Searching theChemical Literature

Information Available in the Literature

• Physical constants– Melting point, boiling point, density, solubility data, toxicity

data, refractive index.

• Synthesis pathways

• Experimental procedures

• Spectroscopy data– FTIR, 1H-NMR, 13C-NMR, MS, UV-VIS

Where to Search

• Google scholar

• PubMed

• Reference books

– Merck Index

– CRC Handbook of Chemistry and Physics

– March

Merck Index• One-volume encyclopedia of chemicals, drugs

and biologicals that contains more than 10,000 monographs.

• Each monograph is a concise description of a single substance or a small group of closely related compounds.

• Since 1889, The Merck Index has become the standard reference for chemists, biochemists, pharmacologists, pharmacists, and related professionals.

Merck Index• human and veterinary drugs • biotech drugs and monoclonal antibodies • substances used for medical imaging • biological and natural products • plants and herbal medicines • nutraceuticals and cosmeceuticals • agricultural chemicals • industrial chemicals • laboratory reagents and catalysts • dyes, colors and indicators • environmentally significant substances

CRC Handbook of Chemistry and Physics

• The Table of Physical Constants for Organic Compounds:• Listed in alphabetical order by parent name.

– For 2-phenylethanol

Ethanol-2-phenyl

• The Table of Physical Constants for Organic Compounds:– Boiling points, etc.

CRC Handbook of Chemistry and Physics

Other Sources

• Chemical Abstracts (http://www.cas.org/) • Beilstein/Reaxys

(http://www.elsevier.com/online-tools/reaxys)

• SciFinder Scholar• Journal articles/Databases– ACS Publications– GALILEO (Current Contents: JACS, JOC)– JStor (Science)

Spectroscopy Databases

• National Institute of Standards and Technology

Chemistry WebBook– Mass Spectrometry and Infrared Spectroscopy data,

thermochemical data, and much, much more.

• Spectral Data Base System for Organic Compounds

(SDBS)– Huge searchable database of spectra, including IR, NMR, and

MS.

Safety Information

• Vermont SIRI MSDS Collection– Provides access to Material Safety Data Sheets

directly from chemical manufacturers and from an online database. Chemical Toxicity reports can also be found at this site.

List of compounds for Lab 1, Question 10

• Viagra• Lipitor• Dilaudid• Trastuzumab• Erlotinib• Taxol• Victoza• Stavudine• Memantine• Dimethyltryptamine• Psilocin• Mescaline