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COST Action MP1002 Nanoscale Insights into Ion Beam Cancer Therapy (NanoIBCT)

European Radiation Dosimetry Group e. V. WG 6 Computational Dosimetry

EMRP Project Biologically Weighted Quantities in Radiotherapy

Workshop registration website: http://www.ptb.de/nanocord/mind-ibct_registration.html

Second announcement and call for registration

International Workshop “Challenges in

micro- and nanodosimetry for ion

beam cancer therapy (MiND-IBCT)” Wiener Neustadt (Austria), 07-09 May 2014

Invitation

In the fields of micro- and nanodosimetry,

measurement and simulation techniques

are developed for a characterization of

charged particle track structure in terms of

measureable physical quantities that are

related to the radiation quality (i.e. biologi-

cal effectiveness) of ion beams.

This development of dosimetric concepts

and of measurement techniques for their

realization is the straightforward transla-

tional research for an uptake of the fun-

damental investigations performed within

the NanoIBCT action into practical applica-

tion in clinics.

With the increasing number of carbon ion

beam therapy facilities that have been or

will be going into operation in Europe, the

development of clinical protocols is immi-

nent and a meeting bringing together the

leading experts in micro- and

nanodosmetry to discuss the optimum

contribution of the two fields to this devel-

opment is more than timely.

Scope of the workshop

The workshop is intended to provide a forum for scientific exchange on the following topics

related to ion beam therapy:

• Microdosimetry

• Nanodosimetry

• Track structure modelling

• Biophysical models linking track structure and biological effects

In addition to sessions with presentations reporting on the state of the art and recent pro-

gress in the respective fields, it is also planned to have ample time for discussions, covering

a broad range of topics from fundamental aspects to specific technical issues or novel ap-

proaches and ideas. To this end, the programme foresees dedicated discussion sessions in




Second announcement MiND-IBCT Workshop page 2/7

which participants are invited to give short presentations sketching their problem or idea such

as to stimulate the discussion on the following focus areas:

• What are the most promising approaches for introducing micro- and nanodosimetric

quantities into clinical practise?

• What level of accuracy is needed, what level of accuracy can we achieve?

• Biophysical models for linking track structure and biological effects.

• What are the relevant properties of track structure that we need to measure and/or

simulate in order to characterize the biological effectiveness of ion radiation?

• How to assess the uncertainty of micro- and nanodosimetric measurements and

simulations?

Scientific Committee

Hans Rabus (PTB, Germany)

Hugo Palmans (NPL, UK)

Reinhard Schulte (LLU, USA)

Carmen Villagrasa (IRSN, France)

Andrey Solov'yov (U Frankfurt, Germany)

Kevin Prise (QUB, UK)

Thorsten Schneider (PTB, Germany)

Giulio Magrin (MedAustron, Austria)

Organising Committee

Thorsten Schneider (PTB, Germany)

Hans Rabus (PTB, Germany)

Heinke Harms (PTB, Germany)

Sandra Prondzinski (PTB, Germany)

Giulio Magrin (MedAustron, Austria)

Petra Wurzer (MedAustron, Austria)

Registration and conference fee

Registration should be done by 15 April 2014 using the link that was sent by email.

The conference fee is 90,- Euros for all

participants and shall be paid by bank

transfer free of charges for the recipient to

the following account:

Account holder: Hans Rabus

IBAN: DE49 1203 0000 1016 9908 04

BIC/SWIFT: BYLADEM1001

Reason for payment: MIND-IBCT + Name

The fee includes participation in the work-

shop, coffee breaks and lunches on all

three days of the workshop, and the con-

ference dinner.

Please send a copy of the bank transfer

(preferentially electronically or by fax) to

Email: [email protected]

Fax: +49 (0)531 592 696501

Travel reimbursement for invited speakers:

Travel and accommodation expenses of invited speakers will be partially reimbursed accord-

ing to the EU COST Actions procedure. Reimbursement forms will be provided by the organ-

isers following the online registration of speakers.


Workshop Programme

Wednesday 7 May

12:00 - 13:00 Welcome Reception and Registration

13:00 - 13:30 H. Rabus Introduction to the workshop

Session 1: Introducing Micro- & Nanodosimetry in clinical practice

13:30 - 14:00 G. Magrin,

R. Mayer

Radiation quality measurements of ion beams:

clinical feasibility and possible implementations.

14:00 - 14:30 S. Greilich Fluorescent nuclear track detectors as a tool for ion-beam

therapy research

14:30 - 15:00 Coffee Break

15:00 - 15:30 E. Scifoni Dose modifiers with particle beams from track structure to

treatment planning

15:30 - 17:30 Discussion: How to introduce Micro- & Nanodosimetry in clinical practice?

David Nikola Radiation effects on tumour progression

T. Friedrich Level of accuracy that is needed

G. Schettino Role of reactive species, Role of radiobiological studies

B. Madas Surviving fractions and statistical physics

S. Lacombe Effects of nano agents and needs of calculations

Thursday 8 May

09:00 - 12:00 Session 2: Biophysical Models: Biological aspects of radiation damage

09:00 - 09:40 K.M. Prise Understanding spatial and temporal track structure effects

with clinically relevant ion beam studies in biological systems

09:40 - 10:20 F. Ballarini A biophysical model linking DNA damage, chromosome ab-

errations and cell death


10:50 - 11:30 T. Friedrich RBE for Therapy: Development of the Local Effect Model

and uncertainty assessment based on the PIDE data base

11:30 - 12:00 G. Cabal The dependency of the alpha and beta paramteres from the

LQ model on LET: a bayesian model selection perspective

12:00 - 13:00 Lunch


Thursday 8 May

13:00 – 16:00 Session 3: Track structure calculations

13:00 - 13:30 W. Friedland Track structure and initial DNA-damage simulation for ion

energies around the Bragg- Peak

13:30 - 14:00 M. Davídková Carbon ion beam quality: LET spectra calculated by Geant4

at different positions along and around ion beam

14:00 - 14:30 M. Bug Simulation of electron tracks in water and DNA medium


15:00 - 15:30 C. Villagrasa Track structure calculations with the Geant4-DNA toolkit and

ongoing developments

15:30 - 16:00 A. Belchior,

R. Schulte

A novel approach to particle therapy radiation metrology

based on nanodosimetry - concepts and first results

16:00 - 18:00 Discussion: Biophysical models linking track structure and biological effects

B. Heide Relation between ionisation cluster size distribution and SSB/DSB

S. Incerti Geant4-DNA status

Friday 9 May

09:00 – 12:00 Session 4: Experimental Nano- and Microdosimetry

09:00 - 09:30 P. Colautti Microdosimetry of therapeutic hadron beams

09:30 - 10:00 S. Chiriotti Critical assessment of physical data to calibrate microdo-

simetric spectra

10:00 - 10:30 S. Galer Micro-calorimeters directly measuring lineal energy


11:00 - 11:30 S. Agosteo Experimental microdosimetry at nanometric level

11:30 - 12:00 S. Pzona Nanodosimetry of electrons

12:00 - 13:00 Lunch

13:00 - 13:30 G. Hilgers Challenges in track structure nanodosimetry

13:30 - 14:00 V. Conte Experimental nanodosimetry of carbon ions

14:00 - 15:30 Discussion: Current problems in experimental micro- and nanodosimetry

D. Moro On the use of mini TEPCs in hadron therapy

15:30 - 16:00 H. Rabus Closing remarks





Venue

The workshop MiND-IBCT takes place at

EBG MedAustron GmbH

Marie Curie-Straße 5

A-2700 Wiener Neustadt

Austria

Local contact

Giulio Magrin

phone +43 2622 26 100 – 611

mobile +43 664 73 460 479

fax +43 2622 26 100 319

email [email protected]

Wiener Neustadt is located about 60 km south of Vienna.

Directions to MedAustron

• BY PLANE

From Vienna International Airport take either bus 1187 to “Wien Meidling” or the City

Airport Train CAT to “Wien Mitte”. Then take a train to Wiener Neustadt (about 70

minutes).

• BY TRAIN

Alight the train at Wiener Neustadt central station (“Wr. Neustadt Hauptbahnhof”)

Please check the train schedule posted in the internet at www.oebb.at.

For connections from Vienna, see www.wienerlinien.at.

From Wiener Neustadt central station to MedAustron take bus line G at the bus ter-

minal “Hauptbahnhof/Busbahnhof” next to the railway station. Departures are at 21

and 51 minutes of every hour. The destination is “Samuel Morse Str./Fa.Stöhr” (or

“FH” or “TFZ”). Alight at stop “Firma Salesianer”. (see map on page 7 ).

• BY CAR from Vienna (from north)

Take the A2 in direction Graz to the exit Wöllersdorf; at the roundabout take the se-

cond exit in direction Wiener Neustadt; at the next roundabout, take the second exit

towards Wiener Neustadt (B21/Gutensteiner-Bundesstraße); at the following round-

about, take the first exit (onto B17); and the next roundabout, take the third exit onto

Nikolaus August Otto Straße; turn right at Prof. Dr. Stephan Koren Straße; turn

left at Johannes Gutenberg Straße; then turn left and take the first exit at the round-

about; the MedAustron building will be on the right side.

• BY CAR from Graz (from south)

Take the A2 direction Wien to the junction Knoten Wiener Neustadt in the direction

Eisenstadt/Wiener Neustadt/-Süd/Mattersburg; keep left, follow the signs to Wie-

ner Neustadt/B17 and take the B17/Neunkirchner Straße; continue on the B1; ; turn

right at Prof. Dr. Stephan Koren Straße; turn left at Johannes Gutenberg Straße;

then turn left and take the first exit at the roundabout; the MedAustron building will be

on the right side.





Accomodation

Hotels located in walking distance from MedAustron (for location refer to map on page 7):

Hotel Steinfeld (“A“)

Nikolaus A. Otto-Strasse 4

2700 Wiener Neustadt

+43-2622-26907

www.hotel-steinfeld.at

Hotel Orange Wings (“B“)

Rudolf Diesel-Straße 32


+43-2622 24380

www.orangewings.com

Hotel Freizeittempel (“C“)

Wiener Werkstraße 109

2700 Wiener Neustadt

+43-2622-20720

www.freizeittempel.at

Hotels in downtown Wiener Neustadt, about 15 minutes by bus from MedAustron:

Hotel Corvinus

Bahngasse 29-33


+43-2622-24134

www.hotel-corvinus.at

Hotel Zentral

Hauptplatz 27


+43-2622-23169

www.hotelzentral.at

Local transportation

To go from downtown Wiener Neustadt to MedAustron take bus line G at the bus terminal

“Hauptbahnhof/Busbahnhof” next to the railway station. Departures are at 21 and 51 minutes

of every hour. The destination is “Samuel Morse Str./Fa.Stöhr” (or “FH” or “TFZ”). Alight at

stop “Firma Salesianer”. (see map on page 7 ).

COST Action MP1002 Nanoscale Insightsinto Ion Beam Cancer Therapy (NanoIBCT)

Second announcement MiND-



EMRP Project Quantities in Radiotherapy

-IBCT Workshop


page 7/7

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