

a

Figure 5.1

Source: SEER 9 areas and US Mortality Files (National Center for Health Statistics, CDC).Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103).Regression lines and APCs are calculated using the Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute.The APC is the Annual Percent Change for the regression line segments. The APC shown on the graph is for the most recent trend.The APC is significantly different from zero (p < 0.05).

a

*

White BlackRate per 100,000 Rate per 100,000

Year of Diagnosis/Death Year of Diagnosis/Death

SEER Incidence APCsDelay Adj, 2006-15 = 0.5Observed, 2005-15 = 0.1

US Mortality APC2004-15 = -0.2

SEER Incidence APCsDelay Adj, 1975-15 = -3.6*Observed, 1975-15 = -3.7*

US Mortality APC2002-15 = -2.4*

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0

5

10

15

20

1975 1985 1995 2005 20150

5

10

15

20

1975 1985 1995 2005 20150

20

40

60

80

1975 1985 1995 2005 20150

20

40

60

80

1975 1985 1995 2005 2015

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence, SEER Delay Adjusted Incidence and US Death RatesCancer of the Cervix Uteri, by Age and Race

a

Figure 5.2

Source: SEER 9 areas and US Mortality Files (National Center for Health Statistics, CDC).Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103).Regression lines and APCs are calculated using the Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute.The APC is the Annual Percent Change for the regression line segments. The APC shown on the graph is for the most recent trend.The APC is significantly different from zero (p < 0.05).

a

*

White Ages

Joinpoint Analyses for Whites and Blacks from 1975-2015and for Asian/Pacific Islanders, American Indians/Alaska Natives and Hispanics from 1992-2015

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20150

5

10

15

20

25

30

35

1975 1985 1995 2005 2015

White

Black

API

AI/AN

Hispanic

SEER Incidence and US Death RatesCancer of the Cervix Uteri

Figure 5.3

Source: Incidence data for whites and blacks are from the SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta).Incidence data for Asian/Pacific Islanders, American Indians/Alaska Natives and Hispanics are from the SEER 13 Areas (SEER 9 Areas, San Jose-Monterey,Los Angeles, Alaska Native Registry and Rural Georgia). Mortality data are from US Mortality Files, National Center for Health Statistics, CDC.Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103).Regression lines are calculated using the Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute. Joinpoint analyses for Whites andBlacks during the 1975-2015 period allow a maximum of 5 joinpoints. Analyses for other ethnic groups during the period 1992-2015 allow a maximum of 4 joinpoints.API = Asian/Pacific Islander.AI/AN = American Indian/Alaska Native. Rates for American Indian/Alaska Native are based on the CHSDA(Contract Health Service Delivery Area) counties.Hispanic is not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives. Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry. Mortality data for Hispanics exclude cases from New Hampshire and Oklahoma.

Incidence MortalityRate per 100,000 Rate per 100,000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

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0

5

10

15

20

25

30

35

1975 1985 1995 2005 20150

5

10

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25

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35

1975 1985 1995 2005 20150

5

10

15

20

25

30

35

1975 1985 1995 2005 2015

SEER 9 Delay-Adj. IncidenceSEER 9 Delay-Adj. Incidence SEER 9 Observed IncidenceSEER 9 Observed Incidence SEER 13 Delay-Adj. IncidenceSEER 13 Delay-Adj. Incidence SEER 13 Observed IncidenceSEER 13 Observed Incidence

SEER Observed Incidence and SEER Delay Adjusted Incidence RatesSEER 9 Areas Compared to SEER 13 Areas

Cancer of the Cervix Uteri, by Race

aFigure 5.4

Source: SEER 9 areas and SEER 13 areas.Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103).Regression lines and APCs are calculated using the Joinpoint Regression Program Version 4.6, February 2018, National Cancer Institute.The APC is the Annual Percent Change for the regression line segments. The APC shown on the graph is for the most recent trend.The APC is significantly different from zero (p < 0.05).

a

*

All Races White BlackRate per 100,000 Rate per 100,000 Rate per 100,000

Year of Diagnosis Year of Diagnosis Year of Diagnosis

SEER 9 APCsDelay Adj, 2007-15 = 0.1Observed, 2007-15 = -0.1

SEER 13 APCsDelay Adj, 2006-15 = -1.3*Observed, 2006-15 = -1.5*

SEER 9 APCsDelay Adj, 2006-15 = 0.5Observed, 2005-15 = 0.1

SEER 13 APCsDelay Adj, 2013-15 = 3.7Observed, 1992-15 = -1.9*



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Figure 5.5

Cancer of the Cervix Uteri5-Year SEER Conditional Relative Survival and

95% Confidence Intervals

Source: SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta,San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA,Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG). California excluding SF/SJM/LA, Kentucky,Louisiana, New Jersey and Georgia excluding ATL/RG contribute cases for diagnosis years 2000 and later.The remaining 13 SEER Areas contribute cases for the entire time period.Percent surviving is not shown if based on less than 25 cases.Confidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error.

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0, 1, or 3 years

1998-2014 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years


Trends in SEER Incidence and US Mortality, All AgesTrends in SEER Incidence and US Mortality, Ages

seer cancer statistics review 1975-2015...seer 13 delay-adjusted incidence b, 1992-2015 all races...

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