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Sumber : Dumont J. Randall, et.al., Acute Spinal Cord Injury, Part I: Pathophysiologic Mechanisms Clinical NeuropharmacologyVol. 24, No. 5, pp. 254–264.(2001). Lippincott Williams & Wilkins, Inc., Philadelphia. Kerusakan primer Perubahan potensial membran dan aktivasi channel ion Faktor sistemik : - Syok neurogenik - Gagal nafas excitotoxicity Pengaruh vaskular Kehilangan autoregulasi, vasospasme, thrombosis, dan perdarahan Peningkatan permeabilitas Edema interstisial dan kompresi korda Iskemia Kematian sel (cell death) Reactive Oxygen Species (ROS) Faktor lokal Inflamasi Glutamate release Mikroglia Neutrofil Pelepasan citokin Aktivasi reseptor glutamat IL-6, TNF, IL-10 Kerusakan membran Perubahan ekspresi genetik apoptosis

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  • Sumber :

    Dumont J. Randall, et.al., Acute Spinal Cord Injury, Part I: Pathophysiologic Mechanisms Clinical

    NeuropharmacologyVol. 24, No. 5, pp. 254264.(2001). Lippincott Williams & Wilkins, Inc., Philadelphia.

    Kerusakan primer

    Perubahan potensial

    membran dan

    aktivasi channel ion

    Faktor sistemik :

    - Syok neurogenik - Gagal nafas

    excitotoxicity

    Pengaruh vaskular

    Kehilangan autoregulasi,

    vasospasme, thrombosis,

    dan perdarahan

    Peningkatan

    permeabilitas

    Edema interstisial

    dan kompresi

    korda

    Iskemia

    Kematian sel (cell death)

    Reactive Oxygen Species

    (ROS)

    Faktor lokal Inflamasi

    Glutamate

    release Mikroglia Neutrofil

    Pelepasan citokin

    Aktivasi reseptor

    glutamat

    IL-6, TNF, IL-10

    Kerusakan

    membran

    Perubahan ekspresi

    genetik

    apoptosis


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